Discrepancies among healthy, subclinical mastitic, and clinical mastitic cows in fecal microbiome and metabolome and serum metabolome by Yue Wang, Xuemei Nan, Yiguang Zhao, Linshu Jiang, Hui Wang, Fan Zhang, Dengke Hua, Jun Liu, Liang Yang, Junhu Yao, Benhai Xiong

“…Higher levels of proinflammatory lipid products (20-trihydroxy-leukotriene-B4, 13,14-dihydro-15-keto-PGE2, and 9,10-dihydroxylinoleic acids) and lower levels of metabolites involved in secondary bile acids (deoxycholic acid, 12-ketolithocholic acid), energy (citric acid and 3-hydroxyisovalerylcarnitine), and purine metabolism (uric acid and inosine) were identified in both SM and CM cows. …”
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MIAOME: Human microbiome affect the host epigenome by Lidan Wang, Wei Zhang, Xianglu Wu, Xiao Liang, Lijie Cao, Jincheng Zhai, Yiyang Yang, Qiuxiao Chen, Hongqing Liu, Jun Zhang, Yubin Ding, Feng Zhu, Jing Tang

“…Based on the types of epigenetic modifications confirmed in the literature review, the MIAOME database captures 1068 (63 genus, 281 species, 707 strains, etc.) human microbes, 91 unique microbiota-derived metabolites & components (16 fatty acids, 10 bile acids, 10 phenolic compounds, 10 vitamins, 9 tryptophan metabolites, etc.) derived from 967 microbes; 50 microbes that secreted 40 proteins; 98 microbes that directly influence the host epigenetic modification, and provides 3 classifications of the epigenome, including (1) 4 types of DNA modifications, (2) 20 histone modifications and (3) 490 ncRNAs regulations, involved in 160 human diseases. …”
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The role of the gut microbiome in colonization resistance and recurrent infection by Anna Maria Seekatz, Nasia Safdar, Sahil Khanna

“…They subsequently reviewed the efficacy and shortcomings of the following treatments for CDI: - Antibiotics - Monoclonal antibodies - Fecal microbiota transplantation (FMT) Results: Commensal intestinal bacteria prevent colonization of the gut by pathogens using mechanisms such as: - Competition for key nutrients - Production of inhibitory bile acids - Short-chain fatty acid production - Lowering the luminal pH - Production of bacteriocins Antibiotic therapy is recommended as a standard treatment for CDI. …”
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Counteracting gemcitabine+nab-paclitaxel induced dysbiosis in KRAS wild type and KRASG12D mutated pancreatic cancer in vivo model by Concetta Panebianco, Federica Pisati, Annacandida Villani, Annapaola Andolfo, Marynka Ulaszewska, Edoardo Bellini, Carmelapia Ferro, Renato Lombardi, Fabrizio Orsenigo, Tiziana Pia Latiano, Beatrice Belmonte, Claudio Tripodo, Francesco Perri, Valerio Pazienza

“…Mice’ serum metabolomic profiles revealed significant drops in many amino acids upon probiotics administration in KRAS wild-type mice while in animals transplanted with PANC-1 KRASG12D mutated all treated groups showed a sharp decline in serum levels of bile acids with respect to control mice. These results suggest that counteracting gemcitabine+nab-paclitaxel-induced dysbiosis ameliorates chemotherapy side effects by restoring a favorable microbiota composition. …”
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Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder by Ameer Luqman, Ameer Luqman, Adil Hassan, Adil Hassan, Adil Hassan, Mehtab Ullah, Sahar Naseem, Mehraj Ullah, Liyuan Zhang, Ahmad Ud Din, Kamran Ullah, Waqar Ahmad, Guixue Wang, Guixue Wang

“…Furthermore, the gut microbiota acts as an endocrine organ, producing bioactive metabolites such as TMA (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), and bile acids, which have a substantial impact on host wellness and disease by multiple mechanisms. …”
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Hepatitis B virus genotype is an independent prognostic factor of telbivudine and tenofovir treatment in hepatitis B surface antigen‐positive pregnant women by Baofang Zhang, Lei Yu, Mingliang Cheng, Quan Zhang, Jun Wu, Jing Yang, Qin Liu, Shuang Lu, Xueke Zhao, KaiSheng Deng, Yongmei Liu, Jun Wang, Peiling Zhao

