Showing 1,101 - 1,120 results of 2,702 for search '"bile acids"', query time: 0.13s Refine Results
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    Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD. by Shafqat, N, Marschall, H, Filling, C, Nordling, E, Wu, X, Björk, L, Thyberg, J, Mårtensson, E, Salim, S, Jörnvall, H, Oppermann, U

    Published 2003
    “…These properties suggest that the human enzyme is involved in glucocorticoid and gestagen catabolism, and participates in bile acid isomerization. Confocal microscopy and electron microscopy studies reveal that the human form is localized to mitochondria, whereas Drosophila 17beta-HSD10 shows a cytosolic localization pattern, possibly due to an N-terminal sequence difference that in human 17beta-HSD10 constitutes a mitochondrial targeting signal, extending into the Rossmann-fold motif.…”
    Journal article
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