Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control by Jody E. Phelan, Anna Turkiewicz, Emilia Manko, Joseph Thorpe, Leen N. Vanheer, Marga van de Vegte-Bolmer, Nguyen Thi Hong Ngoc, Nguyen Thi Huong Binh, Nguyen Quang Thieu, Jesse Gitaka, Debbie Nolder, Khalid B. Beshir, Jamille G. Dombrowski, Silvia Maria Di Santi, Teun Bousema, Colin J. Sutherland, Susana Campino, Taane G. Clark

“…Markers associated with the partial resistance of artemisinin were found in WGS from isolates sourced from Southeast Asia (30.6%). …”
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Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021 by Ameyo Monique Dorkenoo, Marian Warsame, Essoham Ataba, Manani Hemou, Kossi Yakpa, Efoe Sossou, M’badi Mitigmsagou, Carmel Diwaba Teou, Emmanuelle Caspar, Laurence Ma, Koffi Edem Djadou, Tinah Atcha-Oubou, Charlotte Rasmussen, Didier Menard

“…Two isolates carried nonsynonymous mutations not known to be associated with artemisinin partial resistance (ART-R) (A578S and A557S). …”
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Liquid metal injected from interstitial channels for inhibiting subcutaneous hepatoma growth and improving MRI/MAT image contrast by Chaosen Lu, Chaosen Lu, Aocai Yang, Aocai Yang, Fei Xia, Guoqiang Liu, Guoqiang Liu, Hongliang Zhao, Wenwei Zhang, Wenwei Zhang, Yuanyuan Li, Yuanyuan Li, Jian Liu, Jian Liu, Guolin Ma, Guolin Ma, Hui Xia, Hui Xia

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Moderate Rainfall and High Humidity During the Monsoon Season, Negligence in Using Malaria Protection Methods and High Proportion of Mild Symptomatic Patients Were the Driving Forc... by Rahim Ali Ahmed, Rahim Ali Ahmed, Hari Shankar, Syed Shah Areeb Hussain, Ananta Swargiary, Avdhesh Kumar, Mohammad Tarique, Pankaj Prabhakar, Harpal Singh Suri, Kuldeep Singh, Joy Kumar Chakma, Jyoti Singh, Afluza Begum

“…Despite the malaria control efforts like long-lasting insecticidal nets distribution, rounds of indoor residual spray, the introduction of bi-valent rapid diagnostic tests and artemisinin combination therapy, malaria remained consistent in Dolonibasti sub-center of Orang block primary health center (BPHC) under the district Udalguri, Assam state followed by abrupt rise in cases in 2018. …”
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Dopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson’s disease by Bing Chen, Qian Zhang, Xiaoru Zhong, Xinwei Zhang, Xin Liu, Hongyang Wang, Fan Yang, Jingjing Zhang, Jingnan Huang, Yin-Kwan Wong, Piao Luo, Jigang Wang, Jichao Sun

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Selection of <i>pfcrt</i> K76 and <i>pfmdr1</i> N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali by Hamma Maiga, Anastasia Grivoyannis, Issaka Sagara, Karim Traore, Oumar B. Traore, Youssouf Tolo, Aliou Traore, Amadou Bamadio, Zoumana I. Traore, Kassim Sanogo, Ogobara K. Doumbo, Christopher V. Plowe, Abdoulaye A. Djimde

“…Background: Artemether-lumefantrine is a highly effective artemisinin-based combination therapy that was adopted in Mali as first-line treatment for uncomplicated <i>Plasmodium falciparum</i> malaria. …”
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Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen by Wahib M. Atroosh, Hesham M. Al-Mekhlafi, Adel Al-Jasari, Hany Sady, Salwa S. Dawaki, Fatin N. Elyana, Mona A. Al-Areeqi, Nabil A. Nasr, Awatif M. Abdulsalam, Lahvanya R. Subramaniam, Meram Azzani, Init Ithoi, Yee Ling Lau, Johari Surin

“…The emergence in Yemen of parasite resistance to chloroquine (CQ) prompted the adoption of artemisinin combination therapy (ACT) in 2009, which involves the use of artesunate plus sulphadoxine-pyrimethamine (AS + SP). …”
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Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis by Commons, RJ, Rajasekhar, M, Edler, P, Abreha, T, Awab, GR, Baird, JK, Barber, BE, Chu, CS, Cui, L, Daher, A, Gonzalez-Ceron, L, Grigg, MJ, Hwang, J, Karunajeewa, H, Lacerda, MVG, Ladeia-Andrade, S, Lidia, K, Llanos-Cuentas, A, Longley, RJ, Pereira, DB, Pasaribu, AP, Pukrittayakamee, S, Rijal, KR, Sutanto, I, Taylor, WRJ, Thanh, PV, Thriemer, K, Vieira, JLF, Watson, JA, Zuluaga-Idarraga, LM, White, NJ, Guerin, PJ, Simpson, JA, Price, RN

