Rosiglitazone induces hepatocyte injury by increasing DCA accumulation through OATP1A4 inhibiting in mice by Daopeng Tan, Lei Ling, Lin Qin, Yanliu Lu, Di Wu, Yuqi He

“…Results show an obvious Rosiglitazone induced hepatocyte injury in our experiment. Changes in bile acid profiles revealed that Rosiglitazone administration increased the concentration of deoxycholic acid (DCA) in the liver, but decreased those of other bile acids. …”
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Study on the mechanism of cadmium chloride pollution accelerating skin tissue metabolism disorder, aging and inhibiting hair regeneration by Weibin Du, Weibin Du, Yi Dong, Zhenwei Wang, Zhenwei Wang, Sai Yao, Sai Yao, Meijiao Wang, Jinjun Ji, Hongfeng Ruan, Hongfeng Ruan, Renfu Quan, Renfu Quan

“…Non-targeted metabolomics analysis result showed that compared with the Control group, there were 29 different metabolites, mainly including lysophospholipids, fatty acids, and bile acids, in the Low-dose group, and 39 differential metabolites in the High-dose group, in addition to the above compounds, there were more amino acid compounds, and most of the metabolites had a reduced response after administration. …”
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Effects of achilline on lipid metabolism gene expression in cell culture by A. V. Ratkin, Iu. A. Pfarger, O. A. Kaidash, V. V. Ivanov, M. M. Tsyganov, V. S. Chuchalin, S. M. Adekenov, V. V. Novitsky

“…The decrease in cholesterol level may be due to increased synthesis of bile acids from cholesterol, due to increased gene expression of 7-alphahydroxylase (Cyp7a1). …”
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Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication by Masato Furuhashi, Yukimura Higashiura, Akiko Sakai, Masayuki Koyama, Marenao Tanaka, Shigeyuki Saitoh, Kazuaki Shimamoto, Hirofumi Ohnishi

“…There was no significant correlation between the TSK level and body mass index, waist circumference, adiponectin, high-density lipoprotein cholesterol or total bile acids. The multivariable regression analysis showed that high levels of insulin and FGF21 and a low level of total cholesterol were independent determinants of plasma TSK concentration, after adjustment for age, sex and FLI. …”
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Probiotics Interact With Lipids Metabolism and Affect Gut Health by Taoying Wu, Taoying Wu, Guangqiang Wang, Zhiqiang Xiong, Yongjun Xia, Xin Song, Hui Zhang, Yan Wu, Lianzhong Ai

“…Cholesterol can be converted into bile acids to promote lipid absorption and affect microbial survival and colonization. …”
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Bamboo Shoots Modulate Gut Microbiota, Eliminate Obesity in High-Fat-Diet-Fed Mice and Improve Lipid Metabolism by Xiaolu Zhou, SolJu Pak, Daotong Li, Li Dong, Fang Chen, Xiaosong Hu, Lingjun Ma

“…Finally, BS increased many beneficial fecal metabolites, such as fatty acids and bile acids, which are highly relevant to the altered gut microbiota. …”
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Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels by Arijit Nath, Máté András Molnár, Attila Csighy, Kornélia Kőszegi, Ildikó Galambos, Klára Pásztorné Huszár, András Koris, Gyula Vatai

“…Lactose-based prebiotics with probiotics control lipid level in the bloodstream and tissue by (a) suppressing the expressions of lipogenic- genes and enzymes; (b) oxidizing fatty acids in muscle, liver, and adipose tissue; (c) binding cholesterol with cell membrane of probiotics and subsequent assimilation by probiotics; (d) enzymatic-transformations of bile acids; and (e) converting cholesterol to coprostanol and its defecation. …”
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Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid by Shanshan Zhong, Fangxi Liu, Rashid Giniatullin, Jukka Jolkkonen, Yong Li, Zhike Zhou, Xinyu Lin, Chang Liu, Xiuchun Zhang, Zhouyang Liu, Cheng Lv, Qianqian Guo, Chuansheng Zhao

“…These results implicate gut microbiota/bile acids/CCR5 signaling in the induction of PIPN, thus suggesting a target for PIPN treatment.…”
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The regulation of intestinal microbiota and the intervention of Chinese herbal medicine in the treatment of ulcerative colitis by Wang Haiou, Li Jinyou, Huang Wenkang, Ye Yiping, Gao Lijuan

“…Results: This review summarizes the critical role of the intestinal microbiota in maintaining intestinal homeostasis by facilitating the repair of the intestinal epithelial cell barrier, modulating the immune system, and regulating pivotal metabolisms, including bile acids, amino acids, and short-chain fatty acids. …”
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The interplay between herbal medicines and gut microbiota in metabolic diseases by Lijie Wang, Xiaoling Gou, Yin Ding, Jingye Liu, Yue Wang, Yaqian Wang, Jing Zhang, Leilei Du, Wei Peng, Gang Fan, Gang Fan

“…Mechanisms by which herbal medicines treat metabolic diseases include their effects on the gut microbial composition, the intestinal barrier, inflammation, and microbial metabolites (e.g., short-chain fatty acids and bile acids). Herbal medicines can increase the abundance of beneficial bacteria (e.g., Akkermansia and Blautia), reduce the abundance of harmful bacteria (e.g., Escherichia–Shigella), protect the intestinal barrier, and alleviate inflammation. …”
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Multi-omics analyses of gut microbiota via 16S rRNA gene sequencing, LC-MS/MS and diffusion tension imaging reveal aberrant microbiota-gut-brain axis in very low or extremely low b... by Ling Liu, Min Xiang, Xiangsheng Cai, Benqing Wu, Chaohong Chen, Nali Cai, Dang Ao

