Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA by James Lee, David Tomasek, Thiago MA Santos, Mary D May, Ina Meuskens, Daniel Kahne

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Molecular basis for cellular retinoic acid-binding protein 1 in modulating CaMKII activation by Jennifer Nhieu, Michelle C. Miller, Thomas A. Lerdall, Kevin H. Mayo, Li-Na Wei

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Toward Active-Site Compression in Rigid-Rod ?-Barrels by Yoann Baudry, Dawn Ronan, Stefan Matile

Subjects: “…Beta-barrels…”
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Proton Detected Solid-State NMR of Membrane Proteins at 28 Tesla (1.2 GHz) and 100 kHz Magic-Angle Spinning by Evgeny Nimerovsky, Kumar Tekwani Movellan, Xizhou Cecily Zhang, Marcel C. Forster, Eszter Najbauer, Kai Xue, Rıza Dervişoǧlu, Karin Giller, Christian Griesinger, Stefan Becker, Loren B. Andreas

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Evidence for a Widespread Third System for Bacterial Polysaccharide Export across the Outer Membrane Comprising a Composite OPX/β-Barrel Translocon by Johannes Schwabe, María Pérez-Burgos, Marco Herfurth, Timo Glatter, Lotte Søgaard-Andersen

Subjects: “…beta-barrel proteins…”
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Protein induced modulation of chloroplast membrane morphology by Anu B Machettira, Lucia E Groß, Bodo eTillmann, Benjamin LM Weis, Giesela eEnglich, Maik S Sommer, Martina eKöniger, Enrico eSchleiff

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A functional protein pore with a "retro" transmembrane domain. by Cheley, S, Braha, O, Lu, X, Conlan, S, Bayley, H

“…Knowledge about the extraordinary plasticity of the transmembrane beta-barrel of alpha-hemolysin will be very useful in the de novo design of functional membrane proteins based on the beta-barrel motif.…”

Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. by Song, L, Hobaugh, MR, Shustak, C, Cheley, S, Bayley, J, Gouaux, J

“…The interior of the beta barrel is primarily hydrophilic, and the exterior has a hydrophobic belt 28 A wide. …”

Molecular dynamics simulations of a bacterial autotransporter: NalP from Neisseria meningitidis. by Khalid, S, Sansom, MS

“…The crystal structure of the NalP translocator domain revealed a transmembrane beta-barrel containing a central alpha-helix. The role of this alpha-helix, and of the conformational dynamics of the beta-barrel pore have been studied via atomistic molecular dynamics simulations. …”

A multidomain outer membrane protein from Pasteurella multocida: modelling and simulation studies of PmOmpA. by Carpenter, T, Khalid, S, Sansom, MS

“…There is a degree of water penetration into the interior of the beta-barrel, suggestive of a possible transmembrane pore. …”

Probing distance and electrical potential within a protein pore with tethered DNA. by Howorka, S, Bayley, H

“…Binding events of oligonucleotides with an overhang of five bases or more, which threaded into the beta-barrel, exhibited shorter residence times at higher applied potentials. …”

Activity and specificity of human aldolases. by Gamblin, S, Davies, G, Grimes, J, Jackson, R, Littlechild, J, Watson, H

“…The side-chain of the Schiff's base-forming lysine 229 is located towards the centre of an eight-stranded beta-barrel type structure. The C-terminal "tail" extends from the rim of the beta-barrel towards lysine 229, thus forming part of the active site of the enzyme. …”

The binding cavity of mouse major urinary protein is optimised for a variety of ligand binding modes. by Pertinhez, T, Ferrari, E, Casali, E, Patel, J, Spisni, A, Smith, L

“…(15)N and (1)HN chemical shift data and (15)N relaxation studies have been used to characterise the binding of N-phenyl-naphthylamine (NPN) to mouse major urinary protein (MUP). NPN binds in the beta-barrel cavity of MUP, hydrogen bonding to Tyr120 and making extensive non-bonded contacts with hydrophobic side chains. …”

Improving transmembrane protein prediction analysis using machine learning by Kazemian, Hassan

“…The computer simulation results demonstrate that the proposed SVM-GA methodology performs better than most traditional techniques producing an accuracy of 86.71% for cross-validation and 86.43% for jack-knife for randomly selected proteins containing single and multiple transmembrane regions. The beta barrel research presents the applications of a dual Neural Network (NN) and Support Vector Machine (SVM) to prediction and analysis of beta barrel topology. …”
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Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. by Brown, J, Esnouf, R, Jones, M, Linnell, J, Harlos, K, Hassan, A, Jones, E

“…The structure consists of two crossed beta-sheets forming a flattened beta-barrel. Structural analysis identifies the putative IGF-II binding site at one end of the beta-barrel whilst crystal lattice contacts suggest a model for the full-length IGF2R extracellular region. …”

One membrane protein, two structures and six environments: a comparative molecular dynamics simulation study of the bacterial outer membrane protein PagP. by Cox, K, Sansom, MS

“…PagP is a bacterial outer membrane protein consisting of an 8 stranded transmembrane beta-barrel and an N-terminal alpha-helix. It is an enzyme which catalyses transfer of a palmitoyl chain from a phospholipid to lipid A. …”

Modeling and simulations of a bacterial outer membrane protein: OprF from Pseudomonas aeruginosa. by Khalid, S, Bond, P, Deol, S, Sansom, MS

“…Homology models, consisting of an eight-stranded beta-barrel, of the N-terminal domain OprF have been constructed based on the crystal structure of the corresponding domain from E. coli OmpA. …”

Signaling beyond Punching Holes: Modulation of Cellular Responses by Vibrio cholerae Cytolysin by Barkha Khilwani, Kausik Chattopadhyay

“…Vibrio cholerae cytolysin (VCC) is a prominent member of the beta-barrel PFT (beta-PFT) family. It is secreted by most of the pathogenic strains of the intestinal pathogen V. cholerae. …”
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Amino acid distributions in integral membrane protein structures. by Ulmschneider, M, Sansom, MS

“…The resultant 'aromatic belts' were spaced more closely for beta-barrel than for alpha-helical membrane proteins. …”

Interactions of peptides with a protein pore. by Movileanu, L, Schmittschmitt, J, Scholtz, J, Bayley, H

“…Here we examine the exchange of cationic alpha-helical peptides between the bulk aqueous phase and the transmembrane beta-barrel of the alpha-hemolysin (alphaHL) protein pore at the single-molecule level. …”