Pancreatic Involvement in the Course of Inflammatory Bowel Disease in Children—A Multi-Center Study by Urszula Daniluk, Paulina Krawiec, Elżbieta Pac-Kożuchowska, Łukasz Dembiński, Jan Stanisław Bukowski, Aleksandra Banaszkiewicz, Anna Woźniuk-Kaźmierczak, Elżbieta Czkwianianc, Jan Brylak, Jarosław Walkowiak, Agnieszka Borys-Iwanicka, Anna Kofla-Dłubacz, Tomasz Pytrus, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn

“…Idiopathic PI was the most common (57%), followed by drug-induced PI (37%) and azathioprine (AZA). In patients with AZA-induced AP, the successful introduction of 6-mercaptopurine (6-MP) to therapy was noted in 62.5% of the children. …”
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Plasma antioxidant potential measured by total radical trapping antioxidant parameter in a cohort of multiple sclerosis patients by Marge Kartau, Joonas Kartau, Marjatta Pohja, Auli Verkkoniemi‐Ahola

“…The neurological and radiological data were collected from patient records from Helsinki University Hospital during 2012–2013 when first‐line injectables of moderate‐efficacy, natalizumab (NTZ), and fingolimod (FTY) of high efficacy disease modifying therapies and in some cases azathioprine (AZT) were used to treat MS. Results TRAP values were negatively associated with expanded disability status scale (EDSS) score with p‐value .052, β = −28. …”
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Treatment strategies and treatment-related adverse events in MG according to the age of onset by João Moura, João Moura, Joana Fernandes, Maria João Lima, Ana Paula Sousa, Raquel Samões, Raquel Samões, Raquel Samões, Ana Martins Silva, Ana Martins Silva, Ana Martins Silva, Ernestina Santos, Ernestina Santos, Ernestina Santos

“…The most common first-line choice was azathioprine (45.8%), and rituximab was used in 4 patients (1.9%).ConclusionOur study shows that treatment modalities are similar between EOMG and LOMG, while steroid-related adverse events appear to be distinct.…”
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MASS IN THE RIGHT ATRIUM IMITATING A TUMOR IN BEHCET’S DISEASE by A. A. Gorbachenkov, N. V. Krivosheeva, I. V. Erenburg, I. A. Babina, E. A. Piliposyan, M. V. Khodyreva

“…Prescribed immunosuppressive therapy (meripred, azathioprine, colchicine), which is still ongoing, led to a decrease in inflammatory activity (С-reactive protein), reduction of the thrombus in the right atrium and inferior vena cava. …”
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Pharmacoeconomic analysis of the use of tocilizumab in therapy for rheumatoid arthritis:imitation simulation by Dmitry Vladimirovich Goryachev, Sh F Erdes, E L Nasonov

“…The second strategy estimated the sequence of BAID changes in the following order: methotrexate (MT) → leflunomide (LF) → sulfasalazine (SS) → azathioprine → palliative therapy. This strategy was also considered to obtain data for comparison of results. …”
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Therapeutic approaches for anti-sperm-antibodies in the testicular sperm aspiration rat model by Abdel-Kader A. Zaki, Fahad S. Aldahmashi, Abd El-Nasser A. Madboli, Kamal A. Attia, Fahad S. Almulhim, Saleh M. Albarrak

“…The remaining 4 groups were treated with either dexamethasone (DEX), azathioprine (AZA), frankincense, or anti-ASAs secondary antibodies. …”
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Improved Solitary Pancreas Transplant Graft Survival in the Modern Immunosuppressive Era by Jon S. Odorico Ph.D., Yolanda T. Becker, Marilyn Groshek, Cathy Werwinski, Bryan N. Becker, John D. Pirsch, Hans W. Sollinger

“…In the early era, immunosuppressive therapy included cyclosporine (CsA), azathioprine (AZA), corticosteroids, and in half of the patients, ALG or OKT3. …”
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Clinical outcome in patients with suspected inflammatory neuropsychiatric lupus treated with immunosuppression: an observational cohort study by Margreet Kloppenburg, Tom W J Huizinga, Jeroen Eikenboom, Gisela M Terwindt, Liesbeth J J Beaart-van de Voorde, Gerda M Steup-Beekman, Jeroen de Bresser, Rory C Monahan, Huub A M Middelkoop, Nic J A van der Wee, Rolf Fronczek

