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1261
LC/MS-Based Untargeted Metabolomics Analysis in Women with Morbid Obesity and Associated Type 2 Diabetes Mellitus
Published 2023-04-01“…Then, in MO women with T2DM, we found increased levels of glutamate, propionyl-carnitine, bile acids, ceramides, lysophosphatidylcholine 14:0, phosphatidylinositols and phosphoethanolamines, and lower levels of Phe-Ile/Leu. …”
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1262
Hypolipidemic Activity of the Polysaccharide L-rhamnopyranosyl-6-O-methyl-galacturonan in Combined Administration with HMG-CoA Reductase and Cholesterol Absorption Inhibitors
Published 2022-09-01“…The additive effect of the polysaccharide is mainly due to a decrease in the level of bile acids in the blood serum, which indicates its ability to absorb them in the intestinal lumen and interrupt enterohepatic circulation, acting like bile acid sequestrants.Conclusion. …”
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1263
The Fecal Microbiome and Metabolome of Pitt Hopkins Syndrome, a Severe Autism Spectrum Disorder
Published 2021-12-01“…Specific metabolites were associated with PTHS, including bile acids and sphingosines. With a metadata reanalysis tool, we found that PTHS-associated metabolites have previously been identified in inflammatory bowel disease and obesity patients. …”
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1264
New Approaches to Studying Prevalence Gallstone Disease
Published 2020-07-01“…In portions “B” and “C” of bile obtained by multifractional duodenal sounding, the total concentration of bile acids, cholesterol and phospholipids was determined, and lithogenicity indices of bile were calculated: cholate-cholesterol and phospholipid-cholesterol coefficients. …”
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1265
Multiomics Revealed the Multi-Dimensional Effects of Late Sleep on Gut Microbiota and Metabolites in Children in Northwest China
Published 2023-10-01“…In plasma, fatty amides, lipids, amino acids, metabolites, hormones, and related compounds were enriched in children with early bedtime, while bile acids were higher in children with late bedtime. …”
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1266
Effects of xylanase and antibiotic supplementations on the nutritional utilisation of a wheat diet in growing chicks from genetic D+ and D− lines selected for divergent digestion e...
Published 2007-01-01“…Effects of xylanase supplementation and animal genetics on lipid digestibility could not be entirely explained in terms of intestinal bile acids. Other factors should be involved, especially for the lipid digestibility difference induced by animal genetics. …”
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1267
Improvement of obesity-induced fatty liver disease by intermittent hypoxia exposure in a murine model
Published 2023-02-01“…Importantly, IH exposure altered bile acids composition and shifted the hepatic bile acids towards FXR agonism, which was involved in the protection of IH against HFHFD.Conclusion: These results support that the IH pattern in our model prevents liver injury from HFHFD in experimental NAFLD.…”
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1268
PECULIARITIES OF THE DIGESTIVE SYSTEM DEVELOPMENT AND LIPID UPTAKE AMONG PREMATURE INFANTS
Published 2006-09-01“…Women's milk is the only type of food, which is completely adjusted to «the limited capabilities» of the digestive functions of a neonate and meets all the needs of an infant as far as it relates to the food nutrients.Key words: lipids, premature neonate, infants, bile acids, aliphatic acids…”
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1269
Pleiotropic effects of ursodeoxycholic acid
Published 2021-06-01“…In addition to the well-known functions of bile acids, their role has been shown as signaling, endocrine molecules that regulate glucose, lipids, and energy metabolism through pathways mediated by the activation of the nuclear receptor of the farnesoid X receptor and the cell surface G protein-coupled receptor, TGR5. …”
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1270
Continuum of non-alcoholic fatty liver disease: from hepatic steatosis to cardiovascular risk
Published 2016-09-01“…The relationship of NAFLD with atherosclerosis, dyslipidemia, features of bile acids metabolism in NAFLD and ability to influence these components are also considered.…”
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1271
The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease
Published 2020-09-01“…With its unique sulfonic acid makeup, taurine influences cellular functions, including osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids. Taurine exerts anti-inflammatory effects that improve diabetes and has shown benefits to the cardiovascular system, possibly by inhibition of the renin angiotensin system. …”
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1272
The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease
Published 2020-12-01“…The role of the human microbiome in the development and progression of NAFLD is associated with its effects on the risk factors (obesity, insulin resistance, type 2 diabetes), permeability of the intestinal barrier and absorption of such substances as short-chain fatty acids, bile acids, choline and endogenous ethanol. Liver fibrosis constitutes the leading factor determining the prognosis of patients in NAFLD, including cases associated with cardiovascular complications. …”
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1273
Current vire on the biliary insufficiency syndrome
Published 2015-12-01“…The leading pathogenetic link in the development of the disease is the change in the amount of bile and reduced secretion of bile acids into the intestine within an hour after the introduction of the stimulant.…”
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1274
Microbiota and metabolic syndrome
Published 2017-04-01“…In microbial dysbiosis, increase of harmful metabolites and changes to composition of bile acids occur via carbohydrate and protein fermentation. …”
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1275
Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition
Published 2023-01-01“…<h4>Background</h4> We have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile acid and sterol signaling and transport. In the liver, the master circadian gene regulators Bmal/Arntl and Clock drive circadian modulation of hepatic functions, including bile acid synthesis. …”
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1276
Integrated models of blood protein and metabolite enhance the diagnostic accuracy for Non-Small Cell Lung Cancer
Published 2023-07-01“…Results Differential plasma proteomics and metabolic pathways analyses revealed that the majority of DEPs in NSCLC were enriched in the pathways of complement and coagulation cascades, cholesterol and bile acids metabolism. Moreover, 10 DEPs, 14 amino acids, 15 bile acids, as well as 6 classic tumor biomarkers in blood were quantified using clinically validated assays. …”
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1277
Metabolomics and Lipidomics Analyses Aid Model Classification of Type 2 Diabetes in Non-Human Primates
Published 2024-03-01“…Random Forest (RF) analysis of fecal bile acids showed a reduction in the secondary bile acid glycoconjugate, GCDCA, in diseased animals (AUC 0.76[0.64, 0.89]). …”
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1278
Modulation of duodenal and jejunal microbiota by rifaximin in mice with CCl4-induced liver fibrosis
Published 2023-03-01“…As the antimicrobial effect of rifaximin increases by micellization with bile acids, we hypothesized that rifaximin alters the microbiota in the duodenum and jejunum, where the levels of bile acids are abundant. …”
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1279
Intestinal dysbiosis in heart failure - modulation of dysbiosis as a potential therapeutic target
Published 2023-08-01“…Gut microbiota metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids, can have harmful effects on the heart. Diet, probiotics, and fecal microbiota transplantation (FMT) are all potential interventions for improving gut microbiota and reducing the risk of heart failure. …”
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1280
Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
Published 2017“…Further characterization of secreted bile acids in the medium revealed that a glycine-conjugated bile acid was a sensitive marker of dose-dependent toxicity in this three-dimensional liver microphysiological system. …”
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