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1801
High Dose Versus Low Dose Syngeneic Hepatocyte Transplantation in <i>Pex1</i>-G844D NMRI Mouse Model is Safe but Does Not Achieve Long Term Engraftment
Published 2020-12-01“…Clinical (weight and food intake) and biochemical parameters (very long-chain fatty acids, abnormal bile acids, etc.) were in accordance with ZSD phenotype but they were not robustly modified by HT. …”
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1802
Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling
Published 2020-08-01“…Consistent with the deregulation of lipid metabolism pathways, the DKO animals exhibited increased accumulation of FAs in the liver and decreased level of bile acids. Altogether, ligand-dependent Ron receptor activation provides protection from the deregulation of major metabolic pathways that initiate and aggravate non-alcoholic steatohepatitis.…”
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1803
Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases
Published 2023-07-01“…Association analysis revealed that the modulation of intestinal microenvironment played a crucial role in the pharmacodynamics of both drugs, in which their respective superiority on the regulation of gut microbiota composition and intestinal bile acids might contribute to their own merits on lowering glucose or lipids. …”
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1804
Effect of rhubarb on gut microbiota-host co-metabolism in rats
Published 2023-08-01“…Among these differential metabolites, some gut microbial-host co-metabolites, including neurotransmitters, indoles, and bile acids, were observed to alter significantly after rhubarb administration. …”
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1805
The maternal hair metabolome is capable of discriminating intrahepatic cholestasis of pregnancy from uncomplicated pregnancy
Published 2024-01-01“…IntroductionIntrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with elevated bile acids in the blood. Diagnosis typically only occurs after the manifestation of clinical symptoms and the metabolic mechanisms underlying its development remain unclear. …”
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1806
Response of Intestinal Microbiota to the Variation in Diets in Grass Carp (<i>Ctenopharyngodon idella</i>)
Published 2022-11-01“…The intestinal microbial function in grass carp fed with ryegrass was rich in amino acids and exhibited an increased energy metabolism in order to compensate for a low-nutrient diet intake, while the artificial feed elevated the microbial lipid metabolism through the promotion of its synthesis in the primary and secondary bile acids, together with a notable enhancement of fatty acid biosynthesis. …”
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1807
Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice
Published 2022-11-01“…Accumulating evidence suggests that metformin may improve IR through regulating gut microbiota and bile acids. However, the underlying mechanisms remain unclear. …”
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1808
EFFECT OF SESQUITERPENE γ-LACTONE ACHILLIN ON LEVEL OF LIPIDS AND EXPRESSI ON mRNA OF KEY GENES OF LIPID MET ABOLISM IN HEPATOMA TISSUE CULTURE (HTC)
Published 2016-03-01“…Lowering of cholesterol, TAG and Nile Red fluorescence intensity in hepatoma cells in experimental hyperlipidemia under the action of achillin in the final concentration 500 µM could be caused by increase of gene expression carnitine palmitoyltransferase 1 and 2; 7-alpha-hydroxylase, which contributes to increase the transport of fatty acids into the mitochondria, and synthesis of bile acids from cholesterol. In addition, inhibition of acetyl-CoA cholesterol acyltransferase helps to reduce the formation of cholesterol esters and their accumulation in the hepatocytes.…”
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1809
In vitro safety and functional characterization of the novel Bacillus coagulans strain CGI314
Published 2024-01-01“…IntroductionBacillus coagulans species have garnered much interest in health-related functional food research owing to their desirable probiotic properties, including pathogen exclusion, antioxidant, antimicrobial, immunomodulatory and food fermentation capabilities coupled with their tolerance of extreme environments (pH, temperature, gastric and bile acid resistance) and stability due to their endosporulation ability.MethodsIn this study, the novel strain Bacillus coagulans CGI314 was assessed for safety, and functional probiotic attributes including resistance to heat, gastric acid and bile salts, the ability to adhere to intestinal cells, aggregation properties, the ability to suppress the growth of human pathogens, enzymatic profile, antioxidant capacity using biochemical and cell-based methods, cholesterol assimilation, anti-inflammatory activity, and attenuation of hydrogen peroxide (H2O2)-induced disruption of the intestinal-epithelial barrier.ResultsB. coagulans CGI314 spores display resistance to high temperatures (40°C, 70°C, and 90°C), and gastric and bile acids [pH 3.0 and bile salt (0.3%)], demonstrating its ability to survive and remain viable under gastrointestinal conditions. …”
