Spectral Characterization and Antimicrobial Activity of Chenodeoxycholic Acid Complexes with Zn(II), Mg(II), and Ca(II) Ions by Abdulrahman A. Almehizia, Ahmed M. Naglah, Mohamed A. Al-Omar, Mashooq A. Bhat, Fhdah S. Alanazi, Fatimah A. Alotaibi, Asma S. Al-Wasidi, Moamen S. Refat, Abdel Majid A. Adam

“…Chenodeoxycholic acid (CA) is a naturally occurring bile acid that is produced in the liver from cholesterol. …”
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The negative effect of Akkermansia muciniphila-mediated post-antibiotic reconstitution of the gut microbiota on the development of colitis-associated colorectal cancer in mice by Kaicen Wang, Wenrui Wu, Qing Wang, Liya Yang, Xiaoyuan Bian, Xianwan Jiang, Longxian Lv, Ren Yan, Jiafeng Xia, Shengyi Han, Lanjuan Li, Lanjuan Li

“…Furthermore, post-antibiotic A. muciniphila administration changed the bile acid (BA) metabolic profile as indicated by decreased concentrations of secondary BA (SBA), ω–murocholic acid (ωMCA), and murocholic acid (muroCA). …”
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Metabolome-wide association study of four groups of persistent organic pollutants and abnormal blood lipids by Yiran Chen, Jiayun Lv, Lei Fu, Yan Wu, Si Zhou, Shiwei Liu, Linjie Zheng, Wenru Feng, Lin Zhang

“…The mechanism may mainly involves glycerophospholipid metabolism, primary bile acid biosynthesis, and linoleic acid metabolism. …”
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Case report: Cerebrotendinous xanthomatosis with a novel mutation in the CYP27A1 gene mimicking behavioral variant frontotemporal dementia by Min Young Chun, Min Young Chun, Min Young Chun, Nam Jin Heo, Sang Won Seo, Sang Won Seo, Sang Won Seo, Sang Won Seo, Hyemin Jang, Hyemin Jang, Hyemin Jang, Yeon-Lim Suh, Ja-Hyun Jang, Young-Eun Kim, Eun-Joo Kim, So Young Moon, Na-Yeon Jung, Sun Min Lee, Hee Jin Kim, Hee Jin Kim, Hee Jin Kim, Hee Jin Kim

“…Due to the disruption of bile acid synthesis leading to cholesterol and cholestanol accumulation, CTX manifests as premature cataracts, chronic diarrhea, and intellectual disability in childhood and adolescence. …”
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Zearalenone-14-glucoside specifically promotes dysplasia of Gut-Associated Lymphoid Tissue: A natural product for constructing intestinal nodular lymphatic hyperplasia model by Haonan Ruan, Yunyun Wang, Jing Zhang, Ying Huang, Yanan Yang, Chongming Wu, Mengyue Guo, Jiaoyang Luo, Meihua Yang

“…Metabolomic analysis showed that Z14G exposure significantly reduced bile acid, while proteomic analysis found that Z14G exposure significantly reduced the expression of C-type lectins compared to ZEN. …”
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Metabolic perturbations in pregnant rats exposed to low-dose perfluorooctanesulfonic acid: An integrated multi-omics analysis by Guoqi Yu, Jinguo Wang, Yongjie Liu, Tingyu Luo, Xi Meng, Ruiyuan Zhang, Bo Huang, Yan Sun, Jun Zhang

