4-Membered Ring Carbocations: A Positive Development in the Synthesis of 3,3-Disubstituted Oxetanes and Azetidines by Juan J. Rojas, James A. Bull

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Computational bioprospecting of andrographolide derivatives as potent cyclooxygenase-2 inhibitors by Somdutt Mujwar

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(Bio)isosteres of ortho- and meta-substituted benzenes by H. Erik Diepers, Johannes C. L. Walker

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BoBER: web interface to the base of bioisosterically exchangeable replacements by Samo Lešnik, Blaž Škrlj, Nika Eržen, Urban Bren, Stanislav Gobec, Janez Konc, Dušanka Janežič

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Heterocyclic Chemistry Applied to the Design of <i>N</i>-Acyl Homoserine Lactone Analogues as Bacterial Quorum Sensing Signals Mimics by Qiang Zhang, Sizhe Li, Maha Hachicha, Mohamed Boukraa, Laurent Soulère, Mohamed L. Efrit, Yves Queneau

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2-Heteroarylethylamines in medicinal chemistry: a review of 2-phenethylamine satellite chemical space by Carlos Nieto, Alejandro Manchado, Ángel García-González, David Díez, Narciso M. Garrido

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BDSF Analogues Inhibit Quorum Sensing-Regulated Biofilm Production in <i>Xylella fastidiosa</i> by Conor Horgan, Clelia Baccari, Michelle O’Driscoll, Steven E. Lindow, Timothy P. O’Sullivan

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Microwave assisted one pot synthesis of 2-alkyl amino benzimidazoles, 2-alkyl amino benzoxazoles and 2-alkyl amino benzthiazoles by using various carbodiimides by Thirupathi Rapolu, Polkam Naveen, K.V.P. Pavan Kumar, Krishnakanth Reddy Leleti, Raghubabu korapolu

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Reductive Functionalization of Amides in Synthesis and for Modification of Bioactive Compounds by Paweł J. Czerwiński, Bartłomiej Furman

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Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators by Siyuan Tang, Miguel Garzon Sanz, Oliver Smith, Andreas Krämer, Daniel Egbase, Paul W. Caton, Stefan Knapp, Sam Butterworth

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Synthesis and characterization of novel bioactive 1,2,4-oxadiazole natural product analogs bearing the N-phenylmaleimide and N-phenylsuccinimide moieties by Catalin V. Maftei, Elena Fodor, Peter G. Jones, M. Heiko Franz, Gerhard Kelter, Heiner Fiebig, Ion Neda

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Insertion of [1.1.1]propellane into aromatic disulfides by Robin M. Bär, Gregor Heinrich, Martin Nieger, Olaf Fuhr, Stefan Bräse

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Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency by Megan E. Meuser, Michael B. Murphy, Adel A. Rashad, Simon Cocklin

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Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor by Megan E. Meuser, Adel A. Rashad, Gabriel Ozorowski, Alexej Dick, Andrew B. Ward, Simon Cocklin

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Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency by Megan E. Meuser, Michael B. Murphy, Adel A. Rashad, Simon Cocklin

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Effect of Selected Silyl Groups on the Anticancer Activity of 3,4-Dibromo-5-Hydroxy-Furan-2(5<i>H</i>)-One Derivatives by Radoslaw Kitel, Anna Byczek-Wyrostek, Katarzyna Hopko, Anna Kasprzycka, Krzysztof Walczak

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Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications by Daniela Perrone, Elena Marchesi, Lorenzo Preti, Maria Luisa Navacchia

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The emerging role of radical chemistry in the amination transformation of highly strained [1.1.1]propellane: Bicyclo[1.1.1]pentylamine as bioisosteres of anilines by Qiwen Pang, Yang Li, Xin Xie, Jie Tang, Qian Liu, Cheng Peng, Xiang Li, Bo Han

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The Compound <i>(E)</i>-2-Cyano-<i>N</i>,3-diphenylacrylamide (JMPR-01): A Potential Drug for Treatment of Inflammatory Diseases by Pablo Rayff da Silva, Renan Fernandes do Espírito Santo, Camila de Oliveira Melo, Fábio Emanuel Pachú Cavalcante, Thássia Borges Costa, Yasmim Vilarim Barbosa, Yvnni M. S. de Medeiros e Silva, Natália Ferreira de Sousa, Cristiane Flora Villarreal, Ricardo Olímpio de Moura, Vanda Lucia dos Santos

Subjects: “…bioisosterism…”
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Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant by Gabriela Alves de Souza, Soraia John da Silva, Catarina de Nigris Del Cistia, Paulo Pitasse-Santos, Lucas de Oliveira Pires, Yulli Moraes Passos, Yraima Cordeiro, Cristiane Martins Cardoso, Rosane Nora Castro, Carlos Mauricio R. Sant’Anna, Arthur Eugen Kümmerle

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