Human Hepatocyte Nuclear Factors (HNF1 and LXRb) Regulate CYP7A1 in HIV-Infected Black South African Women with Gallstone Disease: A Preliminary Study by Suman Mewa Kinoo, Pragalathan Naidoo, Bhugwan Singh, Anil Chuturgoon, Savania Nagiah

“…HIV-infected patients on combination antiretroviral therapy (cART) are more prone to hypercholesterolemia. Bile acid synthesis is initiated by cholesterol 7-alpha hydroxylase (CYP7A1) and regulated by hepatocyte nuclear factors (HNF1α, HNF4α, and LXRb). …”
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Transcriptome and Gut Microbiota Profiling Analysis of ANIT-Induced Cholestasis and the Effects of Da-Huang-Xiao-Shi Decoction Intervention by Wang Wang, Shujun Jiang, Chengcheng Xu, Lili Tang, Yan Liang, Yang Zhao, Guoxue Zhu

“…ABSTRACT Cholestasis is characterized by bile acid (BA) circulation disorders, which is usually related to damage of hepatocyte barrier function. …”
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Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1 by Rubén Rodríguez-Agudo, Irene González-Recio, Marina Serrano-Maciá, Miren Bravo, Petar Petrov, Delia Blaya, Jose María Herranz, María Mercado-Gómez, Claudia María Rejano-Gordillo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Mikel Azkargorta, Sebastiaan Martijn Van Liempd, Luis Alfonso Martinez-Cruz, A.L. Simão, Félix Elortza, César Martín, Yulia A. Nevzorova, Francisco Javier Cubero, Teresa C. Delgado, Josepmaria Argemi, Ramón Bataller, Kristina Schoonjans, Jesús M. Banales, Rui E. Castro, Pau Sancho-Bru, Matías A. Avila, Josep Julve, Ramiro Jover, Jon Mabe, Jorge Simon, Naroa Goikoetxea-Usandizaga, María L. Martínez-Chantar

“…In this study, inhibiting miR-873-5p exerted hepatoprotective effects against ALD through rescued SIRT1 activity and consequently restored bile acid homeostasis and attenuated the inflammatory response. …”
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Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice by Roni F. Kunst, Isabelle Bolt, Rychon D.J. van Dasselaar, Bart A. Nijmeijer, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf

“…Background & Aims: Intestine-restricted inhibitors of the apical sodium-dependent bile acid transporter (ASBT, or ileal bile acid transporter) are approved as treatment for several inheritable forms of cholestasis but are also associated with abdominal complaints and diarrhoea. …”
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The alleviating effect of Scutellaria amoena extract on the regulation of gut microbiota and its metabolites in NASH rats by inhibiting the NLRP3/ASC/caspase-1 axis by Yu-Ping Lin, Yu-Ping Lin, Qiong-Lian Fang, Sheng-Nan Fu, Xin-Ping Li, Rui Shi, Cheng-Hong Du, Xue Qiao, Xun-Qing Yin, Yong-Cheng Zeng, Xiu-Juan Zhao, Yan Hua

“…Nine metabolic pathways were identified, including primary bile acid biosynthesis, bile secretion, purine metabolism, and secondary bile acid biosynthesis.Conclusion: SA can regulate the intestinal microbial balance and metabolic disorder by inhibiting the NLRP3/ASC/caspase-1 axis to relieve NASH.…”
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Treatment of Dyslipidaemia in Children by Riccardo Fiorentino, Francesco Chiarelli

“…Statins represent the first-line pharmacological option, while ezetimibe and bile acid sequestrants are usually used as second-line drugs. …”
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Breeding Buckwheat for Increased Levels and Improved Quality of Protein by Zlata Luthar, Meiliang Zhou, Aleksandra Golob, Mateja Germ

“…Digestion-resistant peptides are a vehicle for fecal excretion of steroids, and in this way, for bile acid elimination and reduction of cholesterol concentrations in serum. …”
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Genomic instability in liver cells caused by an LPS-induced bystander-like effect. by Igor Kovalchuk, Paul Walz, James Thomas, Olga Kovalchuk

“…Liver cells responded to exposure of whole heat-killed bacteria and LPS with alteration in γH2AX levels and levels of proteins involved in proliferation, DNA methylation (MeCP2, DNMT1, DNMT3A and 3B) or DNA repair (APE1 and KU70) as well as with changes in the expression of genes involved in stress response, cell cycle control and bile acid biosynthesis. Other bacterial components analysed in this study did not lead to any significant changes in the tested molecular parameters. …”
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Family’s Knowledge About Traditional Medication For Cholesterol Sufferers by Ade Irma Triana Siregar

