2′FL and LNnT Exert Antipathogenic Effects against <i>C. difficile</i> ATCC 9689 In Vitro, Coinciding with Increased Levels of <i>Bifidobacteriaceae</i> and/or Secondary Bile Acids by Louise Kristine Vigsnaes, Jonas Ghyselinck, Pieter Van den Abbeele, Bruce McConnell, Frédéric Moens, Massimo Marzorati, Danica Bajic

“…Moreover, 2′FL avoided CDI recurrence, potentially because of increased secondary bile acid production. Overall, while not elucidating the exact antipathogenic mechanisms-of-action, the current study highlights the potential of HMOs to combat CDI recurrence, help the gut microbial community recover after antibiotic treatment, and hence counteract the adverse effects of antibiotic therapies.…”
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Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA by Chong Ma, Chong Ma, Chong Ma, Chong Ma, Chong Ma, Dun Yuan, Stephen James Renaud, Ting Zhou, Ting Zhou, Ting Zhou, Ting Zhou, Fan Yang, Fan Yang, Fan Yang, Fan Yang, Yuligh Liou, Xinjian Qiu, Lu Zhou, Ying Guo, Ying Guo, Ying Guo, Ying Guo

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Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study by Hegade, VS, Kendrick, SFW, Dobbins, RL, Miller, SR, Thompson, D, Richards, D, Storey, J, Dukes, GE, Corrigan, M, Elferink, RPJ, Beuers, U, Hirschfield, GM, Jones, DE

“…We investigated the efficacy and safety of GSK2330672, a selective inhibitor of human ileal bile acid transporter (IBAT), in patients with primary biliary cholangitis with pruritus.…”

Early Deregulation of Cholangiocyte NR0B2 During Primary Sclerosing Cholangitis by Christophe Desterke, Chuhan Chung, David Pan, Michael Trauner, Didier Samuel, Daniel Azoulay, Cyrille Feray

Subjects: “…Bile Acid Metabolism…”
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The exopolysaccharide produced by Pantoea sp. BCCS 001 GH provides hepatoprotection in a rat model of bile duct obstruction by Seyyed Vahid Niknezhad, Younes Ghasemi, Ali Khalili Gashtroudkhani, Hamidreza Mohammadi, Reza Heidari

Subjects: “…bile acid…”
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Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist by An-Na Moon, François Briand, Natalia Breyner, Dong-Keun Song, Martin Rønn Madsen, Hongbin Kim, Keonwoo Choi, Yoonsuk Lee, Wan Namkung

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Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway by Ruixia Bao, Wei Wang, Beibei Chen, Jujie Pan, Qian Chen, Mengyang Liu, Dan Wang, Yuzheng Wu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang

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Factors related to intestine have a role in prevention and treatment for gallstone disease by JIANG Zhaoyan, SHEN Weiyi, HU Hai

Subjects: “…|gallstone disease|intestinal absorption|cholesterol|bile acid…”
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16S rRNA and Metagenomics Combined with UPLC-Q/TOF-MS Metabolomics Analysis Reveals the Potential Mechanism of Radix Astragali Against Hyperuricemia in Mice by Deng S, Cai K, Pei C, Zhang X, Xiao X, Chen Y, Chen Y, Liang R, Chen Y, Li P, Xie Z, Liao Q

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Commentary: Can FXR serve as a potential target for COVID-19 prevention? by Juan Pang, Jia Nuo Feng, Wenhua Ling, Tianru Jin

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Lithocholic Acid Alleviates Deoxynivalenol-Induced Lethal Cholesterol Metabolic Abnormalities in IPI-2I Cells by Yanwei Li, Fang Gu, Haotian Gu, Ping Hu, Hui-Xin Liu, Demin Cai

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Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives by Qingyi Mao, Qingyi Mao, Beibei Lin, Beibei Lin, Wenluo Zhang, Wenluo Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Qian Cao, Qian Cao, Qian Cao, Mengque Xu, Mengque Xu, Mengque Xu

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Predictive Value of Serum Cholic Acid and Lithocholic Acid for the Diagnosis in an Intrahepatic Cholestasis of Pregnancy Population with High Levels of Total Bile Acids and the Correlation with Placental Hypoxia-Inducible Factor-1&alpha; by Cheng CY, Zeng GY, Wang T, Su YH, Xu FD, Luo H, Zhong HT, Chen XL

“…The comparison of the bile acid profiles, the receiver operating characteristic (ROC) curve analysis, and Pearson correlation analysis were conducted successively.Results: Nine types of bile acids were significantly higher in ICP and AHP than in the control group, while CA and LCA serum levels in the AHP group were significantly lower than those in the ICP group (P < 0.05). …”
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Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice by Caijun Zhao, Keyi Wu, Haoyang Hao, Yihong Zhao, Lijuan Bao, Min Qiu, Yuhong He, Zhaoqi He, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu

“…Furthermore, supplementation of mice with secondary bile acids producer Clostridium scindens also activated TGR5 and alleviated S. aureus-induced mastitis in mice. …”
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Supplementation of <i>Weizmannia coagulans</i> BC2000 and Ellagic Acid Inhibits High-Fat-Induced Hypercholesterolemia by Promoting Liver Primary Bile Acid Biosynthesis and Intestinal Cholesterol Excretion in Mice by Long Jin, Hongyang Dang, Jinyong Wu, Lixia Yuan, Xiangsong Chen, Jianming Yao

“…Transcriptome analysis showed that primary bile acid biosynthesis in the liver was significantly activated by EA and <i>W. coagulans</i> BC2000 treatments. …”
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Author Correction: The ratio of 12α to non-12-hydroxylated bile acids reflects hepatic triacylglycerol accumulation in high-fat diet-fed C57BL/6J mice by Wakana Iwasaki, Ryo Yoshida, Hongxia Liu, Shota Hori, Yuki Otsubo, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka

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Modulation of gut microbiota and fecal metabolites by corn silk among high-fat diet-induced hypercholesterolemia mice by Lin Ding, Shan Ren, Yaoxin Song, Chuangang Zang, Yuchao Liu, Hao Guo, Wenqing Yang, Hong Guan, Jicheng Liu, Jicheng Liu

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Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications by Yao Peng, Yuqiang Nie, Jun Yu, Chi Chun Wong

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Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome by Xianmei Gou, Lin Qin, Di Wu, Jian Xie, Yanliu Lu, Qianru Zhang, Yuqi He

Subjects: “…bile acids…”
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Effect of Red-Beetroot-Supplemented Diet on Gut Microbiota Composition and Metabolite Profile of Weaned Pigs—A Pilot Study by Opeyemi O. Adekolurejo, Katie McDermott, Henry M. R. Greathead, Helen M. Miller, Alan R. Mackie, Christine Boesch

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