Survival of Isolated Probiotic Yeast Strains from Kefir Towards Bile and Acidic Environments by Azhar, M. A., M.S., Munaim

“…Only Saccharomyces boulardii and Kodamea ohmeri could survive for 24 hours in 1% bile acid (log 6.41 to log 7.34 CFU/mL), whereas all strains survive in 0.3% bile salt (log 3.42 to 8.95 CFU/mL). …”
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Phyllanthus emblica aqueous extract retards hepatic steatosis and fibrosis in NAFLD mice in association with the reshaping of intestinal microecology by Xiaomin Luo, Boyu Zhang, Yehua Pan, Jian Gu, Rui Tan, Puyang Gong

“…The untargeted metabolomics analysis showed that AEPE restored the disturbed glutathione metabolism, tryptophan metabolism, taurine and hypotaurine metabolism, and primary bile acid biosynthesis of the gut bacterial community in NAFLD mice, which strongly correlated with hepatic steatosis and fibrosis. …”
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Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin by Yan-Shuang Qi, Man-Yu Xiao, Peng Xie, Jin-Bo Xie, Mei Guo, Fang-Fang Li, Xiang-Lan Piao

“…GYP-related metabolic pathways involved six pathways, including alpha-linolenic acid metabolism, glutathione metabolism, sphingolipid metabolism, glycerophospholipid metabolism, tryptophan metabolism, and primary bile acid biosynthesis. 57 genes associated with differential metabolites of GYP recovery and 7 genes of 11 saponins of GYP against LC were screened by network analysis, the STRING database was used to find the association between 57 genes and 7 genes, and a compound-intersection gene-metabolite related gene-metabolite-pathway network was constructed, and STAT3, MAPK14, EGFR and TYMS might be the crucial targets of GYP against LC. …”
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<i>In Vitro</i> Characterisation of Potential Probiotic Bacteria Isolated from a Naturally Fermented Carrot and Ginger Brine by Nontobeko Cele, Babalwa Nyide, Thandeka Khoza

“…The probiotic properties tested included resistance towards gastrointestinal conditions (bile, acid, lysozyme tolerance), cell surface hydrophobicity, antioxidant activity, and antagonistic activity against intestinal pathogens. …”
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Dietary cystine restriction increases the proliferative capacity of the small intestine of mice. by Judith C W de Jong, Kristel S van Rooijen, Edwin C A Stigter, M Can Gülersönmez, Marcel R de Zoete, Janetta Top, Matthijs J D Baars, Yvonne Vercoulen, Folkert Kuipers, Saskia W C van Mil, Noortje Ijssennagger

“…We observed no changes in plasma methionine, cysteine, taurine or glutathione levels or bile acid conjugation after 2 weeks of low cystine feeding. …”
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Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy after in vitro fertilization by Ying Zhu, Le Xu, Rajluxmee Beejadhursing, Fei Li

“…Results Numerical values of transaminases (ALT, alanine aminotransferase; AST, aspartate aminotransferase) and serum total bile acid (TBA) are significantly lower in the IVF group than that in the spontaneous conceived group (p < 0.05). …”
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Fecal Microbiota Transplantation: A Prospective Treatment for Type 2 Diabetes Mellitus by Zhou X, Chen R, Cai Y, Chen Q

“…According to many researches, GM can produce a variety of metabolites such as bile acid, short chain fatty acids, lipopolysaccharides and trimethylamine oxide which play an important role in metabolism. …”
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Effects of Extraction Methods on the Physicochemical Properties and Bioactivities in Vitro of Raspberry (Rubus idaeus L.) Polysaccharides by Yingpeng TIAN, Jie CHEN, Lei WANG, Fei XU

“…And the raspberry polysaccharides obtained by enzyme extraction exhibited higher cholesterol binding capacity (22.92±0.41mg/g) and bile acid-binding capacity (83.55%±0.16%). In conclusion, compared with the other three methods, polysaccharides extracted by enzyme extraction showed stronger biological activity in vitro. …”
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The Role of Phytochemicals and Gut Microbiome in Atherosclerosis in Preclinical Mouse Models by Ann M. Centner, Leila Khalili, Vladimir Ukhanov, Saurabh Kadyan, Ravinder Nagpal, Gloria Salazar

“…</i> Upregulation in CYP7 isoform in the liver, ABC transporters, bile acid excretion, and the level of acetic acid, propionic acid, and butyric acid were also noted in several studies reducing plaque. …”
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Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses by Norris Suzanne, O'Dwyer Michael J, White Mary, Mankan Arun K, Lawless Matthew W

“…Inhibition studies demonstrated that tauroursodeoxycholic acid, an endogenous bile acid, downregulates these events. Finally, we found that the co-existence of both C282Y HFE and Z alpha 1-antitrypsin protein (the protein associated with the liver disease of Z alpha 1-antitrypsin deficiency) expression on ER stress responses acted as potential disease modifiers with respect to each other.…”
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Clinical and genetic analysis in Chinese children with Alagille syndrome by Ying Chen, Mei Sun, Xu Teng

