Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance. by White, N, Pongtavornpinyo, W, Maude, R, Saralamba, S, Aguas, R, Stepniewska, K, Lee, S, Dondorp, A, White, L, Day, N

“…For rapidly eliminated anti-malarials high-grade resistance can arise from a single drug exposure, but low-grade resistance can arise only from repeated inadequate treatments. Resistance to artemisinins is, therefore, unlikely to emerge with single drug exposures. …”

The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study. by Son, D, Thuy-Nhien, N, von Seidlein, L, Le Phuc-Nhi, T, Phu, N, Tuyen, N, Tran, N, Van Dung, N, Van Quan, B, Day, N, Dondorp, A, White, N, Thwaites, G, Hien, T

“…The evaluable P. falciparum isolates had molecular markers indicating resistance to artemisinins (K13-C580Y) and piperaquine (plasmepsin), but none had multiple copies of pfmdr1 associated with mefloquine resistance.…”

Prevalence of malaria resistance-associated mutations in Plasmodium falciparum circulating in 2017–2018, Bo, Sierra Leone by Tomasz A. Leski, Chris Rowe Taitt, Sophie M. Colston, Umaru Bangura, Andrew Holtz, Chadwick Y. Yasuda, Nathanael D. Reynolds, Joseph Lahai, Joseph M. Lamin, Victoria Baio, Rashid Ansumana, Rashid Ansumana, David A. Stenger, Gary J. Vora

“…In particular, progress in the development and administration of chemotherapeutic agents is threatened by evolved resistance to most of the antimalarials currently in use, including artemisinins.MethodsThis study analyzed the prevalence of mutations associated with antimalarial resistance in Plasmodium falciparum from 95 clinical samples collected from individuals with clinically confirmed malaria at a hospital in Bo, Sierra Leone between May 2017 and December 2018. …”
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Treatment-seeking behavior after the implementation of a unified policy of dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Papua, Indonesia by Devine, A, Kenangalem, E, Burdarm, L, Anstey, NM, Poespoprodjo, JR, Price, RN, Yeung, S

“…Artemisinin combination therapy is recommended for the treatment of multidrug resistant Plasmodium falciparum and Plasmodium vivax. …”

Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum by Moses N. Ngemenya, Grace Ntube Abwenzoh, Hermia Nalova Ikome, Denis Zofou, Fidele Ntie-Kang, Simon M. N. Efange

“…Abstract Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. …”
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<it>In vitro</it> antimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon by Zatra Rafika, Lekana-douki Jean, Lekoulou Faustin, Bisvigou Ulrick, Ngoungou Edgard, Ndouo Fousseyni S

“…<p>Abstract</p> <p>Background</p> <p>Malaria remains a major public health problem, due largely to emergence and widespread <it>P. falciparum</it> drug resistance. WHO recommends artemisinine combination based therapy (ACT) to overcome <it>P. falciparum</it> drug resistance, but reports of declining ACT efficacy have been published. …”
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Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery by Abshire, James R. (James Robbins)

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Pulmonary manifestations of malaria: Recognition and management by Taylor, W, Cañon, V, White, N

“…Malaria must be treated with effective drugs, but current choices are few: e.g. parenteral artemisinins, intravenous quinine or quinidine (in the US only). …”

Distribution patterns of molecular markers of antimalarial drug resistance in Plasmodium falciparum isolates on the Thai-Myanmar border during the periods of 1993–1998 and 2002–200... by Phunuch Muhamad, Papichaya Phompradit, Wanna Chaijaroenkul, Kesara Na-Bangchang

“…Abstract Background Polymorphisms of Plasmodium falciparum chloroquine resistance transporter (pfcrt), Plasmodium falciparum multi-drug resistance 1 (pfmdr1) and Plasmodium falciparum kelch 13-propeller (pfk13) genes are accepted as valid molecular markers of quinoline antimalarials and artemisinins. This study investigated the distribution patterns of these genes in P. falciparum isolates from the areas along the Thai-Myanmar border during the two different periods of antimalarial usage in Thailand. …”
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Dimensions de la vulnérabilité liée au paludisme dans deux zones de Madagascar : apports d’une approche mixte by Andry Herisoa Andrianasolo, Emma Raboanary, Chiarella Mattern, Thomas Kesteman, Dolorès Pourette, Christophe Rogier

“…En revanche, l’exposition à l’éducation pour la santé, la compréhension du paludisme, le recours aux agents communautaires et la prise d’une combinaison thérapeutique à base d’artémisinine en cas de prise d’antipaludique, y étaient significativement moins fréquents qu’à Ankazobe.Ainsi, à Brickaville où la prévalence du paludisme était la plus élevée, certaines connaissances, attitudes et pratiques, associées à la prévention ou au traitement étaient plus fréquentes alors que d’autres, notamment en matière thérapeutique, étaient plus souvent inappropriées. …”
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