“…We included studies if they had active follow-up of at least 28 days, and if they included a treatment group with daily primaquine given over multiple days, where primaquine was commenced within 7 days of schizontocidal treatment and was given alone or coadministered with chloroquine or one of four artemisinin-based combination therapies (ie, artemether–lumefantrine, artesunate–mefloquine, artesunate–amodiaquine, or dihydroartemisinin–piperaquine). …”

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network by Hossain, MS, Commons, RJ, Douglas, NM, Thriemer, K, Alemayehu, BH, Amaratunga, C, Anvikar, AR, Ashley, EA, Asih, PBS, Carrara, VI, Lon, C, D’Alessandro, U, Davis, TME, Dondorp, AM, Edstein, MD, Fairhurst, RM, Ferreira, MU, Hwang, J, Janssens, B, Karunajeewa, H, Kiechel, JR, Ladeia-Andrade, S, Laman, M, Mayxay, M, McGready, R, Moore, BR, Mueller, I, Newton, PN, Thuy-Nhien, NT, Noedl, H, Nosten, F, Phyo, AP, Poespoprodjo, JR, Saunders, DL, Smithuis, F, Spring, MD, Stepniewska, K, Suon, S, Suputtamongkol, Y, Syafruddin, D, Tran, HT, Valecha, N, Van Herp, M, Van Vugt, M, White, NJ, Guerin, PJ, Simpson, JA, Price, RN

“…Our study aimed to quantify this risk and the associated determinants using an individual patient data meta-analysis in order to identify populations in which a policy of universal radical cure, combining artemisinin-based combination therapy (ACT) with a hypnozoitocidal antimalarial drug, would be beneficial. …”

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data by Anstey, N, Price, R, Davis, T, Karunajeewa, H, Mueller, I, Karunajeewa, H, D'Alessandro, U, Massougbodji, A, Nikiema, F, Ouedraogo, J, Tinto, H, Zongo, I, Ouedraogo, J, Tinto, H, Same-Ekobo, A, Kone, M, Menan, H, Toure, A, Yavo, W, Yavo, W, Kofoed, P, Alemayehu, B, Jima, D, Baudin, E, Espie, E, Nabasumba, C, Pinoges, L, Schramm, B, Cot, M, Deloron, P, Faucher, J, Cot, M, Deloron, P, Faucher, J, Faucher, J, Guthmann, J, Lell, B, Borrmann, S, Lell, B, Adjei, G, Kofoed, P, Ursing, J, Tjitra, E, Borrmann, S, Marsh, K, Peshu, J, Juma, E, Ogutu, B, Omar, SA, Sawa, P, Talisuna, A, Talisuna, A, Khanthavong, M, Mayxay, M, Newton, P, Mayxay, M, Piola, P, Djimde, A, Doumbo, O, Fofana, B, Sagara, I, Bassat, Q, Gonzalez, R, Menendez, C, Smithuis, F, Smithuis, F, Bousema, T, Kager, P, Mens, P, Mens, P, Schallig, H, Van den Broek, I, Van Vugt, M, Ibrahim, M, Falade, C, Meremikwu, M, Meremikwu, M, Gil, J, Karema, C, Ba, MS, Faye, B, Faye, O, Gaye, O, Ndiaye, J, Pene, M, Sow, D, Sylla, K, Tine, R, Penali, L, Barnes, K, Workman, L, Barnes, K, Workman, L, Bassat, Q, Gonzalez, R, Menendez, C, Mueller, I, Lima, A, Adam, I, Gadalla, N, Malik, E, Bjorkman, A, Gil, J, Martensson, A, Ngasala, B, Ursing, J, Rombo, L, Rombo, L, Rombo, L, Aliu, P, Duparc, S, Filler, S, Genton, B, Genton, B, Hodel, E, Olliaro, P, Abdulla, S, Kamugisha, E, Ngasala, B, Premji, Z, Shekalaghe, SA, Shekalaghe, SA, Ashley, E, Carrara, V, McGready, R, Nosten, F, Ashley, E, Faiz, A, Lee, S, White, N, Carrara, V, Dondorp, A, Smith, J, D'Alessandro, U, Tarning, J, Achan, J, Bukirwa, H, Yeka, A, Arinaitwe, E, Staedke, S, Kamya, MR, Kironde, F, Nabasumba, C, Bousema, T, Drakeley, C, Gadalla, N, Oguike, M, Sutherland, C, Checchi, F, Dahal, P, Flegg, J, Guerin, P, Moreira, C, Newton, P, Nsanzabana, C, Price, R, Sibley, C, Stepniewska, K, Tarning, J, Dahal, P, Dondorp, A, Flegg, J, Guerin, P, Lee, S, Marsh, K, McGready, R, Moreira, C, Newton, P, Nosten, F, Nsanzabana, C, Olliaro, P, Price, R, Tarning, J, White, N, Gething, P, Hay, S, Greenwood, B, Hodel, E, Ward, SA, Staedke, S, Van den Broek, I, Winstanley, P, Dorsey, G, Greenhouse, B, Rosenthal, P, Gadalla, N, Gil, J, Grivoyannis, A, Hamed, K, Hwang, J, Kachur, P, Hwang, J, Sibley, C, Nambozi, M, Resistance, W

