QSAR-Based Virtual Screening of Natural Products Database for Identification of Potent Antimalarial Hits by Letícia Tiburcio Ferreira, Joyce V. B. Borba, José Teófilo Moreira-Filho, Aline Rimoldi, Carolina Horta Andrade, Fabio Trindade Maranhão Costa

“…In this context, biodiversity has been widely exploited as a resourceful channel of biologically active compounds, as exemplified by antimalarial drugs such as quinine and artemisinin, derived from natural products. Thus, combining a natural product library and quantitative structure–activity relationship (QSAR)-based virtual screening, we have prioritized genuine and derivative natural compounds with potential antimalarial activity prior to in vitro testing. …”
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Bioactive Peptides against Human Apicomplexan Parasites by Norma Rivera-Fernández, Jhony Anacleto-Santos, Brenda Casarrubias-Tabarez, Teresa de Jesús López-Pérez, Marcela Rojas-Lemus, Nelly López-Valdez, Teresa I. Fortoul

“…In recent years, great progress has been made in the field of antimalarial drugs and vaccines, although the resistance of <i>P. falciparum</i> to artemisinin has recently gained a foothold in Africa. …”
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Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. by Jamie T Griffin, T Deirdre Hollingsworth, Lucy C Okell, Thomas S Churcher, Michael White, Wes Hinsley, Teun Bousema, Chris J Drakeley, Neil M Ferguson, María-Gloria Basáñez, Azra C Ghani

“…We incorporated the effect of the switch to artemisinin-combination therapy (ACT) and increasing coverage of long-lasting insecticide treated nets (LLINs) from the year 2000 onwards. …”
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Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation by Qilong Li, Quan Yuan, Ning Jiang, Yiwei Zhang, Ziwei Su, Lei Lv, Xiaoyu Sang, Ran Chen, Ying Feng, Qijun Chen

“…Abstract Artemisinin (ART) and dihydroartemisinin (DHA), apart from their profound anti-malaria effect, can also beneficially modulate the host immune system; however, the underlying molecular mechanisms remain unclear. …”
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Time series analysis of malaria cases to assess the impact of various interventions over the last three decades and forecasting malaria in India towards the 2030 elimination goals by Mrigendra P. Singh, Harsh Rajvanshi, Praveen K. Bharti, Anup R. Anvikar, Altaf A. Lal

“…The key interventions of the Enhanced Malaria Control Project (EMCP), Intensified Malaria Control Project (IMCP), use of bivalent rapid diagnostic tests (RDT-Pf/Pv), artemisinin-based combination therapy (ACT), and involvement of the Accredited Social Health Activists (ASHAs) as front-line workers were found to result in the decline of malaria significantly. …”
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Availability of antimalarial medicines and inventory management at the community level: a case study of Bugesera district in Rwanda by Godelive Umulerwa Gakinahe, Eugene Rutungwa, Francois Mbonyinshuti, Egide Kayitare

“…In Rwanda, malaria interventions include the availability of antimalarial medications, notably Artemisinin-based combination treatments (ACTs) and quick diagnostic test kits (RDTs). …”
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Plant Metabolic Engineering by Multigene Stacking: Synthesis of Diverse Mogrosides by Jingjing Liao, Tingyao Liu, Lei Xie, Changming Mo, Xiyang Huang, Shengrong Cui, Xunli Jia, Fusheng Lan, Zuliang Luo, Xiaojun Ma

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Drug Resistance Molecular Markers of <i>Plasmodium falciparum</i> and Severity of Malaria in Febrile Children in the Sentinel Site for Malaria Surveillance of Melen in Gabon: Addit... by Jacques Mari Ndong Ngomo, Denise Patricia Mawili-Mboumba, Noé Patrick M’Bondoukwé, Bridy Moutombi Ditombi, Jeanne Vanessa Koumba Lengongo, Fanny Bertrande Batchy Ognagosso, Marielle Karine Bouyou-Akotet

“…The objective of this study was to analyze the relationship between the frequency of artemisinin-based combination (ACT) drug resistance molecular markers and clinical forms of <i>P. falciparum</i> malaria and parasitemia. …”
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Artesunate Impairs Growth in Cisplatin-Resistant Bladder Cancer Cells by Cell Cycle Arrest, Apoptosis and Autophagy Induction by Fuguang Zhao, Olesya Vakhrusheva, Sascha D. Markowitsch, Kimberly S. Slade, Igor Tsaur, Jindrich Cinatl, Martin Michaelis, Thomas Efferth, Axel Haferkamp, Eva Juengel

“…Since artesunate (ART), a derivative of artemisinin originating from Traditional Chinese Medicine, has been shown to exhibit anti-tumor activity, and to inhibit DNA damage repair, the impact of artesunate on cisplatin-resistant BCa was evaluated. …”
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Heterogeneous nutrient supply modulates root exudation and accumulation of medicinally valuable compounds in Artemisia annua and Hypericum perforatum by Martina Paponov, Juanita Flate, Jörg Ziegler, Cathrine Lillo, Ivan A. Paponov, Ivan A. Paponov

“…This study aims to fill this critical knowledge gap by investigating how deficiency and unequal distributions of nitrogen (N), phosphorus (P), and iron (Fe) affect plant growth and accumulation of the antimalarial drug artemisinin (AN) in leaves and roots of Artemisia annua, as well as AN exudation by roots. …”
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How do malaria testing and treatment subsidies affect drug shop client expenditures? A cross-sectional analysis in Western Kenya by Elizabeth Louise Turner, Jeremiah Laktabai, Diana Menya, Indrani Saran, Theodoor Visser, Aaron Woolsey, Wendy Prudhomme O'Meara

