Peripheral serotonin: An unraveled metabolite in bovines by BANDLA SRINIVAS

“…Besides its principal effect on the gastrointestine, it regulates the excretion of bile acids, glucose and lipid homeostasis, energy balance, immunomodulation, and various other vital processes in the animal system. …”
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Domain 4 (D4) of Perfringolysin O to Visualize Cholesterol in Cellular Membranes—The Update by Masashi Maekawa

“…Among them, cholesterol is crucial for various cellular events (e.g., signaling, viral/bacterial infection, and membrane trafficking) in addition to its essential role as an ingredient of steroid hormones, vitamin D, and bile acids. From a micro-perspective, at the plasma membrane, recent emerging evidence strongly suggests the existence of lipid nanodomains formed with cholesterol and phospholipids (e.g., sphingomyelin, phosphatidylserine). …”
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Microbiota: A potential orchestrator of antidiabetic therapy by Bingyao Liu, Linlin Zhang, Hang Yang, Hongting Zheng, Xiaoyu Liao

“…In general, antidiabetic drugs (α-glucosidase inhibitor, biguanides, incretin-based agents, and traditional Chinese medicine) induce the alteration of microbial diversity and composition, and the levels of bacterial component and derived metabolites, such as lipopolysaccharide (LPS), short chain fatty acids (SCFAs), bile acids and indoles. The altered microbial metabolites are involved in the regulation of gut barrier, inflammation response, insulin resistance and glucose homeostasis. …”
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Crosstalk between Gut Microbiota and Hepatocellular Carcinoma by Chencheng Xie, Christine Pocha

“…The metabolic and immunologic effects mediated by gut-microbiota-derived metabolites, such as bile acids, short-chain fatty acids, and alcohol, could impact the aberrant biological behavior of hepatocellular carcinoma. …”
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Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury by Anca D. Petrescu, Sharon DeMorrow

“…Cholestasis is caused by accumulation of hydrophobic bile acids (BA) in the liver due to dysfunctional BA efflux or bile flow into the gall bladder. …”
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The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer by Julio Plaza-Diaz, Ana Isabel Álvarez-Mercado

“…On the other hand, certain compounds are produced by bacteria in the gut, such as short-chain fatty acids, secondary bile acids, and other metabolites that may be linked to breast cancer development and mediate the chemotherapy response. …”
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Research progress on the inflammatory mechanisms of cholestatic liver injury by KANG Jin-yu, LUO Jia, GAO Ze-tian, ZHENG Wen-tao, LIU Ai-ming, SONG Yu-fei

“…Cholestatic liver injury (CLI) is a liver disease with high mordity. Accumulation of bile acids in the liver is thought to be a major driver of liver injury during cholestasis. …”
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Beneficial Effects of Taurine on Metabolic Parameters in Animals and Humans by Minkyung Bae, Kainat Ahmed, Jung-Eun Yim

“…Evidence from human and animal studies indicates that taurine is involved in conjugation of bile acids and regulation of blood pressure and has anti-oxidative, anti-inflammatory, and anti-obesogenic properties. …”
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Gut microbiota derived metabolites in cardiovascular health and disease by Zeneng Wang, Yongzhong Zhao

“…In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. …”
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Host-microbiome interactions: Gut-Liver axis and its connection with other organs by Swadha Anand, Sharmila S. Mande

“…Liver influences immunity and metabolism in multiple organs in the body, including gut. It releases bile acids and other metabolites into biliary tract from where they enter the systemic circulation. …”
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Bile cast nephropathy: when the kidneys turn yellow by Alissar El Chediak, Khaled Janom, Sahar H. Koubar

“…It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tubules via several mechanisms. …”
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Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment by Karel Kalecký, Teodoro Bottiglieri

“…The affected pathways include neurotransmitters, bile acids, homocysteine metabolism, amino acids, TCA cycle, polyamines, β-alanine metabolism, fatty acids, acylcarnitines, ceramides, phosphatidylcholines, and several microbiome-derived metabolites. …”
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PECULIARITIES OF THE DIGESTIVE SYSTEM DEVELOPMENT AND LIPID UPTAKE AMONG PREMATURE INFANTS by V.V. Dashichev, A.A. Andreev, N.V. Olendar'

“…</p><p><strong><em>Key words: lipids, premature neonate, infants, bile acids, aliphatic acids</em></strong></p>…”
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Host–Microbiota Interactions in Liver Inflammation and Cancer by Julie Giraud, Maya Saleh

“…These pathologies share key characteristics, notably intestinal dysbiosis, increased intestinal permeability and an imbalance in bile acids, choline, fatty acids and ethanol metabolites. …”
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Interventions for non-alcoholic liver disease: a gut microbial metabolites perspective by Jin Guo, Chun-Xia Shi, Qing-Qi Zhang, Wei Deng, Lu-Yi Zhang, Qian Chen, Dan-Mei Zhang, Zuo-Jiong Gong

“…Reportedly, microbial metabolites such as short-chain fatty acids, amino acid metabolites (indole and its derivatives), bile acids (BAs), trimethylamine N-oxide (TMAO), and endogenous ethanol exhibit sophisticated bioactive properties. …”
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Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights by Pengfei Ye, Yue Xi, Zhiying Huang, Pengfei Xu

“…We also summarize the molecular mechanisms linking obesity to CRC in different aspects, including nutriology, adipokines and hormones, inflammation, gut microbiota, and bile acids. The unmet medical needs for obesity-related CRC are still remarkable. …”
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Biological significance of Ascorbic Acid (Vitamin C) in human health – a review by Iqbal, Khalid, Khan, Alam, Khattak, Muhammad Muzaffar Ali Khan

“…Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. …”
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Characterization of mangifera pajang kort, fruit fibres and polysaccharides and their roles in survival and hypocholestrolemic effects of bifidobacteria by Al-Sheragi Mugahed, Sadeq Hasan

“…B. longum BB536 and B.pseudocatenulatum G4 had a positive effect on the lipid profile and bile acids of the rats.…”
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Biotransformed bear bile powder ameliorates diet-induced nonalcoholic steatohepatitis in mice through modulating arginine biosynthesis via FXR/PXR-PI3K-AKT-NOS3 axis by Shan Jiang, Xiaolu Wei, Yan Zhang, Linna Wang, Lianmei Wang, Mengxiao Wang, Yan Rong, Junyi Zhou, Yanyan Zhou, Hongjie Wang, Tao Li, Nan Si, Baolin Bian, Haiyu Zhao

“…BBBP, which mainly contains bile acids, possess various pharmacological properties and some bile acids are available for NASH treatment. …”
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Functional metabolomics revealed functional metabolic-characteristics of chronic hepatitis that is significantly differentiated from acute hepatitis in mice by Tianyu Wang, Longlong Hu, Jiongjiong Lu, Mengqing Xiao, Jinging Liu, Huiyu Xia, Haitao Lu

“…Metabolic-differentiation between A-H and C-H was identified as A-H was largely characterized by the dysregulated purine cycle and amino acid metabolism, while the disorders of hepatic taurine-conjugated bile acids and glycerolipid biosynthesis were observed with C-H. …”
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