Efficacy and safety of ursodeoxycholic acid in children with cholestasis: A systematic review and meta-analysis by Liang Huang, Siyu Li, Jingjing Chen, Yu Zhu, Ke Lan, Linan Zeng, Xuehua Jiang, Lingli Zhang

“…The results of meta-analysis showed that UDCA could improve symptoms of children with cholestasis (risk ratio 1.24, 95% CI 1.18 to 1.29; moderate quality of evidence), and serum levels of alanine aminotransferase, total bilirubin, direct bilirubin and total bile acid (low quality of evidence). For some children with specific cholestasis, UDCA could also effectively drop serum levels of aspartate aminotransferase (parenteral nutrition-associated cholestasis) and γ-glutamyl transferase (infantile hepatitis syndrome, parenteral nutrition-associated cholestasis). …”
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Surgical versus Medical Management of Progressive Familial Intrahepatic Cholestasis—Case Compilation and Review of the Literature by Maria Noelle Hüpper, Judith Pichler, Wolf-Dietrich Huber, Andreas Heilos, Rebecca Schaup, Martin Metzelder, Sophie Langer

“…The end points of our analysis were a decrease in serum bile acid (sBA) levels, reduction of pruritus and delay or avoidance of (LTX). (3) Results: We included 17 case series on SBD with more than 5 patients and a total of 536 patients. …”
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High neutrophil-lymphocyte ratio indicates a worse response to ursodeoxycholic acid in primary biliary cholangitis: a retrospective cohort study by Huiling Zhu, Mengyao Zheng, Haiyu He, Hongtao Lei, Wenlin Tai, Jinhui Yang

“…Results The results of multiple regression analysis showed that NLR at baseline was positively associated with the nonresponse to UDCA treatment after adjustments for potential confounders (age, sex, BMI, hypertension, arterial plaque, thyroid disease, jaundice, albumin, globulin, total bile acid, ALP, GGT, LDLC, total cholesterol, hemoglobin, and APTT) (OR = 1.370, 95% CI 1.066–1.761). …”
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Mangiferin relieves CCl4-induced liver fibrosis in mice by Lijun Zhang, Chuhe Liu, Liufang Yin, Cheng Huang, Shengjie Fan

“…Meanwhile, mangiferin inhibited the expression of inflammatory genes IL-6 and IL-1β, fibrogenic genes α-SMA, TGF-β and MMP-2 and bile acid metabolism genes ABCB4, ABCB11, SULT2A1 in the liver of CCl4-treated mice. …”
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Multi-Omics Reveals Inhibitory Effect of Baicalein on Non-Alcoholic Fatty Liver Disease in Mice by Ping Li, Ping Li, Jianran Hu, Hongmei Zhao, Jing Feng, Baofeng Chai

“…Multi-omics analysis revealed that numerous genes regulated by baicalein were significantly correlated with pathways related to lipid metabolism and biosynthesis and secrection of bile acid, and baicalein might affect lipid metabolism in liver via regulating the ecological structure of gut microbiota in NAFLD mice. …”
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Effect of Olive Oil Rich in Hydroxyl Tyrosol on Hyperlipidemic Mice by YE Wenbin, CHEN Wendong, WANG Yu, ZHANG Kai, HUANG Xinyi, DI Duolong

“…After continuous administration for 28 days, the effect of OHT on fasting blood glucose (FBG), glycated hemoglobin (HbAlc), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total bilirubin (TBIL), total bile acid (TBA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-ammonia acyltransferase (GGT) and alkaline phosphatase (ALP) in mice in each group were analyzed, and the acute and chronic toxicity of OHT was evaluated. …”
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Integration of 16S rRNA sequencing and metabolomics to investigate the modulatory effect of ginsenoside Rb1 on atherosclerosis by Yuqin Liang, Jiaqi Fu, Yunhe Shi, Xin Jiang, Fang Lu, Shumin Liu

“…Moreover, untargeted metabolomics showed that Rb1 considerably improved faecal metabolite profiles, particularly arachidonic acid metabolism and primary bile acid biosynthesis. Conclusion: Rb1 ameliorated the HFD-induced AS, and the mechanism is related to improving intestinal metabolic homeostasis and inhibiting systemic inflammation by regulating gut microbiota.…”
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Product of metabolic activity of intestinal microbium trimethylamine-N-oxide (TMAO) — biomarker of progression of atherosclerosis-copy in the heart of the heart by К.О. Shyshkan-Shyshova, O.V. Zinych

“…The mecha­nisms of the proatherogenic effect of elevated levels of TMAO include effects on bile acid and cholesterol metabolism, platelet hyperactivation, stimulation of inflammatory processes and oxidative stress, induction of endothelial disfunction and endoplasmic reticulum stress. …”
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Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice by Gabriela V. Moreira, Layanne C.C. Araujo, Gilson M. Murata, Sandro L. Matos, Carla R.O. Carvalho

“…Mice receiving the kombucha supplement displayed improved glucose tolerance, reduced hyperinsulinemia, decreased citrate synthase and phosphofructokinase-1 enzyme activities, downregulated G-protein-coupled bile acid receptor, also known as TGR5, and farnesol X receptor gene expression, and attenuated steatosis and hepatic collagen fiber deposition. …”
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Environment-Dependent Variation in Gut Microbiota of an Oviparous Lizard (<i>Calotes versicolor</i>) by Lin Zhang, Fang Yang, Ning Li, Buddhi Dayananda

