Advances and Challenges in Studying Hepatitis B Virus In Vitro by Dvora Witt-Kehati, Maya Bitton Alaluf, Amir Shlomai

“…Recent advances in our understanding of HBV biology, such as the discovery of the bile-acid pump sodium-taurocholate cotransporting polypeptide (NTCP) as a receptor for HBV, enabled the establishment of NTCP expressing hepatoma cell lines permissive for HBV infection. …”
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Symposium: Therapeutic approach. Bariatric surgery and beta cell by Carla Musso

“…The reasons to justify said beneficial changes include postoperative GLP1 and GIP increase, weight decrease with reduction of adipose tissue with proinflammatory cytokines, ghrelin reduction, increased insulin sensitivity and bile acid impact. Considering the main role of beta cells to maintain normoglycemia, a randomized study was carried out exposing serum samples from obesity and diabetes patients undergoing bariatric surgery (vertical gastrectomy) into beta cells culture and comparing it with sera of conventionally treated patients. …”
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Innovative HBV Animal Models Based on the Entry Receptor NTCP by Jochen M. Wettengel, Benjamin J. Burwitz

“…Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter expressed on hepatocytes, has been shown to be one of the key factors in HBV infection, playing a crucial role in the HBV entry process in vitro and in vivo. …”
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A rare treatable cause for atypical frontotemporal dementia with multiple fractures in a young female by Sadanandavalli Retnaswami Chandra, Neeraja Koti, Ganaraja Valakunja Harikrishna, Pooja Mailankody, C Nitin Ramanujam, S Mathuranath Pavagada, Thomas Gregor Issac

“…Cerebro tendinous xantamatosis (CTX) is a rare treatable inborn error of bile acid metabolism. Reported average delay from onset of symptoms to diagnosis is about 16 years as per reports. …”
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Treatment of Cyanobacterial (Microcystin) Toxicosis Using Oral Cholestyramine: Case Report of a Dog from Montana by Michael J. Murray, Stori C. Oates, Kelly A. Rankin, Raphael M. Kudela, Karen A. Alroy, Melissa A. Miller

“…On day five of hospitalization, a bile acid sequestrant, cholestyramine, was administered orally. …”
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Effects of <it>SLC10A2 </it>variant <it>rs9514089 </it>on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts by Tönjes Anke, Wittenburg Henning, Halbritter Jan, Renner Olga, Harsch Simone, Stange Eduard F, Lammert Frank, Stumvoll Michael, Kovacs Peter

“…<p>Abstract</p> <p>Background</p> <p>Recently, a single nucleotide polymorphism (SNP) <it>rs9514089 </it>in <it>SLC10A2 </it>(apical sodium-dependent bile acid transporter gene) has been identified as a susceptibility variant for cholelithiasis in humans.…”
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Olive oil, diet and colorectal cancer: an ecological study and a hypothesis. by Stoneham, M, Goldacre, M, Seagroatt, V, Gill, L

“…The proposed hypothesis is that olive oil may influence secondary bile acid patterns in the colon that, in turn, might influence polyamine metabolism in colonic enterocytes in ways that reduce progression from normal mucosa to adenoma and carcinoma.…”

Cerebrotendinous Xanthomatosis: A practice review of pathophysiology, diagnosis, and treatment by Paulo Ribeiro Nóbrega, Paulo Ribeiro Nóbrega, Anderson Moura Bernardes, Rodrigo Mariano Ribeiro, Sophia Costa Vasconcelos, David Augusto Batista Sá Araújo, Vitor Carneiro de Vasconcelos Gama, Helena Fussiger, Helena Fussiger, Carolina de Figueiredo Santos, Carolina de Figueiredo Santos, Daniel Aguiar Dias, André Luíz Santos Pessoa, André Luíz Santos Pessoa, Wladimir Bocca Vieira de Rezende Pinto, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Paulo Victor Sgobbi de Souza, Pedro Braga-Neto, Pedro Braga-Neto

“…Cerebrotendinous Xanthomatosis represents a rare and underdiagnosed inherited neurometabolic disorder due to homozygous or compound heterozygous variants involving the CYP27A1 gene. This bile acid metabolism disorder represents a key potentially treatable neurogenetic condition due to the wide spectrum of neurological presentations in which it most commonly occurs. …”
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Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis by Daniel Junpyo Lee, An Na Kang, Junbeom Lee, Min-Jin Kwak, Daye Mun, Daseul Lee, Sangnam Oh, Younghoon Kim

