Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells by Johanna Abrigo, Hugo Olguín, Franco Tacchi, Josué Orozco-Aguilar, Mayalen Valero-Breton, Jorge Soto, Mauricio Castro-Sepúlveda, Alvaro A. Elorza, Felipe Simon, Claudio Cabello-Verrugio

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Ethyl Acetate Extract of <i>Dracocephalum heterophyllum</i> Benth Ameliorates Nonalcoholic Steatohepatitis and Fibrosis via Regulating Bile Acid Metabolism, Oxidative Stress and Inhibiting Inflammation by Yan Fang, Dandan Sun, Gang Li, Yue Lv, Jia Li, Qilan Wang, Jun Dang

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Vitamin C and vitamin D3 alleviate metabolic-associated fatty liver disease by regulating the gut microbiota and bile acid metabolism via the gut-liver axis by Qingling Chen, Qingling Chen, Lili Zhao, Ling Mei, Ling Mei, Xiaotong Zhao, Ping Han, Ping Han, Jie Liu, Chao Meng, Ruifang Li, Rui Zhong, Kai Wang, Jia Li

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3′quant mRNA-Seq of Porcine Liver Reveals Alterations in UPR, Acute Phase Response, and Cholesterol and Bile Acid Metabolism in Response to Different Dietary Fats by Maria Oczkowicz, Tomasz Szmatoła, Małgorzata Świątkiewicz, Anna Koseniuk, Grzegorz Smołucha, Wojciech Witarski, Alicja Wierzbicka

“…The most striking difference in liver transcriptomic response between C and B was the activation of the acute phase response and inhibition of bile acid synthesis in the latest group. Our results suggest that excessive consumption of animal fats leads to the activation of a cascade of mutually propelling processes harmful to the liver: inflammation, UPR, and imbalances in the biosynthesis of cholesterol and bile acids via altered organelle membrane composition. …”
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Comparison of fresh and browning lotus roots (Nelumbo nucifera Gaertn.) on modulating cholesterol metabolism via decreasing hepatic cholesterol deposition and increasing fecal bile acid excretion by Jingfang Li, Ting Luo, Xiaoping Li, Xiaoru Liu, Ze-yuan Deng

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Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism by Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao

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Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the FTO gene by Skuladottir GV, Oskarsdottir H, Pisanu C, Sjödin M, Lindberg J, Mwinyi J, Schiöth HB

“…Gudrun Valgerdur Skuladottir,1,2 Harpa Oskarsdottir1 Claudia Pisanu,2,3 Marcus Sj&ouml;din,4 Johan Lindberg,4 Jessica Mwinyi,2 Helgi Birgir Schi&ouml;th2 1Department of Physiology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland; 2Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden; 3Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; 4Swetox, Karolinska Institutet, Unit of Toxicological Sciences, S&ouml;dert&auml;lje, Sweden Purpose: Dietary macronutrient composition, stearoyl-CoA desaturase (SCD) activity indices, and primary bile acid (BA) concentrations are among the factors that have been associated with lipid metabolism and contributed to obesity. …”
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Dietary carbon loaded with nano-ZnO alters the gut microbiota community to mediate bile acid metabolism and potentiate intestinal immune function in fattening beef cattle by Haibo Zhang, Weikun Guan, Lizhi Li, Dongsheng Guo, Xiangfei Zhang, Jiuqiang Guan, Runxiao Luo, Siying Zheng, Jiangwen Fu, Yingying Cheng, Qin He

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<i>Platycodi Radix</i> Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model by Wooyoung Kim, Woon Hee Baek, Sung Ho Yun, Hayoung Lee, Mi Jeong Kim, Sang-Yeop Lee, Gun-Hwa Kim, Seung Il Kim, Hye Gwang Jeong, Edmond Changkyun Park

“…Subsequent network analysis predicted enhanced bile acid synthesis from these proteins. Indeed, the quantity of bile acids, which was reduced in HFD conditions, increased in the PRE group, accompanied by an elevation in the expression of synthesis-related proteins. …”
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<i>Lactiplantibacillus plantarum</i> NKK20 Alleviates High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Regulating Bile Acid Anabolism by Chang Sun, Chenguang Qiu, Yanyan Zhang, Man Yan, Jiajun Tan, Jiayuan He, Dakai Yang, Dongxu Wang, Liang Wu

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Chronic exposure to ambient traffic-related air pollution (TRAP) alters gut microbial abundance and bile acid metabolism in a transgenic rat model of Alzheimer’s disease by Moumita Dutta, Kris M. Weigel, Kelley T. Patten, Anthony E. Valenzuela, Christopher Wallis, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein, Julia Yue Cui

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A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis by Hu Li, Mingjie Wang, Peizhan Chen, Mingyu Zhu, Li Chen

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Virological response to nucleos(t)ide analogues treatment in chronic hepatitis B patients is associated with Bacteroides-dominant gut microbiomeResearch in context by Saisai Zhang, Hau-Tak Chau, Hein Min Tun, Fung-Yu Huang, Danny Ka-Ho Wong, Lung-Yi Mak, Man-Fung Yuen, Wai-Kay Seto

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Circulating Levels of Cathelicidin Antimicrobial Peptide (CAMP) Are Affected by Oral Lipid Ingestion by Alexandra Höpfinger, Thomas Karrasch, Andreas Schäffler, Andreas Schmid

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Alterations in the gut microbiota and serum metabolomics of spontaneous cholestasis caused by loss of FXR signal in mice by Shizhang Wei, Shizhang Wei, Tingting He, Xu Zhao, Manyi Jing, Haotian Li, Lisheng Chen, Ruimao Zheng, Yanling Zhao

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Cooperative Interaction of Phenolic Acids and Flavonoids Contained in Activated Charcoal with Herb Extracts, Involving Cholesterol, Bile Acid, and FXR/PXR Activation in Broilers Fed with Mycotoxin-Containing Diets by Ying Zhang, Zishen Lin, Lixue Wang, Xiangyue Guo, Zhihui Hao, Zhen Li, Lee J. Johnston, Bing Dong

“…CHC also increased concentrations of serum cholesterol, bile acid in the gallbladder, and bile acid in feces. …”
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Gut microbiota-related bile acid metabolism-FXR/TGR5 axis impacts the response to anti-α4β7-integrin therapy in humanized mice with colitis by Bing Han, Xiaodan Lv, Gengfeng Liu, Shiquan Li, Junhua Fan, Lan Chen, Zhixi Huang, Guangfu Lin, Xiaofang Xu, Ziqian Huang, Lingling Zhan, Xiaoping Lv

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Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling by Bei Li, Yong Zhang, Xinyuan Liu, Ziyang Zhang, Shuqing Zhuang, Xiaoli Zhong, Wenbo Chen, Yilin Hong, Pingli Mo, Shuhai Lin, Shicong Wang, Chundong Yu

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NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice by Lin Jia, Yinyan Ma, Jamie Haywood, Long Jiang, Bingzhong Xue, Hang Shi, Paul A. Dawson, Liqing Yu

“…A major metabolic fate of cholesterol is its conversion to bile acids. We found that NPC1L1 knockout (L1-KO) mice fed an HFD had increased energy expenditure, bile acid pool size, and fecal bile acid excretion rates. …”
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Nutritional and Chemical Composition of <i>Sargassum zhangii</i> and the Physical and Chemical Characterization, Binding Bile Acid, and Cholesterol-Lowering Activity in HepG2 Cells of Its Fucoidans by Peichun Lin, Suhua Chen, Siyan Zhong

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