The efficacy of prevention for colon cancer based on the microbiota therapy and the antitumor mechanisms with intervention of dietary Lactobacillus by Fuqiang Xu, Qiaoqiao Li, Shuyang Wang, Miaoyin Dong, Guoqing Xiao, Jin Bai, Junkai Wang, Xisi Sun

“…Microbiome and metabolome analyses reveal that Lactobacillus suppresses colonic tumorigenesis and progression through the modulation of gut microbiota homeostasis and metabolites, including the down-regulation of secondary bile acids, sphingosine 1-phosphate (S1P), and pyrimidine metabolism, as well as the production of anticarcinogenic compounds in tumor-bearing mice. …”
Get full text

Cyberlindnera jadinii Yeast as a Protein Source for Weaned Piglets—Impact on Immune Response and Gut Microbiota by Leidy Lagos, Alexander Kashulin Bekkelund, Adrijana Skugor, Ragnhild Ånestad, Caroline P. Åkesson, Charles McL. Press, Margareth Øverland

“…Analysis of predicted microbial metabolic pathways analysis revealed significant upregulation of short-chain fatty acids, ether lipid metabolisms, secondary bile acids, and several other important biosynthesis pathways in cecum and colon of pigs fed yeast. …”
Get full text

The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance by Rakhee Banerjee, Rakhee Banerjee, Rachel C. Hohe, Rachel C. Hohe, Shijie Cao, Shijie Cao, Bryan M. Jung, Bryan M. Jung, Anthony J. Horak, Iyappan Ramachandiran, Iyappan Ramachandiran, William J. Massey, William J. Massey, William J. Massey, Venkateshwari Varadharajan, Venkateshwari Varadharajan, Natalie I. Zajczenko, Natalie I. Zajczenko, Amy C. Burrows, Amy C. Burrows, Sumita Dutta, Sumita Dutta, Maryam Goudarzi, Maryam Goudarzi, Kala Mahen, Kala Mahen, Abigail Carter, Robert N. Helsley, Robert N. Helsley, Scott M. Gordon, Richard E. Morton, Christopher Strauch, Belinda Willard, Camelia Baleanu Gogonea, Valentin Gogonea, Matteo Pedrelli, Paolo Parini, J. Mark Brown, J. Mark Brown

“…However, the vast majority of bile acids, oxysterols, and steroid hormones were unaltered in Gramd1c−/− mice. …”
Get full text

Intestinal microbiota dysbiosis and liver metabolomic changes during brain death by Ruolin Tao, Wenzhi Guo, Tao Li, Yong Wang, Panliang Wang

“…Short-chain fatty acids, bile acids, and 132 other microbial metabolites remained unchanged in both the intestinal contents and portal vein plasma of the BD group. …”
Get full text

The effects of laparoscopic Roux-en-Y gastric bypass and one-anastomosis gastric bypass on glycemic control and remission of type 2 diabetes mellitus: study protocol for a multi-ce... by A. van Rijswijk, N. van Olst, A. S. Meijnikman, Y. I. Z. Acherman, S. C. Bruin, A. W. van de Laar, C. C. van Olden, O. Aydin, H. Borger, U. H. W. Beuers, H. Herrema, J. Verheij, J. A. Apers, F. Bäckhed, V. E. A. Gerdes, M. Nieuwdorp, L. M. de Brauw

“…Secondary outcome measures are diverse and include weight loss, surgical complications, psychologic status and quality of life, dietary behavior, gastrointestinal symptoms, repetitive bloodwork to identify changes over time, glucose tolerance and insulin sensitivity as measured by mixed meal tests, remission of T2DM, presence of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in liver biopsy, oral and fecal microbiome, cardiovascular performance, composition of bile acids, and the tendency to develop gallstones. …”
Get full text

Hepatic Polarized Differentiation Promoted the Maturity and Liver Function of Human Embryonic Stem Cell-Derived Hepatocytes via Activating Hippo and AMPK Signaling Pathways by Jue Wang, Ping Situ, Sen Chen, Haibin Wu, Xueyan Zhang, Shoupei Liu, Yiyu Wang, Jinghe Xie, Honglin Chen, Yuyou Duan

“…Our results showed that phEHs directionally secreted albumin, urea and bile acids, and afterward, the apical membrane and blood–bile barrier (BBIB) were identified to form in phEHs. …”
Get full text

