Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling by Jing Zhong, Xiaofang He, Xinxin Gao, Qiaohong Liu, Yu Zhao, Ying Hong, Weize Zhu, Juan Yan, Yifan Li, Yan Li, Ningning Zheng, Yiyang Bao, Hao Wang, Junli Ma, Wenjin Huang, Zekun Liu, Yuanzhi Lyu, Xisong Ke, Wei Jia, Cen Xie, Yiyang Hu, Lili Sheng, Houkai Li

“…Abstract Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood. …”
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Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections by Joann Diray-Arce, Maria Giulia Conti, Boryana Petrova, Naama Kanarek, Asimenia Angelidou, Ofer Levy

“…For example, infection induces changes in lipid (e.g., free fatty acids, sphingolipids, and lysophosphatidylcholines) and amino acid pathways (e.g., tryptophan, serine, and threonine), while vaccination can trigger changes in carbohydrate and bile acid pathways. Amino acid, carbohydrate, lipid, and nucleotide metabolism is relevant to immunity and is perturbed by both infections and vaccinations. …”
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Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients by Woonghee Kim, Mengzhen Li, Han Jin, Hong Yang, Hasan Türkez, Mathias Uhlén, Cheng Zhang, Adil Mardinoglu

“…DNL steatosis model exhibited elevated pathways related to glycolysis, cholesterol homeostasis, and bile acid metabolism, reflecting its clinical relevance to MAFLD. …”
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The effect of lypolitics on atherosclerotic plaques of the artery by Darmenov Oralbay, Issayeva Nazym, Zhaksybay Zhuldyz, Sadyrbayeva Gulnur, Bayanbay Nurlan

“…Visual observation, histology, endoscopy, video endoscopy and scanning electron microscopy during an observation period of 5 minutes to 5 days did not reveal significant changes in the structure, consistency, shape and number of arterial atheromas when exposed to 6 lipolytics, with the exception of Bile acid factors and phosphatidylcholine lipolytics. …”
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Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA by Longying Jiang, Xueke Liu, Xujun Liang, Shuyan Dai, Hudie Wei, Ming Guo, Zhuchu Chen, Desheng Xiao, Yongheng Chen

“…Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. …”
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Gut Microbiota and Antibiotic Treatments for the Main Non-Oncologic Hepato-Biliary-Pancreatic Disorders by Federica Di Vincenzo, Alberto Nicoletti, Marcantonio Negri, Federica Vitale, Lorenzo Zileri Dal Verme, Antonio Gasbarrini, Francesca Romana Ponziani, Lucia Cerrito

“…Chronic liver disease and pancreatic disorders can lead to reduced intestinal motility, decreased bile acid synthesis and intestinal immune dysfunction, determining a compositional and functional imbalance in gut microbiota (dysbiosis), with potentially harmful consequences on the host’s health. …”
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Microwave synthesis of novel chenodeoxycholic acid esters and comparative study of chromatographic behavior and lipophilicity by Ksenija Pavlović, Ljubica Grbović, Milica Karadžić Banjac, Strahinja Kovačević, Anamarija Mandić, Sanja Podunavac-Kuzmanović, Bojana Vasiljević

“… In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The synthesized bile acid esters were obtained with high yields (up to 81 %) and purity in a short reaction time (15 min). …”
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Metabolomic Analysis and MRM Verification of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat by Yanan Xu, Weidong Cai, Rui Chen, Xinjiang Zhang, Zhixian Bai, Yu Zhang, Yuting Qin, Ming Gu, Yinggang Sun, Yanzhi Wu, Zeying Wang

“…In addition, we enriched six KEGG pathways, of which cholesterol metabolism, primary bile acid biosynthesis, and bile secretion were enriched in positive and negative modes. …”
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Characterization of Two <i>Parabacteroides distasonis</i> Candidate Strains as New Live Biotherapeutics against Obesity by Bernardo Cuffaro, Denise Boutillier, Jérémy Desramaut, Amin Jablaoui, Elisabeth Werkmeister, François Trottein, Anne-Judith Waligora-Dupriet, Moez Rhimi, Emmanuelle Maguin, Corinne Grangette

“…These beneficial effects are associated with reduced inflammation in adipose tissue and the improvement of lipid and bile acid metabolism markers. <i>P. distasonis</i> supplementation also modified the <i>Actinomycetota</i>, <i>Bacillota</i> and <i>Bacteroidota</i> taxa of the mice gut microbiota. …”
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Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea by Hong Xue, Chun‐Feng Mei, Feng‐Yun Wang, Xu‐Dong Tang