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1810
Gardenia Iridoid Glucosides Protect Against α-Naphthalene Isothiocya-Nate-Induced Cholestatic Rats Through Activation of the FXR-SHP Signaling Pathway
Published 2023-12-01“…GIG demonstrated beneficial effects on bile acid enterohepatic circulation and liver biomarkers in cholestatic rats. …”
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1811
Metabolomic Signatures Associated with Radiation-Induced Lung Injury by Correlating Lung Tissue to Plasma in a Rat Model
Published 2023-09-01“…In addition, the multiple metabolic dysregulations primarily involved amino acids, bile acids and lipid and fatty acid β-oxidation-related metabolites, implying disturbances in the urea cycle, intestinal flora metabolism and mitochondrial dysfunction. …”
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1812
Diet composition influences probiotic and postbiotic effects on broiler growth and physiology
Published 2024-06-01“…Independently of the diet, Pro increased plasma calcium, phosphorus and uric acid at d21 (+6.2, +7.4, and +15.5%, respectively) and d35 (+6.6, +6.2 and +21.0%, respectively) (P < 0.05) while Post increased plasma magnesium only at d21 (+11.3%; P = 0.037). Blood bile acids were affected by additives in an age- and diet-dependent manner, with some opposite effects between dietary conditions. …”
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1813
Altered serotonin metabolism in Takeda G protein-coupled receptor 5 knockout mice protects against diet-induced hepatic fibrosis
Published 2022-12-01“…Metabolic phenotypes were characterized through examination of bile acid synthesis pathways, lipid and cholesterol metabolism pathways, and fibrosis and inflammation pathways. …”
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1814
Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+‐Taurocholate Cotransporting Polypeptide
Published 2018-12-01“…Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic reticulum (ER) stress. …”
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1815
Prospective cholestanol screening of cerebrotendinous xanthomatosis among patients with juvenile-onset unexplained bilateral cataracts
Published 2022-12-01“…Abstract Background Cerebrotendinous xanthomatosis (CTX) is a rare genetic disorder related to CYP27A1 biallelic mutations, leading to decreased synthesis of bile acids and increased cholestanol. Juvenile bilateral cataracts are one of the most common findings in the disease, frequently occurring before the onset of neurological manifestations. …”
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1816
Inhibition of CBP/β‐catenin signaling ameliorated fibrosis in cholestatic liver disease
Published 2022-10-01“…Abstract Chronic cholestatic liver diseases are characterized by injury of the bile ducts and hepatocytes caused by accumulated bile acids (BAs) and inflammation. Wnt/β‐catenin signaling is implicated in organ fibrosis; however, its role in cholestatic liver fibrosis remains unclear. …”
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1817
<i>Auricularia auricula</i> Melanin Protects against Alcoholic Liver Injury and Modulates Intestinal Microbiota Composition in Mice Exposed to Alcohol Intake
Published 2021-10-01“…Besides, the abnormally high levels of bile acids (BAs) and lactate dehydrogenase (LDH) in the liver of mice with alcohol intake were significantly decreased by AAM intervention, while the hepatic levels of glutathione (GSH) and superoxide dismutase (SOD) were appreciably increased. …”
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1818
Heat-Inactivated <i>Akkermansia muciniphila</i> Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr−/−.Leiden Mic...
Published 2022-02-01“…Heat-inactivated <i>A. muciniphila</i> did not affect the development of NASH or associated fibrosis in the liver and did not affect circulating bile acids or markers of liver fibrosis, but did reduce PRO-C4, a type IV collagen synthesis marker, which may be associated with gut integrity. …”
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1819
Single-cell sequencing of a novel model of neonatal bile duct ligation in mice identifies macrophage heterogeneity in obstructive cholestasis
Published 2023-08-01“…Neonatal BDL achieved a 90% survival rate; mice had elevated bile acids, bilirubin, and alanine aminotransferase (ALT) versus controls (p < 0.05 for all). …”
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1820
Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay
Published 2020-09-01“…Lipid analyses revealed that LP-Z particles exhibit lower cholesteryl esters and higher free cholesterol, bile acids, acylcarnitines, diacylglycerides, dihexosylceramides, lysophosphatidylcholines, phosphatidylcholines, triacylglycerides, and fatty acids than low-density lipoprotein (LDL) particles. …”
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