Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism by Kamil Borkowski, Nicholas T. Seyfried, Matthias Arnold, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, John W. Newman

“…Particularly strong associations were observed between cytochrome p450/soluble epoxide hydrolase metabolites, bile acids, and proteins involved in glycolysis, blood coagulation, and vascular inflammation and the regulators of extracellular matrix. …”
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Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis by Yiming Zhao, Congyong Li, Zhe Luan, Jun Chen, Cong Wang, Yujia Jing, Shirui Qi, Zhizhuang Zhao, Hanwen Zhang, Junling Wu, Yi Chen, Zhuanyu Li, Bowen Zhao, Shufang Wang, Yunsheng Yang, Gang Sun

“…Lactobacillus oris isolated from fecal samples of Hainan centenarians showed significantly in vivo lipid lowering ability compared with the controls, and the ability was comparable with mixed probiotics strains in mice The possible mechanisms of lipid-lowering of probiotics and Lactobacillus oris may be associated with HMGR inhibition to suppress the synthesis of endogenous cholesterol; bile acids reabsorption, and intestinal FXR-FGF15 signaling pathways promoting the cholesterol conversion into bile acids secretion.…”
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A rapid and standardized workflow for functional assessment of bacterial biosensors in fecal samples by Ana Zúñiga, Geisler Muñoz-Guamuro, Lucile Boivineau, Pauline Mayonove, Ismael Conejero, Georges-Philippe Pageaux, Romain Altwegg, Jerome Bonnet

“…Finally, by detecting endogenous bile acids, we demonstrate that bacterial biosensors could be used for future metabolite monitoring in feces. …”
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Farnesoid-X receptor as a therapeutic target for inflammatory bowel disease and colorectal cancer by Mengjiao Zhou, Danfeng Wang, Xiang Li, Ying Cao, Chengxue Yi, Dickson Kofi Wiredu Ocansey, Dickson Kofi Wiredu Ocansey, Yuling Zhou, Fei Mao

“…Farnesoid-X receptor (FXR), as a nuclear receptor activated by bile acids, is a vital molecule involved in bile acid metabolism. …”
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Gut Microbiota-Derived Metabolites and Cardiovascular Disease Risk: A Systematic Review of Prospective Cohort Studies by Raul Sanchez-Gimenez, Wahiba Ahmed-Khodja, Yesica Molina, Oscar M. Peiró, Gil Bonet, Anna Carrasquer, George A. Fragkiadakis, Mònica Bulló, Alfredo Bardaji, Christopher Papandreou

“…TMAO was positively associated with adverse cardiovascular events and CVD/all-cause mortality in some, but not all of the included studies. Bile acids were associated with atrial fibrillation and CVD/all-cause mortality, but not with CVD. …”
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Taurocholic acid promotes hepatic stellate cell activation via S1PR2/p38 MAPK/YAP signaling under cholestatic conditions by Jing Yang, Xujiao Tang, Zhu Liang, Mingzhu Chen, Lixin Sun

“…Background/Aims Disrupted bile acid regulation and accumulation in the liver can contribute to progressive liver damage and fibrosis. …”
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ДИСЛИПИДЕМИЯ И АССОЦИИРОВАНЫЕ МЕТАБОЛИЧЕСКИЕ ЗАБОЛЕВАНИЯ by О. Ш. Ойноткинова, Е. И. Дедов

“…The role of natural mechanism of cholesterol homeostasis changing was showed, functional disorders of the enterohepatic circulation of bile acids and intrahepatic cholestasis due to violation of the reticuloendothelial system, entailing disruption of a specific target organ, on the one hand, and the development of atherosclerosis with ischemic syndromes — on the other, were demonstrated. …”
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Changes in Disposition of Ezetimibe and Its Active Metabolites Induced by Impaired Hepatic Function: The Influence of Enzyme and Transporter Activities by Ningjie Xie, Hong Wang, Hua Qin, Zitao Guo, Hao Xue, Jiafeng Hu, Xiaoyan Chen

“…In conclusion, the increased plasma exposure of the parent drug EZE during hepatic dysfunction was attributed to decreased hepatic glucuronide conjugation, whereas the increased exposure of the metabolite EZE-Ph was mainly related to transporter activity, particularly the inhibitory effects of bile acids on OATPs after oral administration.…”
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Curcumin Supplementation Ameliorates Bile Cholesterol Supersaturation in Hamsters by Modulating Gut Microbiota and Cholesterol Absorption by Ting Hong, Jun Zou, Xin Jiang, Jie Yang, Zhuo Cao, Youming He, Dan Feng

“…Results showed that curcumin significantly decreased cholesterol levels in the serum (from 5.10 to 4.10 mmol/L) and liver (from 64.60 to 47.72 nmol/mg protein) in HFD-fed hamsters and reduced the bile cholesterol saturation index (CSI) from 1.64 to 1.08 due to the beneficial modifications in the concentration of total bile acids (BAs), phospholipids and cholesterol (<i>p</i> < 0.05). …”
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Effects of <i>SLCO1B1</i> Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment by Lilian Fernandes Silva, Rowmika Ravi, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso

