<it>Plasmodium falciparum </it>population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria by Carlsson Anja M, Ngasala Billy E, Dahlström Sabina, Membi Christopher, Veiga Isabel M, Rombo Lars, Abdulla Salim, Premji Zul, Gil J, Björkman Anders, Mårtensson Andreas

“…<p>Abstract</p> <p>Background</p> <p>This study aimed to explore <it>Plasmodium falciparum </it>population dynamics during the early phase of anti-malarial drug treatment with artemisinin-based combination therapy in children with clinical malaria in a high transmission area in Africa.…”
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Phytochemicals targeting Alzheimer's disease via the AMP-activated protein kinase pathway, effects, and mechanisms of action by Zheng Zhao, Jun Yan, Lei Huang, Xue Yang

“…Notably, urolithin A, artemisinin, justicidin A, berberine, stigmasterol, arctigenin, and rutaecarpine are promising AMPK agonists with anti-AD effects. …”
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Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment. by Verena Ilona Carrara, Julien Zwang, Elizabeth A Ashley, Ric N Price, Kasia Stepniewska, Marion Barends, Alan Brockman, Tim Anderson, Rose McGready, Lucy Phaiphun, Stephane Proux, Michele van Vugt, Robert Hutagalung, Khin Maung Lwin, Aung Pyae Phyo, Piyanuch Preechapornkul, Mallika Imwong, Sasithon Pukrittayakamee, Pratap Singhasivanon, Nicholas J White, François Nosten

“…Artemisinin combination treatments (ACT) are recommended as first line treatment for falciparum malaria throughout the malaria affected world. …”
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Assessment of the performance and challenges in the implementation of the test, treat and track (T3) strategy for malaria control among children under-five years in Ghana. by Margaret Kweku, Joyce B Der, William K Blankson, Haruna M Salisu, Francis Arizie, Sorengmen A Ziema, Jonathan M Gmanyami, Fortress Y Aku, Martin Adjuik

“…<h4>Background</h4>The World Health Organization recommended the Test, Treat and Track (T3) strategy for malaria control that, every suspected malaria case should be tested prior to treatment with Artemisinin-based combination therapy (ACT) and tracked. …”
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Malaria in pregnancy in India: a 50-year bird’s eye by Loick Pradel Kojom Foko, Vineeta Singh

“…Main challenges and knowledge gaps to MiP control included diagnosis, relapsing malaria, mixed Plasmodium infection treatment, self-medication, low density infections and utility of artemisinin-based combination therapies.ConclusionAll taken together, the findings could be immensely helpful to control MiP in malaria endemic areas.…”
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Starting at the community: Treatment-seeking pathways of children with suspected severe malaria in Uganda. by Nina C Brunner, Aliya Karim, Proscovia Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro, Aita Signorell, Giulia Delvento, Tristan T Lee, Mark Lambiris, Alex Ogwal, Juliet Nakiganda, Flavia Mpanga, Fred Kagwire, Maureen Amutuhaire, Christian Burri, Christian Lengeler, Phyllis Awor, Manuel W Hetzel

“…Children who only went to non-RHF providers were less likely to receive an artemisinin-based combination therapy (ACT) than children who attended a RHF (odds ratio [OR] = 0.64, 95% CI 0.51-0.79, p<0.001). …”
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Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway by Arnau Biosca, Miriam Ramírez, Alex Gomez-Gomez, Aritz Lafuente, Valentín Iglesias, Oscar J. Pozo, Santiago Imperial, Xavier Fernàndez-Busquets

“…The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting antimalarials. …”
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Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study.... by Rella Zoleko-Manego, Dearie G Okwu, Christian Handrich, Lia B Dimessa-Mbadinga, Malick A Akinosho, Wilfrid F Ndzebe-Ndoumba, Saskia D Davi, Daniel Stelzl, Luzia Veletzky, Andrea Kreidenweiss, Tamara Nordmann, Ayola A Adegnika, Bertrand Lell, Peter G Kremsner, Michael Ramharter, Ghyslain Mombo-Ngoma

“…Here, we explore the efficacy on concomitant urogenital schistosomiasis of first-line recommended artemisinin-based combination therapies (ACTs) and investigational second-generation ACTs when administered for the treatment of uncomplicated malaria in Gabon.…”
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Real-life effectiveness of anti-malarial treatment regimens: what are we aiming for? by Dorothea Ekoka Mbassi, Christoph Pfaffendorf, Ghyslain Mombo-Ngoma, Benno Kreuels, Michael Ramharter

“…Abstract Three-day artemisinin-based combination therapy (ACT) is the current standard of care for the treatment of malaria. …”
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From fever to anti-malarial: the treatment-seeking process in rural Senegal by Jones Caroline, Gueye Babacar, Helou Anthony, Diallo Rodio, Gueye Lamine, Bruce Jane, Smith Lucy A, Webster Jayne