“…Background: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. …”

Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis by Rajasekhar, M, Simpson, JA, Ley, B, Edler, P, Chu, CS, Abreha, T, Awab, GR, Baird, JK, Bancone, G, Barber, BE, Grigg, MJ, Hwang, J, Karunajeewa, H, Lacerda, MVG, Ladeia-Andrade, S, Llanos-Cuentas, A, Pukrittayakamee, S, Rijal, KR, Saravu, K, Sutanto, I, Taylor, WRJ, Thriemer, K, Watson, JA, Guerin, PJ, White, NJ, Commons, RJ, Price, RN, WorldWide Antimalarial Resistance Network (WWARN) Vivax Primaquine Dosing Efficacy, Tolerability and Safety Study Group

“…We included studies if they had active follow-up of at least 28 days, if they included a treatment group with daily primaquine given over multiple days where primaquine was commenced within 3 days of schizontocidal treatment and was given alone or coadministered with chloroquine or one of four artemisinin-based combination therapies (ie, artemether–lumefantrine, artesunate–mefloquine, artesunate–amodiaquine, or dihydroartemisinin–piperaquine), and if they recorded haemoglobin or haematocrit concentrations on day 0. …”

The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network. by Mohammad S Hossain, Robert J Commons, Nicholas M Douglas, Kamala Thriemer, Bereket H Alemayehu, Chanaki Amaratunga, Anupkumar R Anvikar, Elizabeth A Ashley, Puji B S Asih, Verena I Carrara, Chanthap Lon, Umberto D'Alessandro, Timothy M E Davis, Arjen M Dondorp, Michael D Edstein, Rick M Fairhurst, Marcelo U Ferreira, Jimee Hwang, Bart Janssens, Harin Karunajeewa, Jean R Kiechel, Simone Ladeia-Andrade, Moses Laman, Mayfong Mayxay, Rose McGready, Brioni R Moore, Ivo Mueller, Paul N Newton, Nguyen T Thuy-Nhien, Harald Noedl, Francois Nosten, Aung P Phyo, Jeanne R Poespoprodjo, David L Saunders, Frank Smithuis, Michele D Spring, Kasia Stepniewska, Seila Suon, Yupin Suputtamongkol, Din Syafruddin, Hien T Tran, Neena Valecha, Michel Van Herp, Michele Van Vugt, Nicholas J White, Philippe J Guerin, Julie A Simpson, Ric N Price

“…Our study aimed to quantify this risk and the associated determinants using an individual patient data meta-analysis in order to identify populations in which a policy of universal radical cure, combining artemisinin-based combination therapy (ACT) with a hypnozoitocidal antimalarial drug, would be beneficial.…”
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Two decades of malaria control in Malawi: Geostatistical Analysis of the changing malaria prevalence from 2000-2022 [version 2; peer review: 1 approved, 3 approved with reservation... by Tapiwa Ntwere, Atupele Kapito-Tembo, Halima Twabi, Esloyn Musa, Don P. Mathanga, Nyanyiwe Masingi-Mbeye, Lumbani Munthali, Maclear Masambuka, Abdoulaye Bangoura, Melody Sakala, Michael Give Chipeta, Dianne J Terlouw, Chimwemwe Ligomba, Austin Gumbo, James Chirombo, Donnie Mategula, Judy Gichuki, Michael Kayange, Benard Banda, Jacob Kawonga, Patrick Ken Kalonde, Alinafe Kalanga, Gracious Hamuza, Colins Kwizombe, Jacob Kafulafula, Vincent Samuel, Colins Mitambo, Dina Kamowa, Akuzike Banda

