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1961
The Impact of Highly Effective CFTR Modulators on Growth and Nutrition Status
Published 2021-08-01“…Below, we summarize the effects of highly effective CFTR modulators on nutritional status overall as well as specific factors including bile acid metabolism, pancreatic function, energy expenditure, and intestinal dysbiosis. …”
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1962
2073
Published 2017-09-01“…Primary outcomes will be fecal bile acid excretion and profile, short-chain fatty acid (SCFA) excretion and profile, colonic transit, and fecal microbiota. …”
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1963
TGR5 Signaling in Hepatic Metabolic Health
Published 2020-08-01“…TGR5 is a G protein-coupled bile acid receptor that is increasingly recognized as a key regulator of glucose homeostasis. …”
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1964
Recurrent Intrahepatic Cholestasis of Pregnancy with History of Fetal Demise
Published 2023-08-01“…Her liver enzymes, bilirubin levels, and serum bile acid levels were all abnormally high. She also disclosed similar symptoms in her previous pregnancy, which resulted in fetal death at the sixth month. …”
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1965
Free Cholesterol Affects the Function and Localization of Human Na<sup>+</sup>/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1)
Published 2022-07-01“…These results demonstrate that increased cholesterol levels can impair NTCP and OCT1 function, suggesting that the free cholesterol content of the liver can alter bile acid and drug uptake into the liver. This could explain the increased plasma bile acid levels in NAFLD and NASH patients and potentially lead to altered drug disposition.…”
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1966
Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA.
Published 2017-01-01“…Bile salt hydrolase (BSH) activity against the bile acid tauro-beta-muricholic acid (T-β-MCA) was recently reported to mediate host bile acid, glucose, and lipid homeostasis via the farnesoid X receptor (FXR) signaling pathway. …”
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1967
Liquiritin ameliorates metabolic and endocrine alterations in a mouse model of polycystic ovary syndrome
Published 2022-06-01“…Objective:. Altered bile acid transformation induces low-grade chronic inflammation and may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS). …”
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1968
Chemical composition of gallstone in Tibetans from Tibet Autonomous Region
Published 2023-09-01“…Results Among 106 cases of cholecystolithiasis, 8.49% (9 cases) were cholesterol gallstones with cholesterol content of 534(528,725)μg/mg; 19.81% (21 cases) were pigment stones, and the content of bile pigment was 320(311,413)μg/mg; 71.69% (76 cases) were other types of stones; At the same time, bile acid with different contents was detected in three types of stones, and the content of bile acid in other types of stones was 22(12,33)μg/mg; The content of calcium, zinc and sulfur in pigment stone was relatively high(P<0.05), but the content of iron didn′t show had significant difference. …”
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1969
Prebiotics Together with Raspberry Polyphenolic Extract Mitigate the Development of Nonalcoholic Fatty Liver Diseases in Zucker Rats
Published 2023-07-01“…These changes may result from the upregulation of FXR and AHR receptors in the liver, which are responsible for regulating lipid metabolism and glucose and bile acid synthesis. The reduced bile acid levels in the cecal contents confirmed the activation of liver mechanisms. …”
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1970
Pseudohypoadrenalism, a subclinical cortisol metabolism disorder in hyperuricemia
Published 2023-11-01“…Unregulated biosynthesis pathway of bile acid expanded bile acid pool, and further aggravated cholestatic liver injury.…”
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1971
Effects of Intestinal FXR-Related Molecules on Intestinal Mucosal Barriers in Biliary Tract Obstruction
Published 2022-06-01“…Background: The farnesoid X receptor (FXR) is a key factor regulating hepatic bile acid synthesis and enterohepatic circulation. …”
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1972
Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin
Published 2005-08-01“…The combination of ezetimibe with other hypolipidemic drugs (statins, fibrates, bile acid sequestrants) is described in detail. Initial doses of various statins, together with one tablet (10 mg) of ezetimibe, reduce low-density cholesterol level as effectively as maximal statin doses.…”
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1973
Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34
Published 2020-12-01“…Similarly, melatonin reduced bile acid-induced proapoptotic caspase 3 and Bim levels. …”
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1974
The Surging Function of Nanotechnology in the Management of Primary Biliary Cholangitis with Obeticholic Acid
Published 2023-05-01“…Obeticholic acid (OCA), also known as 6alpha-ethyl-3alpha,7alpha-dihydroxy-5-cholon-24-oic acid, is a semi-synthetic derivative of chenodeoxycholic acid (CDCA, 3alpha,7alpha, dihydroxy-5-cholon-24-oic acid), a primary bile acid that is produced in the liver from cholesterol and is comparatively hydrophobic. …”
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Article -
1975
Effects of Tartary Buckwheat Protein on Gut Microbiome and Plasma Metabolite in Rats with High-Fat Diet
Published 2021-10-01“…The potential mechanism of action is, on the one hand, to increase the abundance of the Lachnospiraceae and the Ruminococcaceae by modulating the gut microbiota, facilitating the productivity of short-chain fatty acids, and increasing fecal bile acid excretion and, on the other hand, may be related to the improvement of bile acid metabolism.…”
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1976
Biodegradation of Cholesterol by <i>Enterococcus faecium</i> YY01
Published 2023-12-01“…Choloylglycine hydrolase, acyltransferase, and alkyl sulfatase was encoded by gene0586, gene1890, and gene2442, which play crucial roles in converting 3α, 7α, 12α-trihydroxy-5β-choranic acid to choline-CoA and then choline-CoA to bile acid. Notably, choloylglycine hydrolase was closely related to the biosynthesis of both primary and secondary bile acid. …”
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1977
A Pilot Study of whether or Not Vegetable and Fruit Juice Containing <i>Lactobacillus paracasei</i> Lowers Blood Lipid Levels and Oxidative Stress Markers in Thai Patients with Dys...
Published 2022-05-01“…This study investigated the effect of consuming vegetable and fruit juice (VFJ) with (probiotic group) and without probiotic <i>Lactobacillus paracasei</i> (placebo group), on the body weight, body mass index, waist circumference, lipid profile, lipid peroxidation, oxidative stress enzymes, and bile acid level in dyslipidemic patients (n = 20) at Bhumibol Adulyadej Hospital for 30 days. …”
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1978
A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
Published 2022-01-01“…The liquid chromatography–mass spectrometry results showed that the mixed oil promoted bile acid conjugated with taurine and glycine, thus activating G-protein-coupled bile acid receptor 1 for improved lipids metabolism. …”
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1979
Cholesterol-Lowering Effects of Asperidine B, a Pyrrolidine Derivative from the Soil-Derived Fungus <i>Aspergillus sclerotiorum</i> PSU-RSPG178: A Potential Cholesterol Absorption...
Published 2022-07-01“…The results show that both compounds interfered with cholesterol micelle formation by increasing bile acid binding capacity, similar to the action of the bile acid sequestrant drug cholestyramine. …”
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1980
Hepatic‐Accumulated Obeticholic Acid and Atorvastatin Self‐Assembled Nanocrystals Potentiate Ameliorative Effects in Treatment of Metabolic‐Associated Fatty Liver Disease
Published 2024-03-01“…Such carrier‐free nanocrystals (OCAHTs) are self‐assembled, not only improving the stability in gastroenteric environments but also achieving hepatic accumulation through the bile acid transporter‐mediated enterohepatic recycling process. …”
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