The Impact of Highly Effective CFTR Modulators on Growth and Nutrition Status by Rosara Bass, Jefferson N. Brownell, Virginia A. Stallings

“…Below, we summarize the effects of highly effective CFTR modulators on nutritional status overall as well as specific factors including bile acid metabolism, pancreatic function, energy expenditure, and intestinal dysbiosis. …”
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2073 by Andrea Shin, David Nelson, John Wo, Michael Camilleri, Anita Gupta, Arturo Carrillo, Huiping Xu

“…Primary outcomes will be fecal bile acid excretion and profile, short-chain fatty acid (SCFA) excretion and profile, colonic transit, and fecal microbiota. …”
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TGR5 Signaling in Hepatic Metabolic Health by Marlena M. Holter, Margot K. Chirikjian, Viraj N. Govani, Bethany P. Cummings

“…TGR5 is a G protein-coupled bile acid receptor that is increasingly recognized as a key regulator of glucose homeostasis. …”
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Recurrent Intrahepatic Cholestasis of Pregnancy with History of Fetal Demise by Mulu Z, Nur A, Belachew H, Assefa W

“…Her liver enzymes, bilirubin levels, and serum bile acid levels were all abnormally high. She also disclosed similar symptoms in her previous pregnancy, which resulted in fetal death at the sixth month. …”
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Free Cholesterol Affects the Function and Localization of Human Na⁺/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1) by Jessica Y. Idowu, Bruno Hagenbuch

“…These results demonstrate that increased cholesterol levels can impair NTCP and OCT1 function, suggesting that the free cholesterol content of the liver can alter bile acid and drug uptake into the liver. This could explain the increased plasma bile acid levels in NAFLD and NASH patients and potentially lead to altered drug disposition.…”
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Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA. by Michael DiMarzio, Brigida Rusconi, Neela H Yennawar, Mark Eppinger, Andrew D Patterson, Edward G Dudley

“…Bile salt hydrolase (BSH) activity against the bile acid tauro-beta-muricholic acid (T-β-MCA) was recently reported to mediate host bile acid, glucose, and lipid homeostasis via the farnesoid X receptor (FXR) signaling pathway. …”
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Liquiritin ameliorates metabolic and endocrine alterations in a mouse model of polycystic ovary syndrome by Zhi Li, Yan Liu, Hai-Ou Liu, Zhi-Yong Wu, Cong-Jian Xu, Fei-Fei Zhang, Yong-Qing Zhu

“…Objective:. Altered bile acid transformation induces low-grade chronic inflammation and may play an important role in the pathophysiology of polycystic ovary syndrome (PCOS). …”
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Chemical composition of gallstone in Tibetans from Tibet Autonomous Region by CHEN Biao, Dawa, Basangdunzhu, Rensang, Suolangduojie

“…Results Among 106 cases of cholecystolithiasis, 8.49% (9 cases) were cholesterol gallstones with cholesterol content of 534(528,725)μg/mg; 19.81% (21 cases) were pigment stones, and the content of bile pigment was 320(311,413)μg/mg; 71.69% (76 cases) were other types of stones; At the same time, bile acid with different contents was detected in three types of stones, and the content of bile acid in other types of stones was 22(12,33)μg/mg; The content of calcium, zinc and sulfur in pigment stone was relatively high(P＜0.05), but the content of iron didn′t show had significant difference. …”
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Prebiotics Together with Raspberry Polyphenolic Extract Mitigate the Development of Nonalcoholic Fatty Liver Diseases in Zucker Rats by Bartosz Fotschki, Michał Sójka, Monika Kosmala, Jerzy Juśkiewicz

“…These changes may result from the upregulation of FXR and AHR receptors in the liver, which are responsible for regulating lipid metabolism and glucose and bile acid synthesis. The reduced bile acid levels in the cecal contents confirmed the activation of liver mechanisms. …”
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Pseudohypoadrenalism, a subclinical cortisol metabolism disorder in hyperuricemia by Ruixia Bao, Beibei Chen, Jujie Pan, Alexander Wang, Haiyang Yu, Qian Chen, Yi Zhang, Tao Wang, Tao Wang

“…Unregulated biosynthesis pathway of bile acid expanded bile acid pool, and further aggravated cholestatic liver injury.…”
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Effects of Intestinal FXR-Related Molecules on Intestinal Mucosal Barriers in Biliary Tract Obstruction by Meng Yan, Meng Yan, Li Hou, Yaoyao Cai, Hanfei Wang, Yujun Ma, Qiming Geng, Weiwei Jiang, Weibing Tang

“…Background: The farnesoid X receptor (FXR) is a key factor regulating hepatic bile acid synthesis and enterohepatic circulation. …”
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Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin by D. M. Aronov

