Impact of malaria control interventions on malaria infection and anaemia in low malaria transmission settings: a cross-sectional population-based study in Sudan by Khalid Abdelmutalab Elmardi, Ishag Adam, Elfatih Mohamed Malik, Hmooda Toto Kafy, Mogahid Sheikheldien Abdin, Immo Kleinschmidt, Stef Kremers, Jessica Sophia Gubbels

“…Multi-level logistic regression analysis was used to assess the strength of association between real-life community-level utilization of malaria interventions [diagnosis, artemisinin-based combination therapies (ACTs) and long-lasting insecticidal nets (LLINs)] and the study outcomes: malaria infections and anaemia (both overall and moderate-to-severe anaemia). …”
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Prescribing patterns and compliance with World Health Organization recommendations for the management of severe malaria: a modified cohort event monitoring study in public health f... by H. Hilda Ampadu, Kwaku Poku Asante, Samuel Bosomprah, Samantha Akakpo, Pierre Hugo, Helga Gardarsdottir, Hubert G. M. Leufkens, Dan Kajungu, Alexander N. O. Dodoo

“…Abstract Background Injectable artesunate (AS) is the World Health Organization (WHO) recommended medication for the treatment of severe malaria followed with an oral artemisinin-based combination therapy (ACT). There are few studies indicating how physicians prescribe injectable AS, injectable quinine (Q) or injectable artemether (AR) and ACT for severe malaria. …”
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Knowledge and practices of private pharmacy auxiliaries on malaria in Abidjan, Côte d’Ivoire by Valérie A. Bedia-Tanoh, Étienne K. Angora, Sebastien A. J. Miezan, Estelle D. M. Koné-Bravo, Abibatou Konaté-Touré, Henriette Bosson-Vanga, Fulgence K. Kassi, Pulchérie C. M. Kiki-Barro, Vincent Djohan, Hervé E. I. Menan, William Yavo

“…Abstract Background The emergence of resistance to artemisinin derivatives in Southeast Asia constitutes a serious threat for other malaria endemic areas, particularly in Côte d’Ivoire. …”
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Susceptibility of primary, secondary and suspected vectors to Plasmodium vivax and Plasmodium falciparum infection in Ethiopia by Arega Tsegaye, Assalif Demissew, Dawit Hawaria, Hallelujah Getachew, Kassahun Habtamu, Abebe Asale, Guiyun Yan, Delenasaw Yewhalaw

“…Abstract Background Insecticide-based vector control interventions in combination with case management with artemisinin-based combination therapy has reduced malaria incidence and prevalence worldwide. …”
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Prevalence of G6PD deficiency and submicroscopic malaria parasites carriage in malaria hotspot area in Northwest, Tanzania by Alphaxard Manjurano, Eric Lyimo, Coleman Kishamawe, Justin Omolo, Jacklin Mosha, Miyaye Donald, Paul Kazyoba, Saidi Kapiga, John Changalucha

“…It may prevent onward transmission and help contain the spread of artemisinin resistance. However, higher dose of primaquine is associated with the risk of acute haemolytic anaemia in individuals with a deficiency in glucose-6-phosphate dehydrogenase. …”
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Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated <it>Plasmodium fal... by Diallo Mouctar, Lameyre Valérie, Dara Niawanlou, Dicko Yahia, Moor Vicky, Traore Aminata, Forlemu Doris, Ratsimbasoa Arsène, Randrianasolo Laurence, Ndiaye Ibrahima, Faye Babacar, Brasseur Philippe, Sagara Issaka, Randrianarivelojosia Milijaona, Ndiaye Jean, Djimde Abdoulaye, Same-Ekobo Albert, Gaye Oumar

“…<p>Abstract</p> <p>Background</p> <p>The use of artemisinin derivative-based combination therapy (ACT) such as artesunate plus amodiaquine is currently recommended for the treatment of uncomplicated <it>Plasmodium falciparum </it>malaria. …”
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Efficacy and safety of pyronaridine–artesunate versus artemether–lumefantrine in the treatment of acute uncomplicated malaria in children in South-West Nigeria: an open-labelled ra... by Catherine O. Falade, Adebola E. Orimadegun, Fiyinfoluwa I. Olusola, Obaro S. Michael, Oluwafunmibi E. Anjorin, Roland I. Funwei, Aduragbenro D. Adedapo, Abiola L. Olusanya, Bose E. Orimadegun, Olugbenga A. Mokuolu

