uConsent: Addressing the gap in measuring understanding of informed consent in clinical research by Richard F. Ittenbach, J. William Gaynor, Jenny M. Dorich, Nancy B. Burnham, Guixia Huang, Madisen T. Harvey, Jeremy J. Corsmo

“…A total of 109 teens/young adults at a large, pediatric medical center completed the consenting process of a hypothetical biobanking study. Data were analyzed using a combination of classical and modern theory analytic methods to produce a final set of 19 items referred to as the uConsent scale. …”
Get full text

Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma by Johan Mattsson Ulfstedt, Per Venge, Sofia Holmgren, Gunilla Enblad, Staffan Eriksson, Daniel Molin

“…Methods: Serum concentrations of TK1 (S-TK1) were measured in 46 newly diagnosed HL patients using prospectively collected biobanked serum samples. The samples were analyzed using a novel antibody-based TK1 immunosorbent assay (ELISA). …”
Get full text

Metabolomic Changes in Naturally MAP-Infected Holstein–Friesian Heifers Indicate Immunologically Related Biochemical Reprogramming by Emma N. Taylor, Manfred Beckmann, Bernardo Villarreal-Ramos, Hans-Martin Vordermeier, Glyn Hewinson, David Rooke, Luis A. J. Mur, Ad P. Koets

“…Herein, we compare the metabolite profiles of sera from subclinically infected Holstein–Friesian heifers and antibody binding to selected MAP antigens. The study used biobanked serum samples from 10 naturally MAP-infected and 10 control heifers, sampled monthly from ~1 to 19 months of age. …”
Get full text

Establishing the Australian National Endometriosis Clinical and Scientific Trials (NECST) Registry: a protocol paper by Cecilia H M Ng, Andrew G Michelmore, Gita D Mishra, Grant W Montgomery, Peter A Rogers, Jason A Abbott

“…Our data dictionary was developed based on existing and validated questionnaires, tools, meta-data and data cubes – World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project, endometriosis CORE outcomes set, patient-reported outcome measures, the International Statistical Classification of Diseases-10th Revision Australian Modification diagnosis codes and Australian Government datasets: Australian Institute for Health and Welfare (for sociodemographic data), Medicare Benefits Schedule (for medical procedures) and the Pharmaceutical Benefits Scheme (for medical therapies). …”
Get full text

Industrial Development of Standardized Fetal Progenitor Cell Therapy for Tendon Regenerative Medicine: Preliminary Safety in Xenogeneic Transplantation by Alexis Laurent, Philippe Abdel-Sayed, Anthony Grognuz, Corinne Scaletta, Nathalie Hirt-Burri, Murielle Michetti, Anthony S. de Buys Roessingh, Wassim Raffoul, Peter Kronen, Katja Nuss, Brigitte von Rechenberg, Lee Ann Applegate, Salim E. Darwiche

“…Results underlined high robustness of FE002-Ten hFPTs and suitability for sustainable manufacturing upscaling within optimized biobanking workflows. Absence of toxicity or tumorigenicity of hFPTs was demonstrated in ovo and in vitro, respectively. …”
Get full text

Caging the dragon: Research approach to COVID‐19–related thrombosis by Marieke J. H. A. Kruip, Suzanne C. Cannegieter, Hugo ten Cate, Eric C. M. vanGorp, Nicole P. Juffermans, Frederikus A. Klok, Coen Maas, Anton Vonk‐Noordegraaf, Dutch & COVID Thrombosis Coalition study group

“…Within the consortium, clinical data of at least 5000 admitted COVID‐19–infected individuals are available, including substantial collections of biobanked materials in an estimated 3000 people. In addition to considerable experience in preclinical and clinical thrombosis research, the consortium embeds virology‐hemostasis research models within unique biosafety facilities to address fundamental questions on the interaction of virus with epithelial and vascular cells, in relation to the coagulation and inflammatory system. …”
Get full text

