Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4 by Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

“…While the levels of the conventional serological biomarkers alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were all concomitantly elevated in serum and tissues after ANIT-induced injury, the levels of bile acids decreased in bile, increased in serum, and ascended in intrahepatic tissue. …”
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Bifidobacterium-derived short-chain fatty acids and indole compounds attenuate nonalcoholic fatty liver disease by modulating gut-liver axis by Sang Jun Yoon, Jeong Seok Yu, Byeong Hyun Min, Haripriya Gupta, Sung-Min Won, Hee Jin Park, Sang Hak Han, Byung-Yong Kim, Kyung Hwan Kim, Byoung Kook Kim, Hyun Chae Joung, Tae-Sik Park, Young Lim Ham, Do Yup Lee, Ki Tae Suk

“…In particular, short-chain fatty acids and tryptophan metabolites were reverted to normal levels by probiotics, whereas bile acids were partially normalized to those of the NC group. …”
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Blood metabolic and physiological profiles of Bama miniature pigs at different growth stages by Jiayuan Mo, Yujie Lu, Tianqi Xing, Di Xu, Kun Zhang, Shuai Zhang, Yubin Wang, Gang Yan, Ganqiu Lan, Jing Liang

“…The metabolic profiles contained 14 amino acids and derivatives, six bile acids and derivatives, 19 fatty acids and derivatives, and 22 others. …”
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Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice by Yijing Chen, Yinhu Li, Yingying Fan, Shuai Chen, Li Chen, Yuewen Chen, Yu Chen

“…Moreover, we identified diverse peripheral – central metabolic landscapes between AD and WT mice that featured bile acids (e.g. deoxycholic and isodeoxycholic acid) and unsaturated fatty acids (e.g. 11Z-eicosenoic and palmitoleic acid). …”
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Quality uniformity evaluation of Babao Dan capsule based on its 14 main chemical compounds and in vitro anti-inflammatory activity by Anyi Zhao, Yanping Liu, Lianmei Wang, Cong Guo, Jun Zhang, Sha Chen, Qingxia Xu, Jintang Cheng, Yongzhen Lao, Li Che, Zhicheng Lai, Lihua Yang, Yan Liu, An Liu

“…And the correlation was confirmed that the main compounds related to anti-inflammatory in BBDC were bile acids and saponins. Hence, a QUE strategy for BBDC was proposed to improve quality and ensure efficacy. …”
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Rebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity by Arianne Morissette, Alice de Wouters d’Oplinter, Diana Majolli Andre, Marilou Lavoie, Bruno Marcotte, Thibault V. Varin, Jocelyn Trottier, Geneviève Pilon, Martin Pelletier, Patrice D. Cani, Olivier Barbier, Vanessa P. Houde, André Marette

“…Whole-genome shotgun sequencing was performed to profile the gut microbiota. Bile acids were measured in the feces, plasma, and liver. …”
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Comparison of gut microbiome composition in colonic biopsies, endoscopically-collected and at-home-collected stool samples by Christina Nowicki, Christina Nowicki, Lucille Ray, Lucille Ray, Philip Engen, Andrea Madrigrano, Thomas Witt, Thomas Lad, Melody Cobleigh, Ece A. Mutlu, Ece A. Mutlu

“…The findings may have relevance to health and disease states in which bacterial metabolism has a significant impact on molecules/metabolites that are recirculated between the gut lumen and mucosa and systemic circulation, such as estrogens (as in breast cancer) or bile acids.MethodsConcomitant at-home-collected stool, endoscopically-collected stool, and colonic biopsy samples were collected from 48 subjects (24 breast cancer, 24 control.) …”
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Effects of dietary arsenic exposure on liver metabolism in mice by Junli Shao, Chengze Lai, Qiuyi Zheng, Yu Luo, Chengji Li, Bin Zhang, Yanqin Sun, Shizhen Liu, Yingying Shi, Jinglin Li, Zuguo Zhao, Lianxian Guo

“…Fecal primary and secondary bile acids, short-chain fatty acids, and branched-chain amino acids were also elevated. …”
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Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome by Binita M. Kamath, Cathie Spino, Richard McLain, John C. Magee, Emily M. Fredericks, Kenneth D. Setchell, Alexander Miethke, Jean P. Molleston, Cara L. Mack, Robert H. Squires, Estella M. Alonso, Karen F. Murray, Kathleen M. Loomes, M. Kyle Jensen, Saul J. Karpen, Philip Rosenthal, Danny Thomas, Ronald J. Sokol, Benjamin L. Shneider, for the Childhood Liver Disease Research Network (ChiLDReN)

“…Neither CSS nor ItchRO were associated with serum bile acids (r = −0.08, P = 0.6 for both) or autotaxin (r = 0.22, P = 0.2; r = 0.28, P = 0.12). …”
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Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives by Natalia Vallianou, Gerasimos Socrates Christodoulatos, Irene Karampela, Dimitrios Tsilingiris, Faidon Magkos, Theodora Stratigou, Dimitris Kounatidis, Maria Dalamaga

“…Moreover, various metabolites may be involved in the pathogenesis of NAFLD, such as short-chain fatty acids, lipopolysaccharide, bile acids, choline and trimethylamine-N-oxide, and ammonia. …”
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The role of complex interactions between the intestinal flora and host in regulating intestinal homeostasis and inflammatory bowel disease by Siyu Li, Siyu Li, Kan Xu, Kan Xu, Yi Cheng, Lu Chen, Ailin Yi, Zhifeng Xiao, Xuefei Zhao, Minjia Chen, Yuting Tian, Wei Meng, Zongyuan Tang, Shuhong Zhou, Guangcong Ruan, Yanling Wei

