Yak rumen microbiome elevates fiber degradation ability and alters rumen fermentation pattern to increase feed efficiency by Congcong Zhao, Lamei Wang, Shanlin Ke, Xinhua Chen, Ákos Kenéz, Wei Xu, Dangdang Wang, Fan Zhang, Yong Li, Zhanhong Cui, Yu Qiao, Jing Wang, Wenjuan Sun, Jianhua Zhao, Junhu Yao, Zhongtang Yu, Yangchun Cao

“…Differential metabolites are mainly amino acids, carboxylic acids, sugars, and bile acids. Changes in rumen microbial composition could explain the above results. …”
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Fetal Hepatic Lipidome Is More Greatly Affected by Maternal Rate of Gain Compared with Vitamin and Mineral Supplementation at day 83 of Gestation by Ana Clara B. Menezes, Carl R. Dahlen, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, Alison K. Ward, Pawel P. Borowicz, Lawrence P. Reynolds, Kevin K. Sedivec, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Matthew S. Crouse

“…Levels of secondary bile acids were impacted by VMSUP, being greater (<i>p</i> ≤ 0.0048) in NoVTM than in VTM fetal livers. …”
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Plasma, urine, and stool metabolites in response to dietary rice bran and navy bean supplementation in adults at high-risk for colorectal cancer by Emily B. Hill, Bridget A. Baxter, Brigitte Pfluger, Caroline K. Slaughter, Melanie Beale, Hillary V. Smith, Sophia S. Stromberg, Madison Tipton, Hend Ibrahim, Hend Ibrahim, Sangeeta Rao, Heather Leach, Elizabeth P. Ryan, Elizabeth P. Ryan

“…Stool was also analyzed for primary and secondary bile acids (BAs) and short chain fatty acids (SCFAs) by UPLC-MS/MS and microbial community structure via 16S amplicon sequencing. …”
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Laminin 511-E8, an autoantigen in IgG4-related cholangitis, contributes to cholangiocyte protection by David C. Trampert, Remco Kersten, Dagmar Tolenaars, Aldo Jongejan, Stan F.J. van de Graaf, Ulrich Beuers

“…Laminin 511 enhances cholangiocellular barrier function and protects cholangiocytes against T lymphocyte-induced barrier dysfunction, toxic bile acid permeation and bile acid-induced apoptosis. …”
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Sphingosine 1-phosphate receptor 2 promotes the onset and progression of non-alcoholic fatty liver disease-related hepatocellular carcinoma through the PI3K/AKT/mTOR pathway by Ganggang Wang, Xin Zhang, Zhijie Zhou, Chao Song, Wenzhi Jin, Hao Zhang, Weixin Wu, Yong Yi, Hengguan Cui, Ping Zhang, Xinyu Liu, Weiqiang Xu, Xiaowei Shen, Weixing Shen, Xiaoliang Wang

“…Furthermore, the association of Sphingosine 1-phosphate receptor 2 (S1PR2) with various types of tumours is identified, and the metabolism of conjugated bile acids (CBAs) performs an essential function in the onset and development of HCC. …”
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Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior by Monica Barone, Silvia Garelli, Simone Rampelli, Alessandro Agostini, Silke Matysik, Federica D’Amico, Sabrina Krautbauer, Roberta Mazza, Nicola Salituro, Flaminia Fanelli, Patricia Iozzo, Yolanda Sanz, Marco Candela, Patrizia Brigidi, Uberto Pagotto, Silvia Turroni

“…Consistently, high amounts of primary bile acids as well as sterols were found in their feces. …”
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Natural emulsifiers lecithins preserve gut microbiota diversity in relation with specific faecal lipids in high fat-fed mice by Chloé Robert, Armelle Penhoat, Leslie Couëdelo, Magali Monnoye, Dominique Rainteau, Emmanuelle Meugnier, Sofia Bary, Hélène Abrous, Emmanuelle Loizon, Pranvera Krasniqi, Stéphanie Chanon, Aurélie Vieille-Marchiset, François Caillet, Sabine Danthine, Hubert Vidal, Nicolas Guillot, Philippe Gérard, Carole Vaysse, Marie-Caroline Michalski

“…Lecithins did not enhance HFD-induced adiposity nor increased inflammation, did not alter gut barrier markers and caecal bile acids, and contributed to n-3 PUFA status. Lecithins improved gut microbiota diversity. …”
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Rumen-protected choline reduces hepatic lipidosis by increasing hepatic triacylglycerol-rich lipoprotein secretion in dairy cows by U. Arshad, A. Husnain, M.B. Poindexter, R. Zimpel, C.D. Nelson, J.E.P. Santos