Sexual dimorphism of mandibular measures from computed tomographies by Renato Taqueo Placeres ISHIGAME, Alicia PICAPEDRA, Carlos SASSI, Viviane ULBRICHT, Vanessa Gallego Arias PECORARI, Francisco HAITER NETO, Eduardo DARUGE JÚNIOR, Luiz FRANCESQUINI JÚNIOR

“…Objetive: The objective of this study was to analyze mandibular measurements obtained from 225 computed tomography scans of the Osteological and CT Biobanks of Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas, aiming to verify the existence of a relationship between these measures and sexual dimorphism and ancestry. …”
Get full text

Proof of principle study: synchrotron X-ray fluorescence microscopy for identification of previously radioactive microparticles and elemental mapping of FFPE tissues by Letonia Copeland-Hardin, Tatjana Paunesku, Jeffrey S. Murley, Jasson Crentsil, Olga Antipova, LuXi Li, Evan Maxey, Qiaoling Jin, David Hooper, Barry Lai, Si Chen, Gayle E. Woloschak

“…Abstract Biobanks containing formalin-fixed, paraffin-embedded (FFPE) tissues from animals and human atomic-bomb survivors exposed to radioactive particulates remain a vital resource for understanding the molecular effects of radiation exposure. …”
Get full text

Sperm Cryopreservation as a Tool for Amphibian Conservation: Production of F2 Generation Offspring from Cryo-Produced F1 Progeny by Shaina S. Lampert, Isabella J. Burger, Allison R. Julien, Amanda B. Gillis, Andrew J. Kouba, Diane Barber, Carrie K. Kouba

“…Sperm cryopreservation and biobanking are emerging as tools for supporting genetic management of small and threatened populations in amphibian conservation programs. …”
Get full text

Development and validation of a real-time PCR assay for the detection of clinical acanthamoebae by Nessika Karsenti, Rachel Lau, Andrew Purssell, Ann Chong-Kit, Marlou Cunanan, Jason Gasgas, Jinfang Tian, Amanda Wang, Filip Ralevski, Andrea K. Boggild

“…We sought to develop and validate a single Taqman real time PCR assay targeting the Acanthamoeba 18S rRNA gene that could be used to enhance sensitivity and specificity when paired with reference assays. Methods Biobanked DNA from surplus delinked AK clinical specimens and 10 ATCC strains of Acanthamoeba was extracted. …”
Get full text

Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe by Laura Rodriguez Martin, Liese Gilles, Emilie Helte, Agneta Åkesson, Jonas Tägt, Adrian Covaci, Amrit K. Sakhi, An Van Nieuwenhuyse, Andromachi Katsonouri, Anna-Maria Andersson, Arno C. Gutleb, Beata Janasik, Brice Appenzeller, Catherine Gabriel, Cathrine Thomsen, Darja Mazej, Denis Sarigiannis, Elena Anastasi, Fabio Barbone, Hanna Tolonen, Hanne Frederiksen, Jana Klanova, Jani Koponen, Janja Snoj Tratnik, Kim Pack, Koppen Gudrun, Kristin Ólafsdóttir, Lisbeth E. Knudsen, Loïc Rambaud, Loreta Strumylaite, Lubica Palkovicova Murinova, Lucia Fabelova, Margaux Riou, Marika Berglund, Maté Szabados, Medea Imboden, Michelle Laeremans, Milada Eštóková, Natasa Janev Holcer, Nicole Probst-Hensch, Nicole Vodrazkova, Nina Vogel, Pavel Piler, Phillipp Schmidt, Rosa Lange, Sónia Namorado, Szilvia Kozepesy, Tamás Szigeti, Thorhallur I. Halldorsson, Till Weber, Tina Kold Jensen, Valentina Rosolen, Vladimira Puklova, Wojciech Wasowicz, Ovnair Sepai, Lorraine Stewart, Marike Kolossa-Gehring, Marta Esteban-López, Argelia Castaño, Jos Bessems, Greet Schoeters, Eva Govarts

