A Novel Symbiotic Formulation Reduces Obesity and Concomitant Metabolic Syndrome in Rats by Raising the Relative Abundance of Blautia by Xiu-Rong Wu, Zhen-Zhen Chen, Xi-Lan Dong, Qiu-Ping Zhao, Jun Cai

“…Overall, our novel symbiotic combination improved plasma glucose and lipid levels, shrunk adipocyte size, restored liver function, increased the abundance of Blautia and adjusted bile acid and amino acid metabolism.…”
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Caffeine ameliorates the metabolic syndrome in diet-induced obese mice through regulating the gut microbiota and serum metabolism by Li Chen, Xian-jun Wang, Jie-xin Chen, Jing-cheng Yang, Ling Lin, Xian-Bin Cai, Yong-song Chen

“…Conclusions Caffeine exerts a beneficial effect on insulin resistance in HFD-mice, and the underlying mechanism may be partly related to altered gut microbiota and bile acid metabolism.…”
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Acalculous cholecystitis is a common extrahepatic manifestation of hepatitis E and suggests a more serious condition by Xuemei Cao, Wei Jiang, Lingfeng Shi, Yanping Wang, Jie Chen, Wenxiang Huang, Shujun Zhang

“…After correction by multivariate analysis, albumin and total bile acid were found to be closely related to acalculous cholecystitis in HE. …”
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Relevance of β-Glucan Molecular Properties on Its Suitability as Health Promoting Bread Ingredient by Marcus Schmidt, Elisabeth Sciurba, Sharline Nikolay, Alexandra Hüsken, Inga Smit

“…The use of hBG showed higher viscosity and better bile acid retention, indicating cholesterol lowering properties, compared to similar or higher amounts of cBG. …”
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Gut Microbiota in Hypertension and Atherosclerosis: A Review by Barbara J. H. Verhaar, Andrei Prodan, Max Nieuwdorp, Majon Muller

“…In addition, gut microbiota play a key role in bile acid metabolism and some interventions targeting bile acid receptors tend to decrease atherosclerosis. …”
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Contrary effects of the gut metabolites deoxycholate and butyrate on the acetylcholine-evoked calcium response in an enteroendocrine cell model by Beatrix Pfanzagl, Erika Jensen-Jarolim

“…Incubation with the secondary bile acid deoxycholate inhibited the calcium response to acetylcholine but not to histamine. …”
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Cholestatic Pruritus in Children: Conventional Therapies and Beyond by Minna Rodrigo, Xinzhong Dong, Daphne Chien, Wikrom Karnsakul

“…While further investigation regarding underlying etiologies and effective therapies are needed to better understand itch pathogenesis and treatment in pediatric cholestasis, current considerations beyond conventional management include the use of opioid antagonists, selective serotonin reuptake inhibitors, ileal bile acid transport inhibitors, and surgical intervention.…”
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Changes in Serum Lipid Profiles among Canine Patients Suffering from Chronic Hepatitis by Sathidpak Nantasanti Assawarachan, Piyathip Chuchalermporn, Phudit Maneesaay, Naris Thengchaisri

“…A significant positive association was identified between hyperlipidemia, especially hypercholesterolemia, liver enzymes, and bile acid concentration in dogs suffering from chronic hepatitis. …”
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Comparison of three different anastomotic methods of sleeve gastrectomy with transit bipartition using an obese rodent model by Yuxiao Chu, Jason Widjaja, Jian Wang, Wei Wu, Jian Hong, Xiaocheng Zhu, Libin Yao

“…Histological expression and bile acid concentration in the rats in all groups were also evaluated. …”
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Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease by Platt, F, Nicoli, E, Al Eisa, N, Cluzeau, C, Wassif, C, Gray, J, Burkert, K, Smith, D, Morris, L, Cologna, S, Peer, C, Sissung, T, Uscatu, C, Figg, W, Pavan, W, Vite, C, Porter, F

“…The reduced activity of P450 enzymes may be the result of bile acid deficiency/imbalance in Npc1-/- mice, as bile acid treatment significantly rescued P450 enzyme activity in Npc1-/- mice and has the potential to be an adjunctive therapy for NPC disease patients. …”

Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease by Nicoli, E, Al Eisa, N, Cluzeau, C, Wassif, C, Gray, J, Burkert, K, Smith, D, Morris, L, Cologna, S, Peer, C, Sissung, T, Uscatu, C, Figg, W, Pavan, W, Vite, C, Porter, F, Platt, F

“…The reduced activity of P450 enzymes may be the result of bile acid deficiency/imbalance in Npc1-/- mice, as bile acid treatment significantly rescued P450 enzyme activity in Npc1-/- mice and has the potential to be an adjunctive therapy for NPC disease patients. …”

Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice by Mei Li, Ding Cheng, Chuan Peng, Yujiao Huang, Jie Geng, Guangrui Huang, Ting Wang, Anlong Xu

“…In particular, XKY decreased secondary bile acid producing bacteria (Clostridia and Lachnospircaeae) and lowered fecal secondary bile acid (lithocholic acid (LCA) and deoxycholic acid (DCA)) levels to promote hepatic bile acid synthesis by inhibiting the LCA/DCA-FXR-FGF15 signalling pathway. …”
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Coordinated ASBT and EGFR Mechanisms for Optimized Liraglutide Nanoformulation Absorption in the GI Tract by Kweon S, Park SJ, Lee HK, Kang SH, Chang KY, Choi JU, Park J, Shim JH, Park JW, Byun Y

“…This strategy allowed the bile acid moieties to localize at the nanoparticle surface, enhancing the binding affinity for apical sodium-dependent bile acid transporter (ASBT) and improving GI stability. …”
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Intrahepatic cholestasis of pregnancy: from an obstetrician point of view by Mohsen M. A. Abdelhafez, Karim A. M. Ahmed, Win Win Than, Dg Marshitah Pg Baharuddin, Fairrul Kadir, Mohammad Saffree Jeffree, Mohd Firdaus Hayati, Mohd Nazri Mohd Daud, Mohd Nazri Mohd Daud, Kai Xin Tay

“…The disease is characterised by intense pruritus and specifically by elevated bile acid levels and owing to the rarity of data published in this context, the disease carries a great challenge in both diagnosis and management. …”
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‘Saba’ banana (Musa acuminata x balbisiana BBB Group) peel pectin supplementation improves biomarkers of obesity and associated blood lipid disorders in obese hypercholesterolemic... by Paul Alteo A. Bagabaldo, Liezl M. Atienza, Katherine Ann T. Castillo-Israel, Maria Amelita C. Estacio, Prince Joseph V. Gaban, Jonna Rose C. Maniwang, Roxanne P. Gapasin, Abbie Glenn M. Estribillo, Rohani B. Cena-Navarro

“…In vitro assays revealed that SPP had significantly higher cholesterol and bile acid binding capacities at 60 μg/mL and 20 μg/mL, respectively than CCP and bile acid-binding drug, cholestyramine. …”
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Metabolomic profiling implicates mitochondrial and immune dysfunction in disease syndromes of the critically endangered black rhinoceros (Diceros bicornis) by Molly L. Corder, Emanuel F. Petricoin, Yue Li, Timothy P. Cleland, Alexandra L. DeCandia, A. Alonso Aguirre, Budhan S. Pukazhenthi

“…Results suggest dysregulation of propanoate, amino acid metabolism, and bile acid biosynthesis in the subspecies and sex comparisons. …”
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The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing by Ting Li, Chaoyue Yang, Houkang Cao, Siyi Mo, Bo Li, Zhipeng Huang, Ruobing Zhang, Jianzhao Wu, Kefeng Zhang, Ya Gao

“…These differentially expressed genes were mainly enriched in the drug metabolism, bile acid metabolism, Nrf2 pathway and TLR4 pathway. …”
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Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists by Donatella Callegari, Daniele Pala, Laura Scalvini, Massimiliano Tognolini, Matteo Incerti, Silvia Rivara, Marco Mor, Alessio Lodola

“…Recent medicinal chemistry efforts have identified bile acid derivatives as low micromolar binders of the EphA2 receptor. …”
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Ultra-high-performance liquid chromatography-tandem mass spectrometry analysis of serum metabolomic characteristics in people with different vitamin D levels by Li Huan, Xie Xiaomin, Zhang Li, He Yanting, Liu Huili, Qiang Dan, Bai Guirong, Li Ling, Tang Yanpan

“…In conclusion, the disorder of vitamin D metabolism may be related to cholesterol metabolism and bile acid biosynthesis. This study provided a basis for exploring the possible mechanism leading to abnormal vitamin D metabolism.…”
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Fermented Rosa Roxburghii Tratt Juice Alleviates High-Fat Diet-Induced Hyperlipidemia in Rats by Modulating Gut Microbiota and Metabolites by Jiacheng Ji, Jiacheng Ji, Shuo Zhang, Minyan Yuan, Minyan Yuan, Min Zhang, Li Tang, Li Tang, Pengjiao Wang, Yujie Liu, Yujie Liu, Changqian Xu, Changqian Xu, Peng Luo, Xiuli Gao, Xiuli Gao, Xiuli Gao

“…Metabolomics analysis displayed that the metabolisms of bile acid, amino acid and lipid were significantly affected by FRRT. …”
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