“…Our findings suggest that simvastatin exerts its effects on the lowering of low-density lipoprotein (LDL) cholesterol concentrations through several distinct pathways in the carriers of <i>SLCO1B1</i> rs4149056-C, including dicarboxylic acids, bile acids, steroids, and glycerophospholipids.…”
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High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection by Minami Nagai, Miyu Moriyama, Chiharu Ishii, Hirotake Mori, Hikaru Watanabe, Taku Nakahara, Takuji Yamada, Dai Ishikawa, Takamasa Ishikawa, Akiyoshi Hirayama, Ikuo Kimura, Akihito Nagahara, Toshio Naito, Shinji Fukuda, Takeshi Ichinohe

“…High heat-exposed mice increase basal body temperature over 38 °C to enable more bile acids production in a gut microbiota-dependent manner. …”
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Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia by Na Cui, Wensen Zhang, Fazhi Su, Zhihong Zhang, Biao Li, Donghui Peng, Yanping Sun, Yuanning Zeng, Bingyou Yang, Haixue Kuang, Qiuhong Wang

“…Bile acids are the main component of animal bile and are directly involved in the metabolic process of lipids in vivo. …”
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Fluvoxamine ameliorates oxidative stress and inflammation induced by bile-duct ligation in male rats by Zahra Barmoudeh, Hossein Sadeghi, Izadpanah Gheitasi, Bahman Khalvati, Navid Omidifar, Mahdokht Azizi, Zahra Moslemi, Jafar Nikbakht, Amir Hossein Doustimotlagh

“…Introduction: Cholestasis is a disorder that the bile ducts were narrowed and bile acids are not released simply. Bile acids-induced liver damage is exacerbated by inflammation and oxidative stress. …”
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Pathophysiology and Imaging Findings of Bile Duct Necrosis: A Rare but Serious Complication of Transarterial Therapy for Liver Tumors by Satoshi Kobayashi, Kazuto Kozaka, Toshifumi Gabata, Osamu Matsui, Wataru Koda, Miho Okuda, Kenichiro Okumura, Takumi Sugiura, Takahiro Ogi

“…Under the process of BDN formation, ischemia of the PBP induces the disruption of the bile duct epithelial protection mechanism that causes coagulation and fibrinoid necrosis of the surrounding tissue by the detergent action of exuded bile acids, and eventually a biloma forms. Once BDN occurs, persistent tissue damage to the surrounding bile duct is induced by imbibed bile acids, and portal vein thrombosis may also be observed. …”
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The anti-aging effects of Renshen Guben on thyrotoxicosis mice: Improving immunosenescence, hypoproteinemia, lipotoxicity, and intestinal flora by Qin Feng, Guangyan Li, Wenkai Xia, Guoxin Dai, Jidong Zhou, Yan Xu, Deshan Liu, Guimin Zhang

“…The intestinal defense ability of thyrotoxicosis mice was enhanced with the increase of bile acids and lactic acid bacteria by the RSGB treatment. …”
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Percutaneous transvenous coil embolization of an extrahepatic portosystemic shunt in a cat by J Brad Case, Francesca P Solari, Federico Vilaplana Grosso

“…Pre- and postprandial bile acids were markedly elevated. CT was performed, which revealed a single, congenital, left gastrophrenic, extrahepatic portosystemic shunt. …”
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Update on gut microbiota in cardiovascular diseases by Buyun Qian, Kaiyu Zhang, Yuan Li, Kangyun Sun

“…It has also been revealed that intestinal flora-related metabolites, such as trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFA) and bile acids (BAs), are also related to the development, prevention, treatment and prognosis of CVDs. …”
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Cheno and urso compared and contrasted. by R. Hermon Dowling

“…With careful patient selection, efficacy is high and comparable for both bile acids but UDCA depresses HMGCoAR activity (at least in our experience), reduces biliary cholesterol secretion, desaturates fasting duodenal bile, and dissolves cholesterol galistones at 50-66% of the CDCA dose. …”
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Global research trends and focus on the link between colorectal cancer and gut flora: a bibliometric analysis from 2001 to 2021 by Yonglong Chang, Qinling Ou, Qinling Ou, Xuhui Zhou, Jinhui Liu, Sifang Zhang, Sifang Zhang

“…In addition to “intestinal flora” and “colorectal cancer,” high frequency terms in the keyword co-occurrence network analysis included inflammatory bowel disease, Fusobacterium nucleatum, inflammation, long-chain fatty acids, ulcerative colitis, bile acids, and resistant starch. Analysis of keyword trends using burst testing revealed that biomarkers, abnormal crypt foci, bifidobacteria, β-glucuronidase, short-chain fatty acids, bile acids, and DNA methylation are at the forefront of research in this area.ConclusionThe findings of this study provide a bibliometric analysis and visualization of the key research areas in gut microbiota and CRC over the past 20 years. …”
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Comparative Analysis of Urso- and Tauroursodeoxycholic Acid Neuroprotective Effects on Retinal Degeneration Models by Alejandra Daruich, Emilie Picard, Justine Guégan, Thara Jaworski, Léa Parenti, Kimberley Delaunay, Marie-Christine Naud, Marianne Berdugo, Jeffrey H. Boatright, Francine Behar-Cohen

“…On retinal explants, either bile acid reduced apoptosis, necroptosis, and microglia activation at 6 h. …”
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