Causal associations of particulate matter 2.5 and cardiovascular disease: A two-sample mendelian randomization study. by Ye Cao, Yi Feng, Nan Xia, Jiancheng Zhang

“…<h4>Methods</h4>Genome-wide association study (GWAS) statistics for PM2.5 and CVD were collected from the FinnGen and UK Biobanks. Mendelian randomization analyses were applied to explore the causal effects of PM2.5 on CVD by selecting single-nucleotide polymorphisms(SNP) as instrumental variables.…”
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Charting a roadmap for heart failure research in India: Insights from a qualitative survey by Sivadasanpillai Harikrishnan, Linda Koshy, Sanjay Ganapathi, Panniyammakal Jeemon, Raman Krishna Kumar, Adrija Roy, S Reethu, Surya Ramachandran, L R Lakshmikanth, Meenakshi Sharma, Vijay Kumar Chopra, Dorairaj Prabhakaran, C C Kartha

“…Results: The experts identified a paucity of data on HF burden, lack of state-of-the-art diagnostic facilities and trained personnel, overt dependence on imported devices/equipment/reagents, lack of interaction/awareness/information among stakeholders and lack of biobanks, as major barriers in HF research. Three fourths of the experts agreed that lack of interaction among stakeholders was the major challenge with the highest inter-rater agreement in both stages (19 out of 25 and 11 out of 17, respectively). …”
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Sarcoptic mange severity is associated with reduced genomic variation and evidence of selection in Yellowstone National Park wolves (Canis lupus) by Alexandra L. DeCandia, Edward C. Schrom, Ellen E. Brandell, Daniel R. Stahler, Bridgett M. vonHoldt

“…Using gray wolves (Canis lupus) reintroduced to Yellowstone National Park (YNP) as our focal system, we leveraged 25 years of observational data and biobanked blood and tissue to genotype 76,859 loci in over 400 wolves. …”
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<i>Escherichia coli</i> K-12 Transcriptomics for Assessing the Mechanism of Action of High-Power Ultrasound by David Spiteri, Sholeem Griffin, Kimon Andreas Karatzas, Christian Scerri, Vasilis P. Valdramidis

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460 Adaptive Capacity and Preparedness of CTSAs: The Environmental Scan Approach and Findings by Boris B Volkov, Veronica Hoyo

“…Some of the findings include: - Roadmaps for the creation of new collaborative research resources (biobanks; data repositories, etc.); - Rapid clinical and research decision making during public health crises; - New community-based research strategies to facilitate communication, research dissemination, and participant recruitment based on existing trust-based networks; - Innovative resource allocation to guarantee continuity of training and research opportunities for trainees. …”
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Molecular mechanism and potential therapeutic targets of liver metastasis from gastric cancer by Difeng Li, Xin Zhang, Xin Zhang, Xin Zhang, Lili Jiang

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A novel SPINK5 donor splice site variant in a child with Netherton syndrome by Dillon Mintoff, Isabella Borg, Julia Vornweg, Liam Mercieca, Rijad Merdzanic, Johannes Numrich, Susan Aquilina, Nikolai Paul Pace, Judith Fischer

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Current Status and Future Prospects of Perinatal Stem Cells by Paz de la Torre, Ana I. Flores

“…Cord blood has been a well-known source of hematopoietic stem/progenitor cells since 1974. Biobanked cord blood has been used to treat different hematological and immunological disorders for over 30 years. …”
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Building diagnostic systems in Sierra Leone: The role of point-of-care devices in laboratory strengthening by Rashid Ansumana, Fatmata Bah, Kan Biao, Doris Harding, Mohamed B. Jalloh, Ann H. Kelly, Francess Koker, Zikan Koroma, Mambu Momoh, Mohamed H. Rogers, James Rogers, Alice Street, Eva Vernooij, Isatta Wurie

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An Analysis of Mechanisms for Cellular Uptake of miRNAs to Enhance Drug Delivery and Efficacy in Cancer Chemoresistance by Justine M. Grixti, Duncan Ayers, Philip J. R. Day

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Renal tissue thawed for 30 minutes is still suitable for gene expression analysis. by Yi Ma, Xiao-Nan Kang, Wen-Bin Ding, Hao-Zheng Yang, Ye Wang, Jin Zhang, Yi-Ran Huang, Hui-Li Dai

“…Some biosamples obtained from biobanks may go through thawing before processing. …”
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Severity of COVID-19 at elevated exposure to perfluorinated alkylates. by Philippe Grandjean, Clara Amalie Gade Timmermann, Marie Kruse, Flemming Nielsen, Pernille Just Vinholt, Lasse Boding, Carsten Heilmann, Kåre Mølbak

“…<h4>Methods</h4>From Danish biobanks, we obtained plasma samples from 323 subjects aged 30-70 years with known SARS-CoV-2 infection. …”
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A Novel Approach for Ovine Primary Alveolar Epithelial Type II Cell Isolation and Culture from Fresh and Cryopreserved Tissue Obtained from Premature and Juvenile Animals. by Mariola M Marcinkiewicz, Sandy T Baker, Jichuan Wu, Terrence L Hubert, Marla R Wolfson

