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1281
Peripheral serotonin: An unraveled metabolite in bovines
Published 2022-09-01“…Besides its principal effect on the gastrointestine, it regulates the excretion of bile acids, glucose and lipid homeostasis, energy balance, immunomodulation, and various other vital processes in the animal system. …”
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1282
Domain 4 (D4) of Perfringolysin O to Visualize Cholesterol in Cellular Membranes—The Update
Published 2017-03-01“…Among them, cholesterol is crucial for various cellular events (e.g., signaling, viral/bacterial infection, and membrane trafficking) in addition to its essential role as an ingredient of steroid hormones, vitamin D, and bile acids. From a micro-perspective, at the plasma membrane, recent emerging evidence strongly suggests the existence of lipid nanodomains formed with cholesterol and phospholipids (e.g., sphingomyelin, phosphatidylserine). …”
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1283
Microbiota: A potential orchestrator of antidiabetic therapy
Published 2023-01-01“…In general, antidiabetic drugs (α-glucosidase inhibitor, biguanides, incretin-based agents, and traditional Chinese medicine) induce the alteration of microbial diversity and composition, and the levels of bacterial component and derived metabolites, such as lipopolysaccharide (LPS), short chain fatty acids (SCFAs), bile acids and indoles. The altered microbial metabolites are involved in the regulation of gut barrier, inflammation response, insulin resistance and glucose homeostasis. …”
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1284
Crosstalk between Gut Microbiota and Hepatocellular Carcinoma
Published 2023-04-01“…The metabolic and immunologic effects mediated by gut-microbiota-derived metabolites, such as bile acids, short-chain fatty acids, and alcohol, could impact the aberrant biological behavior of hepatocellular carcinoma. …”
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1285
Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury
Published 2021-07-01“…Cholestasis is caused by accumulation of hydrophobic bile acids (BA) in the liver due to dysfunctional BA efflux or bile flow into the gall bladder. …”
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1286
The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer
Published 2023-05-01“…On the other hand, certain compounds are produced by bacteria in the gut, such as short-chain fatty acids, secondary bile acids, and other metabolites that may be linked to breast cancer development and mediate the chemotherapy response. …”
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1287
Research progress on the inflammatory mechanisms of cholestatic liver injury
Published 2022-05-01“…Cholestatic liver injury (CLI) is a liver disease with high mordity. Accumulation of bile acids in the liver is thought to be a major driver of liver injury during cholestasis. …”
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1288
Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans
Published 2022-06-01“…Evidence from human and animal studies indicates that taurine is involved in conjugation of bile acids and regulation of blood pressure and has anti-oxidative, anti-inflammatory, and anti-obesogenic properties. …”
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1289
Gut microbiota derived metabolites in cardiovascular health and disease
Published 2018-05-01“…In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. …”
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1290
Host-microbiome interactions: Gut-Liver axis and its connection with other organs
Published 2022-11-01“…Liver influences immunity and metabolism in multiple organs in the body, including gut. It releases bile acids and other metabolites into biliary tract from where they enter the systemic circulation. …”
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1291
Bile cast nephropathy: when the kidneys turn yellow
Published 2020-03-01“…It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tubules via several mechanisms. …”
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1292
Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment
Published 2023-06-01“…The affected pathways include neurotransmitters, bile acids, homocysteine metabolism, amino acids, TCA cycle, polyamines, β-alanine metabolism, fatty acids, acylcarnitines, ceramides, phosphatidylcholines, and several microbiome-derived metabolites. …”
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1293
PECULIARITIES OF THE DIGESTIVE SYSTEM DEVELOPMENT AND LIPID UPTAKE AMONG PREMATURE INFANTS
Published 2006-01-01“…</p><p><strong><em>Key words: lipids, premature neonate, infants, bile acids, aliphatic acids</em></strong></p>…”
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1294
Host–Microbiota Interactions in Liver Inflammation and Cancer
Published 2021-08-01“…These pathologies share key characteristics, notably intestinal dysbiosis, increased intestinal permeability and an imbalance in bile acids, choline, fatty acids and ethanol metabolites. …”
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1295
Interventions for non-alcoholic liver disease: a gut microbial metabolites perspective
Published 2022-12-01“…Reportedly, microbial metabolites such as short-chain fatty acids, amino acid metabolites (indole and its derivatives), bile acids (BAs), trimethylamine N-oxide (TMAO), and endogenous ethanol exhibit sophisticated bioactive properties. …”
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1296
Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights
Published 2020-05-01“…We also summarize the molecular mechanisms linking obesity to CRC in different aspects, including nutriology, adipokines and hormones, inflammation, gut microbiota, and bile acids. The unmet medical needs for obesity-related CRC are still remarkable. …”
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1297
Biological significance of Ascorbic Acid (Vitamin C) in human health – a review
Published 2004“…Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. …”
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1298
Characterization of mangifera pajang kort, fruit fibres and polysaccharides and their roles in survival and hypocholestrolemic effects of bifidobacteria
Published 2012“…B. longum BB536 and B.pseudocatenulatum G4 had a positive effect on the lipid profile and bile acids of the rats.…”
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1299
Biotransformed bear bile powder ameliorates diet-induced nonalcoholic steatohepatitis in mice through modulating arginine biosynthesis via FXR/PXR-PI3K-AKT-NOS3 axis
Published 2023-12-01“…BBBP, which mainly contains bile acids, possess various pharmacological properties and some bile acids are available for NASH treatment. …”
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1300
Functional metabolomics revealed functional metabolic-characteristics of chronic hepatitis that is significantly differentiated from acute hepatitis in mice
Published 2022-06-01“…Metabolic-differentiation between A-H and C-H was identified as A-H was largely characterized by the dysregulated purine cycle and amino acid metabolism, while the disorders of hepatic taurine-conjugated bile acids and glycerolipid biosynthesis were observed with C-H. …”
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