Genetic and clinical determinants of telomere length by Patrick Allaire, Jing He, John Mayer, Luke Moat, Peter Gerstenberger, Reynor Wilhorn, Sierra Strutz, David S.L. Kim, Chenjie Zeng, Nancy Cox, Jerry W. Shay, Joshua Denny, Lisa Bastarache, Scott Hebbring

“…Using two large patient populations derived from Vanderbilt University and Marshfield Clinic biobanks linked to genomic and phenomic data from medical records, we investigated the inter-relationship between LTL, genomics, and human health. …”
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Pre‐emptive treatment of heart failure exacerbations in patients managed with the HeartLogic™ algorithm by Rodrigue Garcia, Daniel Gras, Jacques Mansourati, Pascal Defaye, Arnaud Bisson, Serge Boveda, Estelle Gandjbakhch, Matthieu Gras, Jean‐Pierre Gueffet, Caroline Himbert, Peggy Jacon, Pierre Khattar, Benoit Lequeux, Anthony Li, Vincent Mansourati, Damien Minois, Eloi Marijon, Bertrand Pierre, Vincent Probst, Bruno Degand, the HeartLogic™ France Cohort Study Investigators

“…Blood samples will be collected for biobanking, and quality of life will be assessed. Finally, the safety of a HeartLogic™‐triggered strategy for initiating or increasing diuretic therapy will be assessed. …”
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Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands by Kiki Streng, Pauline A. de Best, Aura Timen, Marion P.G. Koopmans, Wim H.M. van der Poel, Reina S. Sikkema

“…Barriers for sharing may be overcome by increasing familiarity with legislation, building (international) sharing networks and agreements before crises occur and developing systems for sample registration and biobanking. Proactive setting up of ethical approvals will allow for rapid animal sample collection to identify EID hosts and potential spillovers.…”
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GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer by Alba Galan, Arturo Papaluca, Arturo Papaluca, Ali Nejatie, Ali Nejatie, Emad Matanes, Emad Matanes, Fouad Brahimi, Wenyong Tong, Wenyong Tong, Ibrahim Yaseen Hachim, Amber Yasmeen, Euridice Carmona, Kathleen Oros Klein, Kathleen Oros Klein, Sonja Billes, Ahmed E. Dawod, Prasad Gawande, Anna Milik Jeter, Anne-Marie Mes-Masson, Anne-Marie Mes-Masson, Celia M. T. Greenwood, Celia M. T. Greenwood, Walter H. Gotlieb, Walter H. Gotlieb, H. Uri Saragovi, H. Uri Saragovi, H. Uri Saragovi

“…We investigated the diagnostic utility of GD2 and GD3 for diagnosis of all subtypes and stages of OC.MethodsThis retrospective study evaluated GD2 and GD3 expression in biobanked tissue and serum samples from patients with invasive epithelial OC, healthy donors, non-malignant gynecological conditions, and other cancers. …”
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Platelet removal from human blood plasma improves detection of extracellular vesicle‐associated miRNA by Jillian W. P. Bracht, Mandy Los, Monique A. J. vanEijndhoven, Britta Bettin, Edwin van derPol, D. Michiel Pegtel, Rienk Nieuwland

“…Therefore, we recommend to measure and report the plasma concentration of platelets for EV‐miRNA studies, and to filter plasma before downstream analyses or storage in biobanks.…”
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AI4AD: Artificial intelligence analysis for Alzheimer's disease classification based on a multisite DTI database by Yida Qu, Pan Wang, Bing Liu, Chengyuan Song, Dawei Wang, Hongwei Yang, Zengqiang Zhang, Pindong Chen, Xiaopeng Kang, Kai Du, Hongxiang Yao, Bo Zhou, Tong Han, Nianming Zuo, Ying Han, Jie Lu, Chunshui Yu, Xi Zhang, Tianzi Jiang, Yuying Zhou, Yong Liu

“…Methods: We conducted a competition with diffusion measurements along 18 fiber tracts as features extracted via the automated fiber quantification (AFQ) method based on one of the largest worldwide DTI multisite biobanks (862 individuals, consisting of 279 NCs, 318 ADs, and 265 MCIs). …”
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A comparative profile of total protein and six angiogenically-active growth factors in three platelet products by Custo, Scott, Baron, Byron, Felice, Alex, Seria, Elisa

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Organoid factory: The recent role of the human induced pluripotent stem cells (hiPSCs) in precision medicine by Giuseppe Novelli, Giuseppe Novelli, Giuseppe Novelli, Paola Spitalieri, Michela Murdocca, Eleonora Centanini, Federica Sangiuolo

“…Hence, in the context of drug discovery, Organoid Factories can offer biobanks of validated 3D organoid models that can be used in collaboration with pharmaceutical companies to speed up the drug screening process. …”
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Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers by Shijie Wang, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Aasly, Andrew B. West

“…LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylation at serine 1292 (pS1292) and neurotoxicity in model systems. pS1292-LRRK2 protein can be packaged into exosomes and measured in biobanked urine. Herein we provide evidence that pS1292-LRRK2 protein is robustly expressed in cerebral spinal fluid (CSF) exosomes. …”
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Estimating health related quality of life effects in vitiligo. Mapping EQ-5D-5 L utilities from vitiligo specific scales: VNS, VitiQoL and re-pigmentation measures using data from... by Rabiah Begum, Ralph Crott, Reynaldo Martina, Eleni M. Loizidou, Iftekhar Khan