“…Abstract Chronic diarrhea, including diarrhea‐predominant irritable bowel syndrome (IBS‐D), osmotic diarrhea, bile acid diarrhea, and antibiotic‐associated diarrhea, is a common problem which is highly associated with disorders of the gut microbiota composition such as small intestinal bacterial overgrowth (SIBO) and so on. …”
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Microbial Players in Primary Sclerosing Cholangitis: Current Evidence and ConceptsSummary by Burcin Özdirik, Bernd Schnabl

“…Moreover, we discuss the latest insights into microbe-altering therapeutic approaches involving the gut-liver axis and bile acid metabolism.…”
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The Role of Enterobacteriaceae in Gut Microbiota Dysbiosis in Inflammatory Bowel Diseases by Valerio Baldelli, Franco Scaldaferri, Lorenza Putignani, Federica Del Chierico

“…Despite the mechanism of their expansion still remaining unclear, their expansion could be correlated with the increase in nitrate and oxygen levels in the inflamed gut and with the bile acid dysmetabolism described in IBD patients. …”
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Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors by Xiong, Xueru, Chen, Yunhua, Wang, Zhenxing, Liu, Huan, Le, Mengqi, Lin, Caihong, Wu, Gang, Wang, Lin, Shi, Xuetao, Jia, Yong-Guang, Zhao, Yanli

“…Herein, acrylated β-cyclodextrin with bile acid is self-assembled into a polymerizable pseudorotaxane via precise host-guest recognition, which is photopolymerized with acrylamide to obtain conductive polymerizable rotaxane hydrogels (PR-Gel). …”
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Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients by Bannur, Zakaria, Salleh, Mohd Zaki, Hashim, H., Hennessy, Thomas, Azmi, M. N., Zailani, M. H., Ramasamy, P., Zakaria, Zainul Amiruddin, Suneet, S., Abdullah, Harris Ngow, Henry, G., Teh, Lay Kek

“…Results: Our results show alterations in the metabolism of bile acid, glycolysis and fatty acid in patients. The distinctive metabolite profiles established using PLSDA identify several biomarkers for diagnostic use in clinical settings. …”
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3555 Intrahepatic Cholestasis of Pregnancy (ICP) is associated with higher prevalence of NAFLD: a case-control study. by Erica Monrose, Andres Ramirez Zamudio, Alaina Aristide, Reema Navalurkar, Rashi Bedekar, Lauren Ferrara, Tatyana Kushner

“…Progression of non-alcoholic fatty liver disease (NAFLD) has been linked to the dysregulation of bile acid homeostasis. However, an association of NAFLD with ICP has not been previously evaluated. …”
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Case Report: A 31-year-old Post Cesarean Section Women with Intrahepatic Cholestasis of Pregnancy and Post Partum Bell’s Palsy by Syifa Mustika, RC Tarigan

“…Intrahepatic cholestasis of pregnancy (ICP) is cholestasis condition characterized by pruritus, elevated serum aminotransferase and bile acid levels with onset in the second or third trimester of pregnancy. …”
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Cancer-Associated Microbiota: From Mechanisms of Disease Causation to Microbiota-Centric Anti-Cancer Approaches by Priyankar Dey, Saumya Ray Chaudhuri

“…Experimental evidence supporting the cancer-causing role of gut commensal through the modulation of host-specific processes (e.g., bile acid metabolism, hormonal effects) or by direct DNA damage and toxicity has been discussed. …”
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Protective effect of kaempferol against cognitive and neurological disturbances induced by d-galactose and aluminum chloride in mice by He Lin, Xinhe Wang, Jiarui Zhao, Zhe Lin

“…A total of 12 potential biomarkers were clearly altered after kaempferol treatment in the metabolomics, which related to phenylalanine, tyrosine and tryptophan biosynthesis, primary bile acid biosynthesis, amino acid metabolism and glycerophospholipid metabolism. …”
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Microscopic Colitis: Pathogenesis and Diagnosis by Busara Songtanin, Jason N. Chen, Kenneth Nugent

“…The management of microscopic colitis should be based on each individual’s underlying pathogenesis and involves budesonide, bile acid sequestrants, or immunosuppressive drugs in refractory cases. …”
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Recent Progress in Metabolic Syndrome Research and Therapeutics by Ting-Wei Kao, Chin-Chou Huang

“…Fecal microbiota transplantation, aiming to restore the host’s homeostasis, and targeting of the bile acid signaling pathway are two approaches to combatting MetS. …”
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