“…For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. …”
Get full text

Increased HIV Incidence in <i>Wuchereria bancrofti</i> Microfilaria Positive Individuals in Tanzania by Jonathan Mnkai, Manuel Ritter, Lucas Maganga, Leonard Maboko, Willyhelmina Olomi, Petra Clowes, Jessica Minich, Agola Eric Lelo, Daniel Kariuki, Alexander Yaw Debrah, Christof Geldmacher, Michael Hoelscher, Elmar Saathoff, Mkunde Chachage, Kenneth Pfarr, Achim Hoerauf, Inge Kroidl

“…Methods: CFA positive but HIV negative biobanked human blood samples (<i>n</i> = 350) were analyzed for <i>W. bancrofti MF</i> chitinase using real time PCR. …”
Get full text

Characterizing circulating nucleosomes in the plasma of dogs with lymphoma by Christopher Dolan, Tasha Miller, Jarvis Jill, Jason Terrell, Theresa Kathleen Kelly, Thomas Bygott, Heather Wilson-Robles

“…The LSA patient samples were recruited from TAMU or purchased from various biobanks. All control cases were recruited from TAMU. …”
Get full text

Mass Customized Outlook for Regenerative Heart Failure Care by Satsuki Yamada, Jozef Bartunek, Atta Behfar, Andre Terzic

“…With the prospect of mass customization, cardiopoietic guidance has been streamlined from the demanding, recombinant protein cocktail-based to a protein-free, messenger RNA-based single gene protocol to engineer affordable cardiac repair competent cells. Clinical trial biobanked stem cells enabled a systems biology deconvolution of the cardiopoietic cell secretome linked to therapeutic benefit, exposing a paracrine mode of action. …”
Get full text

Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof‐of‐concept study by Maxime Meloche, Grégoire Leclair, Martin Jutras, Essaïd Oussaïd, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus

“…Our study suggests that randomly drawn blood samples from biobanks can serve as a new approach to discover genetic associations related to drug concentrations and dosing, with potentially broader implications for genomewide association studies on the pharmacogenomics of drug metabolism.…”
Get full text

Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine by Shanqiang Qu, Rongyang Xu, Guozhong Yi, Zhiyong Li, Huayang Zhang, Songtao Qi, Guanglong Huang

“…It emphasizes the importance of patient-derived tumor organoid biobanks for drug development, screening, safety evaluation, and personalized medicine. …”
Get full text

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index. by Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen

“…Here, we further investigate GPR151 with the Pakistan Genome Resource (PGR), which is one of the largest exome biobanks of human homozygous loss-of-function carriers (knockouts) in the world. …”
Get full text

Germ Cell Isolation and Cryopreservation from Reproductive Organs of Brown Mealworm by Do Gyeung Byeun, Byoung-San Moon, Seungki Lee, Jung Kyu Choi

“…These results provide basic data for reproductive studies of other useful insects and contribute to the biobanking and fertility preservation of superior mealworm germ cells and endangered insects.…”
Get full text

Strategy for Use of Genome-Wide Non-Invasive Prenatal Testing for Rare Autosomal Aneuploidies and Unbalanced Structural Chromosomal Anomalies by Pascale Kleinfinger, Laurence Lohmann, Armelle Luscan, Detlef Trost, Laurent Bidat, Véronique Debarge, Vanina Castaigne, Marie-Victoire Senat, Marie-Pierre Brechard, Lucie Guilbaud, Gwenaël Le Guyader, Véronique Satre, Hélène Laurichesse Delmas, Hakima Lallaoui, Marie-Christine Manca-Pellissier, Aicha Boughalem, Mylene Valduga, Farah Hodeib, Alexandra Benachi, Jean Marc Costa

“…Assay performances were determined using Cohort A, which consisted of 192 biobanked plasma samples—42 with ACAs, and 150 without. …”
Get full text

Ethical issues raised by new genomic technologies: the case study of newborn genome screening by Rachel Horton, Anneke Lucassen

“…However, research with adults by initiatives such as population biobanks should shake our confidence in our ability to make clear health predictions from a genetic code – in many cases, we are learning that the links between genomic variants and disease are far less strong than we once thought. …”
Get full text