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2161
Advances and Challenges in Studying Hepatitis B Virus In Vitro
Published 2016-01-01“…Recent advances in our understanding of HBV biology, such as the discovery of the bile-acid pump sodium-taurocholate cotransporting polypeptide (NTCP) as a receptor for HBV, enabled the establishment of NTCP expressing hepatoma cell lines permissive for HBV infection. …”
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2162
Symposium: Therapeutic approach. Bariatric surgery and beta cell
Published 2021-11-01“…The reasons to justify said beneficial changes include postoperative GLP1 and GIP increase, weight decrease with reduction of adipose tissue with proinflammatory cytokines, ghrelin reduction, increased insulin sensitivity and bile acid impact. Considering the main role of beta cells to maintain normoglycemia, a randomized study was carried out exposing serum samples from obesity and diabetes patients undergoing bariatric surgery (vertical gastrectomy) into beta cells culture and comparing it with sera of conventionally treated patients. …”
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2163
Innovative HBV Animal Models Based on the Entry Receptor NTCP
Published 2020-07-01“…Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter expressed on hepatocytes, has been shown to be one of the key factors in HBV infection, playing a crucial role in the HBV entry process in vitro and in vivo. …”
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2164
A rare treatable cause for atypical frontotemporal dementia with multiple fractures in a young female
Published 2018-01-01“…Cerebro tendinous xantamatosis (CTX) is a rare treatable inborn error of bile acid metabolism. Reported average delay from onset of symptoms to diagnosis is about 16 years as per reports. …”
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2165
Treatment of Cyanobacterial (Microcystin) Toxicosis Using Oral Cholestyramine: Case Report of a Dog from Montana
Published 2013-05-01“…On day five of hospitalization, a bile acid sequestrant, cholestyramine, was administered orally. …”
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2166
Effects of <it>SLC10A2 </it>variant <it>rs9514089 </it>on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts
Published 2011-11-01“…<p>Abstract</p> <p>Background</p> <p>Recently, a single nucleotide polymorphism (SNP) <it>rs9514089 </it>in <it>SLC10A2 </it>(apical sodium-dependent bile acid transporter gene) has been identified as a susceptibility variant for cholelithiasis in humans.…”
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2167
Olive oil, diet and colorectal cancer: an ecological study and a hypothesis.
Published 2000“…The proposed hypothesis is that olive oil may influence secondary bile acid patterns in the colon that, in turn, might influence polyamine metabolism in colonic enterocytes in ways that reduce progression from normal mucosa to adenoma and carcinoma.…”
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2168
Cerebrotendinous Xanthomatosis: A practice review of pathophysiology, diagnosis, and treatment
Published 2022-12-01“…Cerebrotendinous Xanthomatosis represents a rare and underdiagnosed inherited neurometabolic disorder due to homozygous or compound heterozygous variants involving the CYP27A1 gene. This bile acid metabolism disorder represents a key potentially treatable neurogenetic condition due to the wide spectrum of neurological presentations in which it most commonly occurs. …”
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2169
Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis
Published 2024-01-01“…Furthermore, fecal metabolomic analysis showed higher excretion of primary bile acid and cholesterol in the groups fed F. venenatum which might lead to a decrease in lipid digestion and hepatic fat accumulation. …”
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2170
Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men
Published 2024-03-01“…RNA sequencing analysis revealed a downregulation of inflammatory pathways and an upregulation of bile acid metabolism, oxidative phosphorylation, and cholesterol pathways in the liver of mice taking finasteride. …”
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2171
Untargeted Metabolomics Reveals the Function of GPRC6A in Amino Acid and Lipid Metabolism in Mice
Published 2022-08-01“…A loss of GPRC6A function may perturb bile acid metabolism, thus leading to abnormal unsaturated fatty acid metabolism. …”
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2172
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
Published 2023-01-01“…Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. …”
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2173
Potential Molecular Mechanisms of Alzheimer’s Disease from Genetic Studies
Published 2023-04-01“…The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. …”
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2174
Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy
Published 2023-04-01“…In this study, we developed a novel peptide and drug conjugate (PDC)-based cathepsin B inhibitor using cathepsin-B-specific peptide (RR) and bile acid (BA). Interestingly, this RR and BA conjugate (RR–BA) was able to self-assemble in an aqueous solution, and as a result, it formed stable nanoparticles. …”
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2175
Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload
Published 2023-04-01“…Combined deficiency, but not deficiency of either alone, results in severe steatohepatitis, hepatic cholesterol overload and crystallization, altered bile acid metabolism, and decreased biliary cholesterol. …”
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2176
A Comprehensive Review of the Cardioprotective Effect of Marine Algae Polysaccharide on the Gut Microbiota
Published 2022-11-01“…In addition, the effects of trimethylamine N-oxide on the gut microbiota composition, bile acid signaling properties, and CVD prevention are also discussed. …”
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2177
Primary biliary cholangitis: molecular pathogenesis perspectives and therapeutic potential of natural products
Published 2023-06-01“…Existing clinical and animal studies have made a good progress in bile acid metabolism, intestinal flora disorder inflammatory response, bile duct cell damage, and autoimmune response mechanisms. …”
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2178
Sanitary Conditions on the Farm Alters Fecal Metabolite Profile in Growing Pigs
Published 2022-06-01“…The metabolites that differed significantly (FDR < 0.1) were from metabolic processes involved in either maintaining nutrient digestive capacity, including purine metabolism, energy metabolism, bile acid breakdown and recycling, or immune system metabolism. …”
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2179
Integrated Lipidomics and Metabolomics Study of Four Chemically Induced Mouse Models of Acute Intrahepatic Cholestasis
Published 2022-06-01“…The results showed that the bile acid profile was altered in all models. The lipid metabolism phenotype of the LCA group was most similar to that of primary biliary cirrhosis (PBC) patients. …”
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2180
Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population
Published 2021-09-01“…In addition, we found a sex-dependent VAI in pathways related to primary bile acid biosynthesis, branched-chain amino acids, and the biosynthesis of pantothenate and coenzyme A (CoA). …”
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