Cholesterol esterification and p53-mediated tumor suppression by Youjun Li, Michael Karin, Edward V. Prochownik

“…Cholesterol is a key lipid needed for the maintenance of membrane function and tissue homeostasis while also serving as a precursor for steroid hormone and bile acid synthesis. An over-abundance of cholesterol can lead to its esterification and storage as cholesterol esters. …”
Get full text

Statin use and risk of diabetes mellitus by Oksana Mikhailovna Drapkina, Marina Viktorovna Kostyukevich

“…At present time four groups of medications are used to correct dyslipidemia: bile acid sequestrants, niacin, fibric acid derivatives andstatins. …”
Get full text

Intestinal metabolomics in premature infants with late-onset sepsis by Jingfei Liu, Li Zhang, Dong Li, Xiaotong Yu, Ying Gao, Ying Zhou

“…Glycine, serine, and threonine metabolism; glyoxylate and dicarboxylic acid metabolism; glutathione metabolism; primary bile acid biosynthesis; steroid synthesis; pentose and glucuronic acid interconversion may be involved in the pathogenesis of LOS in preterm infants. …”
Get full text

Primary sclerosing cholangitis: is any treatment worthwhile? by Barnabas, A, Chapman, R

“…While many therapeutic agents have been evaluated in Primary Sclerosing Cholangitis (PSC), none have been shown in controlled trials to modify the course of disease. The bile acid ursodeoxycholic acid (UDCA) has been widely used in the treatment of PSC but its use remains controversial. …”

Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens by Xiaoli Guo, Qianqian Zhou, Jiaming Jin, Fangren Lan, Chaoliang Wen, Junying Li, Ning Yang, Congjiao Sun

“…Furthermore, the severity of hepatic steatosis was associated with a decrease in cholesterol and bile acid synthesis and an increase in exogenous cholesterol transport. …”
Get full text

Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model by Shu-Yan Gao, Shu-Yan Gao, Jing-Cheng Zhao, Qing Xia, Chen Sun, Maimaiti Aili, Maimaiti Aili, Ainiwaer Talifu, Ainiwaer Talifu, Shi-Xia Huo, Shi-Xia Huo, Yun Zhang, Zhi-Jian Li, Zhi-Jian Li

“…The mRNA expression of target genes in the bile acid metabolic signaling pathway and lipid metabolic pathway was detected by qPCR, and the mechanism of toxicity was initially investigated. …”
Get full text

Reference intervals for hematology, plasma biochemistry, and bone mineral density in captive Ceratophrys cranwelli (Anura: Ceratophryidae) by Siyu Long, Yujing Qiao, Siyu Zhou, Tareen Muhammad-Farooq, Yaoqin Shen

“…Blood biochemistry included 17 analytes, and only total bile acid (TBA), calcium (CA), and phosphorus (PHOS) showed significant differences. …”
Get full text

How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography? by Haoyu Bian, Liping Zhang, Yupu Yao, Fuqi Lv, Jiaoyang Wei

“…For the prevention of recurrence after ERCP, there is no guideline to provide a clear drug regimen, traditional Chinese medicine however has achieved some result in the treatment of liver-related diseases based on the “gut-liver-bile acid axis”. On the basis of this, this article discusses the possibility of traditional Chinese medicine to prevent common bile duct stones (CBDS) after ERCP, and we expect that this article will provide new ideas for the prevention of recurrence of CBDS and for the treatment of cholelithiasis-related diseases with traditional Chinese medicine in future clinical and scientific research.…”
Get full text

Gut microbiota in alcohol-related liver disease: pathophysiology and gut-brain cross talk by Lin Zhu, Yixuan Wang, Calvin Q. Pan, Calvin Q. Pan, Huichun Xing, Huichun Xing

“…The vicious cycles between gut dysbiosis and the disease progression in ALD including: an increase of acetaldehyde production and bile acid secretion, impaired gut barrier, enrichment of circulating microbiota, toxicities of microbiota metabolites, a cascade of pro-inflammatory chemokines or cytokines, and augmentation in the generation of reactive oxygen species. …”
Get full text

The effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass in type 2 diabetes rats by Weijie Chen, Haixin Yin, Jianchun Xiao, Wei Liu, Qiang Qu, Fengying Gong, Xiaodong He

“…The increased range of bile acid of the RYGB-A group was less than that of the RYGB-Y group (80.2 ± 59.3 % vs.212.3 ± 139.0 %, P < 0.01). …”
Get full text

Emerging trends and hotspots in the links between the gut microbiota and MAFLD from 2002 to 2021: A bibliometric analysis by Yixuan Li, Yanyu Zhou, Liya Wang, Xiaoqi Lin, Menghan Mao, Suqing Yin, Ling Zhu, Yingfu Jiao, Weifeng Yu, Po Gao, Liqun Yang