Low-density lipoprotein receptor genotypes modify the sera metabolome of patients with homozygous familial hypercholesterolemia by Zhiyong Du, Fan Li, Linyi Li, Yu Wang, Jianping Li, Ya Yang, Long Jiang, Luya Wang, Yanwen Qin

“…Compared with defective/defective mutation carriers, patients carrying one or two null mutation showed profound alterations in clinical laboratory lipids and serum cholesterol esters, lysophosphocholines, bile acids, and amino acids. Importantly, these altered metabolites are implicated in multiple biochemical reactions and associated with LDL cholesterol. …”
Get full text

The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study by Qian Gao, Xuejiao Li, Li Wang, Xiaozhi Tan, Zhe Li, Chengfang Xu

“…Among the HBV-infected patients with ICP, HBeAg-positive group had a higher level of serum transaminase, bilirubin and bile acid as well as earlier gestational weeks of delivery, lower birth weight of new-borns and a higher rate of NICU admission than HBeAg-negative group (P < 0.05). …”
Get full text

Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model by Yun Zhang, Katherine M. Weh, Bridget A. Tripp, Jennifer L. Clarke, Connor L. Howard, Shruthi Sunilkumar, Amy B. Howell, Laura A. Kresty

“…We recently reported that cranberry proanthocyanidins (C-PACs) inhibit esophageal adenocarcinoma (EAC) by 83% through reversing reflux-induced bacterial, inflammatory and immune-implicated proteins and genes as well as reducing esophageal bile acids, which drive EAC progression. This study investigated whether C-PACs’ mitigation of bile reflux-induced transporter dysregulation mechanistically contributes to EAC prevention. …”
Get full text

Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use by Udhghatri Kolli, Richa Jalodia, Shamsudheen Moidunny, Praveen Kumar Singh, Yuguang Ban, Junyi Tao, Gonzalo Nathaniel Cantu, Eridania Valdes, Sundaram Ramakrishnan, Sabita Roy

“…Integrative analysis of multi-omics data highlighted the associations between Parasutterella excrementihominis, Burkholderiales bacterium 1_1_47, Enterococcus faecalis, Enterorhabdus caecimuris and altered levels of riboflavin, flavonoids, and lipid metabolites including phosphocholines, carnitines, bile acids, and ethanolamines with host gene expression changes involved in inflammation and barrier integrity of intestine. …”
Get full text

Metabolomics and network analysis uncovered profound inflammation-associated alterations in hepatitis B virus-related cirrhosis patients with early hepatocellular carcinoma by Zhiyong Du, Shengju Yin, Bing Liu, Wenxin Zhang, Jiaxu Sun, Meng Fang, Yisheng Xu, Kun Hua, Pengfei Tu, Guoliang Zhang, Ying Ma, Yingyuan Lu

“…Compared to non-HCC patients (N = 108) and health controls (N = 80), we found that patients with early HCC (N = 224) exhibited a specific plasma metabolome map dominated by lipid alterations, including lysophosphatidylcholines, lysophosphatidic acids and bile acids. Pathway and function network analyses indicated that these metabolite alterations were closely associated with inflammation responses. …”
Get full text

Hematology and biochemistry reference intervals for American crocodiles (Crocodylus acutus) in South Florida by Sergio A. Balaguera-Reina, Nicole D. Jennings, Sidney T. Godfrey, Laura A. Brandt, Bryna Daykin, Michiko A. Squires, Frank J. Mazzotti

“…However, we did find moderate-to-strong evidence that sex influenced azurophils % and size class influenced white blood cell (WBC), heterophils %, monocytes %, basophils abs, creatine phosphokinase (CPK), potassium, glucose, bile acids, alpha-1 globulin abs, and alpha-2 globulin pr and abs. …”
Get full text

Cyclocarya paliurus leaves extracts alleviate metabolic phenotypes in Chinese T2DM patients by modulating gut microbiota and metabolites: a clinical randomized controlled trial by Xiaojuan Peng, Xiaojuan Peng, Xiaojuan Peng, Sisi Chen, Lu Zhong, Yuting Li, Chutian Wu, Lixian Zhong, Weiwei Chen, Jinying Yang, Jiahua Zeng, Shaohui Tang

