Safety, pharmacokinetics, and pharmacodynamics in healthy Chinese volunteers treated with SC0062, a highly selective endothelin‐A receptor antagonist by Yun Liu, Wei Wang, Hongjie Qian, Yuzhou Gui, Yating Wang, Rong Song, Qian Chen, Eric Rowinsky, Sheng Wang, Xiaoguang Liang, Kaicun Gu, Bo Zhou, Weiwei Zhang, Liqin Zhang, Chen Yu, Jingying Jia

“…The secondary objectives were to determine the PK behavior of SC0062 and its major active metabolite M18, whereas exploratory objectives focused on PD effects, principally effects on endothelin‐1 (ET‐1) and total bile acids (TBA). Single doses of 10 to 100 mg and multiple daily doses of 20 and 50 mg for 6 days were well tolerated. …”
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Farnesoid X Receptor Activation Protects Liver From Ischemia/Reperfusion Injury by Up‐Regulating Small Heterodimer Partner in Kupffer Cells by Dan Jin, Tianfei Lu, Ming Ni, Han Wang, Jiang Zhang, Chenpeng Zhong, Chuan Shen, Jun Hao, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski, Jianjun Zhang, Ning Xu, Yuan Zhai

“…Farnesoid X receptor (FXR) is the nuclear receptor of bile acids and is involved in innate immune regulation. …”
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Critical Level of Alanine Transaminase to Predict Foetomaternal Outcome in Intrahepatic Cholestasis of Pregnancy: A Case-control Study by Nidhi Ahuja, Anjali Dabral, Sheeba Marwah, Rekha Bharti, Deepti Pachauri, Jyotsna Suri

“…To avoid the adversities, early delivery is indicated before serum bile acids levels of >40 µmol/L is reached. In the settings where bile acid testing is not available, serum transaminases can be used for diagnosis and management of IHCP. …”
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Supplementation of microencapsulated probiotics modulates gut health and intestinal microbiota by Ishwari Gyawali, Guilian Zhou, Guli Xu, Genghui Li, Yujun Wang, Yuxian Zeng, Jincheng Li, Jingjing Zhou, Canjun Zhu, Gang Shu, Qingyan Jiang

“…Abstract The beneficial effect of probiotics on host health is impaired due to the substantial loss of survivability during gastric transit caused by small intestinal enzymes and bile acids. Encapsulation helps to preserve the probiotics species from severe environmental factors. …”
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Comparison of a full-spectrum multi-analyte clinical analyser with six reference instruments using canine and feline blood samples by C.S. Lin, G.H. Chiang, C.H. Liu, H.C. Tsai, C.C. Yang, K. Chen, S.K. Huang, T.L. Cheng, C.C. Chou

“…This was followed by comparison of clinical specimens on the AmiShield analyser in parallel with the Vitros and Hitachi for biochemical parameters, VetScan and SNAPshot for total bile acids, and VetLyte and Biolyte for electrolytes. …”
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Alterations in the gut microbiota and its metabolites contribute to metabolic maladaptation in dairy cows during the development of hyperketonemia by Zhengzhong Luo, Zhenlong Du, Yixin Huang, Tao Zhou, Dan Wu, Xueping Yao, Liuhong Shen, Shumin Yu, Kang Yong, Baoning Wang, Suizhong Cao

“…Our results demonstrate that cows underwent excessive lipid mobilization and insulin insensitivity before hyperketonemia was evident. The bile acids are functional readouts that link gut microbiota and host phenotypes in the development of hyperketonemia. …”
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Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model by Shivdeep S. Hayer, Mackenzie Conrin, Jeffrey A. French, Andrew K. Benson, Sophie Alvarez, Kathryn Cooper, Anne Fischer, Zahraa Wajih Alsafwani, William Gasper, Mallory J. Suhr Van Haute, Haley R. Hassenstab, Shayda Azadmanesh, Missy Briardy, Skyler Gerbers, Aliyah Jabenis, Jennifer L. Thompson, Jonathan B. Clayton

“…There were significant changes in concentrations of several gut metabolites which are either neurotransmitters (e.g., GABA and serotonin) or have been found to be moderators of gut-brain axis communication in rodent models (e.g., short-chain fatty acids and bile acids). There was an increase in affiliative behavior and sociability in antibiotic-administered marmosets, which might be a coping mechanism in response to gut dysbiosis-induced stress. …”
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Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer by Izhar Singh Batth, Shih-Bo Huang, Michelle Villarreal, Jingjing Gong, Divya Chakravarthy, Brian Keppler, Sridharan Jayamohan, Pawel Osmulski, Jianping Xie, Paul Rivas, Roble Bedolla, Michael A. Liss, I-Tien Yeh, Robert Reddick, Hiroshi Miyamoto, Rita Ghosh, Addanki P. Kumar

“…Notably, global metabolomic profiling studies identified significantly higher circulating levels of bile acids in castrated animals that were decreased with 2-ME₂ intervention. …”
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Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas by Fidelia Berenice Prayugo, Tzu-Jen Kao, Gangga Anuraga, Hoang Dang Khoa Ta, Jian-Ying Chuang, Li-Chia Lin, Yung-Fu Wu, Chih-Yang Wang, Kuen-Haur Lee

“…<i>FABP6</i> functions as an intracellular bile-acid transporter in the ileal epithelium. We looked at <i>FABP6</i> expression in CRC since bile acids are important in the carcinogenesis of CRC. …”
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The impact of microbially modified metabolites associated with obesity and bariatric surgery on antitumor immunity by Meng Wang, Meng Wang, Yuhong Huang, Meiling Xin, Tianxing Li, Tianxing Li, Xueke Wang, Xueke Wang, Yini Fang, Yini Fang, Shufei Liang, Tianqi Cai, Xiaoxue Xu, Ling Dong, Chao Wang, Zhengbao Xu, Xinhua Song, Jingda Li, Yanfei Zheng, Wenlong Sun, Lingru Li