“…Cholesterol is one of the precusors for another steroid compound inside the body, for example corticosteroid, sex hormone, bile acid, and vitamin D. cholesterol is synthesized inside the body from Acetyl-CoA established meyalonate through a complex track. …”
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A Clinical & Experimental Obstetrics and Gynecology survey on ursodeoxycholic treatment of intrahepatic cholestasis of pregnancy: scholars’ opinion by Caroline Ovadia, Ugo Indraccolo

“…Despite the unclear roles of ursodeoxycholic acid in ICP, respondents believed that reducing the bile acid using ursodeoxycholic acid was beneficial to prevent adverse pregnancy outcomes. …”
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Regulation of the HBV Entry Receptor NTCP and its Potential in Hepatitis B Treatment by Yan Li, Jun Zhou, Tianliang Li

“…Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been identified as the receptor responsible for the cellular entry of both HBV and its satellite, hepatitis delta virus (HDV). …”
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A Review of Current Evidence on the Relationship between Phosphate Metabolism and Metabolic Syndrome by Sok Kuan Wong

“…For lipid metabolism, adequate phosphate content ensures a balanced lipid profile through regulation of fatty acid biosynthesis, oxidation, and bile acid excretion. In conclusion, phosphate metabolism serves as a potential key feature for the development and progression of MetS. …”
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The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved. by Tamara Somborac, Güleycan Lutfullahoglu Bal, Kaneez Fatima, Helena Vihinen, Anja Paatero, Eija Jokitalo, Ville O Paavilainen, Svetlana Konovalova

“…Peroxisomes are membrane-enclosed organelles with important roles in fatty acid breakdown, bile acid synthesis and biosynthesis of sterols and ether lipids. …”
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Unraveling the Metabolite Signature of Endophytic <i>Bacillus velezensis</i> Strain Showing Defense Response towards <i>Fusarium oxysporum</i> by Yang Cao, Wei Ding, Chang Liu

“…Further investigation revealed that ‘secondary bile acid biosynthesis’ and ‘glycerophospholipid metabolism’ pathways played essential roles in defense response towards <i>F. oxysporum</i>. …”
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High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective. by Cullen, SN, Rust, C, Fleming, K, Edwards, C, Beuers, U, Chapman, R

“…This pilot, randomised dose-ranging trial attempted to determine whether further enrichment of the bile acid pool with UDCA would lead to an improvement in outcome for PSC patients. …”

Interaction of Cytochrome C Oxidase with Steroid Hormones by Ilya P. Oleynikov, Natalia V. Azarkina, Tatiana V. Vygodina, Alexander A. Konstantinov

“…We presume that the hormones bind to CcO at the bile acid binding site described by Ferguson-Miller and collaborators. …”
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Applications of In Silico Models to Predict Drug-Induced Liver Injury by Jiaying Lin, Min Li, Wenyao Mak, Yufei Shi, Xiao Zhu, Zhijia Tang, Qingfeng He, Xiaoqiang Xiang

“…Drug-induced liver injury (DILI) is a major cause of the withdrawal of pre-marketed drugs, typically attributed to oxidative stress, mitochondrial damage, disrupted bile acid homeostasis, and innate immune-related inflammation. …”
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Enhancing Phytochemical Compounds, Functional Properties, and Volatile Flavor Profiles of Pomelo (<i>Citrus grandis</i> (L.) Osbeck) Juices from Different Cultivars through Ferment... by Vernabelle Balmori, Marisa Marnpae, Charoonsri Chusak, Kritmongkhon Kamonsuwan, Kasinee Katelakha, Suvimol Charoensiddhi, Sirichai Adisakwattana

“…Fermentation led to an increase in viable lactic acid bacteria count (8.80–9.28 log cfu/mL), organic acids, total polyphenols, and flavonoids, resulting in improved antioxidant activity, bile acid binding, cholesterol micellization disruption, and inhibition of pancreatic lipase activity. …”
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Mapping transcriptional heterogeneity and metabolic networks in fatty livers at single-cell resolution by Laetitia Coassolo, Tianyun Liu, Yunshin Jung, Nikki P. Taylor, Meng Zhao, Gregory W. Charville, Silas Boye Nissen, Hannele Yki-Jarvinen, Russ B. Altman, Katrin J. Svensson

“…Mechanistically, CAR interacts with four functional modules: cholesterol homeostasis, bile acid metabolism, fatty acid metabolism, and estrogen response. …”
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You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review by Małgorzata Moszak, Monika Szulińska, Paweł Bogdański

“…GM regulates various metabolic pathways in the host, including those involved in energy homeostasis, glucose and lipid metabolism, and bile acid metabolism. The relationship between alterations in intestinal microbiota and diseases associated with civilization is well documented. …”
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