Biosynthesis of artemisinic acid in engineered Saccharomyces cerevisiae and its attractiveness to the mirid bug Apolygus lucorum by Dong TENG, Dan-feng LIU, ADEL Khashaveh, Pei-yao SUN, Ting GENG, Da-wei ZHANG, Yong-jun ZHANG

“…Volatile artemisinic acid of A. annua is a precursor of artemisinin that has been widely investigated in the Chinese herbal medicine field. …”
Get full text

Histopathological Changes in Kidneys of Developing Chick Embryo on Exposure to Artesunate by Rajesh Kumar, Lavlesh Kumar Mittal, Ghazal Mittal

“…It is a subordinate of a group of drugs artemisinin that have the most rapid action of all current drugs against Chloroquine resistant Plasmodium vivax and Plasmodium falciparum malaria. …”
Get full text

The Potentials of Ageratum conyzoides and Other Plants from Asteraceae as an Antiplasmodial and Insecticidal for Malaria Vector: An Article Review by Kusman IT, Pradini GW, Ma'ruf IF, Fauziah N, Berbudi A, Achadiyani A, Wiraswati HL

“…Irfan Taufik Kusman,1 Gita Widya Pradini,2 Ilma Fauziah Ma’ruf,3 Nisa Fauziah,2 Afiat Berbudi,2 Achadiyani Achadiyani,2 Hesti Lina Wiraswati2 1Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 2Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, 45363, Jawa Barat, Indonesia; 3Research Center for Climate and Atmosphere, National Research and Innovation Agency, Bandung, 40135 IndonesiaCorrespondence: Achadiyani Achadiyani; Hesti Lina Wiraswati, Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, 45363, Jawa Barat, Indonesia, Tel +6285795183426, Fax +62222037823, Email achadiyani@unpad.ac.id; hesti.lina@unpad.ac.idBackground: Malaria is a life-threatening disease prevalent in tropical and subtropical regions. Artemisinin combination therapy (ACT) used as an antimalarial treatment has reduced efficacy due to resistance, not only to the parasite but also to the vector. …”
Get full text

Polymorphism Analysis of <i>pfmdr1</i> and <i>pfcrt</i> from <i>Plasmodium falciparum</i> Isolates in Northwestern Nigeria Revealed the Major Markers Associated with Antimalarial R... by Ruqayya Adam, Muhammad M. Mukhtar, Umar F. Abubakar, Hajara A. Damudi, Abdullahi Muhammad, Sulaiman S. Ibrahim

“…Suspicion of failure in the effectiveness of artemisinin-based combination therapies (currently the first-line treatment of malaria, worldwide) is leading to the unofficial use of alternative antimalarials, including chloroquine and sulfadoxine/pyrimethamine, across northern Nigeria. …”
Get full text

Engaging schools in diagnosis and treatment of malaria: Evidence of sustained impact on morbidity and behavior by Andrew J. Macnab, Ronald Mukisa, Sharif Mutabazi, Rachel Steed

“… Background: In low and middle income countries (LMICs) teachers send home children found sick in class devolving subsequent care to parents; where malaria is endemic, morbidity is high as the most parents fail to access WHO-endorsed rapid diagnostic testing (RDT and prompt treatment with artemisinin combination therapy (ACT). Consequently malaria is the principal reason a child misses school; so, we trained teachers to use RDT to evaluate all sick pupils and give ACT promptly to those positive. …”
Get full text

Gut Microbiota and Aging: Traditional Chinese Medicine and Modern Medicine by Li J, Li D, Chen Y, Chen W, Xu J, Gao L

“…However, Nobel laureate Tu Youyou’s research on artemisinin has inspired researchers to study the importance of Traditional Chinese Medicine (TCM). …”
Get full text

Unveiling antiplasmodial alkaloids from a cumulative collection of Strychnos extracts by multi-informative molecular networks by Olivier Bonnet, Mehdi A. Beniddir, Pierre Champy, Gilles Degotte, Lúcia Mamede, Pauline Desdemoustier, Allison Ledoux, Alembert Tiabou Tchinda, Alembert Tiabou Tchinda, Luc Angenot, Michel Frédérich

“…Using the chloroquine-sensitive strain of Plasmodium falciparum (3D7), and artemisinin as positive control, a screening of antiplasmodial activities from 43 crude methanolic extracts from 28 species of the Strychnos genus was carried out in three independent assays. …”
Get full text

Molecular surveillance of anti-malarial drug resistance genes in Plasmodium falciparum isolates in Odisha, India by Ramakanta Rana, Nikhat Khan, Sonali Sandeepta, Sanghamitra Pati, Aparup Das, Madhusmita Bal, Manoranjan Ranjit

“…Mutations on gene associated with CQ (Pfcrt and Pfmdr1) were assessed by PCR amplification and restriction fragment length polymorphism, artemisinin (Pfk13) gene by DNA sequencing and SP (Pfdhfr and Pfdhps) genes by allele-specific polymerase chain reaction (AsPCR). …”
Get full text

“We don’t want our clothes to smell smoke”: changing malaria control practices and opportunities for integrated community-based management in Baringo, Kenya by Jacinter A. Amadi, Daniel O. Olago, George O. Ong’amo, Silas O. Oriaso, Isaac K. Nyamongo, Benson B. A. Estambale

“…Abstract Background The decline in global malaria cases is attributed to intensified utilization of primary vector control interventions and artemisinin-based combination therapies (ACTs). These strategies are inadequate in many rural areas, thus adopting locally appropriate integrated malaria control strategies is imperative in these heterogeneous settings. …”
Get full text