“…Results of transcriptome showed that differentially expressed genes at 0.03 and 0.3 mg/kg·bw·d PFOS exposure were related to several metabolic pathways, such as peroxisome proliferator-activated receptors (PPARs) signaling, ovarian steroid synthesis, arachidonic acid metabolism, insulin resistance, cholesterol metabolism, unsaturated fatty acid synthesis, bile acid secretion. The untargeted metabolomics identified 164 and 158 differential metabolites in 0.03 and 0.3 mg/kg·bw·d exposure groups, respectively under negative ion mode of Electrospray Ionization (ESI-), which could be enriched in metabolic pathways such as α-linolenic acid metabolism, glycolysis/gluconeogenesis, glycerolipid metabolism, glucagon signaling pathway, glycine, serine and threonine metabolism. …”
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Berberine regulates glucose metabolism in largemouth bass by modulating intestinal microbiota by Yun Xia, Yun Xia, Hui-Ci Yang, Hui-Ci Yang, Kai Zhang, Kai Zhang, Jing-Jing Tian, Jing-Jing Tian, Zhi-Fei Li, Zhi-Fei Li, Er-Meng Yu, Er-Meng Yu, Hong-Yan Li, Hong-Yan Li, Wang-Bao Gong, Wang-Bao Gong, Wen-Ping Xie, Wen-Ping Xie, Guang-Jun Wang, Guang-Jun Wang, Jun Xie, Jun Xie

“…BBR improved growth, decreased the hepatosomatic and visceral weight indices, significantly downregulated the serum total cholesterol and GLU levels, and significantly upregulated the serum total bile acid (TBA) levels. The hepatic hexokinase, pyruvate kinase, GLU-6-phosphatase and glutamic oxalacetic transaminase activities in the largemouth bass were significantly upregulated when compared with those in the control group. …”
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Investigating the CYP2E1 Potential Role in the Mechanisms Behind INH/LPS-Induced Hepatotoxicity by Hozeifa M. Hassan, Hozeifa M. Hassan, Bashir A. Yousef, Bashir A. Yousef, Hongli Guo, Liu Xiaoxin, Luyong Zhang, Luyong Zhang, Luyong Zhang, Zhenzhou Jiang, Zhenzhou Jiang

“…These enhancing activities ranged between augmenting the inflammatory stress, oxidative stress, alteration of bile acid homeostasis, and CYP2E1 over-expression. …”
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Changes of Intestinal Flora in Patients with Atrial Fibrillation and Its Correlation with Cardiovascular Risk Factors by Shi Chen, Mingyue Tu, Jiaran Shi, Xiaosheng Hu

“…Methods: According to the inclusion criteria, 53 AF patients were selected as atrial fibrillation group (Group AF), detection of C-reactive protein (CRP), homocysteine (Hcy), total bile acid (TBA), brain natriuretic peptide (BNP), High-sensitivity cardiac troponin (Hs-cTn) and left ventricular ejection fraction (LVEF) were accomplished. …”
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Comparative Analysis of Hepatopancreas RNA-Seq of Juvenile Grass Carp (<i>Ctenopharyngodon idella</i>) Fed Different Starch Diets by Jingjing Zhang, Xue Guo, Zhen Han, Letian Qu, Teng Xia, Xiangning Chen, Jianhe Xu, Zhujin Ding, Chaoqing Wei, Hanliang Cheng

“…These results indicate that the long-term PO ingestion could modulate hepatic lipid metabolism by reducing fatty acid biosynthesis and increasing bile acid biosynthesis. PO may be healthier in contrast to CO alone, which may not be suitable as a starch source in grass carp diet.…”
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Quercetagetin alleviates zearalenone-induced liver injury in rabbits through Keap1/Nrf2/ARE signaling pathway by Fengyang Wu, Fengyang Wu, Fengxia Wang, Zhaohong Tang, Xinyu Yang, Yanhua Liu, Man Zhao, Shudong Liu, Shuaijuan Han, Zhisheng Zhang, Baojiang Chen

“…The intake of ZEN-contaminated diet also significantly increased the activities or levels of alanine transaminase, alkaline phosphatase, total bile acid (TBA), total bilirubin, malondialdehyde, and interleukin-4 (IL-4) and enhanced the abundance of kelch-like ECH-associated protein 1 (Keap1), heat shock protein 70 (HSP70) and cysteine-aspartic acid protease-3 (Caspase-3) mRNA in the blood or liver tissue in ZEN group, compared to the control group (p &lt; 0.05). …”
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Protective effects of Descurainia sophia seeds extract and its fractions on pulmonary edema by untargeted urine and serum metabolomics strategy by Jinying Zhang, Ning Zhou, Ning Zhou, Yongxiang Wang, Tong Liu, Yumin Cao, Weisheng Feng, Weisheng Feng, Weisheng Feng, Xiaoke Zheng, Xiaoke Zheng, Xiaoke Zheng