“…However, clients randomised to receive free treatment (artemisinin combination therapies (ACTs)) if they tested positive for malaria had similar spending levels as those randomised to a 67% ACT subsidy conditional on a positive test. …”
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Scale up of a Plasmodium falciparum elimination program and surveillance system in Kayin State, Myanmar [version 2; referees: 2 approved] by Daniel M. Parker, Jordi Landier, Aung Myint Thu, Khin Maung Lwin, Gilles Delmas, François H. Nosten, The Malaria Elimination Task Force Group

“…Throughout the GMS, Plasmodium falciparum parasites are increasingly resistant to artemisinin combination therapies. Given that there are no current alternative treatment therapies, one proposed solution to the threat of untreatable P. falciparum malaria is to eliminate the parasite from the region. …”
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Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular surveillance study from 200... by Sabyasachi Das, Sabyasachi Das, Satyajit Tripathy, Ankita Das, Meenakshi Kumari Sharma, Ayan Nag, Amiya Kumar Hati, Somenath Roy

“…IntroductionAfter being used vigorously for the previous two decades to treat P. falciparum, chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin-based combination therapy (artesunate-sulfadoxine-pyrimethamine) in an effort to combat multidrug-resistant parasites.MethodsWe set out to assess the genetic variants of sulfadoxine-pyrimethamine resistance and the effectiveness of its treatment in eastern India prior to, during, and 6 to 8 years following the introduction of the new pharmacological regime. …”
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Application of Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung and Trachea Exposure of Pyronaridine and Artesunate in Hamsters by Dong Wook Kang, Kyung Min Kim, Ju Hee Kim, Hea-Young Cho

“…A fixed-dose combination of pyronaridine and artesunate, one of the artemisinin-based combination therapies, has been used as a potent antimalarial treatment regimen. …”
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Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis by Xuanming Guo, Pallavi Asthana, Lixiang Zhai, Ka Wing Cheng, Susma Gurung, Jiangang Huang, Jiayan Wu, Yijing Zhang, Arun Kumar Mahato, Mart Saarma, Mart Ustav, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Pingyi Xu, Zhao-Xiang Bian, Hoi Leong Xavier Wong

“…Herein, we show that treatment with artesunate, an artemisinin derivative approved by the FDA for the treatment of severe malaria, effectively reduces body weight and improves metabolic profiles in preclinical models of obesity, including male mice with overnutrition-induced obesity and male cynomolgus macaques with spontaneous obesity, without inducing nausea and malaise. …”
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Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors by Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco-Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A. Kirkman, Huilin Li, Gang Lin

“…We further show that TDI-8304 kills P. falciparum as quickly as chloroquine and artemisinin and is active against P. cynomolgi at the liver stage. …”
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Three-Carbon Linked Dihydroartemisinin-Isatin Hybrids: Design, Synthesis and Their Antiproliferative Anticancer Activity by Min Dong, Guili Zheng, Feng Gao, Min Li, Chen Zhong

“…A significant part of them (half maximal inhibitory concentration/IC50: 5.72–55.52 μM) demonstrated considerable antiproliferative activity, and the activity was superior to that of dihydroartemisinin (IC50: 69.42–88.03 μM) and artemisinin (IC50: &gt;100 μM). In particular, two hybrids 6a, e (IC50: 5.72–9.84 μM) were not inferior to doxorubicin (IC50: 4.06 μM) and cisplatin (IC50: 9.38 μM) against drug-sensitive A549 cells and were more potent than doxorubicin (IC50: 54.32 and 15.10 μM) and cisplatin (IC50: 19.74 and 66.89 μM) against multidrug-resistant A549/DOX and A549/DDP lung cancer cell lines. …”
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Paediatric malaria case-management with artemether-lumefantrine in Zambia: a repeat cross-sectional study by Chanda Pascalina, Hamer Davidson H, Sipilanyambe Nawa, Ndhlovu Mickey, Zurovac Dejan, Simon Jon L, Snow Robert W

“…<p>Abstract</p> <p>Background</p> <p>Zambia was the first African country to change national antimalarial treatment policy to artemisinin-based combination therapy – artemether-lumefantrine. …”
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Copper- or Zinc-Fortified Nutrient Solution in Vertical Farming System Enriches Copper or Zinc and Elevates Phenolic Acid and Flavonoid Contents in <i>Artemisia annua</i> L. by Yang-Ju Son, Jai-Eok Park, Nakhyun Lee, Young-Woong Ju, Su-Hyeon Pyo, Changmin Oh, Gyhye Yoo, Chu Won Nho

“…The Cu or Zn treatment decreased the artemisinin content; however, these treatments increased the amounts of phenolic acids and flavonoids in <i>A. annua</i>. …”
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The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia. by Kamala Thriemer, Jeanne-Rini Poespoprodjo, Enny Kenangalem, Nicholas M Douglas, Paulus Sugiarto, Nicholas M Anstey, Julie Anne Simpson, Ric N Price

“…Records were collated from patients older than 1 year, with P. vivax infection, who were treated with an artemisinin combination therapy (ACT). The risks of re-presentation, hospitalization, major fall in haemoglobin and death within 30 days were quantified and compared between patients treated with and without PQ using a Cox regression model. …”
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