Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study by Inês ePalmela, Leonor eCorreia, Rui eSilva, Rui eSilva, Hiroyuki eSasaki, Kwang Sik Kim, Dora eBrites, Dora eBrites, Maria A Brito, Maria A Brito

“…Bile acids also prevented the upregulation of interleukin-6 mRNA, whereas only ursodeoxycholic acid abrogated cytokine release. …”
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The Food Contaminants Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis Structure-Dependently in the Human Hepatoma Cell Line HepaRG by Josephin Glück, Marcus Henricsson, Albert Braeuning, Stefanie Hessel-Pras

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Metabolomic Alterations of Volatile Organic Compounds and Bile Acids as Biomarkers of Microbial Shifts in a Murine Model of Short Bowel Syndrome by Vanessa Wolfschluckner, Beate Obermüller, Angela Horvath, Giovanny Rodriguez-Blanco, Patricia Fuchs, Wolfram Miekisch, Barbara Mittl, Christina Flucher, Holger Till, Georg Singer

“…Four weeks postoperatively, the microbial communities of different intestinal segments (jejunum, ileum, colon) and stool were assessed by 16S rRNA gene sequencing. Bile acids in serum and stool and volatile organic compounds (VOCs) in the fecal headspace were assessed using LC-MS and GC-MS techniques. …”
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Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

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Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways by Hee Joon Yoo, Min Cheol Pyo, Kyu Hyun Rhee, Jae-Min Lim, Seon-Ah Yang, Min Ki Yoo, Kwang-Won Lee

“…These results indicate that PFOA and HFPO-DA both cause hepatotoxicity and bile acid metabolism impairment with distinct mechanisms.…”
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Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress by Weijia Cai, Canye Li, Zuanjun Su, Jinming Cao, Zhicong Chen, Yitian Chen, Zhijun Guo, Jian Cai, Feng Xu

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High-Amylose Corn Starch Regulated Gut Microbiota and Serum Bile Acids in High-Fat Diet-Induced Obese Mice by Jiamiao Hu, Peiying Zheng, Jinhui Qiu, Qingyan Chen, Shaoxiao Zeng, Yi Zhang, Shaoling Lin, Baodong Zheng

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<i>Lactobacillus gasseri</i> RW2014 Ameliorates Hyperlipidemia by Modulating Bile Acid Metabolism and Gut Microbiota Composition in Rats by Xianping Li, Yuchun Xiao, Yuanming Huang, Liqiong Song, Mengde Li, Zhihong Ren

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Isomaltulose Exhibits Prebiotic Activity, and Modulates Gut Microbiota, the Production of Short Chain Fatty Acids, and Secondary Bile Acids in Rats by Zhan-Dong Yang, Yi-Shan Guo, Jun-Sheng Huang, Ya-Fei Gao, Fei Peng, Ri-Yi Xu, Hui-Hui Su, Ping-Jun Zhang

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Effects of Bile Acid Supplementation on Lactation Performance, Nutrient Intake, Antioxidative Status, and Serum Biochemistry in Mid-Lactation Dairy Cows by Yuhang Chen, Cong Yuan, Tianyu Yang, Han Song, Kang Zhan, Guoqi Zhao

Subjects: “…bile acid…”
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Infants Fed Breastmilk or 2′-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids by David R. Hill, Rachael H. Buck

“…Most notably, secondary bile acid production was broadly increased in a dose-dependent manner among infants receiving 2′-FL supplemented formula relative to the control formula. 2′-FL supplementation increased secondary bile acid production to levels associated with breastfeeding. …”
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Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice by Ting Zhai, Junjun Wang, Yong Chen

“…However, the effects of HNK on the composition of serum lipids and bile acids (BAs) and gut microbiota (GM) of NASH mice are still unknown.C57BL/6 mice were fed with methionine-choline deficiency (MCD) diet and gavaged with HNK (20 mg/kg/d) for 8 weeks, then the serum lipids and BAs were detected by LC–MS, the composition of ileum microflora and the mRNA expression of hepatic BAs homeostasis related genes were analyzed by 16S rDNA sequencing and RT-qPCR, respectively. …”
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Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins by Heikki V. Sarin, Juha J. Hulmi, Youwen Qin, Michael Inouye, Scott C. Ritchie, Susan Cheng, Jeramie D. Watrous, Thien-Tu C. Nguyen, Joseph H. Lee, Zhezhen Jin, Joseph D. Terwilliger, Teemu Niiranen, Aki Havulinna, Veikko Salomaa, Kirsi H. Pietiläinen, Ville Isola, Juha P. Ahtiainen, Keijo Häkkinen, Mohit Jain, Markus Perola

“…These widespread changes, especially in the bile acid profile, were most strongly explained (FDR < 0.05) by changes in android (visceral) fat mass. …”
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Comprehensive bile acid pool analysis during ex-vivo liver perfusion in a porcine model of ischemia-reperfusion injury by Guillaume Rossignol, Xavier Muller, Thomas Alexandre Brunet, Valeska Bidault, Valerie Hervieu, Yohann Clement, Sophie Ayciriex, Jean-Yves Mabrut, Arnaud Salvador, Kayvan Mohkam

“…Abstract Bile acids (BA) are key for liver regeneration and injury. …”
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HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis by Jiaqi Fu, Yuqin Liang, Yunhe Shi, Donghua Yu, Yu Wang, Pingping Chen, Shumin Liu, Fang Lu

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Western Diet Changes Gut Microbiota and Ameliorates Liver Injury in a Mouse Model with Human‐Like Bile Acid Composition by Junichi Iwamoto, Akira Honda, Teruo Miyazaki, Tadakuni Monma, Hajime Ueda, Yukio Morishita, Sho‐ichiro Yara, Takeshi Hirayama, Tadashi Ikegami

“…Western‐style high‐fat/high‐sucrose diet (HFHSD) changes gut microbiota and bile acid (BA) profiles. Because gut microbiota and BAs could influence each other, the mechanism of changes in both by HFHSD is complicated and remains unclear. …”
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Dairy Intake Modifies the Level of the Bile Acid Precursor and Its Correlation with Serum Proteins Associated with Cholesterol Clearance in Subjects with Hyperinsulinemia by Atena Mahdavi, Jocelyn Trottier, Olivier Barbier, Michel Lebel, Iwona Rudkowska

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Elevated Levels of Toxic Bile Acids in Serum of Cystic Fibrosis Patients with <i>CFTR</i> Mutations Causing Pancreatic Insufficiency by Harold Tabori, Jochen Schneider, Stefan Lüth, Carlos Zagoya, Anton Barucha, Thomas Lehmann, Eberhard Kauf, Astrid Barth, Jochen G. Mainz

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Characterization of Metabolic Correlations of Ursodeoxycholic Acid with Other Bile Acid Species through In Vitro Sequential Metabolism and Isomer-Focused Identification by Wei Li, Wei Chen, Xiaoya Niu, Chen Zhao, Pengfei Tu, Jun Li, Wenjing Liu, Yuelin Song

“…As a first-line agent for cholestasis treatment in a clinic, ursodeoxycholic acid rectifies the perturbed bile acids (BAs) submetabolome in a holistic manner. …”
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Dietary bile acid supplementation in weaned piglets with intrauterine growth retardation improves colonic microbiota, metabolic activity, and epithelial function by Yang Liu, Md. Abul Kalam Azad, Sujuan Ding, Qian Zhu, Francois Blachier, Zugong Yu, Haijun Gao, Xiangfeng Kong

Subjects: “…Bile acid…”
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