Isomaltooligosaccharides inhibit early colorectal carcinogenesis in a 1,2-dimethylhydrazine-induced rat model by Xiao Chen, Shaoli Li, Cuixia Lin, Zhen Zhang, Xiaoyan Liu, Chunhui Wang, Jun Chen, Binbin Yang, Jing Yuan, Zheng Zhang

“…The key variations in the faecal metabolites of the DI group included decreased levels of glucose, bile acids (including deoxycholic acid and chenodeoxycholic acid) and amino acids (including L-glutamic acid and L-alanine). …”
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Whole-exome sequencing expands the roles of novel mutations of organic anion transporting polypeptide, ATP-binding cassette transporter, and receptor genes in intrahepatic cholesta... by Xianxian Liu, Jiusheng Zheng, Siming Xin, Yang Zeng, Xiaoying Wu, Xiaoming Zeng, Hua Lai, Yang Zou

“…Protein structuremodeling and comparison between the reference and modified protein structures were conducted by SWISS-MODEL and Chimera 1.14rc software, respectively.Results: A total of 5,583 mutations were identified in 82 genes related to bile acid transporters and receptors, of which 62 were novel mutations. …”
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Essential Fatty Acid Deficiency Associates with Growth Faltering and Environmental Enteric Dysfunction in Children by Monica Narvaez-Rivas, Kenneth D. R. Setchell, Stephanie L. Galandi, Xueheng Zhao, Najeeha Talat Iqbal, Sheraz Ahmed, Junaid Iqbal, Sana Syed, Syed Asad Ali, Sean R. Moore

“…Serum NEFA were quantified at ages 3–6 and 9 months and correlated with growth outcomes, serum bile acids and EED histopathological biomarkers. Serum NEFA correlated with linear growth-faltering and systemic and gut biomarkers of EED. …”
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Effects of two <it>Lactobacillus </it>strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet by Liu Xiao-Wei, Wang Xue-Hong, Tang Yong, Fu Nian, Wang Zheng-Gen, Yang Jun-Wen, Zhao Xin, Yin Ya-Ni, Cui Yi, Xie Ning, Wang Chun-Lian, Lu Fang-Gen

“…Accordingly, both fecal cholesterol and bile acids levels were significantly increased after LAB administration (p < 0.05). …”
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The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients by Hao Yu, Le Li, Yu Deng, Guolan Zhang, Mimi Jiang, He Huang, Cheng Li, Zhiyu Lv, Yingshun Zhou, Xing Liu, Xing Liu

“…Biomarkers based on three gut microbiotas (Escherichia-Shigella, Subdoligranulum, and Collinsella) and three plasma metabolites(left atrial diameter (LA), low density lipoprotein (LDL), and total bile acids (TBA)) were able to distinguish CHD patients with different numbers of stenotic coronary arteries. …”
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Metabolic Insights into Caffeine’s Anti-Adipogenic Effects: An Exploration through Intestinal Microbiota Modulation in Obesity by Isabela Monique Fortunato, Quélita Cristina Pereira, Fabricio de Sousa Oliveira, Marisa Claudia Alvarez, Tanila Wood dos Santos, Marcelo Lima Ribeiro

“…Microbial lipopolysaccharides (LPS), secondary bile acids (BA), short-chain fatty acids (SCFAs), and trimethylamine (TMA) are the main intestinal metabolites in dyslipidemic states. …”
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Integration of Serum Metabolomics into Clinical Assessment to Improve Outcome Prediction of Metastatic Soft Tissue Sarcoma Patients Treated with Trabectedin by Gianmaria Miolo, Emanuela Di Gregorio, Asia Saorin, Davide Lombardi, Simona Scalone, Angela Buonadonna, Agostino Steffan, Giuseppe Corona

“…The baseline serum metabolomics profile, targeted to 68 metabolites encompassing amino acids and bile acids pathways, was quantified by liquid chromatography-tandem mass spectrometry. …”
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Nutritional management of a dog with hepatic enzymopathy suspected to be secondary to copper-associated hepatitis: a case report by Francisco Manuel Poblanno Silva, Caitlin Elizabeth Grant, Érico de Mello Ribeiro, Adronie Verbrugghe

“…Additional diagnostics included negative Leptospira titters, normal bile acids, and laparoscopic liver biopsy. Histopathology findings were consistent with diffuse moderate vacuole hepatocellular degeneration, mild positive copper staining, mild chronic lymphoplasmacytic hepatitis both portal and central, and mild biliary hyperplasia. …”
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The Influence of Mild Pulsed Electric Field (PEF) on Acid Tolerance, Bile Tolerance, Growth and Protease Activity of the Dairy Culture Bacteria Lactobacillus acidophilus LA-K by Najim H. Najim

“…Lactobacillus acidophilus LA-K exhibited tolerance to the bile conditions and exhibited similar growth patterns in the presence or absence of bile acids but the bacterium reached the stationary phase after 12 hours of incubation in bile conditions compared to 16 hours of incubation in the absence of bile conditions. …”
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Discovery of putative natural compounds inhibitor of the germinant spore receptor CspC in Clostridioides difficile infection: Gaining insights via In silico and bioinformatics appr... by Oluwatosin A. Saibu, Gagandeep Singh, Damilola A. Omoboyowa, Adebimpe K Oyejoke, Sunday A. Olugbodi, Abayomi Bamisaye, Catherine B. Adeniji, Temitope M. Ajayi, Yetunde I. Akinpelu, Christianah A. Ogunwole, Osasenaga M. Ighodaro, Ann Christopher Francis

