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1501
Corn silk polysaccharides attenuate diabetic nephropathy through restoration of the gut microbial ecosystem and metabolic homeostasis
Published 2023-12-01“…We attempted to fully understand the interactions between CSPs, the gut microbiota and the host at the systemic level from a gut microbiota metabolomics perspective to fundamentally elucidate the mechanisms of action that can be used to intervene in DN.ResultsResearch has found that the metabolic pathways with a strong correlation with CSPs were initially identified as glycerophosphate, fatty acid, bile acid, tyrosine, tryptophan and phenylalanine metabolism and involved Firmicutes, Bacteroides, Lachnospiraceae-NK4A136- group and Dubosiella, suggesting that the effect of CSPs on improving DN is related to changes in metabolite profiles and gut microbiota characteristics.DiscussionCSPs could be harnessed to treat the abnormal metabolism of endogenous substances such as bile acids and uremic toxins caused by changes in gut microbiota, thus alleviating kidney damage caused by inflammation. …”
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1502
A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases
Published 2024-02-01“…Results and Discussion We describe key microbial metabolites such as short‐chain fatty acids, amino acids, bile acids and polyamines, elucidating their mechanisms of action, cellular targets and their roles in regulating metabolism within innate and adaptive immune cells. …”
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1503
Cholecystectomy and subsequent risk of Parkinson’s disease: a nationwide retrospective cohort study
Published 2021-11-01“…Abstract Growing evidence has suggested that the gut-brain axis plays an important role in the pathogenesis of Parkinson’s disease (PD), and that this role is mediated by the interactions between bile acids (BAs) and intestinal microbiota. Given that cholecystectomy can lead to alterations in BAs and gut microbiota, we investigated whether cholecystectomy is linked to a higher risk of PD. …”
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1504
The Mechanism of the Gut-Brain Axis in Regulating Food Intake
Published 2023-08-01“…The gastrointestinal tract is not only the site of food digestion and absorption but also contains a variety of appetite-regulating signals such as gut-brain peptides, short-chain fatty acids (SCFAs), bile acids (BAs), bacterial proteins, and cellular components produced by gut microbes. …”
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1505
DHEA Protects Human Cholangiocytes and Hepatocytes against Apoptosis and Oxidative Stress
Published 2022-03-01“…Taken together, these results suggest that DHEA can prevent the deleterious effects of certain potentially toxic bile acids and reactive oxygen species, delaying the onset of liver disease.…”
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1506
Severe Early-Onset Intrahepatic Cholestasis of Pregnancy Following Ovarian Hyperstimulation Syndrome with Pulmonary Presentation after In Vitro Fertilization: Case Report and Syste...
Published 2024-01-01“…Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disease, usually presented in the third trimester with pruritus, elevated transaminase, and serum total bile acids. Evidence shows that it can be developed in the first trimester, more commonly after in vitro fertilization (IVF) procedures, with the presence of ovarian hyperstimulation syndrome (OHSS). …”
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1507
Targeting the gut microbiota and its metabolites for type 2 diabetes mellitus
Published 2023-05-01“…Gut microbiota-derived metabolites, including bile acids, lipopolysaccharide, trimethylamine-N-oxide, tryptophan and indole derivatives, and short-chain fatty acids, have been shown to be involved in the pathogenesis of T2DM, playing a key role in the host-microbe crosstalk. …”
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1508
SCP2 variant is associated with alterations in lipid metabolism, brainstem neurodegeneration, and testicular defects
Published 2022-08-01“…Abstract Background The detoxification of very long-chain and branched-chain fatty acids and the metabolism of cholesterol to form bile acids occur largely through a process called peroxisomal β-oxidation. …”
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1509
Beneficial Effects of Soybean-Derived Bioactive Peptides
Published 2021-08-01“…SPs are expected to be able to prevent and treat atherosclerosis by inhibiting the reabsorption of bile acids in the digestive system, thereby reducing blood cholesterol, low-density lipoprotein, and fat levels. …”
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1510
Characterization of <i>Lactococcus lactis</i> 11/19-B1 Isolated from Kiwi Fruit as a Potential Probiotic and Paraprobiotic