“…Some studies have found that microbial metabolites, such as short-chain fatty acids (SCFAs), inosine bile acids and spermidine, play an important role in anticancer immunity. …”
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Intramuscular Fat Selection in Rabbits Modifies the Fatty Acid Composition of Muscle and Liver Tissues by Agostina Zubiri-Gaitán, Agustín Blasco, Ruth Ccalta, Katy Satué, Pilar Hernández

“…Greater concentrations of plasma triglycerides (D_H-L = −34) and cholesterol (D_H-L = −3.85) were found in the L than in the H line, together with greater plasma concentration of bile acids (D_H-L = −2.13). Nonetheless, the difference was only relevant for triglycerides (P_r = 0.98).…”
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Gut microbiome features and metabolites in non-alcoholic fatty liver disease among community-dwelling middle-aged and older adults by Fangfang Zeng, Xin Su, Xinxiu Liang, Minqi Liao, Haili Zhong, Jinjian Xu, Wanglong Gou, Xiangzhou Zhang, Luqi Shen, Ju-Sheng Zheng, Yu-ming Chen

“…Higher levels of specific gut microbiota-derived metabolites of bile acids (taurocholic acid) might be positively associated with both a higher MRS and NAFLD risk. …”
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Construction and validation of a machine learning-based nomogram to predict the prognosis of HBV associated hepatocellular carcinoma patients with high levels of hepatitis B surfac... by Yiqi Xiong, Wenying Qiao, Wenying Qiao, Qi Wang, Kang Li, Ronghua Jin, Ronghua Jin, Yonghong Zhang

“…The content of the nomogram includes age, BCLC stage, tumor size, globulin, GGT, and bile acids. The C-index (0.682, 0.666, and 0.740) and 1-, 3-, and 5-year AUCs of the training, internal validation, and external validation cohorts proved good discrimination of the nomogram. …”
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Microbiome and PCOS: State-of-Art and Future Aspects by Pierluigi Giampaolino, Virginia Foreste, Claudia Di Filippo, Alessandra Gallo, Antonio Mercorio, Paolo Serafino, Francesco Paolo Improda, Paolo Verrazzo, Giuseppe Zara, Cira Buonfantino, Maria Borgo, Gaetano Riemma, Chiara De Angelis, Brunella Zizolfi, Giuseppe Bifulco, Luigi Della Corte

“…Current evidence has shown the involvement of the gut microbiome in PCOS, seen how humanized mice receiving a fecal transplant from women with PCOS develop ovarian dysfunction, immune changes and insulin resistance and how it is capable of disrupting the secondary bile acid biosynthesis. A future therapeutic approach for PCOS may involve the human administration of IL-22 and bile acid glycodeoxycholic acid.…”
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Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine <i>Ureaplasma parvum</i> Infection Partly Prevents Liver Inflammation without Interfering with the Ent... by Cathelijne Heymans, Lara R. Heij, Kaatje Lenaerts, Marcel den Dulk, Mhamed Hadfoune, Chantal van Heugten, Owen B. Spiller, Michael L. Beeton, Sarah J. Stock, Alan H. Jobe, Matthew S. Payne, Matthew W. Kemp, Boris W. Kramer, Jogchum Plat, Wim G. van Gemert, Tim G.A.M. Wolfs

“…In addition, intestinal bile acids (BAs) accumulation is causally linked to NEC development. …”
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Evaluation of Intestinal Microbial Metabolites in Preterm Infants with Different Initial Feeding Methods by In Vitro Fermentation Modeling System by Yunwei Li, Jingjing Jiang, Liying Zhu, Xin Wang, Weilin Wan, Danhua Wang, Zhenghong Li

“…Group A had lower fecal pH (<i>p</i> = 0.023), ammonia (<i>p</i> = 0.001), and bile acids (<i>p</i> = 0.025). Group B also had higher fecal sIgA levels, both in OD (<i>p</i> = 0.046) and concentration (<i>p</i> < 0.0001) methods. …”
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Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola by Maria João Gouveia, Maria Y. Pakharukova, Gabriel Rinaldi, Viatcheslav A. Mordvinov, Paul J. Brindley, Fátima Gärtner, Nuno Vale, Martin Michaelis

“…F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. …”
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Mitochondrial cholesterol: Metabolism and impact on redox biology and disease by Leire Goicoechea, Laura Conde de la Rosa, Sandra Torres, Carmen García-Ruiz, José C. Fernández-Checa

“…Despite the limited availability of cholesterol in the inner mitochondrial membrane (IMM), the metabolism of cholesterol in the IMM plays important physiological roles, acting as the precursor for the synthesis of steroid hormones and neurosteroids in steroidogenic tissues and specific neurons, respectively, or the synthesis of bile acids through an alternative pathway in the liver. …”
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Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome by Ting Xia, Chaoyan Kang, Xiao Qiang, Xiaodong Zhang, Shaopeng Li, Kai Liang, Yiming Wang, Jianxin Wang, Hui Cao, Min Wang

“…The differential metabolites were mainly included amino acids, carbohydrates and bile acids. Furthermore, after SAV intake, Verrucomicrobia, and Akkermansia closely impacted the related gut metabolites. …”
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Predictive value of serum TBA for 2-year MACEs in ACS patients undergoing PCI: a prospective cohort study by Wen Wen, Qinze Li, Jianqing She, Xiaofang Bai, Lisha Zhang, Ruifeng Li, Yan Wu, Juan Zhou, Zuyi Yuan

“…Abstract Bile acids play important roles in lipid metabolism and glucose homeostasis. …”
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