“…The mechanism was mediated via downregulation of the bile acid biosynthetic pathway.…”
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Dynamic alterations in early intestinal development, microbiota and metabolome induced by in ovo feeding of L-arginine in a layer chick model by Dong Dai, Shu-geng Wu, Hai-jun Zhang, Guang-hai Qi, Jing Wang

“…Simultaneously, metabolomics showed that metabolisms of galactose, taurine-conjugated bile acids and lipids were modulated to direct more energy and nutrients towards rapid growth of intestine at the beginning of post-hatch when embryos received IOF of Arg. …”
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Proteomic and Metabolomic Signatures of Diet Quality in Young Adults by Elizabeth Costello, Jesse A. Goodrich, William B. Patterson, Douglas I. Walker, Jiawen (Carmen) Chen, Brittney O. Baumert, Sarah Rock, Frank D. Gilliland, Michael I. Goran, Zhanghua Chen, Tanya L. Alderete, David V. Conti, Lida Chatzi

“…Overlapping proteins are involved in lipid and amino acid metabolism and in hemostasis, while overlapping metabolites include amino acid derivatives, bile acids, fatty acids, and pesticides. Enriched biological pathways were involved in macronutrient metabolism, immune function, and oxidative stress. …”
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Predictive model and risk analysis for peripheral vascular disease in type 2 diabetes mellitus patients using machine learning and shapley additive explanation by Lianhua Liu, Bo Bi, Li Cao, Mei Gui, Feng Ju

“…The feature importance of ML models and SHAP results indicated that Hemoglobin (Hb), age, total bile acids (TBA) and lipoprotein(a)(LP-a) are the top four important risk factors for PVD in T2DM.ConclusionThe machine learning approach successfully developed a PVD risk prediction model with good performance. …”
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Ethnicity Associated Microbial and Metabonomic Profiling in Newly Diagnosed Ulcerative Colitis by Misra R, Sarafian M, Pechlivanis A, Ding N, Miguens-Blanco J, McDonald J, Holmes E, Marchesi J, Arebi N

“…Faecal conjugated and primary conjugated bile acids concentrations were significantly higher in South Asians (p=0.02 and p=0.03 respectively). …”
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PrsA2 (CD630_35000) of Clostridioides difficile Is an Active Parvulin-Type PPIase and a Virulence Modulator by Can Murat Ünal, Can Murat Ünal, Mareike Berges, Nathiana Smit, Cordelia Schiene-Fischer, Christina Priebe, Till Strowig, Dieter Jahn, Dieter Jahn, Michael Steinert, Michael Steinert, Michael Steinert

“…We concluded that CdPrsA2 is an active PPIase that acts as a virulence modulator by influencing crucial processes like sporulation, germination and bile acid resistance resulting in attenuated mice colonization.…”
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Case Report: Add-on treatment with odevixibat in a new subtype of progressive familial intrahepatic cholestasis broadens the therapeutic horizon of genetic cholestasis by Angela Pepe, Angelo Colucci, Martina Carucci, Lucia Nazzaro, Cristina Bucci, Giusy Ranucci, Angelo Di Giorgio, Pietro Vajro, Claudia Mandato

“…Odevixibat, an ileal bile acid transporter (IBAT) inhibitor, is effective for the treatment of pruritus in children diagnosed with progressive familial intrahepatic cholestasis (PFIC) type 1 and 2. …”
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Transcriptomic (DNA Microarray) and Metabolome (LC-TOF-MS) Analyses of the Liver in High-Fat Diet Mice after Intranasal Administration of GALP (Galanin-like Peptide) by Fumiko Takenoya, Junko Shibato, Michio Yamashita, Ai Kimura, Satoshi Hirako, Yoshihiko Chiba, Naoko Nonaka, Seiji Shioda, Randeep Rakwal

“…Metabolite analysis revealed increased levels of coenzyme Q10 and oleoylethanolamide in the liver tissue, increased levels of deoxycholic acid (DCA) and taurocholic acid (TCA) in the bile acids, increased levels of taurochenodeoxycholic acid (TCDCA), and decreased levels of ursodeoxycholic acid (UDCA). …”
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Chenodeoxycholic Acid from Bile Inhibits Influenza A Virus Replication via Blocking Nuclear Export of Viral Ribonucleoprotein Complexes by Ling Luo, Weili Han, Jinyan Du, Xia Yang, Mubing Duan, Chenggang Xu, Zhenling Zeng, Weisan Chen, Jianxin Chen

“…Chenodeoxycholic acid (CDCA), one of the main primary bile acids, is synthesized from cholesterol in the liver and classically functions in emulsification and absorption of dietary fats. …”
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Gastroesophageal Reflux Disease in Idiopathic Pulmonary Fibrosis: Viewer or Actor? To Treat or Not to Treat? by Barbara Ruaro, Riccardo Pozzan, Paola Confalonieri, Stefano Tavano, Michael Hughes, Marco Matucci Cerinic, Elisa Baratella, Elisabetta Zanatta, Selene Lerda, Pietro Geri, Marco Confalonieri, Francesco Salton

“…<b>Results</b>: We identified several studies that have confirmed the association between GERD and IPF, with an increased acid exposure, risk of gastric aspiration and bile acids levels in these patients. Few studies focused their attention on GERD treatment, showing how antiacid therapy was not able to change IPF evolution. …”
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