“…Feeding RPC tended to increase the concentrations of 89 metabolites in serum, after adjusting for false discovery, including 3 acylcarnitines, 1 AA-related metabolite, 11 bile acids, 1 ceramide, 6 diacylglycerols, 2 dihydroceramides, 1 glycerophospholipid, and 64 triacylglycerols compared with CON. …”
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Altered metabolome and microbiome associated with compromised intestinal barrier induced hepatic lipid metabolic disorder in mice after subacute and subchronic ozone exposure by Wenjia Lu, Chonggui Jiang, Yajie Chen, Zhonghua Lu, Xueli Xu, Liting Zhu, Haotong Xi, Guozhu Ye, Changzhou Yan, Jinsheng Chen, Jie Zhang, Li Zuo, Qiansheng Huang

“…The abundance of Muribaculaceae increased dose-dependently in both colon and cecum, and was associated with the decrease of metabolites such as bile acids, betaine, and L-carnitine, which subsequently disrupted the intestinal barrier and lipid metabolism. …”
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Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers by Vanessa Zhu, Vanessa Zhu, Jürgen Burhenne, Jürgen Burhenne, Johanna Weiss, Johanna Weiss, Mathias Haag, Mathias Haag, Ute Hofmann, Ute Hofmann, Matthias Schwab, Matthias Schwab, Matthias Schwab, Stephan Urban, Stephan Urban, Gerd Mikus, Gerd Mikus, David Czock, David Czock, Walter E. Haefeli, Walter E. Haefeli, Antje Blank, Antje Blank

“…As expected, total bile acids increased substantially (35-fold) compared to baseline during bulevirtide treatment. …”
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Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome but Affects Amino Acid Metabolism in Sera of Obese Girls With Polycystic Ovary Syndrome by Beza Tayachew, Beza Tayachew, Heidi Vanden Brink, Heidi Vanden Brink, Yesenia Garcia-Reyes, Haseeb Rahat, Angelo D'Alessandro, Daniel N. Frank, Charles E. Robertson, Lori Silveira, Lori Silveira, Megan Kelsey, Megan Kelsey, Laura Pyle, Laura Pyle, Melanie Cree-Green, Melanie Cree-Green

“…A higher %relative abundance of family Ruminococcaceae was significantly associated with serum bile acids and HOMA-IR.Conclusion: Despite hormone and serum amino acid differences, girls treated with OCP had similar metabolic and gut microbiome profiles compared to the untreated PCOS group. …”
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禁食和再进食触发胆汁酸谱和肠道微生物群的特异性变化 by Yi Zhang, Hongyan Qi, Long Wang, Chunyan Hu, Aibo Gao, Qihan Wu, Qiaoling Wang, Huibin Lin, Banru Chen, Xingyu Wang, Shuangyuan Wang, Hong Lin, Weiqing Wang, Yufang Bi, Jiqiu Wang, Jieli Lu, Ruixin Liu

“…Abstract Background Bile acids (BAs) are closely related to nutrient supply and modified by gut microbiota. …”
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Harnessing the power within: engineering the microbiome for enhanced gynecologic health by Caitriona Brennan, Kristina Chan, Tanya Kumar, Erica Maissy, Linda Brubaker, Marisol I Dothard, Jack A Gilbert, Katharine E Gilbert, Amanda L Lewis, Varykina G Thackray, Amir Zarrinpar, Rob Knight

“…The gut microbiota’s production of short-chain fatty acids, metabolism of primary bile acids, and modulation of sex steroid levels have significant implications for the interplay between host and microbes throughout the body, ultimately impacting reproductive health. …”
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Influence of dietary supplementation with new Lactobacillus strains on hematology, serum biochemistry, nutritional status, digestibility, enzyme activities, and immunity in dogs by Sathita Areerat, Pipatpong Chundang, Pornsucha Palaseweenun, Nattaphong Akrimajirachoote, Jaruwan Sitdhipo, Punnathorn Thaveethaptaikul, Pennapa Chonpathompikunlert, Kanidta Niwasabutra, Pongsathon Phapugrangkul, Attawit Kovitvadhi

“…Probiotics are characterized by their potential to endure low pH levels and high concentrations of bile acids in the gastrointestinal tract. Lactobacilli are more acid-tolerant and resistant to bile acid, so they are ideal probiotics to be added to the canine diet. …”
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Rosa roxburghii Tratt juice can improve S-adenosylmethionine consumption and liver damage induced by arsenic in rats by Lu MA, Jiaxin LYU, Luming YANG, Daopeng LUO, Kai ZHU, Aihua ZHANG

