Fullerenes’ Interactions with Plasma Membranes: Insight from the MD Simulations by Nililla Nisoh, Viwan Jarerattanachat, Mikko Karttunen, Jirasak Wong-ekkabut

“…Understanding the interactions between carbon nanoparticles (CNPs) and biological membranes is critically important for applications of CNPs in biomedicine and toxicology. …”
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Influence of ω-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver by O. V. Maksymchuk

“…Polyunsaturated fatty acids (PUFAs), ω-3 ones in particular, form phospholipid layer of biological membranes, which provides normal functioning of membrane-associated complexes of enzymes and transmembrane transport. …”

Novel Naproxen Salts with Increased Skin Permeability by Ewelina Świątek, Paula Ossowicz-Rupniewska, Ewa Janus, Anna Nowak, Peter Sobolewski, Wiktoria Duchnik, Łukasz Kucharski, Adam Klimowicz

“…The obtained naproxen derivatives showed improved solubility and higher absorption of drug molecules by biological membranes. Their lipophilicity was lower and increased with the increase in the alkyl chain of the ester. …”
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Nonreplicating Adenoviral Vectors: Improving Tropism and Delivery of Cancer Gene Therapy by Nayara Gusmão Tessarollo, Ana Carolina M. Domingues, Fernanda Antunes, Jean Carlos dos Santos da Luz, Otavio Augusto Rodrigues, Otto Luiz Dutra Cerqueira, Bryan E. Strauss

“…On the other hand, adenoviral vectors are amenable to strategies for the modification of their biological structures, including genetic manipulation of viral proteins, pseudotyping, and conjugation with polymers or biological membranes. Such modifications provide greater specificity to the target cell and better safety in systemic administration; thus, a reduction of antiviral host responses would favor the use of adenoviral vectors in cancer immunotherapy. …”
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Ion channels in neurodevelopment: lessons from the Integrin-KCNB1 channel complex by Alessandro Bortolami, Federico Sesti

“…Ion channels modulate cellular excitability by regulating ionic fluxes across biological membranes. Pathogenic mutations in ion channel genes give rise to epileptic disorders that are among the most frequent neurological diseases affecting millions of individuals worldwide. …”
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Flavonoids: Antiplatelet Effect as Inhibitors of COX-1 by Cristina Zaragozá, Miguel Ángel Álvarez-Mon, Francisco Zaragozá, Lucinda Villaescusa

“…The results obtained showed that quercetin and diosmetin aglycones have a greater antiplatelet effect and inhibit the COX enzyme activity to a greater extent than their heterosides; however, the fact that greater inhibition of the pure recombinant enzyme was achieved by heterosides suggests that these compounds may have difficulty in crossing biological membranes. In any case, in view of the results obtained, it can be concluded that flavonoids could be useful as coadjuvants in the treatment of cardiovascular pathologies.…”
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Topoisomeric Membrane-Active Peptides: A Review of the Last Two Decades by Adam Carrera-Aubesart, Maria Gallo, Sira Defaus, Toni Todorovski, David Andreu

“…In recent decades, bioactive peptides have been gaining recognition in various biomedical areas, such as intracellular drug delivery (cell-penetrating peptides, CPPs) or anti-infective action (antimicrobial peptides, AMPs), closely associated to their distinct mode of interaction with biological membranes. Exploiting the interaction of membrane-active peptides with diverse targets (healthy, tumoral, bacterial or parasitic cell membranes) is opening encouraging prospects for peptides in therapeutics. …”
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Polymer Nanocontainers by Wolfgang Peter Meier

“…The most promising materials in this respect are amphiphilic block copolymers that can be easily designed to mimic biological membranes. Similar to conventional lipids, appropriate amphiphilic block copolymers may also self-assemble in aqueous media to vesicular structures that can be stabilized by polymerization. …”
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Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance by Carole Ayoub Moubareck

“…With an initial known effect on biological membranes, research has uncovered the detailed molecular and chemical interactions that polymyxins have with Gram-negative outer membranes and lipopolysaccharide structure. …”
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Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins by Ng, Benjamin S. H., Shyu Jr., Peter, Ho, Nurulain, Chaw, Ruijie, Seah, Yi Ling, Marvalim, Charlie, Thibault, Guillaume

