Mechanisms and outcomes of metabolic surgery in type 2 diabetes by Mansor, Fazliana, Nor Hanipah, Zubaidah

“…This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk.…”

Macrophage inhibitory cytokine-1 aggravates diet-induced gallstone formation via increased ABCG5/ABCG8 expression. by Min Hee Kim, Eun-Ji Lee, Su-Jeong Kim, Yun-Jae Jung, Woo-Jae Park, Inkeun Park

“…We investigated the mechanisms through which MIC-1 affects bile acid metabolism and gallstone formation, which are poorly understood. …”
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Lingguizhugan Decoction Targets Intestinal Microbiota and Metabolites to Reduce Insulin Resistance in High-Fat Diet Rats by Ning Y, Gong Y, Zheng T, Xie Y, Yuan S, Ding W

“…In addition, the expression of bile acid metabolism related genes was also regulated in IR rats.Conclusion: We showed that LGZGD relieved IR, possibly by regulating the composition of the fecal microbiota and its metabolites. …”
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The role of TGR5 as an onco-immunological biomarker in tumor staging and prognosis by encompassing the tumor microenvironment by Zhiyuan Guan, Liying Luo, Shengfu Liu, Zhiqiang Guan, Qinggang Zhang, Zhong Wu, Kun Tao

“…The regulation of hormone secretion, Rap1 pathway, osteoclast differentiation, and bile acid pathway was involved in the functional mechanism of TGR5. …”
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Prospective Study Comparing Outcome following Complete Polypropylene Suture Ligation versus Partial Thin Film Band Attenuation of Congenital Portosystemic Shunts in Dogs by Victoria Lipscomb, Chloe Cassie, Ben Ritchie, Stephen Greenhalgh, Mickey Tivers

“…Peri-operative complications, mortality, follow-up imaging findings, pre- and post-operative bile acid stimulation test results and details of any revision surgery performed were recorded. …”
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Incidental finding of non-alcoholic steatohepatitis-cirrhosis by Therese Adrian, Mads Hornum, Filip Krag Knop, Lise Lotte Gluud

“…The patient was followed at a gastroenterology department due to Crohn’s disease and post-operative bile acid malabsorption. The patient had no symptoms or biochemical findings suggesting liver disease. …”
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The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity by Magdalena Rausch, Sophia L. Samodelov, Michele Visentin, Gerd A. Kullak-Ublick

“…The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis. …”
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Correction of hepatobiliary pathology by the complex herbal remedy by V. S. Chuchalin, Ye. M. Teplyakova

“…During complex herbal remedy administration, the rheologycal properties of bile are normalized, bile acid pool extends, and total cholesterol in bile reduces. …”
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Safety, tolerability, pharmacokinetics and pharmacodynamics of a novel farnesoid X receptor (FXR) agonist-TQA3526 in healthy Chinese volunteers: a double-blind, randomized, placebo... by Jia Xu, Hong Zhang, Hong Chen, Xiaoxue Zhu, Haiyan Jia, Zhongnan Xu, Dandan Huo, Hong Zhang, Cuiyun Li, Yanhua Ding

“…Alkaline phosphatase (ALP), fibroblast growth factor-19 (FGF19), bile acid precursor C4 (7α-hydroxy-cholest-4-ene-3-one), cholesterol, and bile acid were selected for PD analysis.Results: TQA3526 was well tolerated, and the primary adverse drug reaction was pruritus, as expected. …”
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Isolation of mucosa-associated microbiota dysbiosis in the ascending colon in hepatitis C virus post-sustained virologic response cirrhotic patients by Yohei Midori, Takuto Nosaka, Katsushi Hiramatsu, Katsushi Hiramatsu, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto

“…In PICRUSt analysis, MAM in the ascending colon in the liver cirrhosis (LC) group showed compromised functions associated with the intestinal barrier and bile acid production, and FGF19 expression was markedly decreased in the terminal ileum biopsy tissue in the LC group. …”
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Plumbagin ameliorates bile duct ligation-induced cholestatic liver injury in rats by Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen

“…The activation of nuclear Nrf2 caused by plumbagin correlated well with the improvement in bile acid retention, liver histology, serum biochemical, ductular reaction, mitochondrial dysfunction, oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis, involving interplay of multiple intracellular signaling pathways. …”
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Gut microbiota and metabolites in estrus cycle and their changes in a menopausal transition rat model with typical neuroendocrine aging by Ruoxi Dai, Jianqin Huang, Jianqin Huang, Jianqin Huang, Liyuan Cui, Ruiqi Sun, Xuemin Qiu, Yan Wang, Yan Sun, Yan Sun, Yan Sun

