A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. by Oriol Ros, Pablo José Barrecheguren, Tiziana Cotrufo, Martina Schaettin, Cristina Roselló-Busquets, Alba Vílchez-Acosta, Marc Hernaiz-Llorens, Ramón Martínez-Marmol, Fausto Ulloa, Esther T Stoeckli, Sofia J Araújo, Eduardo Soriano

“…We show that loss-of-function of STX1 results in pre- and post-commissural axonal guidance defects in the midline of fly, chick, and mouse embryos. …”
Get full text

The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord. by Mary Ann Manavalan, Ivana Gaziova, Krishna Moorthi Bhat

“…Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. …”
Get full text

Mucopolysaccharidosis type II zebrafish model exhibits early impaired proteasomal-mediated degradation of the axon guidance receptor Dcc by Rosa Manzoli, Lorenzo Badenetti, Matteo Bruzzone, Maria Carla Macario, Michela Rubin, Marco Dal Maschio, Antonella Roveri, Enrico Moro

“…In this work, we discovered that the axon guidance receptor Deleted in Colorectal Cancer (Dcc) is significantly dysregulated in the brain of ids mutant zebrafish since embryonic stages. …”
Get full text

Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney by Annie Shao, Micah D. Gearhart, Siu Chiu Chan, Zhen Miao, Katalin Susztak, Peter Igarashi

“…These studies show that HNF-1β directly regulates the expression of multiple axon guidance genes in the developing mouse kidney. Dysregulation of axon guidance genes may underlie kidney defects in HNF-1β mutant mice.…”
Get full text

<i>UNC5C</i>: Novel Gene Associated with Psychiatric Disorders Impacts Dysregulation of Axon Guidance Pathways by Simone Treccarichi, Pinella Failla, Mirella Vinci, Antonino Musumeci, Angelo Gloria, Anna Vasta, Giuseppe Calabrese, Carla Papa, Concetta Federico, Salvatore Saccone, Francesco Calì

Subjects: Get full text

Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity by Gauri Kulkarni, Zhennan Xu, Ahmed M. Mohamed, Haichang Li, Xia Tang, Gerard Limerick, William G. Wadsworth

Subjects: Get full text

Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis by Yuko Kawamoto, Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, Yoshio Goshima, Hideyuki Takeuchi, Hiroshi Doi, Fumio Nakamura, Fumiaki Tanaka

Subjects: Get full text

Notch-dependent binary fate choice regulates the Netrin pathway to control axon guidance of Drosophila visual projection neurons by Yu Zhang, Scott Lowe, Andrew Z. Ding, Xin Li

“…Here, we report that Notch-dependent binary fate choice in Drosophila medulla neurons is required to regulate the Netrin axon guidance pathway, which controls targeting of transmedullary (Tm) neurons to lobula. …”
Get full text

MIG-10/Lamellipodin and AGE-1/PI3K Promote Axon Guidance and Outgrowth in Response to Slit and Netrin by Chang, Chieh, Adler, Carolyn E., Krause, Matthias, Clark, Scott G., Tessier-Lavigne, Marc, Bargmann, Cornelia I., Gertler, Frank

“…Surprisingly, filopodia are largely dispensable for accurate axon guidance.…”
Get full text
Get full text

Inhibition of Rho GTPases in Invertebrate Growth Cones Induces a Switch in Responsiveness to Retinoic Acid by Alysha Johnson, Tamara I. N. Nasser, Gaynor E. Spencer

Subjects: “…axon guidance…”
Get full text

Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin by Denise M Poltavski, Pauline Colombier, Jianxin Hu, Alicia Duron, Brian L Black, Takako Makita

Subjects: “…axon guidance…”
Get full text

Interpreting the Entire Connectivity of Individual Neurons in Micropatterned Neural Culture With an Integrated Connectome Analyzer of a Neuronal Network (iCANN) by June Hoan Kim, Jae Ryun Ryu, Boram Lee, Uikyu Chae, Jong Wan Son, Bae Ho Park, Il-Joo Cho, Woong Sun

Subjects: Get full text

SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate by Hugo Ducuing, Thibault Gardette, Aurora Pignata, Karine Kindbeiter, Muriel Bozon, Olivier Thoumine, Céline Delloye-Bourgeois, Servane Tauszig-Delamasure, Valerie Castellani

Subjects: “…axon guidance…”
Get full text

NMDA receptors control development of somatosensory callosal axonal projections by Jing Zhou, Yong Lin, Trung Huynh, Hirofumi Noguchi, Jeffrey O Bush, Samuel J Pleasure

Subjects: “…axon guidance…”
Get full text

Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death by Jenea M. Bin, Dong Han, Karen Lai Wing Sun, Louis-Philippe Croteau, Emilie Dumontier, Jean-Francois Cloutier, Artur Kania, Timothy E. Kennedy

“…Netrin-1−/− mice die earlier and exhibit more severe axon guidance defects than netrin-1 gene-trap mice, revealing that complete loss of function is more severe than previously reported. …”
Get full text

Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies by P. A. Goldsteen, P. A. Goldsteen, A. M. Sabogal Guaqueta, P. P. M. F. A. Mulder, I. S. T. Bos, I. S. T. Bos, M. Eggens, L. Van der Koog, L. Van der Koog, J. T. Soeiro, A. J. Halayko, K. Mathwig, L. E. M. Kistemaker, L. E. M. Kistemaker, L. E. M. Kistemaker, E. M. J. Verpoorte, A. M. Dolga, A. M. Dolga, R. Gosens, R. Gosens

Get full text

Astrocytes of the Anterior Commissure Regulate the Axon Guidance Pathways of Newly Generated Neocortical Neurons in the Opossum <i>Monodelphis domestica</i> by Katarzyna Bartkowska, Paulina Koguc-Sobolewska, Ruzanna Djavadian, Krzysztof Turlejski

Subjects: “…axon guidance mechanisms…”
Get full text

Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary by Serena Brundu, Virginia Napolitano, Giulia Franzolin, Ettore Lo Cascio, Roberta Mastrantonio, Gabriele Sardo, Eliano Cascardi, Federica Verginelli, Sergio Sarnataro, Gennaro Gambardella, Alberto Pisacane, Alessandro Arcovito, Carla Boccaccio, Paolo M Comoglio, Enrico Giraudo, Luca Tamagnone

“…In sum, we found that a novel activating mutation of the axon guidance gene PLXNB2 sustains proliferative autonomy and confers invasive properties to stem cells isolated from cancers of unknown primary, in EGFR‐dependent manner.…”
Get full text

Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases. by Mahekta R Gujar, Aubrie M Stricker, Erik A Lundquist

“…Mutations in fmo-1, fmo-4, fmo-5, and ehbp-1 showed VD/DD axon guidance and branching defects, and variably enhanced unc-40 and unc-5 VD/DD axon guidance defects. …”
Get full text

miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA by Anaïs Bellon, Archana Iyer, Simone Bridi, Flora C.Y. Lee, Cesaré Ovando-Vázquez, Eloina Corradi, Sara Longhi, Michela Roccuzzo, Stephanie Strohbuecker, Sindhu Naik, Peter Sarkies, Eric Miska, Cei Abreu-Goodger, Christine E. Holt, Marie-Laure Baudet

Subjects: Get full text