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1821
Safety, pharmacokinetics, and pharmacodynamics in healthy Chinese volunteers treated with SC0062, a highly selective endothelin‐A receptor antagonist
Published 2024-03-01“…The secondary objectives were to determine the PK behavior of SC0062 and its major active metabolite M18, whereas exploratory objectives focused on PD effects, principally effects on endothelin‐1 (ET‐1) and total bile acids (TBA). Single doses of 10 to 100 mg and multiple daily doses of 20 and 50 mg for 6 days were well tolerated. …”
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1822
Farnesoid X Receptor Activation Protects Liver From Ischemia/Reperfusion Injury by Up‐Regulating Small Heterodimer Partner in Kupffer Cells
Published 2020-04-01“…Farnesoid X receptor (FXR) is the nuclear receptor of bile acids and is involved in innate immune regulation. …”
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1823
Critical Level of Alanine Transaminase to Predict Foetomaternal Outcome in Intrahepatic Cholestasis of Pregnancy: A Case-control Study
Published 2021-05-01“…To avoid the adversities, early delivery is indicated before serum bile acids levels of >40 µmol/L is reached. In the settings where bile acid testing is not available, serum transaminases can be used for diagnosis and management of IHCP. …”
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1824
Supplementation of microencapsulated probiotics modulates gut health and intestinal microbiota
Published 2023-08-01“…Abstract The beneficial effect of probiotics on host health is impaired due to the substantial loss of survivability during gastric transit caused by small intestinal enzymes and bile acids. Encapsulation helps to preserve the probiotics species from severe environmental factors. …”
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1825
Comparison of a full-spectrum multi-analyte clinical analyser with six reference instruments using canine and feline blood samples
Published 2017-06-01“…This was followed by comparison of clinical specimens on the AmiShield analyser in parallel with the Vitros and Hitachi for biochemical parameters, VetScan and SNAPshot for total bile acids, and VetLyte and Biolyte for electrolytes. …”
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1826
Alterations in the gut microbiota and its metabolites contribute to metabolic maladaptation in dairy cows during the development of hyperketonemia
Published 2024-04-01“…Our results demonstrate that cows underwent excessive lipid mobilization and insulin insensitivity before hyperketonemia was evident. The bile acids are functional readouts that link gut microbiota and host phenotypes in the development of hyperketonemia. …”
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1827
Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model
Published 2024-12-01“…There were significant changes in concentrations of several gut metabolites which are either neurotransmitters (e.g., GABA and serotonin) or have been found to be moderators of gut-brain axis communication in rodent models (e.g., short-chain fatty acids and bile acids). There was an increase in affiliative behavior and sociability in antibiotic-administered marmosets, which might be a coping mechanism in response to gut dysbiosis-induced stress. …”
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1828
Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer
Published 2021-02-01“…Notably, global metabolomic profiling studies identified significantly higher circulating levels of bile acids in castrated animals that were decreased with 2-ME<sub>2</sub> intervention. …”
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1829
Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas
Published 2021-10-01“…<i>FABP6</i> functions as an intracellular bile-acid transporter in the ileal epithelium. We looked at <i>FABP6</i> expression in CRC since bile acids are important in the carcinogenesis of CRC. …”
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1830
The impact of microbially modified metabolites associated with obesity and bariatric surgery on antitumor immunity
Published 2023-05-01“…Some studies have found that microbial metabolites, such as short-chain fatty acids (SCFAs), inosine bile acids and spermidine, play an important role in anticancer immunity. …”
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1831
Intramuscular Fat Selection in Rabbits Modifies the Fatty Acid Composition of Muscle and Liver Tissues
Published 2022-03-01“…Greater concentrations of plasma triglycerides (D<sub>H-L</sub> = −34) and cholesterol (D<sub>H-L</sub> = −3.85) were found in the L than in the H line, together with greater plasma concentration of bile acids (D<sub>H-L</sub> = −2.13). Nonetheless, the difference was only relevant for triglycerides (P<sub>r</sub> = 0.98).…”
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1832
Gut microbiome features and metabolites in non-alcoholic fatty liver disease among community-dwelling middle-aged and older adults
Published 2024-03-01“…Higher levels of specific gut microbiota-derived metabolites of bile acids (taurocholic acid) might be positively associated with both a higher MRS and NAFLD risk. …”
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1833
Construction and validation of a machine learning-based nomogram to predict the prognosis of HBV associated hepatocellular carcinoma patients with high levels of hepatitis B surfac...
Published 2024-03-01“…The content of the nomogram includes age, BCLC stage, tumor size, globulin, GGT, and bile acids. The C-index (0.682, 0.666, and 0.740) and 1-, 3-, and 5-year AUCs of the training, internal validation, and external validation cohorts proved good discrimination of the nomogram. …”
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1834
Microbiome and PCOS: State-of-Art and Future Aspects
Published 2021-02-01“…Current evidence has shown the involvement of the gut microbiome in PCOS, seen how humanized mice receiving a fecal transplant from women with PCOS develop ovarian dysfunction, immune changes and insulin resistance and how it is capable of disrupting the secondary bile acid biosynthesis. A future therapeutic approach for PCOS may involve the human administration of IL-22 and bile acid glycodeoxycholic acid.…”
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1835
Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine <i>Ureaplasma parvum</i> Infection Partly Prevents Liver Inflammation without Interfering with the Ent...
Published 2020-05-01“…In addition, intestinal bile acids (BAs) accumulation is causally linked to NEC development. …”
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1836
Evaluation of Intestinal Microbial Metabolites in Preterm Infants with Different Initial Feeding Methods by In Vitro Fermentation Modeling System
Published 2022-07-01“…Group A had lower fecal pH (<i>p</i> = 0.023), ammonia (<i>p</i> = 0.001), and bile acids (<i>p</i> = 0.025). Group B also had higher fecal sIgA levels, both in OD (<i>p</i> = 0.046) and concentration (<i>p</i> < 0.0001) methods. …”
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1837
Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola
Published 2020-01-01“…F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. …”
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1838
Mitochondrial cholesterol: Metabolism and impact on redox biology and disease
Published 2023-05-01“…Despite the limited availability of cholesterol in the inner mitochondrial membrane (IMM), the metabolism of cholesterol in the IMM plays important physiological roles, acting as the precursor for the synthesis of steroid hormones and neurosteroids in steroidogenic tissues and specific neurons, respectively, or the synthesis of bile acids through an alternative pathway in the liver. …”
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1839
Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome
Published 2024-01-01“…The differential metabolites were mainly included amino acids, carbohydrates and bile acids. Furthermore, after SAV intake, Verrucomicrobia, and Akkermansia closely impacted the related gut metabolites. …”
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1840
Predictive value of serum TBA for 2-year MACEs in ACS patients undergoing PCI: a prospective cohort study
Published 2024-01-01“…Abstract Bile acids play important roles in lipid metabolism and glucose homeostasis. …”
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