18β-Glycyrrhetinic Acid Protects against Cholestatic Liver Injury in Bile Duct-Ligated Rats by Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen

“…The concurrent or concomitant activation of Sirt1, FXR, and Nrf2 not only restored the homeostatic regulation of bile acid metabolism, but also alleviated oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis.…”
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Bioactivity Profiling and Untargeted Metabolomics of Microbiota Associated with Mesopelagic Jellyfish <i>Periphylla periphylla</i> by Ernest Oppong-Danquah, Martina Miranda, Martina Blümel, Deniz Tasdemir

“…Various chemical classes such as diketopiperazines, polyhydroxybutyrates (PHBs), bile acids and other lipids were putatively annotated, highlighting the biotechnological potential in <i>P. periphylla</i>-associated microbiota as well as gram-negative bacteria. …”
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Socio-economic issues in the diagnostic approach and decision to treat of a child with familial cholestasis by Raluca Maria Vlad, Alexandra Coroleuca, Irina Dijmarescu, Daniela Pacurar

“…The lab tests show anemia, thrombocytopenia, liver cytolysis, normal gamma-glutamyltransferase, low prothrombin activity, normal renal function, no inflammatory syndrome, increased ammonia level, very high bile acids level. The upper endoscopy describes first degree esophageal varices and portal hypertensive gastropathy. …”
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Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives by Mengfan Li, Lijiao Yang, Chenlu Mu, Yue Sun, Yu Gu, Danfeng Chen, Tianyu Liu, Hailong Cao

“…We emphasized and elaborated recent findings of several potentially protective metabolite classes in IBD, including fatty acids, amino acids and derivatives and bile acids. This article will facilitate a deeper understanding of the new therapeutic approach for IBD by applying metabolome-based adjunctive treatment.…”
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Multi-omics analysis reveals the associations between altered gut microbiota, metabolites, and cytokines during pregnancy by Ting Huang, Xinyuan Liang, Han Bao, Guangyu Ma, Xiaomei Tang, Huijuan Luo, Xiaomin Xiao

“…Our findings revealed that, in comparison to non-pregnant women, pregnant women exhibit a significant increase in the relative abundance of Actinobacteriota and notable differences in metabolic pathways related to bile acid secretion. Furthermore, there was a marked reduction in pro-inflammatory cytokines levels in pregnant women. …”
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Action Mechanisms of Metformin Combined with Exenatide and Metformin Only in the Treatment of PCOS in Obese Patients by Jingwen Gan, Jie Chen, Rui-lin Ma, Yan Deng, Xue-song Ding, Shi-yang Zhu, Ai-jun Sun

“…The COM group may act on the hypothalamic-pituitary-gonadal axis (HPO) and its bypass, regulate multiple metabolism pathways such as phospholipids, amino acids, fatty acids, carnitine, bile acids, and glucose directly or indirectly in obese PCOS patients.…”
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Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications by Miguel A. Ortega, Miguel Angel Alvarez-Mon, Cielo García-Montero, Oscar Fraile-Martinez, Luis G. Guijarro, Guillermo Lahera, Jorge Monserrat, Paula Valls, Fernando Mora, Roberto Rodríguez-Jiménez, Javier Quintero, Melchor Álvarez-Mon

“…In the present review, the main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology. …”
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The contribution of the intestinal microbiome to immune recovery after HCT by Alex E. Wolfe, Kate A. Markey, Kate A. Markey

“…Additionally, preclinical studies suggest an immunomodulatory role for bacterial metabolites (including butyrate, secondary bile acids, and indole derivatives from tryptophan metabolism) in transplant outcomes, though further studies are needed to unravel mechanisms relevant to the post-HCT setting. …”
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Two Polysaccharides from Liupao Tea Exert Beneficial Effects in Simulated Digestion and Fermentation Model In Vitro by Siqi Qiu, Li Huang, Ning Xia, Jianwen Teng, Baoyao Wei, Xiaoshan Lin, Muhammad Rafiullah Khan

“…In simulated digestion, TPS5 was degraded and had good antioxidant effect, whereas TPS2 was not affected. The bile acids binding capacities of TPS2 and TPS5 were 42.79% ± 1.56% and 33.78% ± 0.45%, respectively. …”
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Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential by Yu Liu, Guangyan Li, Fayu Lu, Ziwei Guo, Shuang Cai, Taoguang Huo

“…There is increasing evidence that excess iron intake alters the levels of gut microbiota-derived metabolites such as secondary bile acids (BAs), short-chain fatty acids, indoles, and trimethylamine N-oxide, which play an important role in maintaining homeostasis of the GLA. …”
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Anti-Obesity and Gut Microbiota Regulation Effects of Phospholipids from the Eggs of Crab, Portunus Trituberculatus, in High Fat Diet-Fed Mice by Laijin Su, Hongli Zhu, Sichun Chen, Mengyu Du, Xiaofeng Wan, Yishu Liu, Shiwei Hu, Yangli Xu

