LC/MS-Based Untargeted Metabolomics Analysis in Women with Morbid Obesity and Associated Type 2 Diabetes Mellitus by Teresa Auguet, Laia Bertran, Jordi Capellades, Sonia Abelló, Carmen Aguilar, Fàtima Sabench, Daniel del Castillo, Xavier Correig, Oscar Yanes, Cristóbal Richart

“…Then, in MO women with T2DM, we found increased levels of glutamate, propionyl-carnitine, bile acids, ceramides, lysophosphatidylcholine 14:0, phosphatidylinositols and phosphoethanolamines, and lower levels of Phe-Ile/Leu. …”
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Hypolipidemic Activity of the Polysaccharide L-rhamnopyranosyl-6-O-methyl-galacturonan in Combined Administration with HMG-CoA Reductase and Cholesterol Absorption Inhibitors by E. E. Buyko, V. V. Ivanov, O. A. Kaidash, O. Yu. Rybalkina, E. A. Kiseleva, S. V. Krivoshchekov, T. L. Kiseleva, A. M. Guriev, M. V. Belousov

“…The additive effect of the polysaccharide is mainly due to a decrease in the level of bile acids in the blood serum, which indicates its ability to absorb them in the intestinal lumen and interrupt enterohepatic circulation, acting like bile acid sequestrants.Conclusion. …”
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The Fecal Microbiome and Metabolome of Pitt Hopkins Syndrome, a Severe Autism Spectrum Disorder by Amanda H. Dilmore, Daniel McDonald, Tanya T. Nguyen, James B. Adams, Rosa Krajmalnik-Brown, Emmanuel Elijah, Pieter C. Dorrestein, Rob Knight

“…Specific metabolites were associated with PTHS, including bile acids and sphingosines. With a metadata reanalysis tool, we found that PTHS-associated metabolites have previously been identified in inflammatory bowel disease and obesity patients. …”
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New Approaches to Studying Prevalence Gallstone Disease by N. A. Khokhlacheva, T. S. Kosareva, A. P. Lukashevich

“…In portions “B” and “C” of bile obtained by multifractional duodenal sounding, the total concentration of bile acids, cholesterol and phospholipids was determined, and lithogenicity indices of bile were calculated: cholate-cholesterol and phospholipid-cholesterol coefficients. …”
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Multiomics Revealed the Multi-Dimensional Effects of Late Sleep on Gut Microbiota and Metabolites in Children in Northwest China by Xuesong Xiang, Juanjuan Chen, Mingyu Zhu, Huiyu Gao, Xiaobing Liu, Qi Wang

“…In plasma, fatty amides, lipids, amino acids, metabolites, hormones, and related compounds were enriched in children with early bedtime, while bile acids were higher in children with late bedtime. …”
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Effects of xylanase and antibiotic supplementations on the nutritional utilisation of a wheat diet in growing chicks from genetic D+ and D− lines selected for divergent digestion e... by V. García, J. Gomez, S. Mignon-Grasteau, N. Sellier, B. Carré

“…Effects of xylanase supplementation and animal genetics on lipid digestibility could not be entirely explained in terms of intestinal bile acids. Other factors should be involved, especially for the lipid digestibility difference induced by animal genetics. …”
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Improvement of obesity-induced fatty liver disease by intermittent hypoxia exposure in a murine model by Liya Chen, Liya Chen, Yao Wang, Yao Wang, Weikun Zheng, Weikun Zheng, Hu Zhang, Hu Zhang, Yan Sun, Yan Sun, Yiping Chen, Yiping Chen, Qi Liu, Qi Liu

“…Importantly, IH exposure altered bile acids composition and shifted the hepatic bile acids towards FXR agonism, which was involved in the protection of IH against HFHFD.Conclusion: These results support that the IH pattern in our model prevents liver injury from HFHFD in experimental NAFLD.…”
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PECULIARITIES OF THE DIGESTIVE SYSTEM DEVELOPMENT AND LIPID UPTAKE AMONG PREMATURE INFANTS by V.V. Dashichev, A.A. Andreev, N.V. Olendar'

“…Women's milk is the only type of food, which is completely adjusted to «the limited capabilities» of the digestive functions of a neonate and meets all the needs of an infant as far as it relates to the food nutrients.Key words: lipids, premature neonate, infants, bile acids, aliphatic acids…”
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Pleiotropic effects of ursodeoxycholic acid by Yu.М. Stepanov, А.V. Salenko

“…In addition to the well-known functions of bile acids, their role has been shown as signa­ling, endocrine molecules that regulate glucose, lipids, and energy metabolism through pathways mediated by the activation of the nuclear receptor of the farnesoid X receptor and the cell surface G protein-coupled receptor, TGR5. …”
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Continuum of non-alcoholic fatty liver disease: from hepatic steatosis to cardiovascular risk by O. M. Drapkina, O. N. Korneeva