“…In the past two decades, available malaria control measures have been substantially scaled up, such as insecticide-treated bed nets, artemisinin-based combination therapies, and, more recently, the introduction of the malaria vaccine, the RTS,S/AS01. …”
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Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation by Junhui Chen, Qian Zhang, Jinan Guo, Di Gu, Jing Liu, Piao Luo, Yunmeng Bai, Jiayun Chen, Xinzhou Zhang, Sheng Nie, Chunbo Chen, Yulin Feng, Jigang Wang

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Human ApoE2 protects mice against Plasmodium berghei ANKA experimental cerebral malaria by Rui Liang, Hengjun Rao, Qin Pang, Ruixue Xu, Zhiwei Jiao, Lirong Lin, Li Li, Li Zhong, Yixin Zhang, Yazhen Guo, Nengming Xiao, Shengfa Liu, Xiao-Fen Chen, Xin-zhuan Su, Jian Li

“…Even with timely and effective treatment with antimalarial drugs such as quinine and artemisinin derivatives, survivors of CM may suffer long-term cognitive and neurological impairment. …”
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Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity by Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary

“…In the case of lung (A549) cancer cell lines, these compounds were recognized to be more efficient and selective than standard reference artemisinin (IC₅₀ = 100 µM) and chloroquine (IC₅₀ = 100 µM; SI: 0.03). …”
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Antiplasmodial and Antileishmanial Activities of a New Limonoid and Other Constituents from the Stem Bark of <i>Khaya senegalensis</i> by Gabrielle Ange Amang à Ngnoung, Yves Oscar Nganso Ditchou, Peron Bosco Leutcha, Darline Dize, Simplice Joël Ndendoung Tatsimo, Lauve Rachel Yamthe Tchokouaha, Theodora Kopa Kowa, Babalwa Tembeni, Hamadou Mamoudou, Madan Poka, Patrick Hulisani Demana, Xavier Siwe Noundou, Fabrice Fekam Boyom, Alain Meli Lannang

“…Positive controls consisted of artemisinin and chloroquine for <i>P. falciparum</i>, amphotericin B for <i>L. donovani</i>, and podophyllotoxin for cytotoxicity against RAW 264.7 cells. …”
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A single-cell transcriptomic landscape of mouse testicular aging by Wei Zhang, Siyu Xia, Wei Xiao, Yali Song, Li Tang, Min Cao, Jing Yang, Shuang Wang, Zhijie Li, Chengchao Xu, Jianqiao Liu, Shanchao Zhao, Chuanbin Yang, Jigang Wang

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Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malariaResearch in context by Mavuto Mukaka, Marie A. Onyamboko, Peter Olupot-Olupot, Pimnara Peerawaranun, Kanokon Suwannasin, Watcharee Pagornrat, Jindarat Kouhathong, Wanassanan Madmanee, Winifred Were, Cate Namayanja, Peter Onyas, Harriet Titin, Joy Baseke, Rita Muhindo, Daddy K. Kayembe, Pauline O. Ndjowo, Benjamin B. Basara, Georgette S. Bongo, Charles B. Okalebo, Grace Abongo, Sophie Uyoga, Thomas N. Williams, Chiraporn Taya, Mehul Dhorda, Arjen M. Dondorp, Naomi Waithira, Mallika Imwong, Kathryn Maitland, Caterina Fanello, Nicholas P.J. Day, Joel Tarning, Nicholas J. White, Walter R.J. Taylor

“…Increasing CYP2D6 metaboliser activity score [poor (3/250), intermediate (52/250), normal (150/250), ultrarapid (5/250), indeterminate (40/250)] and baseline haemoglobin were significantly associated with a lower primaquine AUC0-last,which increased with increasing mg/kg dose and age but was independent of the artemisinin treatment used. Interpretation: Age-dosed SLDPQ resulted in variable primaquine exposure that depended on bodyweight-adjusted dose, age, baseline haemoglobin and CYP2D6 metaboliser status, but not on dihydroartemisinin-piperaquine or artemether-lumefantrine. …”
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Anti-BVDV Activity of Traditional Chinese Medicine Monomers Targeting NS5B (RNA-Dependent RNA Polymerase) In Vitro and In Vivo by Nannan Chen, Dongjun Jiang, Baihui Shao, Tongtong Bai, Jinwei Chen, Yu Liu, Zecai Zhang, Yulong Zhou, Xue Wang, Zhanbo Zhu

“…The molecular docking screening showed that daidzein, curcumin, artemisinine, and apigenin could interact with BVDV-NADL-NS5B with the best binding energy fraction. …”
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