“…However, DS-Oli, DS-FG, and DS-FO had more important roles in edema-fluid reabsorption, and reduction of vascular leakage through regulating the metabolism of phenylalanine, sphingolipid and bile acid. Finally, heatmaps and hierarchical clustering analysis indicated DS-Oli, DS-FG, and DS-FO to be more efficacious than DS-Pol or DS-FA against PE. …”
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Anaphylactoid reactions induced by Shuanghuanglian injection and Shenmai injection and metabolomics analysis by Chi Zhang, Chi Zhang, Linqi Ouyang, Xili Zhang, Xili Zhang, Wen Wen, Wen Wen, Yuqin Xu, Shan Li, Yingyu Li, Yingyu Li, Fuyuan He, Fuyuan He, Wenlong Liu, Wenlong Liu, Hongyu Liu

“…The associated metabolic pathways include steroid hormone biosynthesis, tryptophan metabolism, histidine metabolism, arachidonic acid metabolism, nicotinate and nicotinamide metabolism, and primary bile acid biosynthesis.Conclusion: Study showed that both SHLI and SMI can induce varying degrees of anaphylactoid reactions, a positive correlation between response intensity and dose was observed. …”
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NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles by Jonathan C. Behlen, Carmen H. Lau, Drew Pendleton, Yixin Li, Aline Rodrigues Hoffmann, Michael C. Golding, Renyi Zhang, Natalie M. Johnson

“…The expression of inflammatory cytokine genes (<i>Il1β,</i> <i>Tnfα</i>) was significantly increased in <i>Nrf2</i>^−/⁻ placentas from male and female offspring across all exposure groups. Genes related to bile acid metabolism and transport were differentially altered in <i>Nrf2</i>^−/⁻ mice across sex and exposure groups. …”
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Effects of Atractylodes lancea extracts on intestinal flora and serum metabolites in mice with intestinal dysbacteriosis by BaiNian Zhang, Lan Bu, Hui Tian, ZhangQiang You, MingHai Zhao, Jie Tian, YuanYuan Zhang, Qian Wang, ChengJia Tan, Yu Cao, DaRen Feng, ZhenPeng Xi

“…It could relate to lipid metabolism, bile acid metabolism, and amino acid metabolism. These results will provide a basis for further explaining the mechanism by which A. lancea regulats intestinal flora.…”
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Risk Factors for Hepatic Encephalopathy in Hepatocellular Carcinoma After Sorafenib or Lenvatinib Treatment: A Real-World Study by Chen B, Zhang L, Cheng J, Wu T, Lei J, Yang X, Zhang R, Safadi R, Li Y, Si T, Lu Y

“…At time of data cut-off (2021– 12), the incidence of HE in sorafenib group (4.2%, 95% CI:2– 7%) was significantly lower than that in lenvatinib group (11.3%,95% CI:7– 15%) (p = 0.006), with alcoholic cirrhosis [OR: 5.857 (95% CI: 1.519– 22.591)], Child-Pugh > 7 [OR: 3.023 (95% CI: 1.135– 8.053)], blood ammonia ≥ 38.65 μmol/L [OR: 4.693 (95% CI: 1.782– 12.358)], total bile acid ≥ 29.5 μmol/L [OR: 11.047 (95% CI: 4.414– 27.650)] and duration of treatment ≥ 5.6 months [OR: 4.350 (95% CI: 1.701– 11.126)] to be risk factors for the occurrence of HE during first-line systemic therapy.Conclusion: In our study, for off-label uHCC patients (Child-Pugh > 7) with alcoholic cirrhosis, hyperammonemia, hypercholesterolemia, and estimated longer duration of treatment, the application of lenvatinib has to be cautious, which needs to be confirmed in future clinical trials.Keywords: hepatic encephalopathy, hepatocellular carcinoma, liver cirrhosis, sorafenib, lenvatinib…”
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The effects of incretin mimetics on the level of the microbial metabolite trimethylamine-N-oxide, a marker of cardiovascular risk in type 2 diabetic patients by K.O. Shyshkan-Shyshova, O.V. Zinych, N.M. Кushnareva, A.V. Кovalchuk, О.V. Prybyla