“…The treatments mostly consisted of (combinations of) prednisone (97%), methylprednisolone (53%), azathioprine (generally 2 mg/kg daily) (49%) and cyclophosphamide (generally induction 750 mg/m2 every 4 weeks for 24 weeks or 500mg biweekly for 12 weeks) (42%). …”
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O-4 CLINICAL, HISTOLOGICAL AND SEROLOGICAL FEATURES OF AUTOIMMUNE-LIKE ACUTE LIVER INJURY AFTER SARS-COV-2 VACCINATION by Marlene Padilla Lopez, Natalia Sobenko, Lucrecia Garcia Olivera, Agustina Martinez Garmendia, Eduardo Mullen, Paola Casciato, Sebastian Marciano, Alejandra Villamil

“…Most patients tolerated the tapering of steroids and in 6 azathioprine was started before month 3. Conclusions: Long-term follow-up might help to differentiate between induced classical autoimmune hepatitis, autoinflammatory self-limited events, or drug-induced liver injury in these patients.…”
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SARS-CoV-2 Vaccination Response in Japanese Patients with Autoimmune Hepatitis: Results of Propensity Score-Matched Case–Control Study by Kei Moriya, Tomoko Nakakita, Natsuki Nakayama, Yuya Matsuo, Yusuke Komeda, Junichi Hanatani, Daisuke Kaya, Shinsaku Nagamatsu, Hideki Matsuo, Masakazu Uejima, Fumihiko Nakamura

“…Results: In this study, 72.7% and 18.2% of patients with AIH received steroids and azathioprine, respectively. Significant negative correlations were found between age and anti-SARS-CoV-2 spike antibody concentration in both groups; however, no sex differences were found. …”
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A Challenging Sexsomnia Seen as a Deceptive Case of Depression by J. Brás, M. Meira e Cruz, C. Teixeira, R. Andrade, A. P. Costa

“…As for medical or psychiatric history, only Chron’s disease is highlighted, being under control with azathioprine. Likewise, he took 1mg of melatonin/night. …”
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Hyper IgE in Childhood Eczema and Risk of Asthma in Chinese Children by Chantel Ng, Kam Lun Hon, Jeng Sum Charmaine Kung, Nga Hin Pong, Ting-Fan Leung, Chun Kwok Wong

“…Compared with IgE ≤ 2000IU/L (n = 167), patients with hyper-IgE (n = 163) were associated with male gender (p = 0.002); paternal atopy (p = 0.026); personal history of atopic rhinitis (p = 0.016); asthma (p < 0.001); dietary avoidance (p < 0.001); use of wet wrap (p < 0.001); traditional Chinese medicine use (TCM, p < 0.001); immunomodulant use (azathioprine or cyclosporine, p < 0.001); skin prick sensitization by dust mites (p < 0.001), cats (p = 0.012), dogs (p = 0.018), food (p = 0.002); eosinophilia (p < 0.001); more severe disease during childhood (p < 0.0001) and during adolescence (p < 0.0001), but not onset age of eczema or maternal atopy. …”
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Design and rationale for the prospective treatment efficacy in IPF using genotype for NAC selection (PRECISIONS) clinical trial by Anna J. Podolanczuk, John S. Kim, Christopher B. Cooper, Joseph A. Lasky, Susan Murray, Justin M. Oldham, Ganesh Raghu, Kevin R. Flaherty, Cathie Spino, Imre Noth, Fernando J. Martinez, for the PRECISIONS Study Team

“…The National Heart, Lung, and Blood Institute (NHLBI)-sponsored PANTHER (Prednisone Azathioprine and NAC therapy in IPF) trial confirmed the harmful effects of immunosuppression in IPF, and did not show a benefit to treatment with NAC. …”
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Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases by Jerko Štambuk, Frano Vučković, Siniša Habazin, Maja Hanić, Mislav Novokmet, Susanna Nikolaus, Florian Tran, Stefan Schreiber, Andre Franke, Philip Rosenstiel, Gordan Lauc, Konrad Aden, Marija Pezer

“…Secondly, to assess changes in IgG Fc N-glycosylation associated with therapy and remission status, we compared 139 CID patients receiving either azathioprine, infliximab, or vedolizumab therapy. We observed an increase in IgG Fc galactosylation (adjusted <i>p</i>-value range 1.98 × 10⁻²–1.30 × 10⁻¹⁵) and sialylation (adjusted <i>p</i>-value range 3.28 × 10⁻⁶–4.34 × 10⁻¹⁸) during the treatment. …”
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Disease trajectory of SLE clinical endpoints and covariates affecting disease severity and probability of response: Analysis of pooled patient‐level placebo (Standard‐of‐Care) data... by Kosalaram Goteti, Jonathan French, Ramon Garcia, Ying Li, Florence Casset‐Semanaz, Aida Aydemir, Robert Townsend, Cristina Vazquez Mateo, Matthew Studham, Oliver Guenther, Amy Kao, Marc Gastonguay, Pascal Girard, Lisa Benincosa, Karthik Venkatakrishnan