“…There were a higher abundance of genus <i>Bacteroides</i> (Class: <i>Bacteroidia</i>), <i>Coprobacillus</i> and <i>Eubacterium</i> (Class: <i>Erysipelotrichia</i>), <i>Parabacteroides</i> (Family: <i>Porphyromonadaceae</i>) and <i>Ruminococcus</i> (Family: <i>Lachnospiraceae</i>), and Family <i>Odoribacteraceae</i> and <i>Rikenellaceae</i> in the sample from the hindgut. The secondary bile acid biosynthesis, glycosaminoglycan degradation, sphingolipid metabolism and lysosome were significantly higher in the hindgut than that in the small intestine. …”
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Cooked Rice and Oat Meal Similarly Reduce Hypercholesterolemia in Rats by Jaffer S. Dhahir, Hussian J. Al-Hadethi

“…The (R) and (O) diets significantly lowered the total fat content (24.0, 26.16 mg/kg respectively) while (O) diet lowered the cholesterol content (1.36 mg/kg) of the liver compared to the control diet (51.9 and 2.47 mg/kg for total fat and cholesterol respectively). For bile acid content in the feces, there were significant differences (p.0.01) among the different groups; (OC) group showed the highest (10.4 mg/gm of feces) and the control group showed the lowest…”
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Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomic... by Shiying Zhang, Bei Li, Liuting Zeng, Kailin Yang, Junyao Jiang, Fangguo Lu, Ling Li, Weiqing Li

“…Metabolites were mainly involved in primary bile acid biosynthesis, thiamine metabolism, etc. This suggests that MXSGD has a microbial–gut–lung axis regulation effect on mice with influenza A virus pneumonia. …”
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Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice by Yu-Sheng Chen, Hsuan-Miao Liu, Tzung-Yan Lee

“…This is associated with increased hepatic energy expenditure, mitochondria biogenesis, and incorporation of bile acid metabolism (Abca1, Abcg1 mRNA and BSEP, FGFR4, and TGR5 protein). …”
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Physical Activity and Gallstone Disease by I. N. Grigor’eva, T. E. Notova, T. I. Romanova

“…PA favorably affects almost all mechanisms of gallstone formation: improves cholesterol metabolism in bile, increases serum HDL cholesterol, bile acid synthesis, stimulates the release of cholecystokinin, reduces mucin hypersecretion, increases the diversity and richness of the intestinal microbiota. …”
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Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya

“…It includes antidiabetic agents (metformin, thiazolidinediones, glucagon-like peptide-1 receptor agonists, sodium-glucose co-transporter-2 inhibitors), bile acid preparations (e.g., 24-nor-ursodeoxycholic acid), farnesoid X receptor agonists (obeticholic acid, tropifexor), statins, acetylsalicylic acid. …”
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Long-term (52&amp;ndash;78 weeks) treatment with colesevelam HCl added to metformin therapy in type 2 diabetes mellitus patients by Bays HE

“…Compared with baseline values obtained prior to the start of both the base and extension studies, colesevelam improved and maintained improvement in hemoglobin A1c and various lipid parameters.Conclusion: This analysis found colesevelam to be generally safe and effective for long-term therapy in type 2 diabetes mellitus patients with inadequately controlled glucose while treated with metformin monotherapy or metformin combination therapy.Keywords: bile acid sequestrant, open-label, safety…”
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Formation of Intermediate Amylose Rice Starch–Lipid Complex Assisted by Ultrasonication by Paramee Chumsri, Worawan Panpipat, Ling-Zhi Cheong, Manat Chaijan

“…The complexes were capable of binding bile acid, scavenging the DPPH radical, and stimulating the bifidobacterial proliferation better than native starch, which differed depending on the FA inclusion. …”
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Dexamethasone counteracts hepatic inflammation and oxidative stress in cholestatic rats via CAR activation. by Daniela Gabbia, Luisa Pozzo, Giorgia Zigiotto, Marco Roverso, Diana Sacchi, Arianna Dalla Pozza, Maria Carrara, Sara Bogialli, Annarosa Floreani, Maria Guido, Sara De Martin

“…The aims of this study were 1) to assess the therapeutic effect of a 2-week treatment with the GC dexamethasone on hepatic damage in bile duct-ligated rats; 2) to investigate its effect on the activation of the nuclear receptors (NRs) pregnane X receptor (PXR), constitutive androstane receptor (CAR) and GC receptor (GR), and NF-kB, as well as on oxidative stress and bile acid (BA) hepatic composition. Cholestasis was induced by ligation of bile duct (BDL animals) in 16 male Wistar-Kyoto rats, and eight of them were daily treated by oral gavage with 0.125 mg/ml/kg DEX for 14 days. …”
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Familial Hypercholesterolaemia: An Updated Overall Management by Mohd Kasim, Noor Alicezah, An, Chua Yung, Nawawi, Hapizah

“…Combination with ezetimibe and/or bile acid sequestrants is indicated if target LDL-C is not achieved. …”
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Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications by Yeap, S, Harley, H, Thompson, R, Williamson, K, Bate, J, Sethna, F, Farrell, G, Hague, W

“…<p><strong>Background and Aims</strong> Clinical syndromes associated with biallelic mutations of bile acid (BA) transporters usually present in childhood. …”