“…Blood samples were collected at 12–24, 28–32, and 36–40 weeks of pregnancy for the measurement of genotype, HBsAg, hepatitis B e antigen (HBeAg), HBV DNA, HBV RNA, and liver function, including alanine transaminase, aspartate transaminase, total bilirubin, total bile acids, cholinesterase, alkaline phosphatase (ALP), and gamma‐glutamyl transferase. …”
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Chronic exposure to high-density polyethylene microplastic through feeding alters the nutrient metabolism of juvenile yellow perch (Perca flavescens) by Xing Lu, Dong-Fang Deng, Fei Huang, Fabio Casu, Emma Kraco, Ryan J. Newton, Merry Zohn, Swee J. Teh, Aaron M. Watson, Brian Shepherd, Ying Ma, Mahmound A.O. Dawood, Lorena M. Rios Mendoza

“…Compared to the control treatment, fish fed the 8% HDPE diet had significant accumulations of total bile acids and different metabolism pathways such as bile acid biosynthesis, pyruvate metabolism, and carnitine synthesis. …”
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Disorders peculiarities of the bile-formed and bile-excreting liver functions in the early period of traumatic disease on the background of chronic hepatitis by R. Blyzniuk, T. Dzetsiukh

“…Horbachevsky Ternopil State medical University of the Ministry of Health of Ukraine”   Summary In the early manifestations of traumatic disease after experimental polytrauma at the background of concomitant chronic hepatitis occurs more bile-formed function of the liver, than animals without hepatitis manifested low overall bile acids, bilirubin conjugation violation and increasing bile lithogenic properties. …”
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Analysis of Factors Influencing Prognosis and Assessment of 60 Cases of Decompensated Cirrhotic Patients with Portal Hypertension by Li XF, Liu SR, Li JJ, Liu N, Li HM, Ge AN, Wang LL, Dong XM, Wang H, Liu J, Zhang L, Zhang HD, Gou W

“…Multivariate analysis was conducted to explore the risk factors influencing the occurrence of portal hypertension and adverse prognosis in patients with cirrhosis.Results: In Group A patients with portal hypertension, we observed lower levels of aspartate aminotransferase, laminin, serum hyaluronic acid, type III procollagen N-terminal peptide, total bile acids, and cholylglycine acid compared to Group B. …”
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Integrated Analysis of the Alterations in Gut Microbiota and Metabolites of Mice Induced After Long-Term Intervention With Different Antibiotics by Nan Zhang, Jun Liu, Zhiyun Chen, Ning Chen, Fangyan Gu, Qiushui He, Qiushui He, Qiushui He

“…Decreased levels of short-chain and long-chain fatty acids, bile acids, L-arginine, dopamine, L-tyrosine, and phosphatidylcholine (all p < 0.05) were observed in VAN-treated mice. …”
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Combined transcriptome and metabolome analysis reveals breed-specific regulatory mechanisms in Dorper and Tan sheep by Yuhao Ma, Ganxian Cai, Jianfei Chen, Xue Yang, Guoying Hua, Deping Han, Xinhai Li, Dengzhen Feng, Xuemei Deng

“…Purines, pyrimidines, bile acids, and fatty acid substances were more abundant in Dorper sheep. …”
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Prediction of pre-eclampsia complicated by fetal growth restriction and its perinatal outcome based on an artificial neural network model by Ke-Hua Huang, Feng-Yi Chen, Zhao-Zhen Liu, Jin-Ying Luo, Rong-Li Xu, Ling-Ling Jiang, Jian-Ying Yan

“…The correlation between maternal peripheral blood parameters and perinatal outcomes in pregnant patients with PE complicated by FGR was retrospectively analyzed, and an ANN was constructed to assess the value of the changes in maternal blood parameters in predicting the occurrence of PE complicated by FGR and adverse perinatal outcomes.Results: A total of 15 factors—maternal age, pre-pregnancy body mass index, inflammatory markers (neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio), coagulation parameters (prothrombin time and thrombin time), lipid parameters (high-density lipoprotein, low-density lipoprotein, and triglyceride counts), platelet parameters (mean platelet volume and plateletcrit), uric acid, lactate dehydrogenase, and total bile acids—were correlated with PE complicated by FGR. …”
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Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma by Yang Xie, Runzi Sun, Li Gao, Jibin Guan, Jingyuan Wang, Aaron Bell, Junjie Zhu, Min Zhang, Meishu Xu, Peipei Lu, Xinran Cai, Songrong Ren, Pengfei Xu, Satdarshan P. Monga, Xiaochao Ma, Da Yang, Yulan Liu, Binfeng Lu, Wen Xie

