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1541
Gut microbial ecology of Xenopus tadpoles across life stages
Published 2021-11-01“…We interpret our findings in light of bile acids being key molecular components regulating the gut microbiome composition during amphibian development and metamorphosis. …”
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1542
The role of miRNAs in the development of cholangiopathies. Part 2
Published 2023-09-01“…In turn, an excess of bile acids stimulates the proliferation of cholangiocytes and causes the development of liver fibrosis. …”
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1543
Case series of progressive familial intrahepatic cholestasis type 3: Characterization of variants in ABCB4 in China
Published 2022-12-01“…Molecular genetic findings of ATP-binding cassette subfamily B member 4 [ATP binding cassette transporter A4 (ABCB4), https://www.omim.org/entry/171060] were prospectively examined, and clinical records, laboratory readouts, and macroscopic and microscopic appearances of the liver were analyzed.ResultsFour patients experienced cholestasis, mild jaundice, and elevated levels of serum direct bilirubin, γ-glutamyltransferase, or total bile acids. All patients had moderate-to-severe liver fibrosis or biliary cirrhosis, and their liver biopsy specimens stained positive with rhodamine. …”
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1544
In Vitro Bile Salt Hydrolase (BSH) Activity Screening of Different Probiotic Microorganisms
Published 2021-03-01“…<i>Lactobacillus plantarum</i> DGIA1, a potentially probiotic strain isolated from a double cream cheese from Chiapas, Mexico, showed excellent deconjugation activities in the four tested bile acids (69, 100, 81, and 92% for sodium glycocholate, glycodeoxycholate, taurocholate, and taurodeoxycholate, respectively). …”
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1545
Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats
Published 2022-11-01“…Possible mechanisms mainly included enhancement of fatty acids β-oxidation and cholesterol catabolism through bile acids synthesis and excretion, suppression of lipogenesis and cholesterol uptake. …”
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1546
Exploring Individual Variability in Drug-Induced Liver Injury (DILI) Responses through Metabolomic Analysis
Published 2024-03-01“…Through the identification of various metabolites in the plasma (including free and conjugated bile acids and glycerophospholipids), and the integration of this information into predictive models, we were able to evaluate the extent of the hepatocellular or cholestatic phenotype and to assign a numeric value with the contribution of each specific DILI sub-phenotype into the patient’s general condition. …”
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1547
Diet-Microbiota Interactions: A New Approach to Personalized Nutrition
Published 2021-01-01“…Gut microbiota interacts with the human body through releasing metabolites such as short-chain fatty acids and secondary bile acids and fermentation products such as kynurenine, indoles and indole derivatives, tryptophan, serotonin, histamine, and dopamine. …”
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1548
The effect of long-term moderate exercise on myocardial metabolome in rats
Published 2023-01-01“…Results showed that the metabolites categories of bile acids (BAs), fatty acids (FAs), and phenylpropanoic acids were significantly decreased. …”
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1549
Polymeric Compounds of Lingonberry Waste: Characterization of Antioxidant and Hypolipidemic Polysaccharides and Polyphenol-Polysaccharide Conjugates from <i>Vaccinium vitis-idaea</...
Published 2022-09-01“…Additionally, marked hypolipidemic potential of both PPC and acidic polymers bind bile acids, cholesterol, and fat, inhibit pancreatic lipase in the in vitro study, reduce body weight, serum level of cholesterol, triglycerides, low/high-density lipoprotein–cholesterol, and malondialdehyde, and increase the enzymatic activity of superoxide dismutase, glutathione peroxidase, and catalase in the livers of hamsters with a 1% cholesterol diet. …”
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1550
Pyrroles as a Potential Biomarker for Oxidative Stress Disorders
Published 2023-02-01“…The urobilinogen detected in urine forms when gut microflora chemically reduces the bilirubin content of bile acids. In comparison, evidence suggests that the pyrrole fraction originates from the fragmentation of regulatory haem by reactive oxygen species (ROS) such as hydrogen peroxide and super and nitrous oxides. …”
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1551
Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers
Published 2023-03-01“…Cilofexor increased plasma levels of fibroblast growth factor19 (FGF19) and reduced the serum bile acid intermediate 7α‐hydroxy‐4‐cholesten‐3‐one (C4) and bile acids in an exposure‐dependent manner. …”
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1552
Intestinal Flora Derived Metabolites Affect the Occurrence and Development of Cardiovascular Disease
Published 2022-11-01“…The intestinal flora breaks down the food ingested by the host into a series of metabolically active products, including trimethylamine N-Oxide (TMAO), short-chain fatty acids (SCFAs), primary and secondary bile acids, tryptophan and indole derivatives, phenylacetylglutamine (PAGln) and branched chain amino acids (BCAA). …”
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1553
Inclusion of Limited Amounts of Extruded Legumes Plus Cereal Mixes in Normocaloric or Obesogenic Diets for Rats: Effects on Lipid Profile
Published 2020-06-01“…Faecal excretion of bile acids was higher (<i>p</i> < 0.01) for rats fed extruded mixes compared with controls. …”
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1554
Food for thought—The link between Clostridioides difficile metabolism and pathogenesis
Published 2023-01-01“…Although colonisation resistance is mediated by the action of secondary bile acids inhibiting vegetative outgrowth, nutrient competition also plays a role in preventing CDI as the gut microbiota compete for nutrient niches inhibiting C. difficile growth. …”
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1555
Dietary fiber modulates gut microbiome and metabolome in a host sex-specific manner in a murine model of aging
Published 2023-06-01“…However, we note sex-specific effects of inulin including suppression of f_Enteroccaceae:_, Odoribacter, bile acids, malonate, thymine, valine, acetoin, and ethanol while promotion of Dubosiella, pyruvate, and glycine in males. …”
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1556
Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease
Published 2023-10-01“…Furthermore, certain metabolites, especially amino acids, short‐chain fatty acids, and bile acids, were found to be linked to intestinal microbiota alterations in WPE. …”
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1557
The Role of Microbiota in Primary Sclerosing Cholangitis and Related Biliary Malignancies
Published 2021-06-01“…Experimental mouse and observational human data suggest that a diverse set of microbial functions may be relevant, including microbial metabolites and bacterial processing of pharmacological agents, bile acids, or dietary compounds, altogether driving the intrahepatic inflammation. …”
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1558
C-Terminal Truncated HBx Facilitates Oncogenesis by Modulating Cell Cycle and Glucose Metabolism in FXR-Deficient Hepatocellular Carcinoma
Published 2023-03-01“…Farnesoid X receptor (FXR) is a nuclear receptor known to play protective roles in anti-hepatocarcinogenesis and regulation of the basal metabolism of glucose, lipids, and bile acids. FXR expression is low or absent in HBV-associated hepatocarcinogenesis. …”
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1559
Buds and Bugs: A Fascinating Tale of Gut Microbiota and Cannabis in the Fight against Cancer
Published 2024-01-01“…Additionally, the capacity of gut microbiota to activate cannabinoid receptors through the production of secondary bile acids underscores its role in directly influencing the pharmacological activity of cannabinoids. …”
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1560
The role of miRNAs in the development of cholangiopathies. Part 2
Published 2023-09-01“…In turn, an excess of bile acids stimulates the proliferation of cholangiocytes and causes the development of liver fibrosis. …”
Get full text
Article