A female of progressive familial intrahepatic cholestasis type 3 caused by heterozygous mutations of ABCB4 gene and her cirrhosis improved after treatment of ursodeoxycholic acid:... by Fei Qiao, Feng Ren, Weiting Lu, Haoran Yang, Guiling Mo, Shuangshuang Wang, Lina Liu, Xiangtao Xu

“…Case presentation A 25-year-old young woman with recurrent abnormal hepatic function was mainly characterized by increased gamma glutamyl transpeptidase (GGT) and bile acid with cryptogenic cirrhosis. After 7 months of treatment with ursodeoxycholic acid (UDCA), her hepatic pathology suggested there were also obvious widening and venous fibrosis around the portal vein, and slight bile duct hyperplasia at the edge of the portal area. …”
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Perinatal outcomes associated with ICP in twin pregnancies were worse than singletons: an almost 5-year retrospective cohort study by Tingting Xu, Chunyan Deng, Yongchi Zhan, Qing Hu, Guiqiong Huang, Xing Wang, Bing Guo, Haiyan Yu, Xiaodong Wang

“…In addition, a correlation study was performed on the matched total bile acid (TBA) levels from maternal serum, fetal umbilical venous blood, and amniotic fluid of 33 twin pregnancies from twin groups. …”
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Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities by Laura Sisk-Hackworth, Jada Brown, Lillian Sau, Andrew A. Levine, Lai Ying Ivy Tam, Aishwarya Ramesh, Reeya S. Shah, Evelyn T. Kelley-Thackray, Sophia Wang, Anita Nguyen, Scott T. Kelley, Varykina G. Thackray

“…Hypogonadism was significantly associated with bacteria from the Bacteroidaceae, Eggerthellaceae, Muribaculaceae, and Rikenellaceae families, which have genes for bile acid metabolism and mucin degradation. Microbial balances between males and females and between hypogonadal and wild-type mice were also intestinal section-specific. …”
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Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases by Sabrina Azevedo Machado, Gabriel Pasquarelli-do-Nascimento, Debora Santos da Silva, Gabriel Ribeiro Farias, Igor de Oliveira Santos, Luana Borges Baptista, Kelly Grace Magalhães

“…The intestinal microbiome has also been pictured as a key factor in regulating white tissue browning, as it modulates bile acid levels, important molecules for the thermogenic program activation. …”
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Effects of oral tauroursodeoxycholic acid and/or intestinal probiotics on serum biochemical indexes and bile composition in patients with cholecystolithiasis by Fan Gao, Dongyao Guan, Gangliang Wang, Luting Zhang, Junmin He, Wenqiao Lv, Xiaofeng Zhang, Weifeng Tao, YeFeng Dai, Song Xu, Yeqi Chen, Bin Lu

“…Bile samples were identified and extracted during the operation.Results: The results revealed that the levels of serum total bile acid (TBA), serum total cholesterol (TCHOL) and serum triglyceride in groups I, II and III before and after the intervention were statistically significant (p < 0.05). …”
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BIOCHEMICAL AND CHEMICAL PARAMETERS CHANGES IN THE BLOOD OF CHICKENS FOLLOWING TREATMENTS WITH MADURAMYCIN, MONENSIN AND DICLAZURIL by Ines Varga, Nina Bilandzic, Mario Mitak, Luka Cvetnić, Ivana Varenina, Solomun Kolanović Božica, Božić Luburić Đurđica, Marija Perković, Željko Cvetnić

“…Following treatment, blood was sampled for 11 days and analysed for the following biochemical and chemical parameters: aspartate aminotransferase (AST), bile acid (BA), creatine kinase (CK), uric acid (UA), glucose (GLU), cholic acid (CA), total protein (TP), albumin (ALB), globulin (GLOB) and phosphorus (PHOS). …”
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Ionomics-metabolome association analysis as a new approach to the impact of dietary copper levels in suckling piglets model by Feng Zhang, Wen Yao, Xu Ji, Xiaodan Liu, Erhui Jin

