Insights by which TUDCA is a potential therapy against adiposity by Israelle Netto Freitas, Israelle Netto Freitas, Joel Alves da Silva Jr, Kênia Moreno de Oliveira, Bruna Lourençoni Alves, Thiago Dos Reis Araújo, João Paulo Camporez, Everardo Magalhães Carneiro, Everardo Magalhães Carneiro, Ana Paula Davel, Ana Paula Davel

“…In this sense, the ER stress inhibitor tauroursodeoxycholic acid (TUDCA), a bile acid conjugated to taurine with chemical chaperone activity, has emerged as a therapeutic strategy to minimize adipose tissue dysfunction and metabolic alterations associated with obesity. …”
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Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection by Urszula Wnorowska, Ewelina Piktel, Piotr Deptuła, Tomasz Wollny, Grzegorz Król, Katarzyna Głuszek, Bonita Durnaś, Katarzyna Pogoda, Paul B. Savage, Robert Bucki

“…Biodistribution studies indicated that CSA-13 accumulates in kidneys and liver and is eliminated with urine and bile acid. We also observed that ceragenin CSA-13 reverses infection-induced alterations in mechanical properties of mouse bladders tissue, which confirms the preventive role of CSA-13 against bacteria-induced tissue damage and potentially promote the restoration of microenvironment with biophysical features unfavorable for bacterial growth and spreading. …”
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Interplay between Mast Cells and Regulatory T Cells in Immune-Mediated Cholangiopathies by Natalia M. Krajewska, Rémi Fiancette, Ye H. Oo

“…Immune-mediated cholangiopathies are characterised by the destruction of small and large bile ducts causing bile acid stasis, which leads to subsequent inflammation, fibrosis, and eventual cirrhosis of the liver tissue. …”
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Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway by Shuting Wang, Jie Bao, Jie Li, Wanfang Li, Mengyin Tian, Caixia Qiu, Fei Pang, Xin Li, Jianbo Yang, Yuchi Hu, Sujuan Wang, Hongtao Jin

“…In addition, FRA can induce cholestasis by down-regulating bile acid transporters P-gp, Bsep, and Ntcp. The addition of the CYP3A inhibitor ketoconazole (1 μM) significantly reduced the hepatotoxicity of FRA (30 μM), which indicated that FRA induced hepatotoxicity through CYP3A metabolism. …”
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The Gut Microbiome in the First One Thousand Days of Neurodevelopment: A Systematic Review from the Microbiome Perspective by Nathalia F. Naspolini, Paulo A. Schüroff, Maria J. Figueiredo, Gabriela E. Sbardellotto, Frederico R. Ferreira, Daniel Fatori, Guilherme V. Polanczyk, Alline C. Campos, Carla R. Taddei

“…Few studies described mechanistic insights related to NAD salvage, aspartate and asparagine biosynthesis, methanogenesis, pathways involved in bile acid transformation, short-chain fatty acids production, and microbial virulence genes. …”
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Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS). by Wenli Yang, Bingqian Hu, Wei Wu, Sachin Batra, Michael R Blackburn, Joseph L Alcorn, Michael B Fallon, Junlan Zhang

“…Furthermore, we found that administration of TNF-α, the bile acid, chenodeoxycholic acid, and FXR nuclear receptor activation (GW4064) induced apoptosis and impaired SP-B and SP-C production in alveolar epithelial cells in vitro. …”
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Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease by Xiaoli Pan, Yanqiao Zhang, Yuanyuan Ji

“…HNF4α has been shown to regulate bile acid, lipid, glucose, and drug metabolism. In this review, we summarize the recent advances in the understanding of the pathogenesis of NAFLD with a focus on the regulation of HNF4α and the role of hepatic HNF4α in NAFLD. …”
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Targeting S1PRs as a Therapeutic Strategy for Inflammatory Bone Loss Diseases—Beyond Regulating S1P Signaling by Hong Yu

“…Studies from our group and from other labs indicate that S1PRs not only control S1P signaling, they also regulate signaling pathways induced by other stimuli, including bacteria, lipopolysaccharide (LPS), bile acid, receptor activator of nuclear factor κB ligand (RANKL), IL-6, and vitamin D. …”
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Pittadhara Kala Sahayo Majjadhara Kala and brain gut microbiota axis: A comparative review study by Rakesh Ramraj Tiwari, Bhrigupati Pandey

“…Conclusion: While PDK can broadly be linked to small and large microflora and the bile acid and substrate interactions there in, extensive collaborative research is needed to confirm this fundamentally.…”
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The Potential Utility of Prebiotics to Modulate Alzheimer’s Disease: A Review of the Evidence by Jea Woo Kang, Angela M. Zivkovic

