Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice by Chisato Tanaka, Naoki Harada, Yoshiaki Teraoka, Hiroki Urushizaki, Yoh Shinmori, Teruaki Onishi, Yusuke Yotsumoto, Yuta Ito, Tomoya Kitakaze, Takashi Inui, Yuji Murata, Hiroshi Inui, Ryoichi Yamaji

“…Here, we identified the G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) as a target of the triterpenoid mogrol, a class of aglycone mogroside derivative from Siraitia grosvenorii. …”
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Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn’s disease by Bing Han, Daiyuan Tang, Xiaodan Lv, Junhua Fan, Shiquan Li, Hui Zhu, Jiatong Zhang, Shang Xu, Xiaofang Xu, Ziqian Huang, Zhixi Huang, Guangfu Lin, Lingling Zhan, Xiaoping Lv

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The ratio of 12α to non-12-hydroxylated bile acids reflects hepatic triacylglycerol accumulation in high-fat diet-fed C57BL/6J mice by Wakana Iwasaki, Ryo Yoshida, Hongxia Liu, Shota Hori, Yuki Otsubo, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka

“…Abstract In our previous study, enterohepatic 12α-hydroxylated (12α) bile acid (BA) levels were found to be correlated with hepatic triacylglycerol concentration in rats fed high-fat (HF) diet. …”
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Total <i>Sn</i>-2 Palmitic Triacylglycerols and the Ratio of OPL to OPO in Human Milk Fat Substitute Modulated Bile Acid Metabolism and Intestinal Microbiota Composition in Rats by Lin Zhu, Shuaizhen Fang, Hong Zhang, Xiangjun Sun, Puyu Yang, Jianchun Wan, Yaqiong Zhang, Weiying Lu, Liangli Yu

“…In this study, the impact of <i>sn</i>-2 palmitic triacyclglycerols (TAGs) in combination with their ratio of two major TAGs (1-oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL) to 1,3-dioleoyl-2-palmitoylglycerol (OPO)) in human milk fat substitute (HMFS) on bile acid (BA) metabolism and intestinal microbiota composition was investigated in newly-weaned Sprague–Dawley rats after four weeks of high-fat feeding. …”
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Leucine regulates lipid metabolism in adipose tissue through adipokine-mTOR-SIRT1 signaling pathway and bile acid–microbe axis in a finishing pig model by Yunju Yin, Saiming Gong, Mengmeng Han, Jingzun Wang, Hanjing Shi, Xianji Jiang, Liu Guo, Yehui Duan, Qiuping Guo, Qinghua Chen, Fengna Li

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Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice by Francesca Ferlenghi, Carmine Giorgio, Matteo Incerti, Lorenzo Guidetti, Paola Chiodelli, Marco Rusnati, Massimiliano Tognolini, Federica Vacondio, Marco Mor, Alessio Lodola

“…UniPR129, an L-β-homotryptophan conjugate of the secondary bile acid lithocholic acid (LCA), acts as an effective protein-protein interaction (PPI) inhibitor of the Eph–ephrin system but suffers from a poor oral bioavailability in mice. …”
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The role of the gallbladder in humans by J.L. Turumin, V.A. Shanturov, H.E. Turumina

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An impaired pituitary–adrenal signalling axis in stable cirrhosis is linked to worse prognosis by Lukas Hartl, Benedikt Simbrunner, Mathias Jachs, Peter Wolf, David Josef Maria Bauer, Bernhard Scheiner, Lorenz Balcar, Georg Semmler, Michael Schwarz, Rodrig Marculescu, Michael Trauner, Mattias Mandorfer, Thomas Reiberger

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Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis by Tongyao Wang, Xingyu Rong, Chao Zhao, Chao Zhao

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Integrated untargeted and targeted metabolomics to reveal therapeutic effect and mechanism of Alpiniae oxyphyllae fructus on Alzheimer’s disease in APP/PS1 mice by Shengnan Zhou, Shengnan Zhou, Shengnan Zhou, Liwei Liu, Liwei Liu, Liwei Liu, Yuanyuan Zhang, Yuanyuan Zhang, Yuanyuan Zhang, Zhibo Zhang, Zhibo Zhang, Zhibo Zhang, Hanbing Li, Feng Fan, Jiuming He, Jian Kang, Jian Kang, Jian Kang, Lihua Zuo, Lihua Zuo, Lihua Zuo

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Fecal microbiota transplantation in the treatment of astrovirus infection in a recipient of an allogeneic hematopoietic stem cell transplant: a clinical case by Julia A. Bespyatykh, Alina V. Gospodarik, Evgeny A. Zhuravel, George Z. Seregin, Anastacia V. Komarova, Sulejman S. Esiev, Gleb O. Bronin, Yaroslab D. Shansky

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Metabolomic signatures of intestinal colonization resistance against Campylobacter jejuni in mice by Nizar W. Shayya, Rasmus Bandick, Lia V. Busmann, Soraya Mousavi, Stefan Bereswill, Markus M. Heimesaat

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Gut microbiota, metabolites, and cardiovascular diseases by Yi-Qiong Zhang, Yi-Ming Hua, Chen-Xing Li, Bei-Di Lan, Xiao-Ke Wang, Qi Wang, Zu-Yi Yuan, Lu Ma, Yue Wu

Subjects: “…bile acids; cardiovascular diseases; gut microbiome; short-chain fatty acids; trimethylamine…”
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Bacteroides vulgatus Ameliorates Lipid Metabolic Disorders and Modulates Gut Microbial Composition in Hyperlipidemic Rats by Mingchao Xu, Ruiting Lan, Lei Qiao, Xiaoying Lin, Dalong Hu, Suping Zhang, Jing Yang, Juan Zhou, Zhihong Ren, Xianping Li, Guoxing Liu, Liyun Liu, Jianguo Xu

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Enhanced Bilosomal Properties Resulted in Optimum Pharmacological Effects by Increased Acidification Pathways by Armin Mooranian, Thomas Foster, Corina M. Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnston, Elaine Wong, Marcus D. Atlas, Momir Mikov, Hani Al-Salami

Subjects: “…bile acids…”
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Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis? by Yushu Yang, XiaoSong He, Manuel Rojas, Manuel Rojas, Patrick S. C. Leung, Lixia Gao, Lixia Gao

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Gradual dosing of ursodeoxycholic acid in mothers with intrahepatic cholestasis of pregnancy may improve composite neonatal outcome by Amir Hamud, Matan J. Cohen, Drorith Hochner-Celnikier, Benjamin Bar-Oz, Zvi Ackerman

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Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations by Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian, Hani Al-Salami

Subjects: “…bile acids…”
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Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity by Julia Münzker, Nadine Haase, Andreas Till, Robert Sucher, Sven-Bastiaan Haange, Linda Nemetschke, Thorsten Gnad, Elisabeth Jäger, Jiesi Chen, Sjaak J. Riede, Rima Chakaroun, Lucas Massier, Peter Kovacs, Mario Ost, Ulrike Rolle-Kampczyk, Nico Jehmlich, Juliane Weiner, John T. Heiker, Nora Klöting, Gudrun Seeger, Markus Morawski, Verena Keitel, Alexander Pfeifer, Martin von Bergen, Joerg Heeren, Ute Krügel, Wiebke K. Fenske

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A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes by Yifeng Fu, Siying Li, Yunhua Xiao, Gang Liu, Jun Fang

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