“…Discriminatory metabolites were identified involving 90 metabolic pathways among the animal sets, which were enriched for steroid hormone biosynthesis, arachidonic metabolism, primary bile acid synthesis, and ovarian steroidogenesis. A total of 21 metabolites lacking in hormone-associated changes in middle-aged female individuals presented positive or negative correlations with the circulating luteinizing hormone, bile acid, fibroblast growth factor 19, and gut hormones. …”
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Single-cell and spatiotemporal transcriptomic analyses reveal the effects of microorganisms on immunity and metabolism in the mouse liver by Ruizhen Zhao, Wei Cheng, Juan Shen, Weiming Liang, Zhao Zhang, Yifei Sheng, Tailiang Chai, Xueting Chen, Yin Zhang, Xiang Huang, Huanjie Yang, Chunqing Song, Li Pang, Cuoji Nan, Yangrui Zhang, Rouxi Chen, Junpu Mei, Hong Wei, Xiaodong Fang

“…Furthermore, untargeted metabolism experiments of the liver revealed that the propionic acid levels were significantly lower in GF mice, and this reduction may be related to the control of genes involved in bile acid and fatty acid metabolism. In conclusion, the combination of sc/snRNA-seq, Stereo-seq, and untargeted metabolomics revealed immune system defects as well as altered bile acid and lipid metabolic processes at the single-cell and spatial levels in the livers of GF mice. …”
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Opinion paper on the diagnosis and treatment of progressive familial intrahepatic cholestasis by Patrick McKiernan, Jesus Quintero Bernabeu, Muriel Girard, Giuseppe Indolfi, Eberhard Lurz, Palak Trivedi

“…The authors recommend referring patients to an experienced centre, and ensuring that monitoring includes measurements of pruritus, serum bile acid levels, growth, and quality of life following diagnosis and during treatment. …”
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Progress on Enzymatic Properties and Gene Structure of Bile Salt Hydrolase by Fangyun LU, Biao YANG, Jingjing MA, Jing YANG, Pengpeng LI, Weimin XU, Daoying WANG, Ye ZOU

“…This enzyme has been suggested to be involved in the host's bile acid balance, lipid metabolism and metabolic responses. …”
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Food and Gut Microbiota-Derived Metabolites in Nonalcoholic Fatty Liver Disease by Min Kyo Jeong, Byeong Hyun Min, Ye Rin Choi, Ji Ye Hyun, Hee Jin Park, Jung A Eom, Sung Min Won, Jin Ju Jeong, Ki Kwang Oh, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sang Jun Yoon, Mi Ran Choi, Dong Joon Kim, Ki Tae Suk

“…Microbiota-derived metabolites, including tryptophan, short-chain fatty acid, fat, fructose, or bile acid, regulate the pathophysiology of NAFLD. The microbiota metabolize nutrients, and metabolites are closely related to the development of NAFLD. …”
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Intrahepatic cholestasis of pregnancy: Case series of a rare disease in an African setting by Davis Rubagumya, Miriam Mgonja, Munawar Kaguta, Ahmed Jusabani, Muzdalfat Abeid, Nancy Matillya

“…Intrahepatic cholestasis of pregnancy commonly presents in the second and third trimester with unexplained pruritus sine materia , abnormal liver function tests, and/or elevated serum total bile acid concentration. Its incidence ranges from less than 1% to 27.6%, with Araucana Indians from Chile being the highest affected. …”
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A Gut Feeling to Cure Diabetes: Potential Mechanisms of Diabetes Remission after Bariatric Surgery by Young Min Cho

“…In this article, calorie restriction, improved β-cell function, improved insulin sensitivity, and alterations in gut physiology, bile acid metabolism, and gut microbiota are reviewed as potential mechanisms of diabetes remission after Roux-en-Y gastric bypass and sleeve gastrectomy.…”
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The contribution of the gut-liver axis to the immune signaling pathway of NAFLD by Jiayi Liu, Jiayi Liu, Anding Wu, Anding Wu, Jingjing Cai, Zhi-Gang She, Zhi-Gang She, Hongliang Li, Hongliang Li, Hongliang Li, Hongliang Li

“…Many studies have found that the intestinal flora regulates the pathogenesis of NAFLD by affecting energy metabolism, inducing endotoxemia, producing endogenous ethanol, and regulating bile acid and choline metabolism. In this review, we highlighted the updated discoveries in intestinal flora dysregulation and their link to the pathogenesis mechanism of NAFLD and summarized potential treatments of NAFLD related to the gut microbiome.…”
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Complete genome sequence of functional probiotic candidate Lactobacillus amylovorus CACC736 by Soyeon Park, Jung-Ae Kim, Hyun-Jun Jang, Dae-Hyuk Kim, Yangseon Kim

“…The predicted protein-coding genes, which are encoding the clustered regularly interspaced short palindromic repeats (CRISPR)-associated proteins, biosynthesis of bacteriocin (helveticin J), and the related proteins of the bile, acid tolerance. Notably, the genes related to vitamin B-group biosynthesis (riboflavin and cobalamin) were also found in L. amylovorus CACC736. …”
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