“…A prospective target for the therapy of CDI is the germinant spore receptor CspC, a key regulator of the germination mechanism. The detection of bile acids by CspC has been reported to initiate the germination and signaling pathways in CDI. …”
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The role of gut microbiota in liver regeneration by Zhe Xu, Zhe Xu, Nan Jiang, Nan Jiang, Yuanyuan Xiao, Yuanyuan Xiao, Kefei Yuan, Kefei Yuan, Zhen Wang, Zhen Wang

“…And previous research have demonstrated that through enterohepatic circulation, bile acids (BAs), lipopolysaccharide, short-chain fatty acids and other metabolites of gut microbiota associate with liver and may promote liver regeneration through various pathways. …”
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Alcohol Addiction, Gut Microbiota, and Alcoholism Treatment: A Review by Shao-Cheng Wang, Yuan-Chuan Chen, Shaw-Ji Chen, Chun-Hung Lee, Ching-Ming Cheng

“…Bacterial products penetrate the impaired intestinal barrier and cause central inflammation; changes to the gut microbiota impair enterohepatic circulation of bile acids; alcohol abuse causes shortage of vital nutrients such as thiamine. …”
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Cholesterol Induces Oxidative Stress, Mitochondrial Damage and Death in Hepatic Stellate Cells to Mitigate Liver Fibrosis in Mice Model of NASH by Einat Rauchbach, Haim Zeigerman, Diana Abu-Halaka, Oren Tirosh

“…A high cholesterol-to-bile acid ratio may determine the trajectory of the liver disease toward mitigation of fibrosis.…”
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The Age-Accompanied and Diet-Associated Remodeling of the Phospholipid, Amino Acid, and SCFA Metabolism of Healthy Centenarians from a Chinese Longevous Region: A Window into Excep... by Da Cai, Zimo Zhao, Lingjun Zhao, Yanjie Dong, Lei Wang, Shancang Zhao, Quanyang Li

“…The results showed that the characteristic metabolites related to longevity were mostly summarized into phosphatidylserine, lyso-phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol, bile acids, and amino acids (<i>p</i> < 0.05). Six metabolic pathways were found significant relevant to longevity. …”
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Effects of glucose oxidase on growth performance, clinical symptoms, serum parameters, and intestinal health in piglets challenged by enterotoxigenic Escherichia coli by Weiwei Wang, Ruiyan Xie, Qingyun Cao, Hui Ye, Changming Zhang, Zemin Dong, Dingyuan Feng, Jianjun Zuo

“…Functional prediction of gut microbiota revealed that ETEC-induced upregulations (p &lt; 0.05) of certain pathogenicity-related pathways (e.g., bacterial invasion of epithelial cells and shigellosis) were blocked by GOD addition, which also normalized the observed downregulations (p &lt; 0.05) of bacterial pathways related to the metabolism of sugars, functional amino acids, nucleobases, and bile acids in challenged piglets. Collectively, GOD could be used as a potential antibiotic alternative to improve growth and serum parameters, as well as attenuate clinical symptoms and intestinal disruption in ETEC-challenged piglets, which could be associated with its ability to mitigate gut microbiota dysbiosis. …”
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Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice by Stephen G. Andrews, Anthony M. Koehle, Devendra Paudel, Thomas Neuberger, A. Catharine Ross, Vishal Singh, Teodoro Bottiglieri, Rita Castro

“…Widespread changes in the plasma metabolome of HHD mice versus CD animals were detected, including alterations in acylcarnitines, amino acids, bile acids, ceramides, sphingomyelins, triacylglycerol levels, and several indicators of dysfunctional lipid metabolism. …”
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Promising new fixed combination for the treatment of diseases of the hepatobiliar system: Substantiation of pharmacotherapeutic properties and pharmaceutical quality profile by L. B. Bondarenko, N. O. Gorchakova, O. I. Golembiovska, O. Y. Galkin

“…Synthesis of cholesterol supplemented bile with reduced bile acid content significantly increases the risk of gallstones, as well as gallbladder cholesterol. …”
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In Silico Analysis of Changes in Predicted Metabolic Capabilities of Intestinal Microbiota after Fecal Microbial Transplantation for Treatment of Recurrent <i>Clostridioides diffic... by Monica Dahiya, Juan Jovel, Tanya Monaghan, Karen Wong, Wael Elhenawy, Linda Chui, Finlay McAlister, Dina Kao

“…Conclusion: Our findings suggest potential changes in key KO groups post-FMT, which may contribute to FMT efficacy beyond the restored microbial composition/diversity and metabolism of bile acids and short-chain fatty acids. Future larger studies that include a fecal metabolomics analysis combined with animal model validation work are required to further elucidate the molecular mechanisms.…”
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Bifidobacterium lactis Probio-M8 ameliorated the symptoms of type 2 diabetes mellitus mice by changing ileum FXR-CYP7A1 by Chen Ye, Zhao Yaxin, Shen Xin, Zhao Feiyan, Qi Jinxin, Zhong Zhi, Li Dongmei

“…The levels of farnesyl X receptor (FXR) and cytochrome p450 7A1 (CYP7A1) were detected by quantitative polymerase chain reaction and western blot assays. The total bile acids (TBAs), ceramide (CE), glucagon-like peptide-1 (GLP-1), and fibroblast growth factor (FGF)-15 were also detected. …”
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Gut Microbiota Ecosystem Governance of Host Inflammation, Mitochondrial Respiration and Skeletal Homeostasis by Wei-Shiung Lian, Feng-Sheng Wang, Yu-Shan Chen, Ming-Hsien Tsai, How-Ran Chao, Holger Jahr, Re-Wen Wu, Jih-Yang Ko

“…Intestinal microorganisms produce metabolites, including short-chain fatty acids, bile acids, trimethylamine N-oxide, and liposaccharides, affecting mitochondrial function, metabolism, biogenesis, autophagy, and redox reactions in chondrocytes and bone cells to regulate joint and bone tissue homeostasis. …”
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