“…The hair Cu was negatively correlated with serum malondialdehyde (MDA), total bile acid (TBA). The fecal Cu was positively correlated with serum growth hormone (GH). …”
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Integrated Microbiome and Metabolomics Analysis of the Effects of Dietary Supplementation with Corn-Steep-Liquor-Derived <i>Candida utilis</i> Feed on Black Pigs by Huiyu Qi, Ruqi Wang, Chuanqi Wang, Rui Wang, Jinglin Shen, Hengtong Fang, Jing Zhang

“…Regarding the plasma metabolome, the 12 differential metabolites detected were mainly enriched in the histidine, tryptophan, primary bile acid, and caffeine metabolic pathways. Regarding the integrated microbiome–metabolome analysis, differential metabolites correlated with fecal flora to variable degrees, but most of them were beneficial bacteria of <i>Firmicutes</i>. …”
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Clinical Features and Risk Factors of Kawasaki Disease Complicated with Deep Neck Space Involvement: A Summary of 38 Cases by ZHU Xiaona, CHENG Xueying, WENG Ruohang, XIA Yu, LUO Ying, HE Tingyan, YANG Jun

“…In terms of clinical characteristics, the age of onset in the DNSI group was older, the hospital stay was longer and the proportions of cervical lymphadenopathy, cervical lymph node pain, limited neck movement and upper airway obstruction were all higher (all P < 0.05); in terms of laboratory tests, the neutrophil count and its percentage, C-reactive protein (CRP), ferritin (FER), total bile acid, total bilirubin, direct bilirubin, and globulin levels all increased, while platelet and lymphocyte counts and their percentages all decreased(all P < 0.05); in terms of coronary artery damage and treatment effect, the Kobayashi score, Sano score and the proportion of hormone therapy in the DNSI group all increased (all P < 0.05). …”
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Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy by Yao Kong, Yongchi Zhan, Daijuan Chen, Xixi Deng, Xinghui Liu, Tingting Xu, Xiaodong Wang

“…Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is strongly associated with an increased risk of adverse perinatal outcomes. Total bile acid (TBA) levels in the late second or third trimester are a major factor in the diagnosis. …”
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Up‐regulation of miR‐let7a‐5p Leads to Decreased Expression of ABCC2 in Obstructive Cholestasis by Natarajan Balasubramaniyan, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol, Frederick J. Suchy

“…Adenosine triphosphate–binding cassette subfamily C member 2 (ABCC2/Abcc2) is critically important to biliary excretion of many endobiotic and xenobiotic compounds, and is a major driving force for bile acid–independent bile flow. Abcc2 expression is reduced at the messenger RNA (mRNA) and protein levels in various forms of experimental cholestasis. …”
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Determination of Optimal Vitamin D Dosage in Children with Cholestasis by Sirada Chongthavornvasana, Chatmanee Lertudomphonwanit, Pat Mahachoklertwattana, Manassawee Korwutthikulrangsri

“…Abstract Background Vitamin D deficiency in patients with cholestasis is due to impaired intestinal vitamin D absorption, which results from decreased intestinal bile acid concentration. Patients with cholestasis usually do not achieve optimal vitamin D status when a treatment regimen for children without cholestasis is used. …”
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Bicyclol attenuates high fat diet-induced non-alcoholic fatty liver disease/non-alcoholic steatohepatitis through modulating multiple pathways in mice by Jingyi Wu, Shu Jia, Benhong Xu, Xiaokun Yao, Jingping Shao, Jianzuo Yao, Danwei Cen, Xiaomin Yao

“…Furthermore, the beneficial effects of bicyclol were closely associated with the signaling pathways of bile acid metabolism (NPC1, SLCOLA4 and UGT1A1), cytochrome P450-mediated metabolism (CYP2C54, CYP3A11 and CYP3A25), biological processes such as metal ion metabolism (Ceruloplasmin and Metallothionein-1), angiogenesis (ALDH1A1) and immunological responses (IFI204 and IFIT3).Discussion: These findings suggested that bicyclol is a potential preventive agent for NAFLD/NASH by targeting multiple mechanisms in future clinical investigations.…”
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Effect of Gut Microbiota on the Pharmacokinetics of Nifedipine in Spontaneously Hypertensive Rats by Rong Zhou, Haijun Yang, Peng Zhu, Yujie Liu, Yanjuan Zhang, Wei Zhang, Honghao Zhou, Xiong Li, Qing Li