“…Furthermore, fecal metabolomic analysis showed higher excretion of primary bile acid and cholesterol in the groups fed F. venenatum which might lead to a decrease in lipid digestion and hepatic fat accumulation. …”
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Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men by Patrick McQueen, Donald Molina, Ivan Pinos, Samuel Krug, Anna J. Taylor, Michael R. LaFrano, Maureen A. Kane, Jaume Amengual

“…RNA sequencing analysis revealed a downregulation of inflammatory pathways and an upregulation of bile acid metabolism, oxidative phosphorylation, and cholesterol pathways in the liver of mice taking finasteride. …”
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Untargeted Metabolomics Reveals the Function of GPRC6A in Amino Acid and Lipid Metabolism in Mice by Yumin He, Jingyun Su, Hongrui Gao, Jianzhong Li, Zemeng Feng, Yulong Yin

“…A loss of GPRC6A function may perturb bile acid metabolism, thus leading to abnormal unsaturated fatty acid metabolism. …”
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The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review by Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Sandra Kannampuzha, Reshma Murali, Arunraj Namachivayam, Raja Ganesan, Abhijit Dey, Achsha Babu, Kaviyarasi Renu, Balachandar Vellingiri, Gnanasambandan Ramanathan, George Priya Doss C., Nehal Elsherbiny, Amira M. Elsherbini, Alsamman M. Alsamman, Hatem Zayed, Abilash Valsala Gopalakrishnan

“…Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. …”
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Potential Molecular Mechanisms of Alzheimer’s Disease from Genetic Studies by Martin Nwadiugwu, Hui Shen, Hong-Wen Deng

“…The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. …”
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Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy by So-Hyeon Park, Jun-Hyuck Lee, Seong-Bin Yang, Dong-Nyeong Lee, Tae-Bong Kang, Jooho Park

“…In this study, we developed a novel peptide and drug conjugate (PDC)-based cathepsin B inhibitor using cathepsin-B-specific peptide (RR) and bile acid (BA). Interestingly, this RR and BA conjugate (RR–BA) was able to self-assemble in an aqueous solution, and as a result, it formed stable nanoparticles. …”
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Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload by May G. Akl, Lei Li, Raquel Baccetto, Sadhna Phanse, Qingzhou Zhang, Michael J. Trites, Sherin McDonald, Hiroyuki Aoki, Mohan Babu, Scott B. Widenmaier

“…Combined deficiency, but not deficiency of either alone, results in severe steatohepatitis, hepatic cholesterol overload and crystallization, altered bile acid metabolism, and decreased biliary cholesterol. …”
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A Comprehensive Review of the Cardioprotective Effect of Marine Algae Polysaccharide on the Gut Microbiota by Kit-Leong Cheong, Biao Yu, Jing Chen, Saiyi Zhong

“…In addition, the effects of trimethylamine N-oxide on the gut microbiota composition, bile acid signaling properties, and CVD prevention are also discussed. …”
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Primary biliary cholangitis: molecular pathogenesis perspectives and therapeutic potential of natural products by Yanling Zhao, Shizhang Wei, Lisheng Chen, Lisheng Chen, Xuelin Zhou, Xiao Ma

“…Existing clinical and animal studies have made a good progress in bile acid metabolism, intestinal flora disorder inflammatory response, bile duct cell damage, and autoimmune response mechanisms. …”
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Sanitary Conditions on the Farm Alters Fecal Metabolite Profile in Growing Pigs by Soumya K. Kar, Marinus F. W. te Pas, Leo Kruijt, Jacques J. M. Vervoort, Alfons J. M. Jansman, Dirkjan Schokker

“…The metabolites that differed significantly (FDR < 0.1) were from metabolic processes involved in either maintaining nutrient digestive capacity, including purine metabolism, energy metabolism, bile acid breakdown and recycling, or immune system metabolism. …”
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Integrated Lipidomics and Metabolomics Study of Four Chemically Induced Mouse Models of Acute Intrahepatic Cholestasis by Weiwei Li, Weiwei Li, Hui Chen, Yihan Qian, Shouchuan Wang, Zichen Luo, Jinjun Shan, Xiaoni Kong, Yueqiu Gao

“…The results showed that the bile acid profile was altered in all models. The lipid metabolism phenotype of the LCA group was most similar to that of primary biliary cirrhosis (PBC) patients. …”
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Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population by Berenice Palacios-González, Guadalupe León-Reyes, Berenice Rivera-Paredez, Isabel Ibarra-González, Marcela Vela-Amieva, Yvonne N. Flores, Samuel Canizales-Quinteros, Jorge Salmerón, Rafael Velázquez-Cruz

“…In addition, we found a sex-dependent VAI in pathways related to primary bile acid biosynthesis, branched-chain amino acids, and the biosynthesis of pantothenate and coenzyme A (CoA). …”
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