Published 2023-12-01“…In this study, the probiotic properties of the 11/19-B1 strain, such as sensitivity to antimicrobial compounds, biogenic amine production, some virulence genes for human health, antimicrobial activity, tolerance to gastric acid and bile acids, and ability to adhere to the intestinal mucosa, were evaluated. …”
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1511
Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice
Published 2024-01-01“…We also observed increased circulating levels of several sphingolipid species along with reduced levels of eicosanoids and bile acids. The Atp10A −/− mice also displayed hepatic insulin resistance without perturbations to whole-body glucose homeostasis. …”
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1512
Effects of liposoluble components of highland barley spent grains on physiological indexes, intestinal microorganisms, and the liver transcriptome in mice fed a high‐fat diet
Published 2023-06-01“…Transcriptomic analysis showed that lipid‐soluble components of spent grains reduced the mRNA expression of ANGPTL8, CD36, PLTP, and SOAT1 and increased the mRNA expression of CYP7A1 and ABCA1 in the cholesterol metabolism pathway, promoted the transport of cholesterol, and inhibited the absorption of cholesterol, which can decrease cholesterol levels by speeding up the conversion of cholesterol into bile acids.…”
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1513
Licraside as novel potent FXR agonist for relieving cholestasis: structure-based drug discovery and biological evaluation studies
Published 2023-06-01“…Cholestasis is a common clinical disease caused by a disorder in bile acids (BAs) homeostasis, which promotes its development. …”
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1514
Coupling an artificial receptor with macrophage membrane for targeted and synergistic treatment of cholestasis
Published 2022-12-01“…Cholestasis is defined as an impairment of bile acid flow leading to intrahepatic retention of toxic bile acids (BAs), which induce apoptosis or necrosis of hepatocytes and liver inflammation. …”
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1515
Bamboo shoot dietary fiber alleviates gut microbiota dysbiosis and modulates liver fatty acid metabolism in mice with high-fat diet-induced obesity
Published 2023-03-01“…Analysis of fecal metabolomics and gut microbiota metabolites revealed that BSDF increased the levels of several short-chain fatty acids and enriched bile acids, which may be important for improving lipid metabolism. …”
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1516
Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease
Published 2024“…Prioritized features included known IBD-linked chemical families such as bile acids and short-chain fatty acids, and less-explored bilirubin, polyamine, and vitamin derivatives, and other microbial products. …”
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1517
Messengers from the gut: gut microbiota-derived metabolites on host regulation
Published 2022“…In this review, we summarize recent studies in the understanding of the major classes of gut microbiota-derived metabolites, including short-chain fatty acids (SCFAs), bile acids (BAs) and peptidoglycan fragments (PGNs) on their regulatory effects on host functions. …”
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1518
Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes
Published 2015“…These biomarkers include fatty acids, TCA cycle intermediates, carbohydrates, amino acids, choline and bile acids. The biological activities and aetiological pathways of metabolites of interest in driving these intricate processes are explained. …”
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1519
Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites
Published 2022-08-01“…Furthermore, ATR played a positive role in relieving ulcer through reshaping gut microbiota composition including Parabacteroides and Bacteroides and regulating the levels of metabolites including amino acids, short-chain fatty acids (SCFAs), and bile acids.Conclusion: Our work sheded light on the mechanism of ATR treating GU from the perspective of the gut microbiota and explored the correlation between gut microbiota, metabolites, and host phenotype.Keywords: atractylone, gastric ulcer, inflammation, oxidative stress, gut microbiota, metabolomics…”
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1520
Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
Published 2023-08-01“…Here we suggest that pre-existing intrahepatic shunting predicts HE severity post-TIPS. Bile acid levels decrease in the peripheral vein post-TIPS, and the abundances of three specific conjugated di- and tri-hydroxylated bile acids are inversely correlated with HE grade. …”
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