“…The median total bilirubin, direct bilirubin, and total bile acid levels were 138.75 μmol/L (normal, 3.4–20.5 μmol/L), 107.25 μmol/L (normal, 0–8.6 μmol/L), and 110.65 μmol/L (normal, 0.5–10.0 μmol/L), respectively. …”
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Therapeutic Potentials of Immunometabolomic Modulations Induced by Tuberculosis Vaccination by Bhupendra Singh Rawat, Deepak Kumar, Vijay Soni, Eric H. Rosenn

“…For instance, infections can affect lipid and amino acid metabolism while vaccines can trigger bile acid and carbohydrate pathways. Metabolomics as a vaccinomics tool, can provide a broader picture of vaccine-induced biochemical changes and pave a path to potentiate the vaccine efficacy. …”
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Loose ends in the differential diagnosis of IBS-like symptoms by Greger Lindberg, Greger Lindberg, Ghazaleh Mohammadian, Ghazaleh Mohammadian

“…Two thirds of the patients we believed to have IBS in the 1970’s have since been possible to diagnose with treatable conditions like bile acid diarrhea, inflammatory bowel disease, microscopic colitis, celiac disease, disaccharide malabsorption, exocrine pancreatic insufficiency, or rare genetic variants. …”
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Research Progress of Duodenal-Jejunal Bypass Liner in the Treatment of Obesity and Type 2 Diabetes Mellitus by Chen JH, Yu ZH, Liu QLF, Meng QG, Chen X

“…DJBL is reversible, less invasive and is more suitable for the treatment of obesity and T2DM, which is associated with multiple mechanisms, including incretin effect, gastric emptying mechanism, bile acid regulation, intestinal microbiota, inflammatory reaction mechanism and neural mechanism. …”
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A novel, non-GMO surface display in Limosilactobacillus fermentum mediated by cell surface hydrolase without anchor motif by Robie Vasquez, Bernadette B. Bagon, Ji Hoon Song, Nam Soo Han, Dae-Kyung Kang

“…Finally, this study demonstrated that CshA-decorated pretreated Lm. fermentum cells tolerates gastrointestinal stress, such as low pH and presence of bile acid. To our knowledge, this study is the first to characterize and demonstrate the cell-surface display ability of CshA. …”
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Effects of the timing of laparoscopic cholecystectomy after endoscopic retrograde cholangiopancreatography on liver, bile, and inflammatory indices and cholecysto-choledocholithias... by Ming-Jun Gao, Zhi-Lan Jiang

“…Three days after LC, total bile acid (TBA) levels increased, and cholesterol (CHO), unconjugated bilirubin (UCB), and TBiL levels were reduced in both groups, but were not statistically different (p>0.05). …”
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Early bile drainage improves native liver survival in biliary atresia without cholangitis by Fei Liu, Xiaogang Xu, Zijian Liang, Boyuan Tao, Menglong Lan, Jixiao Zeng

“…Higher gamma-glutamyl transferase (γ- GT) and total bile acid (TBA) before KPE were risk factors for cholangitis (P &lt; 0.05). …”
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Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease by Maria Valentina Ignat, Teodora Emilia Coldea, Liana Claudia Salanță, Elena Mudura

“…Recent studies on mulberry leaves extracts indicated that they could decrease palmitic acid-induced lipotoxicity, increase total cholesterol and bile acid excretion, improve superoxide dismutase expression, and improve insulin resistance. …”
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Host and HBV Interactions and Their Potential Impact on Clinical Outcomes by Alexis Jose-Abrego, Sonia Roman, Saul Laguna-Meraz, Arturo Panduro

“…Furthermore, HBV can modulate host metabolic pathways involved in glucose and lipid metabolism and bile acid absorption, influencing disease progression. …”
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Metabolome combined with gut microbiome revealed the lipid-lowering mechanism of Xuezhiping capsule on hyperlipidemic hamster induced by high fat diet by Li Wang, Zhixin Zhang, Gan Luo, Ying Wang, Ke Du, Xiaoyan Gao

“…XZP increased diversity index and the ratio of Firmicutes and Bacteroidetes, regulated seventeen genera, and illustrated strong correlations with liver lipid metabolism and phenotypic indicators.Discussion: These findings suggest that XZP reduced blood lipid and liver lipid, protected liver function, anti inflammation and anti-oxidation, ameliorate lipid metabolic disorders by modulating alpha linolenic acid and linoleic acid metabolism, bile acid metabolism, arachidonic acid metabolism, and regulated gut microbiota composition of high-fat diet (HFD) hamsters.…”
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