-
2101
Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review
Published 2021-01-01“…Several studies in humans and animal models have demonstrated an association between gut microbial metabolites such as trimethylamine-<i>N</i>-oxide (TMAO), short-chain fatty acids, and bile acid metabolites (amino acid breakdown products) with CVD. …”
Get full text
Article -
2102
Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies
Published 2019-01-01“…Fibroblast growth factor receptor 4 (FGFR4), a tyrosine kinase receptor for FGFs, is involved in diverse cellular processes, including the regulation of cell proliferation, differentiation, migration, metabolism, and bile acid biosynthesis. High activation of FGFR4 is strongly associated with the amplification of its specific ligand FGF19 in many types of solid tumors and hematologic malignancies, where it acts as an oncogene driving the cancer development and progression. …”
Get full text
Article -
2103
Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes
Published 2016“…NTCP regulates HCV infection by augmenting the bile-acid-mediated repression of interferon-stimulated genes (ISGs), including IFITM3. …”
Journal article -
2104
Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation
Published 2022-02-01“…Our previous study indicate that TKT could promote the development of liver cancer by affecting bile acid metabolism. And in this study, we discovered that TKT expression was remarkably upregulated in colorectal cancer, abnormal high expression of TKT is associated with poor prognosis of colorectal cancer. …”
Get full text
Article -
2105
Anti-Inflammatory Effects of Lipid-Lowering Drugs and Supplements—A Narrative Review
Published 2023-03-01“…Thus, the aim of this narrative review was to evaluate the anti-inflammatory properties of currently available lipid-lowering medications including statins, ezetimibe, bile acid sequestrants (BAS), proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, fibrates, omega-3 fatty acids, and niacin, as well as dietary supplements and novel drugs used in modern times.…”
Get full text
Article -
2106
Petromylidenes A–C: 2-Alkylidene Bile Salt Derivatives Isolated from Sea Lamprey (Petromyzon marinus)
Published 2018-09-01“…Three novel bile acid derivatives, petromylidenes A–C (1–3), featuring uncommon alkylidene adductive scaffolds, were isolated from water conditioned with sexually mature male sea lampreys (Petromyzon marinus). …”
Get full text
Article -
2107
Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites
Published 2022-10-01“…In addition, Pae increased the abundance of gut microbiota, partially reversed the disturbance of intestinal biota composition, including Lactobacillus and Bacteroides, and regulated metabolite levels, such as bile acid (BA) and short-chain fatty acid (SCFA). In conclusion, our study provides new insight on Pae remission of UC.…”
Get full text
Article -
2108
Microbial bile salt hydrolase activity influences gene expression profiles and gastrointestinal maturation in infant mice
Published 2022-12-01“…Bacterial bile salt hydrolase (BSH) acts as a putative colonization factor that influences bile acid signatures and microbe-host signaling pathways and we considered whether this activity can influence infant gut development. …”
Get full text
Article -
2109
Garlic (Allium sativum) polysaccharides ameliorates hepatic injury and fat accumulation in mice with metabolic associated fatty liver disease (MAFLD)
Published 2022-12-01“…In addition, GP also had a substantial impact on bile acid metabolic pathways. These findings provide new insights into the pathogenesis of MAFLD and provide further evidence for the potential use of GP as an alternative functional ingredient.…”
Get full text
Article -
2110
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance
Published 2023-10-01“…Subtype M1 was found to be dependent on bile-acid biosynthesis, whereas M2 showed reliance on methionine pathway, and M3 engaged fatty-acid, nucleotide, and glucose metabolism. …”
Get full text
Article -
2111
Merit of an Ursodeoxycholic Acid Clinical Trial in COVID-19 Patients
Published 2020-06-01“…Bear bile is rich in UDCA, comprising up to 40–50% of the total bile acid. UDCA is a logical and attainable replacement for bear bile that is available in pill form and merits clinical trial consideration.…”
Get full text
Article -
2112
Association between Intestinal Microecological Changes and Atherothrombosis
Published 2023-05-01“…Additionally, intestinal microecology promotes the progression of AS by interfering with the normal bile acid metabolism of the body. In this review, we summarize the research on the correlation between maintaining a dynamic balance of intestinal microecology and AS, which may be potentially helpful for the treatment of AS.…”
Get full text
Article -
2113
Peripheral neuronal activation shapes the microbiome and alters gut physiology
Published 2024-04-01“…The resulting multi-omics datasets support broad roles for discrete peripheral neuronal subtypes in shaping microbiome structure, including modulating bile acid profiles and fungal colonization. Physiologically, activation of either ChAT+ or TH+ neurons increases fecal output, while only ChAT+ activation results in increased colonic contractility and diarrhea-like fluid secretion. …”
Get full text
Article -
2114
The role of cholesterol metabolism in tumor therapy, from bench to bed
Published 2023-04-01“…Cholesterol metabolism participates in bile acid production and steroid hormone biosynthesis. …”
Get full text
Article -
2115
The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis
Published 2023-09-01“…In mice, poorly absorbed dietary long-chain SFA, particularly stearic acid, induce a shift in bile acid profile and improved metabolism and steatosis. …”
Get full text
Article -
2116
A look at new therapeutic opportunities in patients with non-alcoholic fatty liver disease
Published 2019-12-01“…FXR agonists can claim to be a new promising drug for the treatment of NAFLD and related diseases influencing carbohydrate metabolism, fat metabolism, bile acid metabolism, as well as inflammatory processes in the liver to ensure metabolic homeostasis.…”
Get full text
Article -
2117
Opportunities for Nanomedicine in <i>Clostridioides difficile</i> Infection
Published 2021-08-01“…<i>C. difficile</i> spores can germinate quickly after being exposed to bile acid and co-germinant in a suitable environment. …”
Get full text
Article -
2118
A selective gut bacterial bile salt hydrolase alters host metabolism
Published 2018-07-01“…Using isogenic strains of wild-type and BSH-deleted Bacteroides thetaiotaomicron, we selectively modulated the levels of the bile acid tauro-β-muricholic acid in monocolonized gnotobiotic mice. …”
Get full text
Article -
2119
Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes
Published 2023-05-01“…CDO1 is involved in a spectrum of physiological processes including lipid metabolism, adipogenesis, osteoblastic differentiation, redox homeostasis, fertility, bile acid metabolism, sulfide metabolism, and organismal growth and development. …”
Get full text
Article -
2120
Aged oolong tea alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and its metabolites
Published 2024-03-01“…Anti-inflammatory effects are exerted through the stimulation of metabolic pathways associated with amino acid, fatty acid and bile acid metabolites. Importantly, the study identified key bacteria (e.g., Sutterella, Clostridiaceae_Clostridium, Mucispirillum, Oscillospira and Ruminococcus) for the development and remission of inflammation. …”
Get full text
Article