“…<p>Abstract</p> <p>Background</p> <p>Currently less than 15% of children under five with fever receive recommended artemisinin-combination therapy (ACT), far short of the Roll Back Malaria target of 80%. …”
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Knowledge and behaviour as determinants of anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya by Abong'o Benard, Kaseje Dan, Raballah Evans, Jura Walter GZO, Watsierah Carren A, Ouma Collins

“…</p> <p>Results</p> <p>Consumers' knowledge on dosage and duration/frequency demonstrated that only 29.4% used the correct artemisinin-based combination therapy (ACT) dosage. …”
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Optimization of tomato (Solanum lycopersicum L.) juice fermentation process and analysis of its metabolites during fermentation by Lei Zhao, Ruxianguli Maimaitiyiming, Jingyang Hong, Liang Wang, Ying Mu, Bingze Liu, Huimin Zhang, Keping Chen, Aihemaitijiang Aihaiti

“…Terpenoids (16-deacetylgairin, (+)-Royleanone, artemisinin) were increased to varying degrees, which gives them good nutritional value and biological activity. …”
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Asymptomatic malaria infections and Pfmdr1 mutations in an endemic area of Nigeria by Titilope M. Dokunmu, Cynthia U. Adjekukor, Omolara F. Yakubu, Adetutu O. Bello, Jarat O. Adekoya, Olugbenga Akinola, Emmanuel O. Amoo, Abiodun H. Adebayo

“…These parasites harbour mutations on Pfmdr1 which contribute to artemisinin partner drug resistance; surveillance strategies to reduce the spread of drug resistance in endemic areas are needed to eliminate the reservoir of malaria parasites that can mitigate the eradication of malaria in Nigeria.…”
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Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites by Manel Ouji, Guillaume Barnoin, Álvaro Fernández Álvarez, Jean-Michel Augereau, Catherine Hemmert, Françoise Benoit-Vical, Heinz Gornitzka

“…The emergence of <i>Plasmodium falciparum</i> parasites, responsible for malaria disease, resistant to antiplasmodial drugs including the artemisinins, represents a major threat to public health. …”
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Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity by Valery M. Dembitsky, Ekaterina Ermolenko, Nick Savidov, Tatyana A. Gloriozova, Vladimir V. Poroikov

“…Lastly, the third group includes endoperoxides, which are 33.9% and show strong antiprotozoal activity with a confidence level of 90 to 99.6%. Interestingly, artemisinin and its analogs show strong antiprotozoal activity with 79 to 99.6% confidence against obligate intracellular parasites which belong to the genera Plasmodium, Toxoplasma, Leishmania, and Coccidia. …”
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Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death by Kuan-Yi Lu, Charisse Flerida A Pasaje, Tamanna Srivastava, David R Loiselle, Jacquin C Niles, Emily Derbyshire

“…Phosphatidylinositol 3-phosphate (PI(3)P) levels in Plasmodium falciparum correlate with tolerance to cellular stresses caused by artemisinin and environmental factors. However, PI(3)P function during the Plasmodium stress response was unknown. …”
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Dihydroartemisinin induces apoptosis and inhibits proliferation, migration, and invasion in epithelial ovarian cancer via inhibition of the hedgehog signaling pathway by Yanmei Liu, Shujun Gao, Jie Zhu, Ya Zheng, Haiyan Zhang, Hong Sun

“…Abstract Dihydroartemisinin (DHA), the primary of artemisinin extracted from the traditional Chinese medicine Artemisia annua, has been used in malaria treatment for a long time. …”
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Implementation of the Revised National Malaria Control Guidelines: Compliance and Challenges in Public Health Facilities in a Southern Nigerian State by Ubong Akpan, Ekpo Edet, Kazeem Arogundade, Chinyere Akpanika, Mabel Ekott, Saturday Etuk

“…More than 60% of uncomplicated malaria were being treated with parenteral artemether instead of oral artemisinin combination therapy (ACTs) as recommended. …”
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Malaria control in South Africa 2000–2010: beyond MDG6 by Moonasar Devanand, Nuthulaganti Tej, Kruger Philip S, Mabuza Aaron, Rasiswi Eric S, Benson Frew G, Maharaj Rajendra

“…A series of interventions have attributed to this decrease, these include: drug policy change from monotherapy to artemisinin combination therapy, insecticide change from pyrethroids back to DDT; cross border collaboration (South Africa with Mozambique and Swaziland through the Lubombo Spatial Development Initiative– LSDI) and financial investment in malaria control. …”
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A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score by Jimmy R. Angupale, Jonans Tusiimire, Ndidi C. Ngwuluka

“…Uganda, a malaria endemic country is experiencing malaria parasite resistance to some of the drugs used in the artemisinin-based combination therapy (ACT). In an effort to prioritize herbal medicines for new product development, this review synthesized the available safety and efficacy literature on the Ugandan anti-malarial plants to suggest most effective herbal plants. …”
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