“…Histopathological changes of rat liver were observed by hematoxylin-eosin (HE) staining. Total bile acids (TBA) and γ-glutamyl transpeptidase (γ-GT) were detected by enzyme cycle method and rate method, respectively. …”
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Integrative metabolomic and transcriptomic analysis reveals difference in glucose and lipid metabolism in the longissimus muscle of Luchuan and Duroc pigs by Liyan Deng, Liyan Deng, Liyan Deng, Liyan Deng, Wangchang Li, Wangchang Li, Wangchang Li, Wangchang Li, Wangchang Li, Weiwei Liu, Weiwei Liu, Weiwei Liu, Weiwei Liu, Yanwen Liu, Yanwen Liu, Yanwen Liu, Bingkun Xie, Martien A. M. Groenen, Ole Madsen, Xiaogan Yang, Zhonglin Tang, Zhonglin Tang, Zhonglin Tang, Zhonglin Tang, Zhonglin Tang

“…Most differentially accumulated metabolites (DAMs) upregulated in Luchuan were glycerophospholipids, fatty acids, oxidized lipids, alcohols, and amines, while metabolites downregulated in Luchuan were mostly amino acids, organic acids and nucleic acids, bile acids and hormones. From our RNA-sequencing (RNA-seq) data we identified a total of 3638 differentially expressed genes (DEGs), 1802 upregulated and 1836 downregulated in Luchuan skeletal muscle compared to Duroc. …”
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Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach by Jesús M. Urman, José M. Herranz, Iker Uriarte, María Rullán, Daniel Oyón, Belén González, Ignacio Fernandez-Urién, Juan Carrascosa, Federico Bolado, Lucía Zabalza, María Arechederra, Gloria Alvarez-Sola, Leticia Colyn, María U. Latasa, Leonor Puchades-Carrasco, Antonio Pineda-Lucena, María J. Iraburu, Marta Iruarrizaga-Lejarreta, Cristina Alonso, Bruno Sangro, Ana Purroy, Isabel Gil, Lorena Carmona, Francisco Javier Cubero, María L. Martínez-Chantar, Jesús M. Banales, Marta R. Romero, Rocio I.R. Macias, Maria J. Monte, Jose J. G. Marín, Juan J. Vila, Fernando J. Corrales, Carmen Berasain, Maite G. Fernández-Barrena, Matías A. Avila

“…Comprehensive analyses of lipids, bile acids and small molecules were carried out using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (¹H-NMR) in all patients. …”
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Mass Spectrometry in Metabolomics : Methods and Protocols / by Raftery, Daniel, editor

Role of brain-gut-muscle axis in human health and energy homeostasis by Yunju Yin, Yunju Yin, Qiuping Guo, Xihong Zhou, Yehui Duan, Yuhuan Yang, Yuhuan Yang, Saiming Gong, Saiming Gong, Mengmeng Han, Mengmeng Han, Yating Liu, Zhikang Yang, Qinghua Chen, Fengna Li, Fengna Li

“…Intestinal microbial metabolites, such as short-chain fatty acids (SCFAs), bile acids (BAs) and tryptophan metabolites, communicate with the central nervous system (CNS) by binding to their receptors. …”
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Cholecystectomy is associated with a higher risk of irritable bowel syndrome in the UK Biobank: a prospective cohort study by Jinyu Zhao, Jinyu Zhao, Liang Tian, Liang Tian, Bin Xia, Bin Xia, Bin Xia, Ningning Mi, Ningning Mi, Qiangsheng He, Qiangsheng He, Qiangsheng He, Man Yang, Danni Wang, Siqing Wu, Zijun Li, Shiyong Zhang, Xianzhuo Zhang, Xianzhuo Zhang, Ping Yue, Yanyan Lin, Haitong Zhao, Baoping Zhang, Baoping Zhang, Zelong Ma, Zelong Ma, Ningzu Jiang, Ningzu Jiang, Matu Li, Matu Li, Jinqiu Yuan, Jinqiu Yuan, Jinqiu Yuan, Peng Nie, Linzhi Lu, Wenbo Meng, Wenbo Meng

“…Background: Recent studies have shown that bile acids are essential in irritable bowel syndrome (IBS) pathology, and cholecystectomy has direct effects on bile acid metabolism. …”
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