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1861
Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4
Published 2022-12-01“…While the levels of the conventional serological biomarkers alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were all concomitantly elevated in serum and tissues after ANIT-induced injury, the levels of bile acids decreased in bile, increased in serum, and ascended in intrahepatic tissue. …”
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1862
Bifidobacterium-derived short-chain fatty acids and indole compounds attenuate nonalcoholic fatty liver disease by modulating gut-liver axis
Published 2023-03-01“…In particular, short-chain fatty acids and tryptophan metabolites were reverted to normal levels by probiotics, whereas bile acids were partially normalized to those of the NC group. …”
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1863
Blood metabolic and physiological profiles of Bama miniature pigs at different growth stages
Published 2022-08-01“…The metabolic profiles contained 14 amino acids and derivatives, six bile acids and derivatives, 19 fatty acids and derivatives, and 22 others. …”
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1864
Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice
Published 2024-12-01“…Moreover, we identified diverse peripheral – central metabolic landscapes between AD and WT mice that featured bile acids (e.g. deoxycholic and isodeoxycholic acid) and unsaturated fatty acids (e.g. 11Z-eicosenoic and palmitoleic acid). …”
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1865
Quality uniformity evaluation of Babao Dan capsule based on its 14 main chemical compounds and in vitro anti-inflammatory activity
Published 2023-11-01“…And the correlation was confirmed that the main compounds related to anti-inflammatory in BBDC were bile acids and saponins. Hence, a QUE strategy for BBDC was proposed to improve quality and ensure efficacy. …”
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1866
Rebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity
Published 2024-02-01“…Whole-genome shotgun sequencing was performed to profile the gut microbiota. Bile acids were measured in the feces, plasma, and liver. …”
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1867
Comparison of gut microbiome composition in colonic biopsies, endoscopically-collected and at-home-collected stool samples
Published 2023-06-01“…The findings may have relevance to health and disease states in which bacterial metabolism has a significant impact on molecules/metabolites that are recirculated between the gut lumen and mucosa and systemic circulation, such as estrogens (as in breast cancer) or bile acids.MethodsConcomitant at-home-collected stool, endoscopically-collected stool, and colonic biopsy samples were collected from 48 subjects (24 breast cancer, 24 control.) …”
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1868
Effects of dietary arsenic exposure on liver metabolism in mice
Published 2024-04-01“…Fecal primary and secondary bile acids, short-chain fatty acids, and branched-chain amino acids were also elevated. …”
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1869
Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome
Published 2020-07-01“…Neither CSS nor ItchRO were associated with serum bile acids (r = −0.08, P = 0.6 for both) or autotaxin (r = 0.22, P = 0.2; r = 0.28, P = 0.12). …”
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1870
Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives
Published 2021-12-01“…Moreover, various metabolites may be involved in the pathogenesis of NAFLD, such as short-chain fatty acids, lipopolysaccharide, bile acids, choline and trimethylamine-N-oxide, and ammonia. …”
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1871
The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease
Published 2023-06-01“…Enterobacterial metabolites such as SCFAs, bile acids, and tryptophan also play important roles in enterobacterial interactions, especially in the progression of IBD. …”
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1872
The Expression Profiles and Deregulation of UDP-Glycosyltransferase (<i>UGT</i>) Genes in Human Cancers and Their Association with Clinical Outcomes
Published 2021-09-01“…The human UDP-glycosyltransferase (UGTs) superfamily has 22 functional enzymes that play a critical role in the metabolism of small lipophilic compounds, including carcinogens, drugs, steroids, lipids, fatty acids, and bile acids. The expression profiles of <i>UGT</i> genes in human cancers and their impact on cancer patient survival remains to be systematically investigated. …”
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1873
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota
Published 2018“…Some mice were fed with a cholestyramine-containing diet for 7 days to sequester their bile acids. Feces were collected and proportions of microbiota were analyzed by 16S rRNA amplicon sequencing and quantitative PCR. …”
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1874
High soluble fiber promotes colorectal tumorigenesis through modulating gut microbiota and metabolites in mice
Published 2024“…Soluble fiber induced gut dysbiosis with Bacteroides uniformis enrichment and Bifidobacterium pseudolongum depletion, accompanied by increased fecal butyrate and serum bile acids and decreased inosine. We also identified a positive correlation between inulin dosage and colorectal tumorigenesis. …”
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Journal Article -
1875
Expression of STING in Women with Morbid Obesity and Nonalcoholic Fatty Liver Disease
Published 2023-03-01“…Positive correlations were observed among hepatic STING mRNA abundance and gamma-glutamyl transferase and alkaline phosphatase levels, hepatic Toll-like receptor 9 expression and some circulating microbiota-derived bile acids. In conclusion, STING may be involved in the outcome and progression of NAFLD and may be related to hepatic lipid metabolism. …”
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1876
Protective effect of the novel cyclic peptide ASK0912 on mice with sepsis induced by Acinetobacter baumannii
Published 2023-08-01“…ASK0912 attenuated organ damage, including reduced levels of total bile acids, urea, and creatinine, aggregation of inflammatory cells, and mitigation of structural changes in septic mice, as demonstrated by biochemical analysis and hematoxylin & eosin staining. …”
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1877
Pharmacokinetic Imaging Using <sup>99m</sup>Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats
Published 2022-03-01“…Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. <sup>99m</sup>Tc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. …”
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1878
Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease
Published 2023-11-01“…Administration of APB-R3 effectively attenuated key diagnostic parameters of PSC such as plasma ALP and GGT levels as well as bile acids levels. We also observed that blockade of IL-18 suppressed ductular reactive and proliferative phenotypes of cholangiocytes. …”
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1879
Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management
Published 2021-02-01“…These protective effects were associated with changes in the hypothalamic gene expression of leptin and leptin receptor as well as with changes in the composition of gut microbiota and the profile of bile acids. This study provides crucial clues to identify new potential probiotics as effective therapeutic approaches in the management of obesity, while also providing some insights into their mechanisms of action.…”
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1880
Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis
Published 2023-03-01“…Farnesoid X receptor-stimulating secondary bile acids including 7-oxo-lithocholic acids upregulated MMP12 and TLR4 in myeloid cells in vitro. …”
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Article