“…Phospholipid homeostasis in biological membranes is essential to maintain functions of organelles such as the endoplasmic reticulum. …”
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Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. by Lemberg, M, Menendez, J, Misik, A, Garcia, M, Koth, C, Freeman, M

“…Our results suggest that detergent-solubilised rhomboid activity mimics its activity in biological membranes in many aspects. Analysis of purified mutant proteins suggests that rhomboids use a serine protease catalytic dyad instead of the previously proposed triad. …”

Structure and assembly of calcium homeostasis modulator proteins by Syrjanen, JL, Michalski, K, Chou, T-H, Grant, T, Rao, S, Simorowski, N, Tucker, SJ, Grigorieff, N, Furukawa, H

“…The biological membranes of many cell types contain large-pore channels through which a wide variety of ions and metabolites permeate. …”

Computational studies of membrane proteins: from sequence to structure to simulation. by Stansfeld, P

“…In this review, I discuss the recent advances in computational approaches to studying membrane protein structures, covering the latest methods for predicting a protein structure from its amino acid sequence, through to methods for assessing the structural dynamics and lipid interactions within molecular simulations of complex biological membranes. These approaches have not only benefited from advances in the computational software and architectures, but have also been assisted by a prodigious rise in the number of both the molecular sequences and experimentally determined membrane protein structures. …”

A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates by Rao, S, Klesse, G, Stansfeld, PJ, Tucker, SJ, Sansom, M

“…Ion channel proteins control ionic flux across biological membranes through conformational changes in their transmembrane pores. …”

Novel Chloro-Substituted Salicylanilide Derivatives and Their β-Cyclodextrin Complexes: Synthesis, Characterization, and Antibacterial Activity by Ioana Maria Carmen Ienașcu, Adina Căta, Mariana Nela Ştefănuț, Iuliana Popescu, Gerlinde Rusu, Paula Sfîrloagă, Daniel Ursu, Cristina Moşoarcă, Anamaria Dabici, Corina Danciu, Delia Muntean, Raluca Pop

“…In order to improve water solubility, chemical and physical stability, and drug distribution through biological membranes, the inclusion complexes of the ethyl esters in β-cyclodextrin were also obtained using kneading. …”
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Investigation of nano- and microdomains formed by ceramide 1 phosphate in lipid bilayers by Dominik Drabik, Mitja Drab, Samo Penič, Aleš Iglič, Aleksander Czogalla

“…Abstract Biological membranes are renowned for their intricate complexity, with the formation of membrane domains being pivotal to the successful execution of numerous cellular processes. …”
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The Bacteriostatic Activity of 2-Phenylethanol Derivatives Correlates with Membrane Binding Affinity by Isabel S. Kleinwächter, Stefanie Pannwitt, Alessia Centi, Nadja Hellmann, Eckhard Thines, Tristan Bereau, Dirk Schneider

“…While aromatic alcohols, such as 2-phenylethanol, also insert into lipid bilayers and disturb the membrane organization, the impact of aromatic alcohols on the structure of biological membranes, as well as the potential physiological implication of membrane incorporation has only been studied to a limited extent. …”
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Amorphous Inclusion Complexes: Molecular Interactions of Hesperidin and Hesperetin with HP-Β-CD and Their Biological Effects by Kamil Wdowiak, Natalia Rosiak, Ewa Tykarska, Marcin Żarowski, Anita Płazińska, Wojciech Płaziński, Judyta Cielecka-Piontek

“…Permeability studies revealed that Hed has difficulties in crossing biological membranes, in contrast with Het, which can be considered to be well absorbed. …”
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Simulation toolkits at the molecular scale for trans-scale thermal signaling by Ikuo Kurisaki, Madoka Suzuki

“…Additionally, theoretical simulations to estimate these thermal properties in biological membranes and proteins are introduced. Finally, we envisage the future direction of this research field.…”
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Recent Advances in Hybrid Biomimetic Polymer-Based Films: from Assembly to Applications by Agata Krywko-Cendrowska, Stefano di Leone, Maryame Bina, Saziye Yorulmaz-Avsar, Cornelia G. Palivan, Wolfgang Meier

“…Biological membranes, in addition to being a cell boundary, can host a variety of proteins that are involved in different biological functions, including selective nutrient transport, signal transduction, inter- and intra-cellular communication, and cell-cell recognition. …”
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