Fecal Metabolomics Reveals Distinct Profiles of Kidney Transplant Recipients and Healthy Controls by Soumaya Kouidhi, Oumaima Zidi, Muhanad Alhujaily, Nessrine Souai, Amor Mosbah, Tareg M. Belali, Kais Ghedira, Imene El Kossai, Jamelddine El Manaa, Wissem Mnif, Ameur Cherif

“…Furthermore, the most notable altered metabolic pathways in kidney transplants include ubiquinone and other terpenoid-quinone biosynthesis, tyrosine metabolism, tryptophan biosynthesis, and primary bile acid biosynthesis. Fecal metabolites could effectively distinguish stable transplant recipients from controls, supporting the potential utility of metabolomics in rapid and non-invasive diagnosis to produce relevant biomarkers and to help clinicians in monitoring kidney transplants. …”
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Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach by Junyi Bai, Junyi Bai, Tingting Xiong, Xiao Wang, Yanfen Cheng, Ruifeng Luo, Xiangdong Yang, Chaomei Fu

“…These metabolites are mainly involved in 12 metabolic pathways, including nicotate and nicotinamide metabolism, glycospholipid metabolism, arginine and proline metabolism, primary bile acid biosynthesis, and pantothenate and CoA biosynthesis. …”
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Comprehensive bibliometric and visualized analysis of research on gut-liver axis published from 1998 to 2022 by Yongtian Wen, Tai Zhang, Beihua Zhang, Fengyun Wang, Xiuxiu Wei, Yuchen Wei, Xiangxue Ma, Xudong Tang

“…Thematic hotspots and frontiers were focused on gut microbiota, microbial metabolite, intestinal permeability, bacterial translocation, bile acid, non-alcoholic steatohepatitis, and alcoholic liver disease. …”
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Large intestinal nutritional and physicochemical parameters from different dog sizes reshape canine microbiota structure and functions in vitro by Charlotte Deschamps, Delphine Humbert, Sandrine Chalancon, Caroline Achard, Emmanuelle Apper, Sylvain Denis, Stéphanie Blanquet-Diot

“…CANIM-ARCOL was set up to reproduce nutrient availability, bile acid profiles, colonic pH, and transit time from small, medium, or large dogs according to in vivo data, while bioreactors were all inoculated with a fecal sample collected from medium size dogs (n = 2). …”
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Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads by Emily B. Hill, Li Chen, Michael T. Bailey, Amrik Singh Khalsa, Ross Maltz, Kelly Kelleher, Colleen K. Spees, Jiangjiang Zhu, Brett R. Loman

“…Differential modeling of microbiome composition identified taxa associated with total diet quality, whole grain intake, and LCA elimination including recognized fiber-degrading bacteria such as Subdoligranulum, and bile acid metabolizing organisms like Bifidobacterium. …”
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Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis by Tao Li, Shaoqing Yang, Xiaoyan Liu, Yanxiao Li, Zhenglong Gu, Zhengqiang Jiang

“…Functional profiling of gut microbiota composition indicated that NAT treatment regulated the glucolipid and bile acid-related metabolic pathways. Interestingly, NAT treatment ameliorated cognitive impairment, attenuated amyloid-β (Aβ) and Tau pathology, and regulated the gut microbiota composition and SCFAs receptor-related pathway of Alzheimer’s disease (AD) mice. …”
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Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling by Joana Saraiva Rodrigues, Andreia Faria-Pereira, Sérgio Póvoas Camões, Ana Sofia Serras, Vanessa Alexandra Morais, Jorge Lira Ruas, Joana Paiva Miranda

“…This work focused on modulating glucose homeostasis and glucocorticoid concentration to improve the suitability of a mesenchymal stem-cell (MSC)-derived hepatocyte-like cell (HLC) human model for studying hepatic insulin action and disease modeling.MethodsWe have investigated the role of insulin, glucose and dexamethasone on mitochondrial function, insulin signaling and carbohydrate metabolism, namely AKT phosphorylation, glycogen storage ability, glycolysis and gluconeogenesis, as well as fatty acid oxidation and bile acid metabolism gene expression in HLCs. In addition, we evaluated cell morphological features, albumin and urea production, the presence of hepatic-specific markers, biotransformation ability and mitochondrial function.ResultsUsing glucose, insulin and dexamethasone levels close to physiological concentrations improved insulin responsiveness in HLCs, as demonstrated by AKT phosphorylation, upregulation of glycolysis and downregulation of Irs2 and gluconeogenesis and fatty acid oxidation pathways. …”
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Liver Protein Expression in NASH Mice on a High-Fat Diet: Response to Multi-Mineral Intervention by James Varani, Shannon D. McClintock, Randall N. Knibbs, Isabelle Harber, Dania Zeidan, Mohamed Ali H. Jawad-Makki, Muhammad N. Aslam

“…Cholesterol metabolism and bile acid formation were especially sensitive to diet. …”
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Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites by Kathleen Yan, Adelina Hung, Caitlin Parmer, Hui Yang, Dhanpat Jain, Bentley Lim, Andrew L. Goodman, Guadalupe Garcia‐Tsao

“…We hypothesized that obeticholic acid (OCA), a semisynthetic bile acid, would change the microbiome composition and reduce bacterial translocation in experimental cirrhosis. …”
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Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer by Lei Zhou, Yan Zhang, Ming Wei, Kangming Du, Jing Lin, Lihong Wei