“…Abstract Background In Nigeria, declining responsiveness to artemether–lumefantrine (AL), the artemisinin-based combination therapy (ACT) of choice since 2005, has been reported. …”
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Plasmodium pitheci malaria in Bornean orang-utans at a rehabilitation centre in West Kalimantan, Indonesia by Karmele Llano Sanchez, Alex D. Greenwood, Aileen Nielsen, R. Taufiq P. Nugraha, Wendi Prameswari, Andini Nurillah, Fitria Agustina, Gail Campbell-Smith, Anik Budhi Dharmayanthi, Rahadian Pratama, Indra Exploitasia, J. Kevin Baird

“…Illness and parasitaemia quickly resolved following administration of artemisinin-combined therapies. High levels of parasitaemia also sometimes occurred in asymptomatic cases, in which case, parasitaemia cleared spontaneously. …”
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Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro by H.M.P. Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Russell S. Addison, Sasha Hayes, Topul Rali, Tao Wang, Anson V. Koehler, Bill C.H. Chang, Andreas Hofmann, Rohan A. Davis, Robin B. Gasser

“…The Nobel Prize-winning discovery and development of the anti-parasitic drugs avermectin and artemisinin has renewed the interest in exploring natural products as anthelmintics. …”
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Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of <i>Artemisia nilagirica</i> (C.B. Clarke) Pamp by Jawaher J. Albaqami, Tancia P. Benny, Hamida Hamdi, Ammar B. Altemimi, Aswathi Moothakoottil Kuttithodi, Joice Tom Job, Anju Sasidharan, Arunaksharan Narayanankutty

“…The results of the phytochemical screening indicated a higher level of polyphenols and flavonoids in the extract and the LCMS analysis revealed the presence of various bioactive constituents including artemisinin.…”
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Effectiveness of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Pregnancy: Low Coverage and High Prevalence of <i>Plasmodium falciparum</i> dhfr-dhps Quintuple... by Carole Else Eboumbou Moukoko, Loick Pradel Kojom Foko, Angèle Ayina, Bernard Tornyigah, Annie Rachel Epote, Ida Calixte Penda, Patricia Epee Eboumbou, Serge Bruno Ebong, Gaetan Texier, Sandrine Eveline Nsango, Lawrence Ayong, Nicaise Tuikue Ndam, Albert Same Ekobo

“…The <i>Pfk13</i> gene mutations associated with artemisinin resistance were not detected. This study highlights the role of ANC in achieving optimal SP coverage in pregnant women, the mitigated impact of IPTp-SP on malaria outcomes, and the high prevalence of multiple SP-resistant <i>P. falciparum</i> parasites in the city of Douala that could compromise the efficacy of IPTp-SP.…”
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Risk of sudden unexplained death after use of dihydroartemisinin-piperaquine for malaria: A systematic review and Bayesian meta-analysis by Chan, X, Win, Y, Mawer, L, Tan, J, Brugada, J, White, N

“… <h4>Background</h4> <p>Dihydroartemisinin–piperaquine is an effective and well tolerated artemisinin-based combination therapy that has been assessed extensively for the prevention and treatment of malaria. …”

Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria by Mukaka, M, Onyamboko, MA, Olupot-Olupot, P, Peerawaranun, P, Suwannasin, K, Pagornrat, W, Kouhathong, J, Madmanee, W, Were, W, Namayanja, C, Onyas, P, Titin, H, Baseke, J, Muhindo, R, Kayembe, DK, Ndjowo, PO, Basara, BB, Bongo, GS, Okalebo, CB, Abongo, G, Uyoga, S, Williams, TN, Taya, C, Dhorda, M, Dondorp, AM, Waithira, N, Imwong, M, Maitland, K, Fanello, C, Day, NPJ, Tarning, J, White, NJ, Taylor, WRJ

“…Increasing CYP2D6 metaboliser activity score [poor (3/250), intermediate (52/250), normal (150/250), ultrarapid (5/250), indeterminate (40/250)] and baseline haemoglobin were significantly associated with a lower primaquine AUC0-last,which increased with increasing mg/kg dose and age but was independent of the artemisinin treatment used.</p> <p><strong>Interpretation:</strong> Age-dosed SLDPQ resulted in variable primaquine exposure that depended on bodyweight-adjusted dose, age, baseline haemoglobin and CYP2D6 metaboliser status, but not on dihydroartemisinin-piperaquine or artemether-lumefantrine. …”

Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005-2015, Ghana by Aregawi, M, Malm, KL, Wahjib, M, Kofi, O, Allotey, N-K, Yaw, PN, Abba-Baffoe, W, Segbaya, S, Owusu-Antwi, F, Kharchi, AT, Williams, RO, Saalfeld, M, Workneh, N, Shargie, EB, Noor, AM, Bart-Plange, C

“…<strong>Background</strong> Since 2005, the Government of Ghana and its partners, in concerted efforts to control malaria, scaled up the use of artemisinin-based combination therapy (ACT) and insecticide-treated nets (ITNs). …”

The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis by Chan, XHS, Haeusler, IL, Win, YN, Pike, J, Hanboonkunupakarn, B, Hanafiah, M, Lee, SJ, Djimdé, A, Fanello, CI, Kiechel, J-R, Lacerda, MVG, Ogutu, B, Onyamboko, MA, Siqueira, AM, Ashley, EA, Taylor, WRJ, White, NJ

“…The meta-analysis included 2,681 patients from 4 randomised controlled trials evaluating artemisinin-based combination therapies (ACTs) containing amodiaquine (n = 725), lumefantrine (n = 499), piperaquine (n = 716), and pyronaridine (n = 566), as well as monotherapy with chloroquine (n = 175) for uncomplicated malaria. …”

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a... by Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M.J. Koolen, Saman Honarnejad, Martijn W. Vos, Tonnie Huijs, Rob W.M. Henderson, Elodie Chenu, Benoît Laleu, Bailey C. Montefiore, Matthew D. Segall, James E.J. Mills, Eric M. Guantai, James Duffy, Maëlle Duffey

“…A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism of action. …”
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Galectins, Eosinophiles, and Macrophages May Contribute to Schistosoma japonicum Egg-Induced Immunopathology in a Mouse Model by Zhanhong Ye, Shiguang Huang, Yanxia Zhang, Xu Mei, Huanqin Zheng, Meiyu Li, Jianhuang Chen, Fangli Lu

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A Cross-Sectional Survey on the Malaria Control and Prevention Knowledge, Attitudes, and Practices of Caregivers of Children Under-5 in the Western Area of Sierra Leone by Joan Mabinty Koroma, Yuji Wang, Xiang Guo, Xiaoqing Zhang, Jone Jama Kpanda Ngobeh, Ahmed Mohamed Elamin Ali Gabir, Ziyao Li, Li Li, Rangke Wu, Xiaohong Zhou

“…Meanwhile, more urban caregivers (79.8%) followed a complete malaria treatment course of artemisinin-based combination therapies than the rural (63.3%), but in view of insecticide treated net use, more rural caregivers presented positive attitudes (85.3%) and practices (70.1%) than the urban (69.9%, 52.0%). (4) Conclusions: For better protection of children under-5 against lethal malaria, it is essential to provide better guidance at the community level for their caregivers, especially young mothers, in order to reduce some misconceptions and inappropriate behaviors. …”
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Biomedical Text Link Prediction for Drug Discovery: A Case Study with COVID-19 by Kevin McCoy, Sateesh Gudapati, Lawrence He, Elaina Horlander, David Kartchner, Soham Kulkarni, Nidhi Mehra, Jayant Prakash, Helena Thenot, Sri Vivek Vanga, Abigail Wagner, Brandon White, Cassie S. Mitchell

“…Examples of highly ranked predicted links to SARS-CoV-2: human leukocyte interferon, recombinant interferon-gamma, cyclosporine, antiviral therapy, zidovudine, chloroquine, vaccination, methotrexate, artemisinin, alkaloids, glycyrrhizic acid, quinine, flavonoids, amprenavir, suramin, complement system proteins, fluoroquinolones, bone marrow transplantation, albuterol, ciprofloxacin, quinolone antibacterial agents, and hydroxymethylglutaryl-CoA reductase inhibitors. …”
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Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD by Yifan Xu, Yifan Xu, Jing Li, Jing Li, Zhiwei Lin, Weiquan Liang, Lijie Qin, Jiabin Ding, Shuqi Chen, Shuqi Chen, Luqian Zhou

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