“…These data demonstrate a cell culture methodology using fresh or cryopreserved tissue to support study of ovine primary ATII cell function and responses, to support expanded use of biobanked tissues, and to further understanding of mechanisms that contribute to in vivo function of the lung.…”
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A structural variation reference for medical and population genetics

“…Structural variants (SVs) rearrange large segments of DNA1 and can have profound consequences in evolution and human disease2,3. As national biobanks, disease-association studies, and clinical genetic testing have grown increasingly reliant on genome sequencing, population references such as the Genome Aggregation Database (gnomAD)4 have become integral in the interpretation of single-nucleotide variants (SNVs)5. …”
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A structural variation reference for medical and population genetics by Lander, Eric Steven

“…Structural variants (SVs) rearrange large segments of DNA1 and can have profound consequences in evolution and human disease2,3. As national biobanks, disease-association studies, and clinical genetic testing have grown increasingly reliant on genome sequencing, population references such as the Genome Aggregation Database (gnomAD)4 have become integral in the interpretation of single-nucleotide variants (SNVs)5. …”
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Toll-like receptor 7 protects from atherosclerosis by constraining "inflammatory" macrophage activation. by Salagianni, M, Galani, I, Lundberg, A, Davos, C, Varela, A, Gavriil, A, Lyytikäinen, L, Lehtimäki, T, Sigala, F, Folkersen, L, Gorgoulis, V, Lenglet, S, Montecucco, F, Mach, F, Hedin, U, Hansson, G, Monaco, C, Andreakos, E

“…METHODS AND RESULTS: We used experimental mouse models, human atheroma cultures, and well-established human biobanks to investigate the role of TLR7 in atherosclerosis. …”

Toll-like receptor 7 protects from atherosclerosis by constraining inflammatory macrophage activation by Salagianni, M, Galani, I, Lundberg, A, Davos, C, Varela, A, Gavriil, A, Lyytikäinen, L, Lehtimäki, T, Sigala, F, Folkersen, L, Gorgoulis, V, Lenglet, S, Montecucco, F, MacH, F, Hedin, U, Hansson, G, Monaco, C, Andreakos, E

“…Methods and Results: We used experimental mouse models, human atheroma cultures, and well-established human biobanks to investigate the role of TLR7 in atherosclerosis. …”

Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies. by Fortier, I, Burton, P, Robson, P, Ferretti, V, Little, J, L'Heureux, F, Deschênes, M, Knoppers, B, Doiron, D, Keers, J, Linksted, P, Harris, JR, Lachance, G, Boileau, C, Pedersen, N, Hamilton, C, Hveem, K, Borugian, M, Gallagher, R, McLaughlin, J, Parker, L, Potter, J, Gallacher, J, Kaaks, R, Liu, B

“…METHODS: This conceptual article describes the origins, purpose and scientific foundations of the DataSHaPER (DataSchema and Harmonization Platform for Epidemiological Research; http://www.datashaper.org), which has been created by a multidisciplinary consortium of experts that was pulled together and coordinated by three international organizations: P³G (Public Population Project in Genomics), PHOEBE (Promoting Harmonization of Epidemiological Biobanks in Europe) and CPT (Canadian Partnership for Tomorrow Project). …”

Exploring the crop epigenome: a comparison of DNA methylation profiling techniques by Dolores Rita Agius, Dolores Rita Agius, Aliki Kapazoglou, Evangelia Avramidou, Miroslav Baranek, Elena Carneros, Elena Caro, Stefano Castiglione, Angela Cicatelli, Aleksandra Radanovic, Jean-Paul Ebejer, Daniel Gackowski, Francesco Guarino, Andrea Gulyás, Norbert Hidvégi, Hans Hoenicka, Vera Inácio, Frank Johannes, Erna Karalija, Michal Lieberman-Lazarovich, Federico Martinelli, Stéphane Maury, Velimir Mladenov, Leonor Morais-Cecílio, Ales Pecinka, Eleni Tani, Pilar S. Testillano, Dimitar Todorov, Luis Valledor, Valya Vassileva

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Elevated UTI Biomarkers in Symptomatic Patients with Urine Microbial Densities of 10,000 CFU/mL Indicate a Lower Threshold for Diagnosing UTIs by Laura K. S. Parnell, Natalie Luke, Mohit Mathur, Richard A. Festa, Emery Haley, Jimin Wang, Yan Jiang, Lori Anderson, David Baunoch

“…The objective was to identify the microbial densities associated with significant elevation of these biomarkers in order to determine an optimal threshold for diagnosing symptomatic UTIs. Biobanked midstream voided urine samples were analyzed for microbial identification and quantification using standard urine culture (SUC) and multiplex-polymerase chain reaction (M-PCR) testing, while NGAL, IL-8, and IL-1β levels were measured via enzyme-linked immunosorbent assay (ELISA). …”
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