Gut microbial ecology of Xenopus tadpoles across life stages by Scalvenzi, Thibault, Clavereau, Isabelle, Bourge, Mickaël, Pollet, Nicolas

“…We interpret our findings in light of bile acids being key molecular components regulating the gut microbiome composition during amphibian development and metamorphosis. …”
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The role of miRNAs in the development of cholangiopathies. Part 2 by A.E. Abaturov, V.L. Babуch

“…In turn, an excess of bile acids stimulates the proliferation of cholangiocytes and causes the development of liver fibrosis. …”
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Case series of progressive familial intrahepatic cholestasis type 3: Characterization of variants in ABCB4 in China by Jinlin Cheng, Ling Gong, Xiaoxiao Mi, Xiangyan Wu, Jun Zheng, Wenjun Yang

“…Molecular genetic findings of ATP-binding cassette subfamily B member 4 [ATP binding cassette transporter A4 (ABCB4), https://www.omim.org/entry/171060] were prospectively examined, and clinical records, laboratory readouts, and macroscopic and microscopic appearances of the liver were analyzed.ResultsFour patients experienced cholestasis, mild jaundice, and elevated levels of serum direct bilirubin, γ-glutamyltransferase, or total bile acids. All patients had moderate-to-severe liver fibrosis or biliary cirrhosis, and their liver biopsy specimens stained positive with rhodamine. …”
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In Vitro Bile Salt Hydrolase (BSH) Activity Screening of Different Probiotic Microorganisms by Jimmy G. Hernández-Gómez, Argelia López-Bonilla, Gabriela Trejo-Tapia, Sandra V. Ávila-Reyes, Antonio R. Jiménez-Aparicio, Humberto Hernández-Sánchez

“…<i>Lactobacillus plantarum</i> DGIA1, a potentially probiotic strain isolated from a double cream cheese from Chiapas, Mexico, showed excellent deconjugation activities in the four tested bile acids (69, 100, 81, and 92% for sodium glycocholate, glycodeoxycholate, taurocholate, and taurodeoxycholate, respectively). …”
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Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats by Xiaoyue Li, Beibei Zeng, Lu Wen, Yingcai Zhao, Zhaojie Li, Changhu Xue, Tiantian Zhang, Yuming Wang

“…Possible mechanisms mainly included enhancement of fatty acids β-oxidation and cholesterol catabolism through bile acids synthesis and excretion, suppression of lipogenesis and cholesterol uptake. …”
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Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis by Marta Moreno-Torres, Guillermo Quintás, Teresa Martínez-Sena, Ramiro Jover, José V. Castell

“…Through the identification of various metabolites in the plasma (including free and conjugated bile acids and glycerophospholipids), and the integration of this information into predictive models, we were able to evaluate the extent of the hepatocellular or cholestatic phenotype and to assign a numeric value with the contribution of each specific DILI sub-phenotype into the patient’s general condition. …”
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Diet-Microbiota Interactions: A New Approach to Personalized Nutrition by Hanieh Malmir, Shirin Hasani-Ranjbar, Ahmad-Reza Soroush, Mandana Hasanzad, Ahmad Esmaillzadeh, Hanieh-Sadat Ejtahed, Bagher Larijani

“…Gut microbiota interacts with the human body through releasing metabolites such as short-chain fatty acids and secondary bile acids and fermentation products such as kynurenine, indoles and indole derivatives, tryptophan, serotonin, histamine, and dopamine. …”
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The effect of long-term moderate exercise on myocardial metabolome in rats by Zheng Ping, Xiao Li Zhang, Zi Wen Wang, Xue Bin Cao

“…Results showed that the metabolites categories of bile acids (BAs), fatty acids (FAs), and phenylpropanoic acids were significantly decreased. …”
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Polymeric Compounds of Lingonberry Waste: Characterization of Antioxidant and Hypolipidemic Polysaccharides and Polyphenol-Polysaccharide Conjugates from <i>Vaccinium vitis-idaea</... by Daniil N. Olennikov, Vladimir V. Chemposov, Nadezhda K. Chirikova

“…Additionally, marked hypolipidemic potential of both PPC and acidic polymers bind bile acids, cholesterol, and fat, inhibit pancreatic lipase in the in vitro study, reduce body weight, serum level of cholesterol, triglycerides, low/high-density lipoprotein–cholesterol, and malondialdehyde, and increase the enzymatic activity of superoxide dismutase, glutathione peroxidase, and catalase in the livers of hamsters with a 1% cholesterol diet. …”
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Pyrroles as a Potential Biomarker for Oxidative Stress Disorders by Brett Lambert, Annalese Semmler, Cristina Beer, Joanne Voisey