“…Then, biological enrichment analysis indicated that the CXCL14 is predominantly involved in the activating of the WNT/β/catenin pathway, pancreas beta cells, peroxisome and bile acid metabolism. Immune infiltration analysis showed that for the patients with high CXCL14 levels, the plasma B cells, CD8 + T cells, neutrophil and NK cells might infiltrate more, in contrast to B cells, monocyte and macrophages. …”
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Altered fecal microbiome and metabolome profiles in rat models of short bowel syndrome by Yuhua Huang, Jian Jiao, Danhua Yao, Feilong Guo, Yousheng Li

“…The typical signatures of SBS fecal metabolome comprised reduced short-chain fatty acids and products of amino acid metabolism (indole derivatives and p-cresol), as well as altered bile acid spectrum. We revealed 215 robust associations between representative differentially abundant microbial species and metabolites, the species with the same changing trend tended to have a similar correlation with some certain metabolites.ConclusionThe fecal microbiome and metabolome significantly altered in SBS. …”
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Plasma Metabolic Disturbances in Parkinson’s Disease Patients by Paulina Gątarek, Joanna Sekulska-Nalewajko, Barbara Bobrowska-Korczaka, Małgorzata Pawełczyk, Karol Jastrzębski, Andrzej Głąbiński, Joanna Kałużna-Czaplińska

“…The metabolic pathways involved were associated with linoleic acid metabolism, mitochondrial electron transport chain, glycerolipid metabolism, and bile acid biosynthesis. These abnormal metabolic changes in the plasma of patients with PD were mainly related to the amino acid metabolism, TCA cycle metabolism, and mitochondrial function.…”
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Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice by Marlena M. Holter, Margot K. Chirikjian, Daniel A. Briere, Adriano Maida, Kyle W. Sloop, Kristina Schoonjans, Bethany P. Cummings

“…The bile acid receptor, TGR5, is a key regulator of glucose homeostasis, but the mechanisms by which TGR5 signaling improves glucose regulation are incompletely defined. …”
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Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis by Eman A. Ahmed, Marwa O. El-Derany, Ali Mostafa Anwar, Essa M. Saied, Sameh Magdeldin

“…Cholesterol metabolism, DNA repair, methylation pathway, bile acid, and salts metabolism were significantly upregulated in NASH-HCC compared to the NASH group. …”
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Role of antispasmodics in the treatment of irritable bowel syndrome by V. N. Drozdov, K. I. Arefev, S. Yu. Serebrova, I. A. Komissarenko, E. V. Shikh, A. K. Starodubtsev

“…These include opioid receptor agonists, bile acid sequestrants, guanylate cyclase agonists, chlorine channel activators, as well as antibiotics, probiotics, antidepressants, 5-HT3 receptor antagonists, and antispasmodics.Myotropic antispasmodics. …”
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Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism by Minji Woo, Yeong Ok Song, Keon-Hee Kang, Jeong Sook Noh

“…Plasma and hepatic lipid levels were significantly reduced by downregulating the hepatic protein expression levels for fatty acid synthesis (sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC)) and cholesterol synthesis (SREBP-2 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)) and upregulating those for β-oxidation (peroxisome proliferator-activated receptor alpha (PPAR-α) and carnitine palmitoyltransferase 1 (CPT1)) and synthesis of bile acid (cytochrome P450 family 7 subfamily A member 1 (CYP7A1)) (p < 0.05). …”
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Isolation and characterization of the lactobacillus strain from honey and its probiotic properties by Mohammad Ebrahim Goli Mehdi Abadi, Ahmad Hosseini-Safa, Sina Habibi, Mohammadreza Dehghan, Mohamad Javad Forouzani-moghaddam, Mojgan Oshaghi

“…Probiotic tests were performed on the isolated Lactobacillus strains, including hemolytic activity, bile, acid, and pepsin resistance. Additionally, the antibiotic resistance of the obtained strains was investigated using seven different antibiotics. …”
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Protective Effect and Mechanism of Fucoidan on Alcohol-Induced Liver Injury in Mice by YANG Jia, DANG Kai, XUE Meilan, LIANG Hui, ZHANG Nan, WANG Qing, PEI Zhongqian, QIN Yimin

“…Results: Fucoidan could improve the pathological changes of liver tissue, reduce the levels of serum alanine (aminotransferase (ALT) and aspartate aminotransferase (AST)) and blood lipids (triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and total bile acid (TBA)) (P < 0.05), and decrease the levels of serum inflammatory factors (TNF-α, IL-1β and IL-6) and the proportion of Th1, Th2 and Th17 (P < 0.05). …”
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<i>Clostridium butyricum</i> Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care by Lin Liu, Xiang Chen, Lu Liu, Huanlong Qin

“…Based on our results obtained during a relatively short intervention time, <i>C. butyricum</i> might have great potential for improving nutrition and immunity in elderly people in long-term care with malnutrition through the alteration of gut microbiota, increasing the abundance of beneficial bacteria and activating the metabolism in SCFA and cofactor/vitamin production, bile acid metabolism, along with efficient energy generation.…”
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Research into the characteristic molecules significantly affecting liver cancer immunotherapy by Junhong Chen, Hengwei Jin, Hao Zhou, Xufei Hei, Kai Liu

“…Gene Set Enrichment Analysis showed that many metabolism pathways were activated in patients with a high CombinedScore, including butanoate metabolism, bile acid metabolism, fatty acid metabolism, glycine serine and threonine metabolism, and propanoate metabolism. …”
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