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Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells
Published 2023-06-01Subjects: Get full text
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3′quant mRNA-Seq of Porcine Liver Reveals Alterations in UPR, Acute Phase Response, and Cholesterol and Bile Acid Metabolism in Response to Different Dietary Fats
Published 2020-09-01“…The most striking difference in liver transcriptomic response between C and B was the activation of the acute phase response and inhibition of bile acid synthesis in the latest group. Our results suggest that excessive consumption of animal fats leads to the activation of a cascade of mutually propelling processes harmful to the liver: inflammation, UPR, and imbalances in the biosynthesis of cholesterol and bile acids via altered organelle membrane composition. …”
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Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the FTO gene
Published 2018-10-01“…Gudrun Valgerdur Skuladottir,1,2 Harpa Oskarsdottir1 Claudia Pisanu,2,3 Marcus Sjödin,4 Johan Lindberg,4 Jessica Mwinyi,2 Helgi Birgir Schiöth2 1Department of Physiology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland; 2Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden; 3Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; 4Swetox, Karolinska Institutet, Unit of Toxicological Sciences, Södertälje, Sweden Purpose: Dietary macronutrient composition, stearoyl-CoA desaturase (SCD) activity indices, and primary bile acid (BA) concentrations are among the factors that have been associated with lipid metabolism and contributed to obesity. …”
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<i>Platycodi Radix</i> Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model
Published 2024-03-01“…Subsequent network analysis predicted enhanced bile acid synthesis from these proteins. Indeed, the quantity of bile acids, which was reduced in HFD conditions, increased in the PRE group, accompanied by an elevation in the expression of synthesis-related proteins. …”
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Circulating Levels of Cathelicidin Antimicrobial Peptide (CAMP) Are Affected by Oral Lipid Ingestion
Published 2023-07-01Subjects: Get full text
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835
Alterations in the gut microbiota and serum metabolomics of spontaneous cholestasis caused by loss of FXR signal in mice
Published 2023-05-01Subjects: Get full text
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836
Cooperative Interaction of Phenolic Acids and Flavonoids Contained in Activated Charcoal with Herb Extracts, Involving Cholesterol, Bile Acid, and FXR/PXR Activation in Broilers Fed with Mycotoxin-Containing Diets
Published 2022-11-01“…CHC also increased concentrations of serum cholesterol, bile acid in the gallbladder, and bile acid in feces. …”
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Gut microbiota-related bile acid metabolism-FXR/TGR5 axis impacts the response to anti-α4β7-integrin therapy in humanized mice with colitis
Published 2023-12-01Subjects: Get full text
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838
Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling
Published 2024-04-01Subjects: Get full text
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839
NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice
Published 2021-12-01“…A major metabolic fate of cholesterol is its conversion to bile acids. We found that NPC1L1 knockout (L1-KO) mice fed an HFD had increased energy expenditure, bile acid pool size, and fecal bile acid excretion rates. …”
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