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Record linkage based patient intersection cardinality for rare disease studies using Mainzelliste and secure multi-party computation by Tobias Kussel, Torben Brenner, Galina Tremper, Josef Schepers, Martin Lablans, Kay Hamacher

“…Abstract Background The low number of patients suffering from any given rare diseases poses a difficult problem for medical research: With the exception of some specialized biobanks and disease registries, potential study participants’ information are disjoint and distributed over many medical institutions. …”
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Global, regional, and national burden and trends analysis of gallbladder and biliary tract cancer from 1990 to 2019 and predictions to 2030: a systematic analysis for the Global Bu... by Jiao Su, Yuanhao Liang, Xiaofeng He

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Whole‐exome sequencing provides insights into monogenic disease prevalence in Northwest Russia by Yury A. Barbitoff, Rostislav K. Skitchenko, Olga I. Poleshchuk, Anton E. Shikov, Elena A. Serebryakova, Yulia A. Nasykhova, Dmitrii E. Polev, Anna R. Shuvalova, Irina V. Shcherbakova, Mikhail A. Fedyakov, Oleg S. Glotov, Andrey S. Glotov, Alexander V. Predeus

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Aragon workers’ health study – design and cohort description by Casasnovas José A, Alcaide Victor, Civeira Fernando, Guallar Eliseo, Ibañez Borja, Borreguero Jesús, Laclaustra Martin, León Montserrat, Peñalvo José, Ordovás José M, Pocovi Miguel, Sanz Ginés, Fuster Valentín

“…Study participants will undergo annual clinical exams and laboratory assays, and baseline and triennial collection of biological materials for biobanking and cardiovascular imaging exams (carotid, femoral and abdominal ultrasonography, coronary calcium score, and ankle-arm blood pressure index). …”
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The plasma degradome reflects later development of NASH fibrosis after liver transplant by Jiang Li, Toshifumi Sato, María Hernández-Tejero, Juliane I. Beier, Khaled Sayed, Panayiotis V. Benos, Daniel W. Wilkey, Abhinav Humar, Michael L. Merchant, Andres Duarte-Rojo, Gavin E. Arteel

“…To investigate whether liver injury caused by post-LT NASH would yield a unique degradome profile that is predictive of severe post-LT NASH fibrosis, a retrospective analysis of 22 biobanked samples from the Starzl Transplantation Institute (12 with post-LT NASH after 5 years and 10 without) was performed. …”
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Levels of angiogenesis markers in patients with different heart failure phenotypes by R. N. Shepel, O. M. Drapkina

“…All patients included in the study signed an informed consent to personal data processing, participation in a clinical trial and consent to blood biobanking. All patients were divided into three groups: HF with reduced ejection fraction (HFrEF)  — left ventricular (LV) EF <40%, HF with mildly reduced EF (HFmrEF) — LVEF from 40 to 49%, HF with preserved EF (HFpEF)  — LVEF >49%. …”
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Can Intelligence Affect Alcohol-, Smoking-, and Physical Activity-Related Behaviors? A Mendelian Randomization Study by Hansen Li, Xing Zhang, Xinyue Zhang, Zhenhuan Wang, Siyuan Feng, Guodong Zhang

“…We obtained genome-wide association study (GWAS) datasets concerning these variables from separate studies or biobanks and used inverse-variance weighted (IVW) or MR-Egger estimator to evaluate the causal effects according to an MR protocol. …”
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Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. by Jennifer R Malinowski, Joshua C Denny, Suzette J Bielinski, Melissa A Basford, Yuki Bradford, Peggy L Peissig, David Carrell, David R Crosslin, Jyotishman Pathak, Luke Rasmussen, Jennifer Pacheco, Abel Kho, Katherine M Newton, Rongling Li, Iftikhar J Kullo, Christopher G Chute, Rex L Chisholm, Gail P Jarvik, Eric B Larson, Catherine A McCarty, Daniel R Masys, Dan M Roden, Mariza de Andrade, Marylyn D Ritchie, Dana C Crawford

“…The Electronic Medical Records and Genomics (eMERGE) Network is a collaboration across institutions with biobanks linked to electronic medical records (EMRs). …”
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First report of cutaneous leishmaniasis caused by Leishmania donovani in Ethiopia by Gashaw Azanaw Amare, Gebeyaw Getnet Mekonnen, Mekibib Kassa, Ayenew Addisu, Desalegn Adane Kendie, Banchamlak Tegegne, Adugna Abera, Dagimawie Tadesse, Seid Getahun, Yenesew Mihret Wondmagegn, Behailu Merdekios, Mezgebu Silamsaw Asres, Johan van Griensven, Gert Van der Auwera, Saskia van Henten, Myrthe Pareyn

“…Methods We analyzed stored routine samples and biobanked DNA isolates from previously conducted studies of CL patients from different centers in the north, center and south of Ethiopia. …”
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Cardiomyocyte Injury Following Acute Ischemic Stroke: Protocol for a Prospective Observational Cohort Study by Stengl, Helena, Ganeshan, Ramanan, Hellwig, Simon, Blaszczyk, Edyta, Fiebach, Jochen B, Nolte, Christian H, Bauer, Axel, Schulz-Menger, Jeanette, Endres, Matthias, Scheitz, Jan F

“…In addition, they will receive 3 Tesla cardiovascular MRI and transthoracic echocardiography within 5 days of symptom onset to provide myocardial tissue characterization and assess cardiac function, 20-min high-resolution electrocardiogram for analysis of cardiac autonomic function, and extensive biobanking. A follow-up for cardiovascular events will be conducted 3 and 12 months after inclusion. …”
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