Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes por Junyoung Park, Andrés Peña-Tauber, Lia Talozzi, Michael D. Greicius, Yann Le Guen

“…We conducted a survival analysis in European ancestry participants of the UK Biobank, using age-at-death (N=35,551) and last-known-age (N=358,282). …”
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“It’s Actually Part of Clinical Care”. Mediating Biobanking Assets in the Entrepreneurial Hospital por Martin French, Fiona A. Miller, Renata Axler

Materias: “…biobanks…”
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Generalizability of PGS313 for breast cancer risk in a Los Angeles biobank por Helen Shang, Yi Ding, Vidhya Venkateswaran, Kristin Boulier, Nikhita Kathuria-Prakash, Parisa Boodaghi Malidarreh, Jacob M. Luber, Bogdan Pasaniuc

“…One of the most well-validated PGSs in breast cancer to date is PGS313, which was developed from a Northern European biobank but has shown attenuated performance in non-European ancestries. …”
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Prediction of atrial fibrillation and stroke using machine learning models in UK Biobank por Areti Papadopoulou, Daniel Harding, Greg Slabaugh, Eirini Marouli, Panos Deloukas

“…Methods: To develop ML models for prediction of 1) AF in the general population and 2) ischemic stroke in patients with AF we constructed XGBoost, LightGBM, Random Forest, Deep Neural Network, Support Vector Machine and Lasso penalised logistic regression models using UK-Biobank's extensive real-world clinical data, questionnaires, as well as biochemical and genetic data, and their predictive performances were compared. …”
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TransferGWAS of T1-weighted brain MRI data from UK Biobank. por Alexander Rakowski, Remo Monti, Christoph Lippert

“…Nowadays, large-scale cohorts such as UK Biobank (UKB) collect imaging data with sample sizes large enough to perform genetic association testing. …”
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Investigating the impact of steroid dependence on gastrointestinal surgical outcomes from UK Biobank por Uri Kartoun, Akira Koseki, Akihiro Kosugi, Kingsley Njoku, Tesfaye Yadete, Eileen Koski, Joao Bettencourt-Silva, Natasha Mulligan, Jianying Hu, Julia Liu, Thaddeus Stappenbeck, Vibha Anand

“…We identified subjects in the UK Biobank general practice dataset with at least one major GI surgery and followed them for at least 5 years to evaluate subsequent operations. …”
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Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank por Thomas G. Brooks, Nicholas F. Lahens, Gregory R. Grant, Yvette I. Sheline, Garret A. FitzGerald, Carsten Skarke

“…Here, we investigated the association of wrist temperature amplitudes with a future onset of disease in the UK Biobank one year after actigraphy. Among 425 disease conditions (range n = 200-6728) compared to controls (range n = 62,107-91,134), a total of 73 (17%) disease phenotypes were significantly associated with decreased amplitudes of wrist temperature (Benjamini-Hochberg FDR q < 0.05) and 26 (6.1%) PheCODEs passed a more stringent significance level (Bonferroni-correction α < 0.05). …”
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A Survey on the Role of Artificial Intelligence in Biobanking Studies: A Systematic Review por Gopi Battineni, Mohmmad Amran Hossain, Nalini Chintalapudi, Francesco Amenta

Materias: “…biobanks…”
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Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort por Neave ME Corcoran, Frances S Mair, Barbara Nicholl, Sara Macdonald, Bhautesh Dinesh Jani

“…Methods Longitudinal analysis of the UK Biobank cohort, participants recruited 2006–2010; N = 500,195; excluding previous CRC at baseline. …”
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Detecting Parkinson’s Disease from Wrist-Worn Accelerometry in the U.K. Biobank por James R. Williamson, Brian Telfer, Riley Mullany, Karl E. Friedl

Materias: Enlace del recurso

Association between household size and risk of incident dementia in the UK Biobank study por Chao-Hua Cong, Pan-Long Li, Yuan Qiao, Yu-Na Li, Jun-Ting Yang, Lei Zhao, Xi-Rui Zhu, Shan Tian, Shan-Shan Cao, Jian-Ren Liu, Jing-Jing Su

“…This prospective cohort study was based on UK Biobank participants aged ≥ 50 years without a history of dementia. …”
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Alcohol consumption and its correlation with medical conditions: a UK Biobank study por Craig S. Mayer, Paul Fontelo

Materias: Enlace del recurso

Evolving population data linkage services to transform large-scale biobanking services por Katie Irvine, Vivienna Ong, Simon Cooper, Sarah Thackway

“…Conclusion/Implications Modest changes to population data infrastructure have significant potential to enhance biobank research infrastructure. By fast tracking biospecimen accrual for diseases of population subgroups of strategic importance, this new service is intended to promote biobank viability, accelerate the pace of clinical trials recruitment and improve patient access to trials.…”
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Association between constipation and incident chronic kidney disease in the UK Biobank study por Kipyo Kim, Won-Hee Cho, Seun Deuk Hwang, Seoung Woo Lee, Joon Ho Song

“…We analyzed longitudinal data from the UK Biobank, which links baseline assessment data with follow-up data from hospital episode statistics and general practice records. …”
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Non-Fungible Tokens for Organoids: Decentralized Biobanking to Empower Patients in Biospecimen Research por William Sanchez, Larue Linder, Robert Miller, Amelia Hood, Marielle Gross

Materias: “…blockchain, decentralized biobanking, human cancer models, non-fungible tokens, organoids, web3…”
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Association of cigarette smoking, smoking cessation with the risk of cardiometabolic multimorbidity in the UK Biobank por Shuo Zhang, Zhou Jiang, Hao Zhang, Yuxin Liu, Jike Qi, Yu Yan, Ting Wang, Ping Zeng

Materias: Enlace del recurso

Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank por Kathryn E. Kemper, Julia Sidorenko, Huanwei Wang, Ben J. Hayes, Naomi R. Wray, Loic Yengo, Matthew C. Keller, Michael Goddard, Peter M. Visscher

“…Here, we investigate the genetic determinants of within-person trait variability of 8 repeatedly measured anthropometric traits in 50,117 individuals from the UK Biobank. We found that within-person (non-directional) variability had a SNP-based heritability of 2–5% for height, sitting height, body mass index (BMI) and weight (P $$\le$$ ≤ 2.4 × 10− 3). …”
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Economics of Biobanking: Business or Public Good? Literature Review, Structural and Thematic Analysis por Vladimír Baláž, Tomáš Jeck, Miroslav Balog

Materias: “…biobanking…”
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Beyond the Formal Mechanisms of Public Engagement. Communicating Biobanking Research with Other Means por Lorenzo Beltrame, Lucia Martinelli, Ilaria Ampollini

Materias: Enlace del recurso

Identification of phenomic data in the pathogenesis of cancers of the gastrointestinal (GI) tract in the UK biobank por Shirin Hui Tan, Catherina Anak Guan, Mohamad Adam Bujang, Wei Hong Lai, Pei Jye Voon, Edmund Ui Hang Sim

“…Given the small proportion of Asians within the UK Biobank, the association between race and GI cancers requires further confirmation.…”
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