Experience and confidence in health technologies: evidence from malaria testing and treatment in Western Kenya by Judith N. Mangeni, Lucy Abel, Steve M. Taylor, Andrew Obala, Wendy Prudhomme O’Meara, Indrani Saran

“…In the case of malaria, effective tools such as malaria rapid diagnostic tests (RDTs) and artemisinin-combination therapies (ACTs) are both under-used and used inappropriately. …”
Get full text

Compounds targeting GPI biosynthesis or N-glycosylation are active against Plasmodium falciparum by Àngel Fenollar, Albert Ros-Lucas, María Pía Alberione, Nieves Martínez-Peinado, Miriam Ramírez, Miguel Ángel Rosales-Motos, Ling Y. Lee, Julio Alonso-Padilla, Luis Izquierdo

“…The emergence of resistance to first-line antimalarials, including artemisinin, the last effective malaria therapy in some regions, stresses the urgent need to develop new effective treatments against this disease. …”
Get full text

The Effect of Mass Testing, Treatment and Tracking on the Prevalence of Febrile Illness in Children under 15 in Ghana by Collins Stephen Ahorlu, Ignatius Cheng Ndong, Daniel Okyere, Benedicta A. Mensah, Chuo Ennestine Chu, Juliana Y. Enos, Benjamin Abuaku

“…The MTTT implementation involved testing all household members for malaria using RDTs, and positive cases were treated with Artemisinin-based combination therapy (ACT). Febrile illnesses among this cohort in the two weeks prior to the prevalence survey at baseline and endline were recorded to constitute date for analysis. …”
Get full text

Proactive community case management in Senegal 2014–2016: a case study in maximizing the impact of community case management of malaria by Seynabou Gaye, Janelle Kibler, Jean Louis Ndiaye, Mame Birame Diouf, Annē Linn, Alioune Badara Gueye, Fatou Ba Fall, Médoune Ndiop, Ibrahima Diallo, Moustapha Cisse, Mady Ba, Julie Thwing

“…Abstract The Senegal National Malaria Control Programme (NMCP) introduced home-based malaria management for all ages, with diagnosis by rapid diagnostic test (RDT) and treatment with artemisinin-based combination therapy (ACT) in 2008, expanding to over 2000 villages nationwide by 2014. …”
Get full text

Bibliometric analysis of antimalarial drug resistance by Jialu Zhang, Jialu Zhang, Muhammad Shahbaz, Muhammad Shahbaz, Muhammad Shahbaz, Muhammad Ijaz, Muhammad Ijaz, Huimin Zhang

“…Antimalarial drugs such as chloroquine and artemisinin have been the main compounds used to treat malaria. …”
Get full text

A three-dimensional microfluidic tumor cell migration assay to screen the effect of anti-migratory drugs and interstitial flow by Kalchman, Johann, Fujioka, Shingo, Chung, Seok, Kikkawa, Yamato, Mitaka, Toshihiro, Tanishita, Kazuo, Sudo, Ryo, Kamm, Roger Dale

“…In addition, the effect of Artemisinin, an anti-migratory compound, on HepG2 cells was quantitatively analyzed. …”
Get full text
Get full text

Reverse transcription PCR to detect low density malaria infections by Christensen, Peter, Bozdech, Zbynek, Watthanaworawit, Wanitda, Imwong, Mallika, Rénia, Laurent, Malleret, Benoît, Ling, Clare, Nosten, François

Get full text

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites by Wang, Chengqi, Dong, Yibo, Li, Chang, Oberstaller, Jenna, Zhang, Min, Gibbons, Justin, Pires, Camilla Valente, Xiao, Mianli, Zhu, Lei, Jiang, Rays H. Y., Kim, Kami, Miao, Jun, Otto, Thomas D., Cui, Liwang, Adams, John H., Liu, Xiaoming

“…Further analysis reveals chromatin accessibility changes at Plasmodium falciparum rings are partly associated with artemisinin resistance. MalariaSED illuminates the potential functional roles of noncoding variants in malaria parasites.…”
Get full text

Evolution and expansion of multidrug resistant malaria in Southeast Asia: a genomic epidemiology study by Hamilton, W, Amato, R, Tripura, R, Peto, T, Dhorda, M, Chan, X, Maude, R, Pearson, R, Rockett, K, White, N, Day, N, Kwiatkowski, D, Miotto, O

“…Previously unpublished samples were provided by two large-scale multisite projects: the Tracking Artemisinin Resistance Collaboration II (TRAC2) and the Genetic Reconnaissance in the Greater Mekong Subregion (GenRe-Mekong) project. …”

Efficacy and safety of artemether-lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: a... by Banda, C, Chaponda, M, Mukaka, M, Mulenga, M, Hachizovu, S, Kabuya, J, Mulenga, J, Sikalima, J, Kalilani-Phiri, L, Terlouw, D, Khoo, S, Lalloo, D, Mwapasa, V

“…<p><strong>BACKGROUND:</strong> HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. …”

The cost of uncomplicated childhood fevers to Kenyan households: implications for reaching international access targets. by Larson, B, Amin, A, Noor, A, Zurovac, D, Snow, R, Larson, B, Amin, A, Noor, A, Zurovac, D, Snow, R

“…Additional financing mechanisms that further reduce the costs of accessing care at a HCF and/or that make artemisinin-based combination therapies (ACTs) accessible for home management need to be developed and evaluated as a top priority.…”