“…A significant decrease in the level of TMAO microbial metabolite in the blood serum was recorded, which may reflect the antiatherogenic effect of GLP1ra, associated with the control of cholesterol and bile acid metabolism, the stimulation of VLDL-C receptors, and the effect on the secretion of insulin, glucagon, ghrelin, leptin, incretins. …”
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Transcriptome Sequencing Analysis Reveals Dynamic Changes in Major Biological Functions during the Early Development of Clearhead Icefish, <i>Protosalanx chinensis</i> by Xuemei Tang, Shulun Jiang, Henglin Wang, Yanfeng Zhou, Fei Peng, Xizhao Zhang, Yifan Zhou, Shiyue Guo, Yang You

“…Through the enrichment analysis and hub gene identification results of these nine modules, it was found that the pathways related to eye, bone, and heart development were significantly enriched in the YL stage, and the <i>ccnd2</i>, <i>seh1l</i>, <i>kdm6a</i>, <i>arf4,</i> and <i>ankrd28</i> genes that are associated with cell proliferation and differentiation played important roles in these developmental processes; the <i>pak3</i>, <i>dlx3</i>, <i>dgat2,</i> and <i>tas1r1</i> genes that are associated with jaw and tooth development, TG (triacylglycerol) synthesis, and umami amino acid receptors were identified as hub genes for the PM stage; the pathways associated with aerobic metabolism and unsaturated fatty acid synthesis were significantly enriched in the KK stage, with the <i>foxk</i>, <i>slc13a2_3_5</i>, <i>ndufa5</i>, and <i>lsc2</i> genes playing important roles; the pathways related to visual perception were significantly enriched in the LC stage; and the bile acid biosynthetic and serine-type peptidase activity pathways were significantly enriched in the SL stage. …”
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Microbiota modulation by dietary oat beta-glucan prevents steatotic liver disease progression by Julius W. Jaeger, Annette Brandt, Wenfang Gui, Timur Yergaliyev, Angélica Hernández-Arriaga, Mukil Marutha Muthu, Karolina Edlund, Ahmed Elashy, Antonio Molinaro, Diana Möckel, Jan Sarges, Emina Halibasic, Michael Trauner, Florian Kahles, Ulrike Rolle-Kampczyk, Jan Hengstler, Carolin Victoria Schneider, Twan Lammers, Hanns-Ulrich Marschall, Martin von Bergen, Amélia Camarinha-Silva, Ina Bergheim, Christian Trautwein, Kai Markus Schneider

“…Mechanistically, this protective effect was not mediated by changes in bile acid composition or signaling, but was dependent on gut microbiota and was lost upon broad-spectrum antibiotic treatment. …”
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Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (H... by Bevin E. Blake, Colette N. Miller, Helen Nguyen, Vesna A. Chappell, Trina P. Phan, Dhiral P. Phadke, Michele R. Balik-Meisner, Deepak Mav, Ruchir R. Shah, Suzanne E. Fenton

“…Upregulated DEPs identified across all groups included Fatty Acid Metabolism, Peroxisome, Oxidative Phosphorylation, Adipogenesis, and Bile Acid Metabolism. Transcriptome-phenotype correlation analyses demonstrated > 1000 maternal liver DEGs were significantly correlated with maternal relative liver weight (R2 >0.92). …”
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