“…The urobilinogen detected in urine forms when gut microflora chemically reduces the bilirubin content of bile acids. In comparison, evidence suggests that the pyrrole fraction originates from the fragmentation of regulatory haem by reactive oxygen species (ROS) such as hydrogen peroxide and super and nitrous oxides. …”
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Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers by Islam R. Younis, Brian J. Kirby, Andrew N. Billin, Deqing Xiao, Qinghua Song, Timothy R. Watkins, Ahmed A. Othman

“…Cilofexor increased plasma levels of fibroblast growth factor19 (FGF19) and reduced the serum bile acid intermediate 7α‐hydroxy‐4‐cholesten‐3‐one (C4) and bile acids in an exposure‐dependent manner. …”
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Intestinal Flora Derived Metabolites Affect the Occurrence and Development of Cardiovascular Disease by Wen Y, Sun Z, Xie S, Hu Z, Lan Q, Sun Y, Yuan L, Zhai C

“…The intestinal flora breaks down the food ingested by the host into a series of metabolically active products, including trimethylamine N-Oxide (TMAO), short-chain fatty acids (SCFAs), primary and secondary bile acids, tryptophan and indole derivatives, phenylacetylglutamine (PAGln) and branched chain amino acids (BCAA). …”
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Inclusion of Limited Amounts of Extruded Legumes Plus Cereal Mixes in Normocaloric or Obesogenic Diets for Rats: Effects on Lipid Profile by Luis A. Rubio, Isabel Aranda-Olmedo, Mercedes Martín-Pedrosa

“…Faecal excretion of bile acids was higher (<i>p</i> < 0.01) for rats fed extruded mixes compared with controls. …”
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Food for thought—The link between Clostridioides difficile metabolism and pathogenesis by Andrew Marshall, John W. McGrath, Robert Graham, Geoff McMullan

“…Although colonisation resistance is mediated by the action of secondary bile acids inhibiting vegetative outgrowth, nutrient competition also plays a role in preventing CDI as the gut microbiota compete for nutrient niches inhibiting C. difficile growth. …”
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Dietary fiber modulates gut microbiome and metabolome in a host sex-specific manner in a murine model of aging by Saurabh Kadyan, Gwoncheol Park, Bo Wang, Ravinder Nagpal

“…However, we note sex-specific effects of inulin including suppression of f_Enteroccaceae:_, Odoribacter, bile acids, malonate, thymine, valine, acetoin, and ethanol while promotion of Dubosiella, pyruvate, and glycine in males. …”
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Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease by Caijiao Dai, Xin Chen, Shiyu Qian, Yihui Fan, Lijuan Li, Junfa Yuan

“…Furthermore, certain metabolites, especially amino acids, short‐chain fatty acids, and bile acids, were found to be linked to intestinal microbiota alterations in WPE. …”
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The Role of Microbiota in Primary Sclerosing Cholangitis and Related Biliary Malignancies by Burcin Özdirik, Tobias Müller, Alexander Wree, Frank Tacke, Michael Sigal

“…Experimental mouse and observational human data suggest that a diverse set of microbial functions may be relevant, including microbial metabolites and bacterial processing of pharmacological agents, bile acids, or dietary compounds, altogether driving the intrahepatic inflammation. …”
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C-Terminal Truncated HBx Facilitates Oncogenesis by Modulating Cell Cycle and Glucose Metabolism in FXR-Deficient Hepatocellular Carcinoma by Xuejun Wu, Zhengzhong Ni, Tiantian Song, Wenya Lv, Yan Chen, Danmei Huang, Yangmin Xie, Weiyi Huang, Yongdong Niu

“…Farnesoid X receptor (FXR) is a nuclear receptor known to play protective roles in anti-hepatocarcinogenesis and regulation of the basal metabolism of glucose, lipids, and bile acids. FXR expression is low or absent in HBV-associated hepatocarcinogenesis. …”
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Buds and Bugs: A Fascinating Tale of Gut Microbiota and Cannabis in the Fight against Cancer by Ahmad K. Al-Khazaleh, Kayla Jaye, Dennis Chang, Gerald W. Münch, Deep Jyoti Bhuyan

“…Additionally, the capacity of gut microbiota to activate cannabinoid receptors through the production of secondary bile acids underscores its role in directly influencing the pharmacological activity of cannabinoids. …”
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The role of miRNAs in the development of cholangiopathies. Part 2 by A.E. Abaturov, V.L. Babуch

“…In turn, an excess of bile acids stimulates the proliferation of cholangiocytes and causes the development of liver fibrosis. …”
Get full text