“…The co-citation keywords cluster label displayed ten main clusters: probiotics, bile acid, immune function, adolescents, nutritional genomics, high fat diet, systems biology, lipopolysaccharides, phosphatidylcholine, and oxidative stress. …”
Get full text

24-Norursodeoxycholic acid ameliorates experimental alcohol-related liver disease and activates hepatic PPARγ by Christoph Grander, Moritz Meyer, Daniel Steinacher, Thierry Claudel, Bela Hausmann, Petra Pjevac, Felix Grabherr, Georg Oberhuber, Manuel Grander, Natascha Brigo, Almina Jukic, Julian Schwärzler, Günter Weiss, Timon E. Adolph, Michael Trauner, Herbert Tilg

“…Background &amp; Aims: Alcohol-related liver disease (ALD) is a global healthcare challenge with limited treatment options. 24-Norursodeoxycholic acid (NorUDCA) is a synthetic bile acid with anti-inflammatory properties in experimental and human cholestatic liver diseases. …”
Get full text

Changes in Metabolites During an Oral Glucose Tolerance Test in Early and Mid-Pregnancy: Findings from the PEARLS Randomized, Controlled Lifestyle Trial by Danielle E. Haslam, Jun Li, Liming Liang, Marijulie Martinez, Cristina Palacios, Maria A. Trak-Fellermeier, Paul W. Franks, Kaumudi Joshipura, Shilpa N. Bhupathiraju

“…PCA identified distinct Δfast-120 min in fatty acid, acyl carnitine, bile acid, ketone body, and amino acid levels at mid- compared to early pregnancy. …”
Get full text

A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. by Alessio Lodola, Davide Branduardi, Marco De Vivo, Luigi Capoferri, Marco Mor, Daniele Piomelli, Andrea Cavalli

“…In the present study, we used free energy simulations in the quantum mechanics/molecular mechanics framework to determine the reaction mechanism of amide hydrolysis catalyzed by the prototypical cysteine Ntn-hydrolase, conjugated bile acid hydrolase (CBAH). The computational analyses, which were confirmed in water and using different CBAH mutants, revealed the existence of a chair-like transition state, which might be one of the specific features of the catalytic cycle of Ntn-hydrolases. …”
Get full text

Nuclear Receptor Small Heterodimer Partner in Apoptosis Signaling and Liver Cancer by Li Wang, Yuxia Zhang

“…SHP is a critical transcriptional regulator affecting diverse biological functions, including bile acid, cholesterol and lipid metabolism, glucose and energy homeostasis, and reproductive biology. …”
Get full text

Chlorogenic acid protects against cholestatic liver injury in rats by Duohu Wu, Chuanyu Bao, Longhe Li, Mingliang Fu, Desen Wang, Jinyuan Xie, Xiaoguang Gong

“…Blood biochemistry results revealed that CA decreased alanine transaminase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, direct bilirubin and total bile acid. PCR analysis indicated that collagen I, collagen III, transforming growth factor and vascular endothelial growth factor mRNA were increased markedly by BDL treatment but these increases were suppressed by CA. …”
Get full text

Pharmacological advances in the treatment of nonalcoholic fatty liver diseases : focused on global results of randomized controlled trials by Jihyun An, Joo Hyun Sohn

“…Furthermore, therapeutic agents targeting NASH pathogenesis, including bile acid signaling, insulin resistance, and lipid metabolism, are in various phases of clinical development. …”
Get full text

Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles by Piché, D, Tavernaro, I, Fleddermann, J, Lozano, J, Varambhia, A, Maguire, M, Koch, M, Ukai, T, Rodríguez, A, Jones, L, Dillon, F, Molina, I, Mitzutani, M, Dalmau, E, Maekawa, T, Nellist, P, Kraegeloh, A, Grobert, N

“…The particles were functionalised with bile-acid which improved biocompatibility by significant reduction of reactive oxygen species generation and is a first step towards liver-targeted T1 MRI. …”

Dysbiotic Gut Bacteria in Obesity: An Overview of the Metabolic Mechanisms and Therapeutic Perspectives of Next-Generation Probiotics by Jonathan Breton, Marie Galmiche, Pierre Déchelotte

“…In particular, we discuss gut microbiota’s contribution to host energy homeostatic changes, low-grade inflammation, and regulation of fat deposition and bile acid metabolism via bacterial metabolites, such as short-chain fatty acids, and bacterial components, such as lipopolysaccharides, among others. …”
Get full text

Effects of different extraction methods on the physicochemical properties and biological activities of polysaccharides from maca roots by Eun Jeong Kim, Kyung Young Yoon

“…Additionally, MRP-DU exhibited the highest antidiabetic and absorption-retarding effects on glucose and bile acid. These results suggest that MRP obtained using DES-based UAE have high application potential as functional food materials and could also serve as antidiabetic and cholesterol-lowering agents.…”
Get full text