“…Accumulations of secondary bile acids and oxysterols were found in both the serum and liver tissue of LXRα activated mice. …”
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Diet‐Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice by Dominique Debray, Haquima El Mourabit, Fatiha Merabtene, Loïc Brot, Damien Ulveling, Yves Chrétien, Dominique Rainteau, Ivan Moszer, Dominique Wendum, Harry Sokol, Chantal Housset

“…Compared with Cftr+/+ littermates, they displayed increased intestinal permeability and a lack of secondary bile acids together with a low expression of ileal bile acid transporters. …”
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Mechanism of crocin I on ANIT-induced intrahepatic cholestasis by combined metabolomics and transcriptomics by Dandan Song, Pei Zhu, Yankai Dong, Mengchao Wang, Anna Zhao, Hongdong Xia, Yunting Chen, Qingguang Zhou, Lun Xiang, Junyi Zhang, Guangming Luo, Yangjing Luo

“…The serum biochemical indices, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA), total bilirubin (TBIL), direct bilirubin (DBIL), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β), as well as the liver oxidative stress indexes and the pathological characteristics of the liver were analyzed. …”
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The Effect of <i>Yucca schidigera</i> Extract on Serum Metabolites of Angus Crossbreed Steers with Metabolomics by Ziqi Deng, Baoyun Wu, Xin Yi, Jinglei Ma, Yue Liu, Luiz Gustavo Nussio, Qingxiang Meng, Zhenming Zhou, Hao Wu

“…Furthermore, YSE may also increase the expression of bile acid synthesis, thereby promoting DMD, which, in turn, offers more nutrients available for growth.…”
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Dachaihu decoction inhibits hypernutrition-induced liver metastasis from colorectal cancer by maintaining the gut vascular barrier by Ruolei Wang, Fengjing Jia, Zhenguo Zhao, Liqing Du, Lianheng Lu, Dongkui Xu, Feng He

“…The effects of DCHD and OCA on HFD-induced outcomes were evaluated, and human umbilical vein endothelial cells (HUVECs) treated with bile acids (BAs) and DCHD were used to study the underlying mechanisms in vitro. …”
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A multi-omic assessment of the mechanisms of intestinal microbes used to treat diarrhea in early-weaned lambs by Hongran Guo, Jiuzeng Cui, Qian Li, Xuhui Liang, Junda Li, Bohua Yang, Peter Kalds, Yulin Chen, Yuxin Yang

“…In addition, the levels of Streptococcus, Enterococcus, and Escherichia Shigella decreased in the jejunum, cecum, and colon of the lambs; meanwhile, the levels of Bifidobacterium and multiple secondary bile acids, such as ursodeoxycholic acid, increased in the colon. …”
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Maturation of the gut metabolome during the first year of life in humans by Runze Ouyang, Juan Ding, Yan Huang, Fujian Zheng, Sijia Zheng, Yaorui Ye, Qi Li, Xiaolin Wang, Xiao Ma, Yuxin Zou, Rong Chen, Zhihong Zhuo, Zhen Li, Qi Xin, Lina Zhou, Xin Lu, Zhigang Ren, Xinyu Liu, Petia Kovatcheva-Datchary, Guowang Xu

“…Lipid metabolism, especially acylcarnitines and bile acids, was the most abundant metabolic pathway in the newborn gut. …”
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Structure Optimization of 12β-<em>O</em>-γ-Glutamyl Oleanolic Acid Derivatives Resulting in Potent FXR Antagonist/Modulator for NASH Therapy by Hao Ma, Yunyang Bao, Shuaishuai Niu, Shaorong Wang, Yiming Li, Hongwei He, Na Zhang, Weishuo Fang

“…The farnesoid X receptor (FXR) plays a crucial role in regulating the metabolism of bile acids, lipids, and sugars. Consequently, it is implicated in the treatment of various diseases, including cholestasis, diabetes, hyperlipidemia, and cancer. …”
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