“…The relative abundance of <i>Bacteroides dorei</i> was negatively correlated with AUC_0–t (<i>r</i> = −0.881, <i>p</i> = 0.004) and <i>C</i>_max (<i>r</i> = −0.714, <i>p</i> = 0.047). Analysis of serum bile acid (BA) profiles indicated that glycoursodeoxycholic acid (GUDCA) and glycochenodeoxycholic acid (GCDCA) were significantly increased in the SHRs. …”
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New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats by Li Y, Tian C, Song X, Du M, Zhang G, Liu H

“…Pharmacodynamics results demonstrated that IMB16-4-HME prominently decreased the serum levels of total bile acid (TBA) and alkaline phosphatase (ALP), but elevated the level of total bilirubin (TBIL) and direct bilirubin (DBIL). …”
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The endoribonuclease YbeY is linked to proper cellular morphology and virulence in 2 Brucella abortus by Budnick, James A., Sheehan, Lauren M., Colquhoun, Jennifer M., Dunman, Paul M., Roop, Martin, Jr., Walker, Graham C.

“…The ΔybeY strain also showed increased sensitivities to several in vitro applied stressors, including bile acid, hydrogen peroxide, SDS, and paraquat. Transcriptomic analysis revealed that a multitude of mRNA transcripts are dysregulated in the ΔybeY strain, and many of the identified mRNAs encode proteins involved in metabolism, nutrient transport, transcriptional regulation, and flagellum synthesis. …”
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Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. by Chappell, L, Bell, J, Smith, A, Linsell, L, Juszczak, E, Dixon, P, Chambers, J, Hunter, R, Dorling, J, Williamson, C, Thornton, J, Pitches Study Group

“…<p><strong>BACKGROUND:</strong> Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth, and neonatal unit admission. …”

Hepatic Expression of the Na⁺-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation by Roman Tremmel, Anne T. Nies, Barbara A. C. van Eijck, Niklas Handin, Mathias Haag, Stefan Winter, Florian A. Büttner, Charlotte Kölz, Franziska Klein, Pascale Mazzola, Ute Hofmann, Kathrin Klein, Per Hoffmann, Markus M. Nöthen, Fabienne Z. Gaugaz, Per Artursson, Matthias Schwab, Elke Schaeffeler

“…Specific CpG sites in <i>SLC10A1</i> as well as single metabolic alterations and pathways (e.g., peroxisomal and bile acid synthesis) were significantly associated with expression. …”
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A New Method for Rapid Subcellular Localization and Gene Function Analysis in Cotton Based on Barley Stripe Mosaic Virus by Weiwei Chen, Chaolin Huang, Chenmeng Luo, Yongshan Zhang, Bin Zhang, Zhengqing Xie, Mengyuan Hao, Hua Ling, Gangqiang Cao, Baoming Tian, Fang Wei, Gongyao Shi

“…The overexpression of a cotton Bile Acid Sodium Symporter GhBASS5 using the BSMV system indicated that GhBASS5 negatively regulated salt tolerance in cotton by transporting Na⁺ from underground to the shoots. …”
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Comparison of Hematological Parameters Between First-Episode Schizophrenia and Anti-NMDAR Encephalitis by Kai Huang, Yamei Tang, Zhiheng Chen, Shan Ding, Hongtao Zeng, Yuxu Zhao, Qi Yu, Yong Liu

“…Other parameters such as the white blood cell (WBC), platelet (PLT), uric acid (UA), total bilirubin (TBIL), total bile acid (TBA), and serum albumin counts were also used to compare inflammation ratios between these two diseases.Results: SII, NLR, PLR, MLR, and serum albumin levels were statistically significantly different between these three groups (p &lt; 0.05). …”
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