“…The combination of ezetimibe with other hypolipidemic drugs (statins, fibrates, bile acid sequestrants) is described in detail. Initial doses of various statins, together with one tablet (10 mg) of ezetimibe, reduce low-density cholesterol level as effectively as maximal statin doses.…”
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Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34 by Ewa Ostrycharz, Urszula Wasik, Agnieszka Kempinska-Podhorodecka, Jesus M. Banales, Piotr Milkiewicz, Malgorzata Milkiewicz

“…Similarly, melatonin reduced bile acid-induced proapoptotic caspase 3 and Bim levels. …”
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The Surging Function of Nanotechnology in the Management of Primary Biliary Cholangitis with Obeticholic Acid by Devyani Patil, Javesh Patil, Mamta Patil, Tejasweeni Girase, Kiran Patel

“…Obeticholic acid (OCA), also known as 6alpha-ethyl-3alpha,7alpha-dihydroxy-5-cholon-24-oic acid, is a semi-synthetic derivative of chenodeoxycholic acid (CDCA, 3alpha,7alpha, dihydroxy-5-cholon-24-oic acid), a primary bile acid that is produced in the liver from cholesterol and is comparatively hydrophobic. …”
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Effects of Tartary Buckwheat Protein on Gut Microbiome and Plasma Metabolite in Rats with High-Fat Diet by Jing Liu, Yu Song, Qi Zhao, Yuguo Wang, Congshou Li, Liang Zou, Yichen Hu

“…The potential mechanism of action is, on the one hand, to increase the abundance of the Lachnospiraceae and the Ruminococcaceae by modulating the gut microbiota, facilitating the productivity of short-chain fatty acids, and increasing fecal bile acid excretion and, on the other hand, may be related to the improvement of bile acid metabolism.…”
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Biodegradation of Cholesterol by <i>Enterococcus faecium</i> YY01 by Ruimin Yang, Shahbaz Ahmad, Hongyan Liu, Qianqian Xu, Chunhua Yin, Yang Liu, Haiyang Zhang, Hai Yan

“…Choloylglycine hydrolase, acyltransferase, and alkyl sulfatase was encoded by gene0586, gene1890, and gene2442, which play crucial roles in converting 3α, 7α, 12α-trihydroxy-5β-choranic acid to choline-CoA and then choline-CoA to bile acid. Notably, choloylglycine hydrolase was closely related to the biosynthesis of both primary and secondary bile acid. …”
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A Pilot Study of whether or Not Vegetable and Fruit Juice Containing <i>Lactobacillus paracasei</i> Lowers Blood Lipid Levels and Oxidative Stress Markers in Thai Patients with Dys... by Pattharaparn Siripun, Chaiyavat Chaiyasut, Narissara Lailerd, Netnapa Makhamrueang, Ekkachai Kaewarsar, Sasithorn Sirilun

“…This study investigated the effect of consuming vegetable and fruit juice (VFJ) with (probiotic group) and without probiotic <i>Lactobacillus paracasei</i> (placebo group), on the body weight, body mass index, waist circumference, lipid profile, lipid peroxidation, oxidative stress enzymes, and bile acid level in dyslipidemic patients (n = 20) at Bhumibol Adulyadej Hospital for 30 days. …”
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A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice by Sisi Yan, Sha Liu, Jianyu Qu, Xiaowen Li, Jiahao Hu, Linyu Zhang, Xiangyan Liu, Xin Li, Xianglin Wang, Lixin Wen, Ji Wang

“…The liquid chromatography–mass spectrometry results showed that the mixed oil promoted bile acid conjugated with taurine and glycine, thus activating G-protein-coupled bile acid receptor 1 for improved lipids metabolism. …”
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Cholesterol-Lowering Effects of Asperidine B, a Pyrrolidine Derivative from the Soil-Derived Fungus <i>Aspergillus sclerotiorum</i> PSU-RSPG178: A Potential Cholesterol Absorption... by Atcharaporn Ontawong, Acharaporn Duangjai, Yaowapa Sukpondma, Kwanruthai Tadpetch, Chatchai Muanprasat, Vatcharin Rukachaisirikul, Jakkapong Inchai, Chutima S. Vaddhanaphuti

“…The results show that both compounds interfered with cholesterol micelle formation by increasing bile acid binding capacity, similar to the action of the bile acid sequestrant drug cholestyramine. …”
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Hepatic‐Accumulated Obeticholic Acid and Atorvastatin Self‐Assembled Nanocrystals Potentiate Ameliorative Effects in Treatment of Metabolic‐Associated Fatty Liver Disease by Huanfen Lu, Zhenglan Ban, Kai Xiao, Madi Sun, Yongbo Liu, Fangman Chen, Tongfei Shi, Li Chen, Dan Shao, Ming Zhang, Wei Li

“…Such carrier‐free nanocrystals (OCAHTs) are self‐assembled, not only improving the stability in gastroenteric environments but also achieving hepatic accumulation through the bile acid transporter‐mediated enterohepatic recycling process. …”
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