“…<i>Pt</i>-PL reduced fecal lipopolysaccharide and total bile acids, and elevated fecal short chain fatty acid (SCFA) concentrations, particularly acetate and butyrate. …”
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Water Extract of Rice False Smut Balls Activates Nrf2/HO-1 and Apoptosis Pathways, Causing Liver Injury by Zhang Guomei, Li Han, Liu Shanshan, Zhou Xuming, Lu Mingyang, Tang Liang, Sun Lihua

“…The contents of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bile acids in the serum of mice from Institute of Cancer were significantly up-regulated by RBWE. …”
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Intestinal FXR Activation via Transgenic Chimera or Chemical Agonism Prevents Colitis-Associated and Genetically-Induced Colon Cancer by Marica Cariello, Roberta Zerlotin, Emanuela Pasculli, Elena Piccinin, Claudia Peres, Emanuele Porru, Aldo Roda, Raffaella Maria Gadaleta, Antonio Moschetta

“…The Farnesoid X Receptor (FXR) is the master regulator of Bile Acids (BA) homeostasis orchestrating their synthesis, transport and metabolism. …”
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Molecular and Clinical Links between Drug-Induced Cholestasis and Familial Intrahepatic Cholestasis by Giovanni Vitale, Alessandro Mattiaccio, Amalia Conti, Sonia Berardi, Vittoria Vero, Laura Turco, Marco Seri, Maria Cristina Morelli

“…Two of the most known proteins involved in bile acids’ (BAs) metabolism and transport are BSEP and MDR3. …”
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PRIMIS: design of a pivotal, randomized, phase 3 study evaluating the safety and efficacy of the nonsteroidal farnesoid X receptor agonist cilofexor in noncirrhotic patients with p... by Michael Trauner, Chuhan Chung, Kate Sterling, Xiangyu Liu, Xiaomin Lu, Jun Xu, Clare Tempany-Afdhal, Zachary D. Goodman, Martti Färkkilä, Atsushi Tanaka, Palak Trivedi, Kris V. Kowdley, Christopher L. Bowlus, Cynthia Levy, Robert P. Myers

“…Secondary objectives include evaluation of changes in liver biochemistry, serum bile acids, liver fibrosis assessed by noninvasive methods, health-related quality of life, and safety of cilofexor. …”
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Herbivorous Juvenile Grass Carp (<i>Ctenopharyngodon idella</i>) Fed with Genetically Modified MON 810 and DAS-59122 Maize Varieties Containing Cry Toxins: Intestinal Histological,... by Gergő Gyurcsó, Béla Darvas, Ferenc Baska, László Simon, Eszter Takács, Szandra Klátyik, András Székács

“…No differences appeared in levels of inorganic phosphate, calcium, fructosamine, bile acids, triglycerides, cholesterol, and alanine and aspartame aminotransferases. …”
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Chenodeoxycholic Acid Improves Embryo Implantation and Metabolic Health through Modulating Gut Microbiota–Host Metabolites Interaction during Early Pregnancy by Meixia Chen, Ying Zhao, Haifeng Ji, Lu Li, Hui Liu, Sixin Wang, Dongyan Zhang, Jingdong Yin, Jing Wang, Xin Zhang

“…Chenodeoxycholic acid (CDCA), a primary bile acid, contributes to metabolic improvements and protects against intrahepatic cholestasis of pregnancy. …”
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The Hepatoprotective Effect of Taurisolo, a Nutraceutical Enriched in Resveratrol and Polyphenols, Involves Activation of Mitochondrial Metabolism in Mice Liver by Nadia Badolati, Raffaello Masselli, Eduardo Sommella, Serena Sagliocchi, Alessandro Di Minno, Emanuela Salviati, Pietro Campiglia, Monica Dentice, Gian Carlo Tenore, Mariano Stornaiuolo, Ettore Novellino

“…On the contrary, Taurisolo reduces anabolic reactions like biosynthesis of cholesterol, bile acids, and plasma membrane lipids.…”
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Can carotenoids cure or protect us? by Cvetković Biljana R., Kolarov-Bjelobrk Ivana N., Radić Jelena P., Bosanac Milana M., Janičić Stefan D., Stupar Alena M., Samardžić-Lukić Maja V., Ćuk Dragomir R., Tovilović Vanja G., Andrejić-Višnjić Bojana M.

“…Topic: After being metabolised in intestinal mucosa (with the help of bile acids) and absorbed, carotenoids are mainly stored in the liver and adipose tissue. …”
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The regulatory effects of second-generation antipsychotics on lipid metabolism: Potential mechanisms mediated by the gut microbiota and therapeutic implications by Hui Chen, Hui Chen, Hui Chen, Hui Chen, Ting Cao, Ting Cao, Ting Cao, Ting Cao, Bikui Zhang, Bikui Zhang, Bikui Zhang, Bikui Zhang, Hualin Cai, Hualin Cai, Hualin Cai, Hualin Cai

“…The subsequent effects involve the generation of different categories of signaling molecules by gut microbes such as endogenous cannabinoids, cholesterol, short-chain fatty acids (SCFAs), bile acids (BAs), and gut hormones that regulate lipid metabolism. …”
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