Microbiome Metabolites and Thyroid Dysfunction by Piotr Bargiel, Małgorzata Szczuko, Laura Stachowska, Piotr Prowans, Norbert Czapla, Marta Markowska, Jan Petriczko, Jakub Kledzik, Alicja Jędrzejczyk-Kledzik, Joanna Palma, Paulina Zabielska, Dominika Maciejewska-Markiewicz

“…In addition, we raise issues related to the influence of bacterial metabolites, such as short-chain fatty acids or secondary bile acids, in the functioning of the thyroid gland. …”
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Potential tactics with certain gut microbiota for the treatment of unresectable hepatocellular carcinoma by Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Yuka Ikeda, Tomoko Asai, Ai Tsuji, Satoru Matsuda

“…Gut microbiota and their metabolites including several bile acids could contribute to modulating the responses of the immune checkpoint immunotherapy. …”
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Metabolic Profiles and Blood Biomarkers to Discriminate between Benign Thyroid Nodules and Papillary Carcinoma, Based on UHPLC-QTOF-ESI⁺-MS Analysis by Gabriela Maria Berinde, Andreea Iulia Socaciu, Mihai Adrian Socaciu, Gabriel Emil Petre, Carmen Socaciu, Doina Piciu

“…There were 11 classes of putative biomarkers selected that were involved in altered metabolic pathways, e.g., polar molecules (amino acids and glycolysis metabolites, purines and pyrimidines, and selenium complexes) and lipids including free fatty acids, bile acids, acylated carnitines, corticosteroids, prostaglandins, and phospholipids. …”
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Activation of WNT/Beta‐Catenin Signaling and Regulation of the Farnesoid X Receptor/Beta‐Catenin Complex After Murine Bile Duct Ligation by Rong Zhang, Toshimasa Nakao, Jing Luo, Yuhua Xue, Pamela Cornuet, Michael Oertel, Karis Kosar, Sucha Singh, Kari Nejak‐Bowen

“…We have recently shown that loss of β‐catenin prevents the development of cholestatic liver injury and fibrosis after bile duct ligation (BDL) due to loss of the inhibitory farnesoid X receptor (FXR)/β‐catenin complex, which results in decreased hepatic bile acids (BAs) through activation of FXR. To further understand the role of Wnt/β‐catenin signaling in regulating BA metabolism and cholestasis, we performed BDL on mice in which hepatocyte Wnt signaling is deficient but β‐catenin is intact (low‐density lipoprotein receptor‐related protein [LRP]5/6 knockout [DKO]) as well as mice that have enhanced hepatocyte β‐catenin expression (serine 45 mutated to aspartic acid [S45D] transgenic [TG] mice). …”
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A Comprehensive Metabolomics Analysis of Fecal Samples from Advanced Adenoma and Colorectal Cancer Patients by Oiana Telleria, Oihane E. Alboniga, Marc Clos-Garcia, Beatriz Nafría-Jimenez, Joaquin Cubiella, Luis Bujanda, Juan Manuel Falcón-Pérez

“…Among the 25 significant metabolites, sphingomyelins (SM), lactosylceramides (LacCer), secondary bile acids, polypeptides, formiminoglutamate, heme and cytidine-containing pyrimidines were found to be dysregulated in CRC patients. …”
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New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases by Jiali Chen, Yuhang Xiao, Dongmei Li, Shiqing Zhang, Yingzi Wu, Qing Zhang, Weibin Bai

“…Several studies have proven that HFD has a negative impact on gut microbiota, also exacerbating the course of many chronic diseases through increased populations of Erysipelotrichaceae, facultative anaerobic bacteria, and opportunistic pathogens. Since bile acids, lipopolysaccharide, short‐chain fatty acids, and trimethylamine N‐oxide have long been known as common features of bacterial metabolites, we will explore the possibility of synergistic mechanisms among those metabolites and gut microbiota in the context of HFD‐induced chronic diseases. …”
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Metabolomics study of COVID-19 patients in four different clinical stages by Alberto Valdés, Lorena Ortega Moreno, Silvia Rojo Rello, Antonio Orduña, David Bernardo, Alejandro Cifuentes

“…These metabolites are mainly involved in the metabolism of carnitines, ketone bodies, fatty acids, lysophosphatidylcholines/phosphatidylcholines, tryptophan, bile acids and purines, but also omeprazole. In addition, the levels of several of these metabolites decreased to “normal” values at hospital discharge, suggesting some of them as early prognosis biomarkers in COVID-19 at diagnose.…”
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Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human by Sofia Tsouka, Pavitra Kumar, Patcharamon Seubnooch, Katrin Freiburghaus, Marie St-Pierre, Jean-François Dufour, Mojgan Masoodi

“…Triglycerides, phospholipids, and bile acids are increased significantly in mouse MASH liver, confirming our initial observations. …”
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Global trends in gut microbiota and clostridioides difficile infection research: A visualized study by Zitong Li, Haoran Ke, Qianyun Lin, Zefeng Shen, Ye Chen

“…The keywords with the highest frequency in recent years include: gut dysbiosis, antibiotic resistance, bile-acids, 16 s sequencing, multidrug-resistant bacteria, and short chain fatty acids. …”
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Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Cli... by Biljana Lakić, Ranko Škrbić, Snežana Uletilović, Nebojša Mandić-Kovačević, Milkica Grabež, Mirna Popović Šarić, Miloš P. Stojiljković, Ivan Soldatović, Zorica Janjetović, Anastasija Stokanović, Nataša Stojaković, Momir Mikov

