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2141
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
Published 2023-09-01“…Abstract Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood. …”
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2142
Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections
Published 2020-11-01“…For example, infection induces changes in lipid (e.g., free fatty acids, sphingolipids, and lysophosphatidylcholines) and amino acid pathways (e.g., tryptophan, serine, and threonine), while vaccination can trigger changes in carbohydrate and bile acid pathways. Amino acid, carbohydrate, lipid, and nucleotide metabolism is relevant to immunity and is perturbed by both infections and vaccinations. …”
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2143
Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients
Published 2023-10-01“…DNL steatosis model exhibited elevated pathways related to glycolysis, cholesterol homeostasis, and bile acid metabolism, reflecting its clinical relevance to MAFLD. …”
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2144
The effect of lypolitics on atherosclerotic plaques of the artery
Published 2024-01-01“…Visual observation, histology, endoscopy, video endoscopy and scanning electron microscopy during an observation period of 5 minutes to 5 days did not reveal significant changes in the structure, consistency, shape and number of arterial atheromas when exposed to 6 lipolytics, with the exception of Bile acid factors and phosphatidylcholine lipolytics. …”
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2145
Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA
Published 2023-01-01“…Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. …”
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2146
Gut Microbiota and Antibiotic Treatments for the Main Non-Oncologic Hepato-Biliary-Pancreatic Disorders
Published 2023-06-01“…Chronic liver disease and pancreatic disorders can lead to reduced intestinal motility, decreased bile acid synthesis and intestinal immune dysfunction, determining a compositional and functional imbalance in gut microbiota (dysbiosis), with potentially harmful consequences on the host’s health. …”
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2147
Microwave synthesis of novel chenodeoxycholic acid esters and comparative study of chromatographic behavior and lipophilicity
Published 2023-12-01“… In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The synthesized bile acid esters were obtained with high yields (up to 81 %) and purity in a short reaction time (15 min). …”
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2148
Metabolomic Analysis and MRM Verification of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat
Published 2022-08-01“…In addition, we enriched six KEGG pathways, of which cholesterol metabolism, primary bile acid biosynthesis, and bile secretion were enriched in positive and negative modes. …”
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2149
Characterization of Two <i>Parabacteroides distasonis</i> Candidate Strains as New Live Biotherapeutics against Obesity
Published 2023-04-01“…These beneficial effects are associated with reduced inflammation in adipose tissue and the improvement of lipid and bile acid metabolism markers. <i>P. distasonis</i> supplementation also modified the <i>Actinomycetota</i>, <i>Bacillota</i> and <i>Bacteroidota</i> taxa of the mice gut microbiota. …”
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2150
Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea
Published 2023-10-01“…Abstract Chronic diarrhea, including diarrhea‐predominant irritable bowel syndrome (IBS‐D), osmotic diarrhea, bile acid diarrhea, and antibiotic‐associated diarrhea, is a common problem which is highly associated with disorders of the gut microbiota composition such as small intestinal bacterial overgrowth (SIBO) and so on. …”
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2151
Microbial Players in Primary Sclerosing Cholangitis: Current Evidence and ConceptsSummary
Published 2024-01-01“…Moreover, we discuss the latest insights into microbe-altering therapeutic approaches involving the gut-liver axis and bile acid metabolism.…”
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2152
The Role of Enterobacteriaceae in Gut Microbiota Dysbiosis in Inflammatory Bowel Diseases
Published 2021-03-01“…Despite the mechanism of their expansion still remaining unclear, their expansion could be correlated with the increase in nitrate and oxygen levels in the inflamed gut and with the bile acid dysmetabolism described in IBD patients. …”
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2153
Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors
Published 2023“…Herein, acrylated β-cyclodextrin with bile acid is self-assembled into a polymerizable pseudorotaxane via precise host-guest recognition, which is photopolymerized with acrylamide to obtain conductive polymerizable rotaxane hydrogels (PR-Gel). …”
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Journal Article -
2154
Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
Published 2014“…Results: Our results show alterations in the metabolism of bile acid, glycolysis and fatty acid in patients. The distinctive metabolite profiles established using PLSDA identify several biomarkers for diagnostic use in clinical settings. …”
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2155
3555 Intrahepatic Cholestasis of Pregnancy (ICP) is associated with higher prevalence of NAFLD: a case-control study.
Published 2019-03-01“…Progression of non-alcoholic fatty liver disease (NAFLD) has been linked to the dysregulation of bile acid homeostasis. However, an association of NAFLD with ICP has not been previously evaluated. …”
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2156
Case Report: A 31-year-old Post Cesarean Section Women with Intrahepatic Cholestasis of Pregnancy and Post Partum Bell’s Palsy
Published 2020-07-01“…Intrahepatic cholestasis of pregnancy (ICP) is cholestasis condition characterized by pruritus, elevated serum aminotransferase and bile acid levels with onset in the second or third trimester of pregnancy. …”
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2157
Cancer-Associated Microbiota: From Mechanisms of Disease Causation to Microbiota-Centric Anti-Cancer Approaches
Published 2022-05-01“…Experimental evidence supporting the cancer-causing role of gut commensal through the modulation of host-specific processes (e.g., bile acid metabolism, hormonal effects) or by direct DNA damage and toxicity has been discussed. …”
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2158
Protective effect of kaempferol against cognitive and neurological disturbances induced by d-galactose and aluminum chloride in mice
Published 2023-01-01“…A total of 12 potential biomarkers were clearly altered after kaempferol treatment in the metabolomics, which related to phenylalanine, tyrosine and tryptophan biosynthesis, primary bile acid biosynthesis, amino acid metabolism and glycerophospholipid metabolism. …”
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2159
Microscopic Colitis: Pathogenesis and Diagnosis
Published 2023-07-01“…The management of microscopic colitis should be based on each individual’s underlying pathogenesis and involves budesonide, bile acid sequestrants, or immunosuppressive drugs in refractory cases. …”
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2160
Recent Progress in Metabolic Syndrome Research and Therapeutics
Published 2021-06-01“…Fecal microbiota transplantation, aiming to restore the host’s homeostasis, and targeting of the bile acid signaling pathway are two approaches to combatting MetS. …”
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Article