P1265: UNRELATED FEMALE-TO-MALE BONE MARROW TRANSPLANTATION SHOULD BE PREFERRED OVER CORD BLOOD TRANSPLANTATION IN MALE RECIPIENTS. by Masaharu Tamaki, Yu Akahoshi, Yosuke Okada, Naoyuki Uchida, Masatsugu Tanaka, Noriko Doki, Masashi Sawa, Yumiko Maruyama, Yasunori Ueda, Shigesaburo Miyakoshi, Yuta Katayama, Toshiro Kawakita, Takafumi Kimura, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Ryu Yanagisawa, Kimikazu Yakushijin, Junya Kanda, Hideki Nakasone

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Circulating TNF receptor levels are associated with estimated glomerular filtration rate even in healthy individuals with normal kidney function by Tomohito Gohda, Maki Murakoshi, Terumi Shibata, Yusuke Suzuki, Hiroyuki Takemura, Koji Tsuchiya, Tomoki Okada, Mitsuru Wakita, Yuki Horiuchi, Yoko Tabe, Nozomu Kamei

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Solid cancer incidence risk in in the Ural cohort of the accidentally exposed population: 1956–2017 by L. Yu. Krestinina, S. S. Silkin, L. D. Mikryukova, S. B. Epifanova, A. V. Akleyev

“…The sex and age-averaged excess relative risk value of 0.075/100 mGy (the 95% confidence interval is 0.039–0.113) is comparable to that obtained in the studies of the Japanese cohort of atomic bomb survivors. The statistically significant excess relative risk value of 0.047/100 mGy, obtained separately for men, is in good agreement with that in professional cohorts where men prevail – in the cohort of the Chernobyl NPP accident clean-up workers and in the cohort of professional workers in the three countries (UK, France, USA). …”
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A new risk-assessment tool for venous thromboembolism in advanced lung cancer: a prospective, observational study by Yukari Tsubata, Takamasa Hotta, Kosuke Hamai, Naoki Furuya, Toshihide Yokoyama, Ryota Saito, Atsushi Nakamura, Takeshi Masuda, Megumi Hamaguchi, Shoichi Kuyama, Ryoichi Honda, Tadashi Senoo, Masamoto Nakanishi, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka, Tetsuya Kubota, Kunihiko Kobayashi, Takeshi Isobe

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PRRT2 mutation in a Japanese woman: Adult-onset focal epilepsy coexisting with movement disorders and cerebellar atrophy by Rie Motoyama, Takashi Matsudaira, Kiyohito Terada, Naotaka Usui, Koh-ichiro Yoshiura, Yukitoshi Takahashi

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Proof of principle study: synchrotron X-ray fluorescence microscopy for identification of previously radioactive microparticles and elemental mapping of FFPE tissues by Letonia Copeland-Hardin, Tatjana Paunesku, Jeffrey S. Murley, Jasson Crentsil, Olga Antipova, LuXi Li, Evan Maxey, Qiaoling Jin, David Hooper, Barry Lai, Si Chen, Gayle E. Woloschak

“…Abstract Biobanks containing formalin-fixed, paraffin-embedded (FFPE) tissues from animals and human atomic-bomb survivors exposed to radioactive particulates remain a vital resource for understanding the molecular effects of radiation exposure. …”
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Serum Concentration of Growth Differentiation Factor 15 and Atherosclerosis among General Older Japanese Individuals with Normal Weight by Yuji Shimizu, Naomi Hayashida, Hirotomo Yamanashi, Yuko Noguchi, Shin-Ya Kawashiri, Midori Takada, Kazuhiko Arima, Seiko Nakamichi, Yasuhiro Nagata, Takahiro Maeda

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Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique by Susumu Fukahori, Yasushi Obase, Chizu Fukushima, Daisuke Takao, Jun Iriki, Mutsumi Ozasa, Yoshiaki Zaizen, Noboru Takamura, Junya Fukuoka, Kazuto Ashizawa, Hiroshi Mukae

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Development and characterization of a novel variable low-dose rate irradiator for in vivo mouse studies by Davidson, Matthew Allen, Hembrador, Sheena, Olipitz, Werner, Yanch, Jacquelyn C, Engelward, Bevin P

“…Our limited knowledge of the biological effects of low dose radiation is mainly based on data from the atomic bomb Life Span Study (LSS) cohort. However, the total doses and dose rates in the LSS cohort are still higher than most environmental and occupational exposures in humans. …”
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Association Between Patient Preference for Inhaler Medications and Asthma Outcomes by Nakanishi Y, Iwamoto H, Miyamoto S, Nakao S, Higaki N, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Matsumoto N, Nakashima T, Onari Y, Fujitaka K, Haruta Y, Hamada H, Hozawa S, Hattori N

“…Yu Nakanishi,1 Hiroshi Iwamoto,1 Shintaro Miyamoto,1 Satoshi Nakao,1 Naoko Higaki,1 Kakuhiro Yamaguchi,1 Shinjiro Sakamoto,1 Yasushi Horimasu,1 Takeshi Masuda,1 Naoko Matsumoto,2 Taku Nakashima,1 Yojiro Onari,3 Kazunori Fujitaka,1 Yoshinori Haruta,4 Hironobu Hamada,5 Soichiro Hozawa,6 Noboru Hattori1 1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Respiratory Medicine, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, Hiroshima, Japan; 3Department of Respiratory Medicine, Hiroshima Mazda Hospital, Hiroshima, Japan; 4Haruta Respiratory Clinic, Hiroshima, Japan; 5Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences Hiroshima University, Hiroshima, Japan; 6Hiroshima Allergy and Respiratory Clinic, Hiroshima, JapanCorrespondence: Hiroshi Iwamoto, Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan, Tel +81-82-257-5196, Email iwamotohiroshig@gmail.comPurpose: Asthma guidelines recommend considering the patient preference to optimize medication choices. …”
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Risk Factors for Bleeding Events in Japanese Patients with Advanced Lung Cancer: Data from the Rising-VTE/NEJ037 Study by Keita Kawakado, Yukari Tsubata, Takamasa Hotta, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka, Tetsuya Kubota, Kunihiko Kobayashi, Takeshi Isobe

