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1981
A Novel Symbiotic Formulation Reduces Obesity and Concomitant Metabolic Syndrome in Rats by Raising the Relative Abundance of Blautia
Published 2023-02-01“…Overall, our novel symbiotic combination improved plasma glucose and lipid levels, shrunk adipocyte size, restored liver function, increased the abundance of Blautia and adjusted bile acid and amino acid metabolism.…”
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1982
Caffeine ameliorates the metabolic syndrome in diet-induced obese mice through regulating the gut microbiota and serum metabolism
Published 2023-03-01“…Conclusions Caffeine exerts a beneficial effect on insulin resistance in HFD-mice, and the underlying mechanism may be partly related to altered gut microbiota and bile acid metabolism.…”
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Article -
1983
Acalculous cholecystitis is a common extrahepatic manifestation of hepatitis E and suggests a more serious condition
Published 2023-04-01“…After correction by multivariate analysis, albumin and total bile acid were found to be closely related to acalculous cholecystitis in HE. …”
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Article -
1984
Relevance of β-Glucan Molecular Properties on Its Suitability as Health Promoting Bread Ingredient
Published 2022-04-01“…The use of hBG showed higher viscosity and better bile acid retention, indicating cholesterol lowering properties, compared to similar or higher amounts of cBG. …”
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1985
Gut Microbiota in Hypertension and Atherosclerosis: A Review
Published 2020-09-01“…In addition, gut microbiota play a key role in bile acid metabolism and some interventions targeting bile acid receptors tend to decrease atherosclerosis. …”
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1986
Contrary effects of the gut metabolites deoxycholate and butyrate on the acetylcholine-evoked calcium response in an enteroendocrine cell model
Published 2024-06-01“…Incubation with the secondary bile acid deoxycholate inhibited the calcium response to acetylcholine but not to histamine. …”
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Article -
1987
Cholestatic Pruritus in Children: Conventional Therapies and Beyond
Published 2023-05-01“…While further investigation regarding underlying etiologies and effective therapies are needed to better understand itch pathogenesis and treatment in pediatric cholestasis, current considerations beyond conventional management include the use of opioid antagonists, selective serotonin reuptake inhibitors, ileal bile acid transport inhibitors, and surgical intervention.…”
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1988
Changes in Serum Lipid Profiles among Canine Patients Suffering from Chronic Hepatitis
Published 2021-10-01“…A significant positive association was identified between hyperlipidemia, especially hypercholesterolemia, liver enzymes, and bile acid concentration in dogs suffering from chronic hepatitis. …”
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1989
Comparison of three different anastomotic methods of sleeve gastrectomy with transit bipartition using an obese rodent model
Published 2023-12-01“…Histological expression and bile acid concentration in the rats in all groups were also evaluated. …”
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1990
Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease
Published 2016“…The reduced activity of P450 enzymes may be the result of bile acid deficiency/imbalance in Npc1-/- mice, as bile acid treatment significantly rescued P450 enzyme activity in Npc1-/- mice and has the potential to be an adjunctive therapy for NPC disease patients. …”
Journal article -
1991
Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease
Published 2016“…The reduced activity of P450 enzymes may be the result of bile acid deficiency/imbalance in Npc1-/- mice, as bile acid treatment significantly rescued P450 enzyme activity in Npc1-/- mice and has the potential to be an adjunctive therapy for NPC disease patients. …”
Journal article -
1992
Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice
Published 2023-05-01“…In particular, XKY decreased secondary bile acid producing bacteria (Clostridia and Lachnospircaeae) and lowered fecal secondary bile acid (lithocholic acid (LCA) and deoxycholic acid (DCA)) levels to promote hepatic bile acid synthesis by inhibiting the LCA/DCA-FXR-FGF15 signalling pathway. …”
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Article -
1993
Coordinated ASBT and EGFR Mechanisms for Optimized Liraglutide Nanoformulation Absorption in the GI Tract
Published 2024-03-01“…This strategy allowed the bile acid moieties to localize at the nanoparticle surface, enhancing the binding affinity for apical sodium-dependent bile acid transporter (ASBT) and improving GI stability. …”
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Article -
1994
Intrahepatic cholestasis of pregnancy: from an obstetrician point of view
Published 2022“…The disease is characterised by intense pruritus and specifically by elevated bile acid levels and owing to the rarity of data published in this context, the disease carries a great challenge in both diagnosis and management. …”
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1995
‘Saba’ banana (Musa acuminata x balbisiana BBB Group) peel pectin supplementation improves biomarkers of obesity and associated blood lipid disorders in obese hypercholesterolemic...
Published 2022-01-01“…In vitro assays revealed that SPP had significantly higher cholesterol and bile acid binding capacities at 60 μg/mL and 20 μg/mL, respectively than CCP and bile acid-binding drug, cholestyramine. …”
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1996
Metabolomic profiling implicates mitochondrial and immune dysfunction in disease syndromes of the critically endangered black rhinoceros (Diceros bicornis)
Published 2023-09-01“…Results suggest dysregulation of propanoate, amino acid metabolism, and bile acid biosynthesis in the subspecies and sex comparisons. …”
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Article -
1997
The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing
Published 2023-07-01“…These differentially expressed genes were mainly enriched in the drug metabolism, bile acid metabolism, Nrf2 pathway and TLR4 pathway. …”
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1998
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists
Published 2015-09-01“…Recent medicinal chemistry efforts have identified bile acid derivatives as low micromolar binders of the EphA2 receptor. …”
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Article -
1999
Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels
Published 2023-03-01“…In conclusion, the disorder of vitamin D metabolism may be related to cholesterol metabolism and bile acid biosynthesis. This study provided a basis for exploring the possible mechanism leading to abnormal vitamin D metabolism.…”
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2000
Fermented Rosa Roxburghii Tratt Juice Alleviates High-Fat Diet-Induced Hyperlipidemia in Rats by Modulating Gut Microbiota and Metabolites
Published 2022-05-01“…Metabolomics analysis displayed that the metabolisms of bile acid, amino acid and lipid were significantly affected by FRRT. …”
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