“…Enterobacterial metabolites such as SCFAs, bile acids, and tryptophan also play important roles in enterobacterial interactions, especially in the progression of IBD. …”
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The Expression Profiles and Deregulation of UDP-Glycosyltransferase (<i>UGT</i>) Genes in Human Cancers and Their Association with Clinical Outcomes by Dong Gui Hu, Shashikanth Marri, Peter I. Mackenzie, Julie-Ann Hulin, Ross A. McKinnon, Robyn Meech

“…The human UDP-glycosyltransferase (UGTs) superfamily has 22 functional enzymes that play a critical role in the metabolism of small lipophilic compounds, including carcinogens, drugs, steroids, lipids, fatty acids, and bile acids. The expression profiles of <i>UGT</i> genes in human cancers and their impact on cancer patient survival remains to be systematically investigated. …”
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Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota by Wellman, Alicia S., Metukuri, Mallikarjuna R., Kazgan, Nevzat, Xu, Xiaojiang, Xu, Qing, Ren, Natalie S.X., Shanahan, Michael T., Kang, Ashley, Chen, Willa, Azcarate-Peril, M. Andrea, Gulati, Ajay S., Fargo, David C., Li, Xiaoling, Guarente, Leonard Pershing, Czopik, Agnieszka

“…Some mice were fed with a cholestyramine-containing diet for 7 days to sequester their bile acids. Feces were collected and proportions of microbiota were analyzed by 16S rRNA amplicon sequencing and quantitative PCR. …”
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High soluble fiber promotes colorectal tumorigenesis through modulating gut microbiota and metabolites in mice by Yang, Jia, Wei, Hong, Lin, Yufeng, Chu, Eagle S. H., Zhou, Yunfei, Gou, Hongyan, Guo, Shang, Lau, Harry C. H., Cheung, Alvin H. K., Chen, Huarong, To, Ka Fei, Sung, Joseph Jao Yiu, Wang, Yong, Yu, Jun

“…Soluble fiber induced gut dysbiosis with Bacteroides uniformis enrichment and Bifidobacterium pseudolongum depletion, accompanied by increased fecal butyrate and serum bile acids and decreased inosine. We also identified a positive correlation between inulin dosage and colorectal tumorigenesis. …”
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Expression of STING in Women with Morbid Obesity and Nonalcoholic Fatty Liver Disease by Laia Bertran, Laia Adalid, Mercè Vilaró-Blay, Andrea Barrientos-Riosalido, Carmen Aguilar, Salomé Martínez, Fàtima Sabench, Daniel del Castillo, José Antonio Porras, Ajla Alibalic, Cristóbal Richart, Teresa Auguet

“…Positive correlations were observed among hepatic STING mRNA abundance and gamma-glutamyl transferase and alkaline phosphatase levels, hepatic Toll-like receptor 9 expression and some circulating microbiota-derived bile acids. In conclusion, STING may be involved in the outcome and progression of NAFLD and may be related to hepatic lipid metabolism. …”
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Protective effect of the novel cyclic peptide ASK0912 on mice with sepsis induced by Acinetobacter baumannii by Chunyang Xie, Penghe Wang, Huige Wu, Xinxin Hu, Tongying Nie, Xue Li, Pengbo Pang, Guoqing Li, Yun Lu, Xinyi Yang, Xiukun Wang, Congran Li, Xuefu You

“…ASK0912 attenuated organ damage, including reduced levels of total bile acids, urea, and creatinine, aggregation of inflammatory cells, and mitigation of structural changes in septic mice, as demonstrated by biochemical analysis and hematoxylin &amp; eosin staining. …”
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Pharmacokinetic Imaging Using ^99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats by Solène Marie, Irene Hernández-Lozano, Marc Le Vée, Louise Breuil, Wadad Saba, Maud Goislard, Sébastien Goutal, Charles Truillet, Oliver Langer, Olivier Fardel, Nicolas Tournier

“…Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. ^99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. …”
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Disruption of IL-18 signaling via engineered IL-18BP biologics alleviates experimental cholestatic liver disease by Dong-Hyun Kim, Kyeong-Jin Lee, JinJoo Park, Susan Chi, Jaekyu Han, Yewon Bang, Sun-Mi Kim, Seung Goo Kang, Sang-Hoon Cha, Yong-Hyun Han

“…Administration of APB-R3 effectively attenuated key diagnostic parameters of PSC such as plasma ALP and GGT levels as well as bile acids levels. We also observed that blockade of IL-18 suppressed ductular reactive and proliferative phenotypes of cholangiocytes. …”
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Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management by Jeanne Alard, Benoit Cudennec, Denise Boutillier, Véronique Peucelle, Amandine Descat, Raphaël Decoin, Sarah Kuylle, Amin Jablaoui, Moez Rhimi, Isabelle Wolowczuk, Bruno Pot, Anne Tailleux, Emmanuelle Maguin, Sophie Holowacz, Corinne Grangette

“…These protective effects were associated with changes in the hypothalamic gene expression of leptin and leptin receptor as well as with changes in the composition of gut microbiota and the profile of bile acids. This study provides crucial clues to identify new potential probiotics as effective therapeutic approaches in the management of obesity, while also providing some insights into their mechanisms of action.…”
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Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis by Yoichi Takimoto, Po-sung Chu, Nobuhiro Nakamoto, Yuya Hagihara, Yohei Mikami, Kentaro Miyamoto, Rei Morikawa, Toshiaki Teratani, Nobuhito Taniki, Sota Fujimori, Takahiro Suzuki, Yuzo Koda, Rino Ishihara, Masataka Ichikawa, Akira Honda, Takanori Kanai

“…Farnesoid X receptor-stimulating secondary bile acids including 7-oxo-lithocholic acids upregulated MMP12 and TLR4 in myeloid cells in vitro. …”
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