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Impact of anti-thymocyte globulin on survival outcomes in female-to-male allogeneic hematopoietic stem cell transplantation by Masaharu Tamaki, Yu Akahoshi, Masahiro Ashizawa, Yukiko Misaki, Satoshi Koi, Sung-Won Kim, Yukiyasu Ozawa, Shin-ichiro Fujiwara, Shinichi Kako, Ken-ichi Matsuoka, Masashi Sawa, Yuta Katayama, Makoto Onizuka, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Kimikazu Yakushijin, Hideki Nakasone

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Radiation-induced bystander effect and its clinical implications by Haoyi Tang, Luwei Cai, Xiangyang He, Zihe Niu, Haitong Huang, Wentao Hu, Huahui Bian, Hao Huang

“…Epidemiological studies of Japanese atomic bomb survivors have proposed the linear-non-threshold model as the dominant standard in the field of radiation protection. …”
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Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response by Sudip Banerjee, Tyler Alexander, Debajyoti Majumdar, Thomas Groves, Frederico Kiffer, Jing Wang, Akshita Gorantla, Antiño R. Allen, Snehalata A. Pawar

“…All these factors contribute to the increased radiation sensitivity in the elderly as shown by epidemiological studies of the Japanese atomic bomb survivors. There is a global increase in the aging population, who may be at increased risk of exposure to ionizing radiation (IR) as part of cancer therapy or accidental exposure. …”
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Optimizing cardiac amyloidosis assessment: utility of 1-h and 3-h 99mTc-PYP imaging by Aiganym Imakhanova, Reiko Ideguchi, Hiroaki Kawano, Koji Maemura, Takashi Kudo

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Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10) by Hiroki Mizumaki, Ken Ishiyama, Jun Aoki, Jinichi Mori, Shohei Mizuno, Noriko Doki, Takahiro Fukuda, Naoyuki Uchida, Masahito Onizuka, Masatsugu Tanaka, Yuta Katayama, Yukiyasu Ozawa, Kazuhiro Ikegame, Satoru Takada, Toshiro Kawakita, Nobuyuki Aotsuka, Yoshiko Atsuta, Masamitsu Yanada

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Epidemiological studies of low-dose ionizing radiation and cancer: Summary bias assessment and meta-analysis by Hauptmann, M, Daniels, RD, Cardis, E, Cullings, HM, Kendall, G, Laurier, D, Linet, MS, Little, MP, Lubin, JH, Preston, DL, Richardson, DB, Stram, DO, Thierry-Chef, I, Schubauer-Berigan, MK, Gilbert, ES, Berrington de Gonzalez, A

“…Furthermore, the magnitude of the cancer risks from these low-dose radiation exposures was statistically compatible with the radiation dose-related cancer risks of the atomic bomb survivors.…”

Clinical features of children with polycythemia vera, essential thrombocythemia, and primary myelofibrosis in Japan: A retrospective nationwide survey by Hisashi Ishida, Yuji Miyajima, Nobuyuki Hyakuna, Satoru Hamada, Takeo Sarashina, Risa Matsumura, Katsutsugu Umeda, Tetsuo Mitsui, Naoto Fujita, Daisuke Tomizawa, Kevin Y. Urayama, Yasushi Ishida, Takashi Taga, Masatoshi Takagi, Souichi Adachi, Atsushi Manabe, Toshihiko Imamura, Katsuyoshi Koh, Akira Shimada, Leukemia/Lymphoma Committee of the Japanese Society of Pediatric Hematology Oncology (JSPHO)

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Development of Innate-Immune-Cell-Based Immunotherapy for Adult T-Cell Leukemia–Lymphoma by Maho Nakashima, Yoshimasa Tanaka, Haruki Okamura, Takeharu Kato, Yoshitaka Imaizumi, Kazuhiro Nagai, Yasushi Miyazaki, Hiroyuki Murota

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A Tunguska sized airburst destroyed Tall el-Hammam a Middle Bronze Age city in the Jordan Valley near the Dead Sea by Ted E. Bunch, Malcolm A. LeCompte, A. Victor Adedeji, James H. Wittke, T. David Burleigh, Robert E. Hermes, Charles Mooney, Dale Batchelor, Wendy S. Wolbach, Joel Kathan, Gunther Kletetschka, Mark C. L. Patterson, Edward C. Swindel, Timothy Witwer, George A. Howard, Siddhartha Mitra, Christopher R. Moore, Kurt Langworthy, James P. Kennett, Allen West, Phillip J. Silvia

“…The proposed airburst was larger than the 1908 explosion over Tunguska, Russia, where a ~ 50-m-wide bolide detonated with ~ 1000× more energy than the Hiroshima atomic bomb. A city-wide ~ 1.5-m-thick carbon-and-ash-rich destruction layer contains peak concentrations of shocked quartz (~ 5–10 GPa); melted pottery and mudbricks; diamond-like carbon; soot; Fe- and Si-rich spherules; CaCO3 spherules from melted plaster; and melted platinum, iridium, nickel, gold, silver, zircon, chromite, and quartz. …”
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