“…In addition to the standard treatment of T2DM, a potential strategy has been focused on the use of bile acids (BAs) as an additional treatment. Ursodeoxycholic acid (UDCA), as the first BA used in humans, improves glucose and lipid metabolism and attenuates oxidative stress. …”
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Constitutive Androstane Receptor: A Peripheral and a Neurovascular Stress or Environmental Sensor by Fabiana Oliviero, Céline Lukowicz, Badreddine Boussadia, Isabel Forner-Piquer, Jean-Marc Pascussi, Nicola Marchi, Laila Mselli-Lakhal

“…By direct and indirect activation, CAR is implicated in hepatic detoxification of xenobiotics, environmental contaminants, and endogenous molecules (bilirubin, bile acids). Importantly, CAR participates in physiological stress adaptation responses, hormonal and energy homeostasis due to glucose and lipid sensing. …”
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Effects of inoculation with active microorganisms derived from adult goats on growth performance, gut microbiota and serum metabolome in newborn lambs by Lin Fu, Liaochuan Wang, Li Liu, Li Zhang, Ziyao Zhou, Yan Zhou, Gaofu Wang, Juan J. Loor, Peng Zhou, Xianwen Dong

“…Metabolomics analysis shown that RF stimulated the metabolism of bile acids, small peptides, fatty acids and Trimethylamine-N-Oxide, which were found the correlation relationship with gut microorganisms. …”
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Fermented sorghum improves type 2 diabetes remission by modulating gut microbiota and their related metabolites in high fat diet-streptozotocin induced diabetic mice by Fred Kwame Ofosu, Fazle Elahi, Eric Banan-Mwine Daliri, Simon Okomo Aloo, Ramachandran Chelliah, Sang-Ik Han, Deog-Hwan Oh

“…FS increased the levels of phenylpropionate, phenyl sulfate, valine, bile acids (taurocholic acid, ursodeoxycholic acid and cholic acid) inversely associated with T2D. …”
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Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH by Silvia Marchianò, Michele Biagioli, Elva Morretta, Cristina Di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Ginevra Urbani, Carmen Massa, Maria Chiara Monti, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci

“…Additionally, the combination of the two agents redirected the bile acid metabolism toward bile acid species that are GPBAR1 agonist while reduced liver bile acid content and increased fecal excretion. …”
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Regulation of viable/inactivated/lysed probiotic Lactobacillus plantarum H6 on intestinal microbiota and metabolites in hypercholesterolemic mice by Yue Li, Mengling Chen, Yuxuan Ma, Yue Yang, Ying Cheng, Huijing Ma, Dayong Ren, Ping Chen

“…The v/i/uH6 cells increased the intestinal flora metabolism of vitamins-cofactors, as well as amino acids, while decreasing the relative content of primary bile acids. The Pearson correlation analysis showed that norank_f__Muribaculaceae and Lactobacillus had a negative correlation with blood lipid levels. …”
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Baicalin Alleviates Short-Term Lincomycin-Induced Intestinal and Liver Injury and Inflammation in Infant Mice by Shunfen Zhang, Ruqing Zhong, Shanlong Tang, Hui Han, Liang Chen, Hongfu Zhang

“…Bile acids can regulate intestinal immunity and strengthen hepatoenteric circulation. …”
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Gut microbiota and cardiac arrhythmia by Hongxuan Fan, Xuchang Liu, Zhaoyu Ren, Xiaoning Fei, Jing Luo, Xinyu Yang, Yaya Xue, Fenfang Zhang, Bin Liang

“…We proposed to explore the relationship between the metabolites produced by GM dysbiosis including short-chain fatty acids(SCFA), Indoxyl sulfate(IS), trimethylamine N-oxide(TMAO), lipopolysaccharides(LPS), phenylacetylglutamine(PAGln), bile acids(BA), and the currently recognized mechanisms of cardiac arrhythmias including structural remodeling, electrophysiological remodeling, abnormal nervous system regulation and other disease associated with cardiac arrythmia, detailing the processes involving immune regulation, inflammation, and different types of programmed cell death etc., which presents a key aspect of the microbial-host cross-talk. …”
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The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline by Evangelia M. Stavroulaki, Jan S. Suchodolski, Rachel Pilla, Geoffrey T. Fosgate, Chi-Hsuan Sung, Jonathan Lidbury, Jörg M. Steiner, Panagiotis G. Xenoulis

“…Alterations in the pattern of serum amino acids, antioxidants, purines, and pyrimidines, as well as fecal bile acids, sterols, and fatty acids, were observed in antibiotic-treated groups that were not observed in control cats. …”
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Quantitative metabolic analysis of plasma extracellular vesicles for the diagnosis of severe acute pancreatitis by Doudou Lou, Keqing Shi, Hui-Ping Li, Qingfu Zhu, Liang Hu, Jiaxin Luo, Rui Yang, Fei Liu

“…Results A total of 313 metabolites were detected, mainly including organic acids, amino acids, fatty acids, and bile acids. The results showed that the metabolic composition of EVs derived from SAP and MAP was significantly different from those derived from healthy controls and identified specific differences between EVs derived from patients with SAP and MAP. …”
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Multi-omics analysis of fecal samples in colorectal cancer Egyptians patients: a pilot study by Randa H. Khattab, Rana H. Abo-Hammam, Mohammed Salah, Amro M. Hanora, Sarah Shabayek, Samira Zakeer

“…Some of the differential metabolites, Taurine, Taurocholic acid, 7-ketodeoxycholic acid, Glycochenodeoxycholic acid, Glycocholic acid, and Taurochenodeoxycholic acid that belong to bile acids metabolites. Conclusions Some bacterial species, proteins, and metabolites could be used as diagnostic biomarkers for CRC. …”
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