“…T2DM-associated metabolic phenotypes, gut microbiota and metabolites including short-chain fatty acids (SCFAs) and bile acids (BAs) were detected.ResultsAt the end of intervention, CP, like Glipizide, significantly improved HbA1c level and other glucose metabolism parameters (fasting plasma glucose (FBG), 2-hour post-meal blood glucose (2hPBG), the area under curve of oral glucose tolerance test glucose (OGTT glucose AUC)). …”
Get full text

<i>Lactobacillus salivarius</i> SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens by Lihui Zhu, Rongrong Liao, Jiwen Huang, Changfeng Xiao, Yunzhou Yang, Huiying Wang, Daqian He, Huaxiang Yan, Changsuo Yang

“…Targeted metabolomic analysis revealed that acetate, butyrate, and propionate were the most abundant short-chain fatty acids, while cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, and tauroursodeoxycholic acid were the four most-enriched bile acids among <i>L. salivarius</i> SNK-6 metabolites. …”
Get full text

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites by Yexun Zhou, Yexun Zhou, Liang Chen, Hui Han, Hui Han, Bohui Xiong, Ruqing Zhong, Yue Jiang, Lei Liu, Haiqing Sun, Jiajian Tan, Xiaowei Cheng, Martine Schroyen, Yang Gao, Yong Zhao, Hongfu Zhang

“…Conversely, TAX decreased 10 different kinds of bile acids in the plasma. Moreover, TAX increased “beneficial” microbes such as Intestinimonas, Coprococcus, Butyrivibrio, and Clostridium_XlVa at the Genus level. …”
Get full text

Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury by Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol

“…Importantly, following BDL, TrxR1LKO induced periportal hepatocyte expression of Nrf2-dependent antioxidant proteins and increased mRNA expression of basolateral bile acid transporters with reduced expression of bile acid synthesis genes. …”
Get full text

Gallstone Formation Follows a Different Trajectory in Bariatric Patients Compared to Nonbariatric Patients by Sylke Haal, Maimoena S. S. Guman, Yair I. Z. Acherman, Johannes P. G. Jansen, Michel van Weeghel, Henk van Lenthe, Eric J. M. Wever, Victor E. A. Gerdes, Rogier P. Voermans, Albert K. Groen

“…We observed a higher concentration of total lipids (9.9 vs. 5.8 g/dL), bile acids (157.7 vs. 81.5 mM), cholesterol (10.6 vs. 5.4 mM), and phospholipids (30.4 vs. 21.8 mM) in bariatric gallstone patients compared to nonbariatric gallstone patients. …”
Get full text

Safety and Effects of <i>Lactobacillus paracasei</i> TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atherosclerosis-Related Parameters in Subjects with Hypercho... by Jurairat Khongrum, Pratoomporn Yingthongchai, Kongsak Boonyapranai, Wachira Wongtanasarasin, Paitoon Aobchecy, Suriya Tateing, Aree Prachansuwan, Jaruwan Sitdhipol, Kanidta Niwasabutra, Punnathon Thaveethaptaikul, Pongsathon Phapugrangkul, Pennapa Chonpathompikunlert

“…No changes in serum total cholesterol, high-density lipoprotein-cholesterol, triglyceride, total bile acids, and monocyte chemoattractant protein-1 were observed during <i>L. paracasei</i> TISTR 2593 supplementation. …”
Get full text

Epithelial, metabolic and innate immunity transcriptomic signatures differentiating the rumen from other sheep and mammalian gastrointestinal tract tissues by Ruidong Xiang, Victor Hutton Oddy, Alan L. Archibald, Phillip E. Vercoe, Brian P. Dalrymple

“…The expression patterns of several membrane transporters (chloride, zinc, nucleosides, amino acids, fatty acids, cholesterol and bile acids) along the GIT was very similar in sheep, pig and humans. …”
Get full text

Glycomacropeptide as an Efficient Agent to Fight Pathophysiological Mechanisms of Metabolic Syndrome by Mathilde Foisy Sauvé, Francis Feldman, Alain Théophile Sané, Mireille Koudoufio, Natalie Patey, Schohraya Spahis, James Butcher, Haonan Duan, Daniel Figeys, Valérie Marcil, Alain Stintzi, Emile Levy

“…A trend toward a decrease in bile acids without any marked changes in intestinal microbiota composition characterized GMP-treated animals compared to those administered Bipro. …”
Get full text