“…Though there is a paucity of human clinical trials demonstrating the effectiveness of prebiotics in altering gut microbiome-mediated health outcomes in AD, current evidence highlights the potential of various prebiotic approaches for beneficially altering the gut microbiota or gut physiology by promoting the production of butyrate, indoles, and secondary bile acid profiles that further regulate gut immunity and mucosal homeostasis, which are associated with beneficial effects on the central immune system and brain functionality.…”
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Key Factors for “Fishing” NTCP as a Functional Receptor for HBV and HDV by Huan Yan, Chunli Wang

“…About ten years ago, Wenhui Li’s research group in China identified the sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter predominantly expressed in the liver, as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis delta virus (HDV) through biochemical and genetic studies. …”
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Probiotics, Prebiotics and Synbiotics—A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases? by Beata Olas

“…It has been proposed that probiotics lower cholesterol levels, and may protect against CVD, by increasing bile salt synthesis and bile acid deconjugation. Similar effects have also been observed for prebiotics and synbiotics; however, probiotics also appear to have anti-oxidative, anti-platelet and anti-inflammatory properties. …”
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Dandy Walker-like malformation in an adult cat with seizures: clinical description and MRI characteristics by Sara Formoso, Hannah Padley, Lisa Alves

“…Complete blood count, biochemistry, bile acid stimulation test, urinalysis, cisternal cerebrospinal fluid (CSF) analysis, Toxoplasma gondii serology and T gondii polymerase chain reaction in CSF were all unremarkable. …”
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Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System by Yehualashet AS, Yikna BB

“…Besides, the role of bile acid (BA) stimulated receptors to have a significant role in liver metabolism, and pathophysiology of liver-based metabolic diseases has also been investigated. …”
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Impact of HCV Infection on Hepatocyte Polarity and Plasticity by Jean Agnetti, Christophe Desterke, Ama Gassama-Diagne

“…Importantly, it has been shown that some of the deregulations induced by HCV are maintained despite a sustained virologic response (SVR), including the down-regulation of some hepatocyte functions such as bile acid metabolism, exemplifying cell dedifferentiation, and the up-regulation of the epithelial–mesenchymal transition (EMT). …”
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Analysis of reproduction-related transcriptomes on pineal-hypothalamic-pituitary-ovarian tissues during estrus and anestrus in Tan sheep by Shihao Wei, Xiaolong Kang, Chaoyun Yang, Feng Wang, Tianshu Dai, Xingru Guo, Ziming Ma, Chenglong Li, Hongxi Zhao, Xingang Dan

“…Meanwhile, KEGG enrichment analysis showed that the bile acid secretion pathway and the neuroactive ligand-receptor interaction pathway were significantly enriched. …”
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Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever. by Matthew S J Mangan, Matthew S J Mangan, Friederike Gorki, Karoline Krause, Alexander Heinz, Anne Pankow, Thomas Ebert, Dieter Jahn, Karsten Hiller, Veit Hornung, Marcus Maurer, Florian I Schmidt, Ralf Gerhard, Eicke Latz

“…Unlike human monocytes and murine macrophages, we determined that hMDM failed to activate Pyrin in response to known Pyrin activators Clostridioides difficile (C. difficile) toxins A or B (TcdA or TcdB), as well as the bile acid analogue BAA-473. The Pyrin inflammasome response was enabled in hMDM by prolonged priming with either LPS or type I or II interferons and required an increase in Pyrin expression. …”
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Non-alcoholic steatohepatitis in pregnancy: a case report by Jonathan Cordivani, Lamy Clotilde, Boulvain Michel, Riera Catherine

“…She did not have intrahepatic cholestasis of pregnancy (bile acid at 7) and also no organic hepatic etiology (negative serologies and imaging). …”
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Roles of FGFs as paracrine or endocrine signals in liver development, health, and disease by Nobuyuki eItoh, Yoshiaki eNakayama, Morichika eKonishi

“…FGF15/19, which is produced in the ileum, is a negative regulator of bile acid metabolism and a stimulator of gallbladder filling. …”
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Direct regulation of pluripotency genes by Nr5a2. by Shue, Bing Hong.

“…Nuclear receptor subfamily 5 group A member 2 (Nr5a2), also known as Liver Receptor Homolog -1 or LRH-1, is an orphan nuclear receptor found to be involved in important metabolic processes such as bile acid metabolism, steroidogenesis and liver development. …”
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