“…No discernible differences were observed in the trajectory of response to placebo + SoC across different SoC medications (antimalarial and immunosuppressant such as mycophenolate, methotrexate, and azathioprine). Across all endpoints, disease trajectory showed no difference in Asian versus non‐Asian patients, supporting Asia‐inclusive global SLE drug development. …”
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Multicenter analysis of immunosuppressive medications on the risk of malignancy following adult solid organ transplantation by Reid Shaw, Ali R. Haque, Tyler Luu, Timothy E. O’Connor, Adam Hamidi, Jack Fitzsimons, Bianca Varda, Danny Kwon, Cody Whitcomb, Alex Gregorowicz, Gregory W. Roloff, Bradford C. Bemiss, Eric R. Kallwitz, Patrick A. Hagen, Stephanie Berg

“…Random forest variable importance calculations and time-dependent multivariate cox proportional hazard analysis identified an increased risk of cancer in patients receiving immunosuppressive therapy with sirolimus (HR 1.41, 95% CI 1.05 – 1.9, p = 0.04), azathioprine (HR 2.1, 95% CI 1.58 – 2.79, p &lt; 0.001), and cyclosporine (HR 1.59, 95% CI 1.17 – 2.17, p = 0.007), while tacrolimus (HR 0.59, 95% CI 0.44 – 0.81, p &lt; 0.001) was associated with low rates of post-transplant neoplasia.ConclusionOur results show varying risks of immunosuppressive medications associated with the development of post-transplant malignancy, demonstrating the importance of cancer detection and surveillance strategies in solid organ transplant recipients.…”
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Cost-utility analysis of biologic disease-modifying antirheumatic drugs (bDMARDs), targeted synthetic DMARDs (tsDMARDs) and biosimilar DMARDs (bsDMARDs) combined with methotrexate... by Juthamas Prawjaeng, Pattara Leelahavarong, Nuttakarn Budtarad, Songyot Pilasant, Chonticha Chanjam, Wanruchada Katchamart, Pongthorn Narongroeknawin, Tasanee Kitumnuaypong

“…Alternative treatment strategies including five bDMARDs, two tsDMARDs, and four bsDMARDs in combination with methotrexate (MTX) were compared with the standard of care (SoC), i.e., cyclosporine and azathioprine. Direct and non-medical care costs were estimated by identifying the resources used, then multiplied by the standard costing menu in the year 2022. …”
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CLINICAL AND MORPHOLOGICAL APPROACH TO DIAGNOSIS OF "IDIOPATHIC" ARRHYTHMIAS AND DILATED CARDIOMYOPATHY SYNDROME AS A BASIS FOR DIFFERENTIATED THERAPY. Part II (Treatment) by O. V. Blagova, A. V. Nedostup, E. A. Kogan, V. A. Sulimov, Yu. V. Osipova, V. P. Sedov, A. G. Kupriyanova, V. A. Zaydenov, A. E. Donnikov, V. V. Kadochnikova

“…The algorithm of noninvasive nosological diagnostics was developed; it allowed to verify diagnosis in 95% of IA patients and 89% DCM patients</p><p>The basic therapy (antiviral drugs, corticosteroids, hydroxychloroquine, azathioprine) was performed in some patients with myocarditis. …”
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Juvenile idiopathic inflammatory myopathies: results of an open single-center retrospective study by M. I. Kaleda, I. P. Nikishina, S. O. Salugina, E. S. Fedorov, S. V. Arsenyeva, A. N. Shapovalenko, T. N. Pachkoria, V. G. Matkava

“…Myositis-specific autoantibodies were found in 10.8% of patients with JIIM.All patients received glucocorticoids, 81.0% methotrexate, 18.9% hydroxychloroquine, 8.1% cyclophosphamide, 8.1% cyclosporine, 2.7% mycophenolate mofetil, 2.7% azathioprine, 67.6% - intravenous immunoglobulin. Biologic disease modifying antirheumatic drugs (bDMARDs) were prescribed to 26% of patients with JDM and to all patients with OM (only in 51.3% of cases with JIIM). …”
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Centrally acting ACE inhibitor (cACEi) and angiotensin receptor blocker (cARB) use and cognitive dysfunction in patients with SLE by Dorcas Beaton, Maria Carmela Tartaglia, Jiandong Su, Michelle Barraclough, Zahi Touma, Robin Green, Lesley Ruttan, Joan Wither, Dennisse Bonilla, Kathleen Bingham, Mahta Kakvan, Mary Sano, Chrisanna Dobrowolski, Milica Tanic

“…Caucasian ethnicity, current employment status and azathioprine cumulative dose were each associated with reduced odds of SLE-CD. …”
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