“…The relationship of NAFLD with atherosclerosis, dyslipidemia, features of bile acids metabolism in NAFLD and ability to influence these components are also considered.…”
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The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease by Tawar Qaradakhi, Laura Kate Gadanec, Kristen Renee McSweeney, Jemma Rose Abraham, Vasso Apostolopoulos, Anthony Zulli

“…With its unique sulfonic acid makeup, taurine influences cellular functions, including osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids. Taurine exerts anti-inflammatory effects that improve diabetes and has shown benefits to the cardiovascular system, possibly by inhibition of the renin angiotensin system. …”
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The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease by T. S. Krolevets, M. A. Livzan, S. I. Mozgovoy

“…The role of the human microbiome in the development and progression of NAFLD is associated with its effects on the risk factors (obesity, insulin resistance, type 2 diabetes), permeability of the intestinal barrier and absorption of such substances as short-chain fatty acids, bile acids, choline and endogenous ethanol. Liver fibrosis constitutes the leading factor determining the prognosis of patients in NAFLD, including cases associated with cardiovascular complications. …”
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Current vire on the biliary insufficiency syndrome by O. N. Minushkin, I. V. Zverkov, D. V. Volodin, O. I. Ivanova

“…The leading pathogenetic link in the development of the disease is the change in the amount of bile and reduced secretion of bile acids into the intestine within an hour after the introduction of the stimulant.…”
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Microbiota and metabolic syndrome by Yüksel Altuntaş, Adnan Batman

“…In microbial dysbiosis, increase of harmful metabolites and changes to composition of bile acids occur via carbohydrate and protein fermentation. …”
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Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition by Colin T. Shearn, Aimee L. Anderson, Michael W. Devereaux, Karim C. El Kasmi, David J. Orlicky, Ronald J. Sokol

“…<h4>Background</h4> We have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile acid and sterol signaling and transport. In the liver, the master circadian gene regulators Bmal/Arntl and Clock drive circadian modulation of hepatic functions, including bile acid synthesis. …”
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Integrated models of blood protein and metabolite enhance the diagnostic accuracy for Non-Small Cell Lung Cancer by Runhao Xu, Jiongran Wang, Qingqing Zhu, Chen Zou, Zehao Wei, Hao Wang, Zian Ding, Minjie Meng, Huimin Wei, Shijin Xia, Dongqing Wei, Li Deng, Shulin Zhang

“…Results Differential plasma proteomics and metabolic pathways analyses revealed that the majority of DEPs in NSCLC were enriched in the pathways of complement and coagulation cascades, cholesterol and bile acids metabolism. Moreover, 10 DEPs, 14 amino acids, 15 bile acids, as well as 6 classic tumor biomarkers in blood were quantified using clinically validated assays. …”
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Metabolomics and Lipidomics Analyses Aid Model Classification of Type 2 Diabetes in Non-Human Primates by Peining Tao, Stacey Conarello, Thomas P. Wyche, Nanyan Rena Zhang, Keefe Chng, John Kang, Theodore R. Sana

“…Random Forest (RF) analysis of fecal bile acids showed a reduction in the secondary bile acid glycoconjugate, GCDCA, in diseased animals (AUC 0.76[0.64, 0.89]). …”
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Modulation of duodenal and jejunal microbiota by rifaximin in mice with CCl4-induced liver fibrosis by Kazuhiko Ikeuchi, Takeya Tsutsumi, Aya Ishizaka, Taketoshi Mizutani, Ayako Sedohara, Michiko Koga, Satoru Tamaoki, Hiroshi Yotsuyanagi

“…As the antimicrobial effect of rifaximin increases by micellization with bile acids, we hypothesized that rifaximin alters the microbiota in the duodenum and jejunum, where the levels of bile acids are abundant. …”
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Intestinal dysbiosis in heart failure - modulation of dysbiosis as a potential therapeutic target by Joanna Osiak, Łukasz Wołowiec, Xawery Żukow, Dagmara Fydrych, Albert Jasniak, Kinga Gawłowska, Agata Staniewska, Grzegorz Grześk

“…Gut microbiota metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids, can have harmful effects on the heart. Diet, probiotics, and fecal microbiota transplantation (FMT) are all potential interventions for improving gut microbiota and reducing the risk of heart failure. …”
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Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Further characterization of secreted bile acids in the medium revealed that a glycine-conjugated bile acid was a sensitive marker of dose-dependent toxicity in this three-dimensional liver microphysiological system. …”
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